著者

後藤 由夫 阿部 隆三 及川 真一 佐野 隆一 藤井 豊

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.12, no.6, pp.1351-1357, 1985

著者

阿部 隆三 及川 真一 佐野 隆一 藤井 豊 義江 和子 後藤 由夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.12, no.4, pp.951-956, 1984

---

In the present study, effect of probucol (500mg×2, daily) on serum lipids and lipoproteins in S. F. family who showed typical familial hyper-cholesterolemia (FH) were investigated. The results were as follows:<br>1) The values of serum cholesterol (TC) before and after treatment of probucol were 348±14mg/dl and 220±12mg/dl, respectively. These data shows significant reduction of serum cholesterol after treatment of probucol. The percent of reduction of serum cholesterol was 36.4%. This value was significantly higher than the value (17%) in the other FH.<br>2) Though levels of LDL- and HDL-C were decreased after treatment of probucol, LDL-C level was markedly decrease in S. F family as compared with other FH. Reduction of HDL-C after treatment of probucol was not significant difference between in S. F family and other FH.<br>3) Total biliary lipids after treatment of probucol increased from 68.8μmol/ml to 141.9μmol/ml in a patient of S. F family. Level of bile acid increased after treatment of probucol, especially, in this case. On the other hand, the change of biliary lipids after treatment of probucol was not seen in other FH.<br>From these data, though mechanism of marked reduction of LDL-C in S. F family after treatment of probucol was still unclear, metabolism of cholesterol to synthesis of bile acid might have especially involved to marked reduction of serum LDL-C in S. F family.

著者

佐野 隆一 藤井 豊 義江 和子 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.13, no.2, pp.349-353, 1985

---

Three dysbetalipoproteinemic subjects with the E 2/2 homozygous phenotype were analysed serum lipoproteins and serum apolipoprotein E and B levels. Two subjects were normocholesterolemic and one was hypercholesterolemic (type III hyperlipoproteinemia). A patient with type III phenotype had cholesterol-rich VLDL, although the other two normocholesterolemic subjects didn't have it. Both normo- and hypercholesterolemic subjects had elevated levels of serum apo E and a reduction in serum apo B. Therefore, serum apo E/apo B ratio of a patient with type III phenotype was extremely high as compared with other lipoprotein disorders. These ratio of normocholesterolemic dysbetalipoproteinemia was also high as compared with those except for type V hyperlipoproteinemia. It is suggested that dysbetalipoproteinemia might be easily caught in general population by screening examination of serum apo E/apo B ratio.

著者

佐野 隆一 阿部 隆三 平川 秀紀 金沢 義彦 小泉 勝 豊田 隆謙 後藤 由夫 及川 真一

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.11, no.3, pp.671-676, 1983

---

In the present study, the effect of probucol (500mg×2, daily) on serum lipids and lipoproteirs level were studied in 9 patients with familial hypercholesterolemia (FH) during 3-4 months. The diagnosis of FH was established according to the criteria both of Fredrickson et al and of Makuchi et al. Thickness of Achilles tendon was over 9mm in all patients and the xanthomas were observed in 4 of 9 patients.<br>Before and 3-4 months after treatment of probucol the measurement of serum triglyceride (TG), total cholesterol (TC) and apolipoprotein (Apo) A-I and A-II were made. At the same time, serum VLDL, LDL, HDL₂ and HDL₃ were separated by successive ultracentrifugation. Thereafter, TG, TC and protein of each lipoprotein fraction were measured.<br>TG and TC were determined by enzymatic method, Apo A-I and A-II were done by single immunodiffusion assay, and protein was done by dye-binding method.<br>All data were expressed as mean ±S.E. and statistically analized by Student's t-test.<br>The results were as follows:<br>1) VLDL-TG levels were slightly increased, although no significance was found between VLDL-TG level before and after treatment.<br>2) The levels of serum TC were 388±37mg/dl and 308±28mg/dl (-21%, p<0.05) before and after probucol administration, respectively. LDL-cholesterol (LDL-C) levels decreased from 325±37mg/dl before treatment to 262±32mg/dl (-19%, p<0.05) after treatment. HDL-C values significantly decreased from 42±5mg/dl to 26±4mg/dl (-38%, p<0.01), and especially HDL₂-C showed significant fall (-48%, p<0.01).<br>3) Serum Lecithin: Cholesterol Acyltransferase (LCAT) activities were not changed.<br>4) The concentrations of Apo LDL decreased from 139±18mg/dl to 106±17mg/dl (-29%), but it was not significant statistically. Apo A-I levels decreased significantly from 92±10mg/dl to 66±10mg/dl (-28%, p<0.01). On the other hand, Apo A-II levels were unchanged.<br>These observations suggested that probucol would be a useful drug to improve serum and LDL cholesterol levels in FH. However, we should take care to use this drug because of its effect on HDL metabolism.

