- 著者
-
西谷 春香
水野 洋
円城寺 克也
則武 健一
- 出版者
- 日本毒性学会
- 雑誌
- 日本毒性学会学術年会
- 巻号頁・発行日
- vol.47, pp.P-175, 2020
<p>【Introduction】We compared body temperature (BT) in non-rodents between a temperature-sensing microchip (IPTT-300, BMDS) and traditional rectal thermometer (RT) or telemetry devices. We also compared the BT changes in several implantation sites to seek the optimal implantation site for microchips.</p><p>【Methods】Microchips were implanted subcutaneously at 3 sites (chest, thigh, and interscapular region) in telemetered monkeys (4 males), and at 3 sites (chest, neck, and interscapular region) in dogs (2 males and 2 females). Animals were dosed intramuscularly with medetomidine (α2 adrenergic agonist) at 0.15 mg/kg (monkeys) and 0.2 mg/kg (dogs) , and BT was measured predose and at 15 min intervals postdose until recovery using the microchips, RT, and telemetry devices (monkeys only).</p><p>【Results】All three methods recorded decreases in BTs with medetomidine. In monkeys, The interscapular microchips BTs were similar to the rectal and telemetry temperatures, and other 2 sites were lower than them. In dogs, there were no clear differences in BTs in the 3 sites, and degree of changes in BT by microchips was similar to the RT.</p><p>【Conclusion】Microchips are useful tools for BT measurement. The advantage of microchips include that there are quick and less invasive compared to a RT. The best implantation site of microchips was interscapular subcutis in both dogs and monkeys.</p>