著者

藤井 豊 鈴木 教敬 堀 三郎 佐野 隆一 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化

巻号頁・発行日

vol.13, no.6, pp.1385-1387, 1986

---

Diabetes mellitus is frequently complicated with atherosclerosis. PWV (pulse wave velocity) is an indicator for the sclerotic change of thoratic and abdominal aorta. We studied the relation between PWV and lipid metabolism in diabetics.<br>The subjects who took part in this study were 54 diabetics who were aged from 50 to 59 years old and had a duration of illness over 5 years. Fasting blood sugar level and the concentration of glycosylated hemoglobin (HbA₁) were measured. Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), apo B and apo A-I were measured by enzymatic methods and SRID, respectively. PWV was measured by the methods of Hasegawa, et al.<br>We concluded that (1) PWV increased in poorly controlled diabetics (FBS 180mg/dl) more than in well controlled diabetics (FBS 119mg/dl), and (2) PWV had significant positive-relation to serum TC, TG, apo B, apo A-I and apo B/A-I ratio, and had significant negative-relation to HDL-C.<br>According to these data we should improve not only glucose metabolism but also derangement of lipid metabolism.

著者

及川 眞一 阿部 隆三 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.9, no.6, pp.1035-1039, 1982

被引用文献数

2

---

It is thought that multi-factors may relate to the occurence and exaggeration of arterial sclerosis in diabetes mellitus. We pointed out the calcification of peripheral arteries in the legs on X-ray photographs as a sign of arteriosclerosis, and studied its prevalence in diabetics and nondiabetics. Furthermore, in order to clarify what correlates with the arteriosclerosis, we analysed the laboratory data and studied the differences between the diabetics with or without the peripheral arterial calcification.<br>We concluded that the incidence of the peripheral arterial calcification in diabetics (32%) was twofold higher than that in non-diabetics (16%).<br>It was clarified that the incidence of the calcification increased significantly in diabetics who had insulin treatment as compared with those who had oral agents or only diet therapy. Similarly, it was significantly higher in diabetics who were complicated with proliferative retinopathy than those who had simple or no retinopathy. And also, diabetics with longer duration of illness had significantly high incidence of the calcification as compared with those with shorter duration.<br>It was relatively higher frequency in diabetics who had hypertention and were controled poorly than those who had normotention and were controled well, respectively, but there was no significance between them.<br>There were no relationships between the peripheral arterial calcification and obesity, serum concentration of lipids, ischemic changes on ECG and aortic arch-calcification in diabetics.<br>These results suggested that the peripheral arterial calcification might relate to the metabolic derangement in diabetes mellitus.

著者

山田 憲一 阿部 隆三 鈴木 進 及川 真一 後藤 由夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.10, no.3, pp.489-495, 1982

---

Diabetic autopsy cases were collected from the Annual Report of Pathological Autopsy Cases published by Japanese of Pathology for the year 1976-1978. 2089 primary diabetic cases were collected and the cause of death and pathoanatomical findings in various organs were analysed in these primary diabetic cases, and following results were obtained.<br>1) The main causes of death were cardiovascular diseases (43.1%), malignant neoplasma (22.6%), infections (16.2%), diabetic coma (1.9%) and hypoglycemia (0.3%).<br>2) In cardiovascular diseases, the leading cause was diabetic nephropathy (15.6%), followed by cerebral (14.6%) and coronary (10.5%) artery disease.<br>3) The frequency of arteriosclerotic cardiovascular diseases and malignant neoplasmas as cause of death increased with age. Diabetic nephropathy appeared as a cause of death in 3rd decade and the leading cause of death was diabetic nephropathy in 3rd decade (52%) and 4th decade (32%), and over 5th decade decreased with age. Cerebral vascular and coronary artery diseases increased with age and cerebral vascular disease was the leading cause of death over 6th decade.<br>4) In pathoanatomical findings, the frequencies of glomerulosclerosis, myocardial infarction, cerebral infarction and homorrhage were 40.9%. 17.2%, 15.6% and 7.0%, respectively. Myocrdial infarction and cerebral infarction were found in 4th decade and increased with age, while cerebral hemorrhage decreased over 6th decade with age. Diabetic glomerulosclerosis was found in the cases of 2nd decade and high frequencies of glomerulosclerosis were found in all decade and it was higher than those of other vascular lesions.<br>These results showed the characteristics in the causes of death of diabetics in Japan are a lower incidence of coronary artery disease and a high incidence of diabetic nephropathy.

著者

佐野 隆一 阿部 隆三 及川 真一 藤井 豊 後藤 由夫 高瀬 貞夫

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.15, no.4, pp.1005-1008, 1987

---

The lipid levels of serum and lipoproteins were examined in eleven patients with myotonic dystrophy (MD) and ten normal subjects. Hyperlipoproteinemia was seen in six patients, including type IIb of three patients, type IIa of two and type V of one. Total cholesterol (C) and triglyceride (TG) levels of serum and lipoproteins in MD were not significant. TG/C ratio of lipoproteins in MD were not so high compared with normals.<br>The mean age of the patients with hyperlipoproteinemia was significantly higher than that of normolipoproteinemia. The correlation coefficients between age and lipid levels of serum and lipoproteins were examined. The age was positively correlated to serum C and VLDL-TG levels. Further, in the MD patients except for case 1 with type V hyperlipoproteinemia, the age was positively correlated to LDL-TG and LDL-C levels, and negatively correlated to HDL-TG levels.<br>In conclusion, the LDL levels increased and the HDL levels decreased with age in MD. These results suggest that the abnormalities of serum lipid metabolism is one of the characteristic changes in MD.

著者

阿部 隆三 丸浜 喜亮 奥口 文宣 及川 真一 柿崎 正栄 鈴木 勃志 後藤 由夫

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.69, no.11, pp.1452-1457, 1980

---

30才,男性で5~6才頃から黄色腫を有し,著明な高コレステロール血症を呈した症例の家族検診,および培養線維芽細胞の検討成績から家族性高コレステロール血症ホモ接合体と診断した症例を報告する.家族検診の脂質検査では, 11例中9例に高コレステロール血症がみられ,そのうち, 8例にIIa型高脂血症がみられた.また,本症例の弟に著明な黄色腫が認められた.一方,心電図所見では, 1例に虚血性変化がみられた.培養線維芽細胞の検討では,本症のアセテートからステロールへの合成能が,正常人培養線維芽細胞に比べ約18倍高い.また,本症例細胞のHMG-CoA reductase活性は,正常人細胞と比べ約15倍高い.さらに,正常人細胞では,培養液をリポ蛋白deficient mediumにすると,細胞内HMG CoA-reductaseの酵素誘導がおこり増加するが,本症例では全く誘導がみられない.以上の結果から, LDLレセプターを直接測定していないが, Goldsteinらの提唱しているLDLレセプターの完全欠損症,すなわち,家族性高コレステロール血症ホモ接合体の症例であることを証明しえた.本症例の治療成績では,クロフィブレートやコレスチポールに全く抵抗を示し,他の強力な治療法を行なう必要があると考えられる.

著者

阿部 隆明

出版者

日本精神病理・精神療法学会

雑誌

臨床精神病理 (ISSN:03893723)

巻号頁・発行日

vol.34, no.1, pp.53-59, 2013-04-10

参考文献数

26

著者

堀部 秀二 有吉 護 阿部 隆伸 平岡 弘二 史野 根生

出版者

West-Japanese Society of Orthopedics & Traumatology

雑誌

整形外科と災害外科 (ISSN:00371033)

巻号頁・発行日

vol.40, no.1, pp.1-3, 1991-11-25 (Released:2010-02-25)

参考文献数

4

---

Healing process of torn human anterior cruciate ligament (ACL) was studied histologically. Torn anterior cruciate ligaments were obtained from 21 patients at primary ACL reconstruction and stained with hematoxylin and eosin. Patients age was from 16 to 40 years. The interval between initial injury and operation ranged from 2 to 30 days. At 2 days after ACL injury, fibroblasts were not seen in the torn ligament and lymphocytes appeared in the injured ligament. Although vascular endothelial capillary buds and fibroblasts appeared around the torn ligament at 11 days, few fibroblasts were seen in it. At 30 days, torn ligament shrank macroscopically and resembled scar tissue with irregular alignment of fibroblast and collagen fiber. In conclusion, torn ligament is not healed probably due to few fibroblasts proliferation.

著者

進藤 順治 阿部 隆士 山口 隆幸 小林 寛

出版者

Japanese Society of Zoo and Wildlife Medicine

雑誌

日本野生動物医学会誌 (ISSN:13426133)

巻号頁・発行日

vol.5, no.1, pp.105-109, 2000 (Released:2018-11-03)

参考文献数

19

---

フンボトルペンギンの精子形態と大きさに関する報告はない。今回, フンボルトペンギンの精子形態を走査電子顕微鏡(SEM)で観察し, また各部位の長さを測定した。精子は, 紐状で頭部は細長くやや湾曲していた。全長ならびに各部位の長さを測定した結果, 全長は73.8±3.6μmであった。頭部は11.4±0.9μmで, 先体は1.1±0.2μm, 核は10.3±0.8μmであった。尾部は62.6±3.8μmで, 中片部は2.8±0.2μmであった。フンボルトペンギンの精子形態は典型的なnon-passerine birdsのグループに属し, また全長は他種よりもやや小型であった。

著者

朝倉 俊成 野崎 征支郎 清野 弘明 阿部 隆三

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.42, no.7, pp.537-540, 1999-07-30 (Released:2011-03-02)

参考文献数

6

被引用文献数

4

---

外食時のインスリン自己注射には, 心理的な要因等によるコンプライアンスの低下が予想される. そこで, 当院でインスリン自己注射している糖尿病患者716名を対象とし, アンケートにより外食時のインスリン注射の実態を検討した. 回答は501名 (年齢55.9±15.5歳: M±SD, 回収率70.0%) から得られた. 結果は, 「他の客が気になる」が63.1%, 「注射時間が気になる」が65.9%で, いすれも若年層で有意に高かった. 注射することを気にしている患者の56.7%が「注射場所の有無」について考慮していた. 注射場所はトイレが46.9%, 洗面所が32.1%, 食事する席が28.9%であった. 本調査により, 注射場所を具体的に想定したインスリン注射指導を取り入れる必要性があると思われた. さらに, 注射操作法の工夫や簡便な注射器の開発, そして自然に自己注射が行える社会的な環境整備を行うよう働きかける必要があると思われた.

著者

阿部 隆明

出版者

医学書院

雑誌

精神医学 (ISSN:04881281)

巻号頁・発行日

vol.56, no.5, pp.447-449, 2014-05-15

---

はじめに コタール症候群は抗うつ薬や電気痙攣療法(ECT)の導入によって減少したと指摘されるが,最近では英語圏での関心の高まりを受けて,臨床報告や神経生物学的研究が相次いでいる。とはいえ,臨床的な文脈と無関係に,自分が死んでいるという妄想的信念を持つだけで,その診断がなされる傾向もある3)。これは,器官の否定,不死・巨大妄想,永罰・悪魔憑き(possession)妄想などの特徴をセットで指摘したCotardの原著からの大きな逸脱である。操作的な診断基準が存在しないので仕方ない面もあるが,筆者自身はCotardの意図を最大限尊重する立場である。ここでは原著に立ち返るとともに,その後の諸研究もまとめていくが,特に最近の文献は必ずしも古典的なコタール症候群を扱っているわけではないことを念頭に置いていただきたい。なお,本概念は日本でも繰り返し紹介されている8,9,11)ので,こちらも参照されたい。

著者

阿部 隆博 前田 隼 山形 知実

出版者

公益社団法人 日本雪氷学会/日本雪工学会

雑誌

雪氷研究大会講演要旨集 雪氷研究大会(2016・名古屋) (ISSN:18830870)

巻号頁・発行日

pp.176, 2016 (Released:2017-02-18)

著者

山崎 慶太 奥田 清明 阿部 隆之 内川 義則 志村 徹 小谷 誠

出版者

公益社団法人 日本磁気学会

雑誌

日本応用磁気学会誌 (ISSN:02850192)

巻号頁・発行日

vol.16, no.6, pp.769-774, 1992-12-01 (Released:2013-01-11)

参考文献数

7

被引用文献数

6 7

---

This paper describes the design and the development of a prefabricated magnetically-shielded-room (PMSR) of the hexagonal type for high sensitive measurement of neuro-magnetic fields such as magnetoencephalography (MEG) mainly using SQUIDs with first and/or second-order gradiometers. This PMSR consists of prefabricated plywood panels 1.2 m wide×2.4 m high×24 mm thick. It covers a floor area of about 9 m2. The panel is sandwiched by two layers of high-μ metal sheets 1 mm thick. The shielding factor at the center of PMSR against the external magnetic field is 20 to 40 dB in the range of DC to 120 Hz. Magnetic noise inside PMSR measured by a second-order gradiometer was less than hundreds fT above 0.5 Hz excepting 50 Hz. In this case, a second order gradiometer was able to eliminate the common mode magnetic noise of about 20 Hz, which was essentially observed by a magnetometer, caused by the vibration of PMSR. These results were discussed and compared with the calculations.

著者

山口 日吉 清野 弘明 三崎 麻子 坂田 芳之 北川 昌之 山崎 俊朗 菊池 宏明 阿部 隆三

出版者

THE JAPAN DIABETES SOCIETY

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.46, no.3, pp.211-215, 2003

---

Imagawaらは, ケトアシドーシスにて発症し, 発症時のHbA1cが正常かもしくは軽度の上昇にとどまり, 膵β細胞の自己抗体が陰性で発症時にインスリン分泌能の著しく低下している例を非自己免疫性劇症1型糖尿病として疾患概念を提唱した. 当院において, この劇症1型糖尿病のスクリーニング基準を満たす7例の臨床像と6例のインスリン分泌能を経年的にグルカゴン負荷試験にて検討してきた. 発症時にグルカゴン負荷試験を検査しえた6例中5例で, グルカゴン負荷6分後の血清CPRは0.1ng/m<I>l</I>以下であり, 発症時に膵臓β細胞の完全破壊が示唆された. さらに, 発症後約6ヵ月ことにグルカゴン負荷試験を施行し, インスリン分泌能を経年的に最長7年間検討してきたが, 6例全例でグルカゴン負荷6分後の血清CPRは0.1ng/m<I>l</I>以下でありインスリン分泌能の回復を認めた例はいなかった.

著者

清野 弘明 大久保 健太郎 山口 日吉 木村 美奈子 宮口 修一 山崎 俊朗 三崎 麻子 菊池 宏明 阿部 隆三

出版者

THE JAPAN DIABETES SOCIETY

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.46, no.4, pp.333-335, 2003-04-30

参考文献数

8

被引用文献数

3

---

症例は31歳の男性, 2002年5月12日より口渇感, 全身倦怠感が出現し5月15日に初診した. 初診時血糖値778mgd<SUB>l</SUB>, 尿ケトン体強陽性, 動脈血分析ではpH7.249, HCO<SUB>3</SUB>13.6mmo<I>l</I>, 血中総ケトン体9800μmol<I>l</I>で糖尿病性ケトアシドーシスと診断した. 入院時のHbA<SUB>1c</SUB>は6.1%であった.入院中3回測定した尿中CPRは (3.4, <1.0, <1.0μg/day) でグルカゴン負荷試験でも負荷前・負荷6分後の血清CPRは検出限界の0.2ng/m<I>l</I>以下でβ 細胞の完全破壊が示唆された. 以上より本例は劇症1型糖尿病のスクリーニング基準を満たしたが, 2回測定した抗GAD抗体は, 11.6Um<I>l</I>, 10.2Um<I>l</I>と陽性であった. 本例は劇症1型糖尿病と考えられるが, 抗GAD抗体が陽性であったことより自己免疫の関与が示唆される劇症1型糖尿病であり, 興味ある症例である.

著者

阿部 隆 立木 孝 村上 裕 遠藤 芳彦 伊藤 俊也

出版者

Japan Audiological Society

雑誌

AUDIOLOGY JAPAN (ISSN:03038106)

巻号頁・発行日

vol.33, no.2, pp.110-117, 1990

---

Kemp & Bray製作のILO88を用いて内耳性難聴者90名154耳のclickに対するeOAEを測定し, 内耳性難聴の程度との関連を検討した。 (1), eOAE波形が認められかつ再現性が40%以上の場合をeOAE (+) とすると, 0.5k-4kHzの4周波数平均聴力が35dB未満の81耳では, 94%の確実性でeOAE記録が可能, 35dB以上の73耳及び40dB以上の63耳では, 89%及び92%の確実性でeOAE記録が不能であった。 1kHzと2kHzの2周波数平均聴力が40dB以上の64耳では, 94%の確実性でeOAE記録が不能であった。 (2), eOAE記録可能の84耳では, 内耳性難聴の程度とeOAEパワー (total echo power及びFFT解析図のhighest peak power) の間に負の相関 (r=-0.44) が認められた。 以上の結果から, ILO88を用いて, 4周波数平均聴力レベル35-40dB以上の内耳性難聴のスクリーニングが可能と思われた。

著者

阿部 隆夫

出版者

徳島大学

巻号頁・発行日

1994

---

博士論文