著者

Satoshi Inomata Hiroshi Tanimoto Hiroyuki Yamada

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.43, no.4, pp.538-540, 2014-04-05 (Released:2014-04-05)

参考文献数

21

被引用文献数

19 2

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The detection properties of alkanes by proton-transfer-reaction plus switchable reagent ion mass spectrometry (PTR + SRI-MS) were investigated. Alkanes (RH) were commonly detected as R+ by PTR + SRI-MS using NO+ as the reagent ion, and detection sensitivities were comparable to those of aromatics observed by H3O+ ionization. It can be concluded that sensitive online measurement of multiple alkanes is possible by PTR + SRI-MS using NO+ as the reagent ion.

著者

Toshiyasu OGATA Hiroshi ABE Kazuhiro SAMURA Omi HAMADA Masani NONAKA Mitsutoshi IWAASA Toshio HIGASHI Hiroyuki FUKUDA Etsuji SHIOTA Yoshio TSUBOI Tooru INOUE

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.oa.2015-0209, (Released:2015-10-28)

参考文献数

11

被引用文献数

1 20

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The efficacy of hybrid assistive limb (HAL) rehabilitation in the acute phase of stroke remains unclear. The purpose of this study was to evaluate the outcomes of patients with acute intracranial hemorrhage (ICH) who were treated with or without HAL rehabilitation. Among 270 patients with acute ICH from 2009 to 2014, 91 patients with supratentorial ICH were included in this retrospective study. Of these, 14 patients (HAL group) received HAL rehabilitation at approximately 1 week after ICH occurrence, while the remaining 77 patients received usual rehabilitation without HAL (N-HAL group). We obtained various patient data from the hospitals where the patients were moved to for further rehabilitation. Statistical comparisons were performed for the characteristics of the ICH patients, and outcomes between the HAL and N-HAL groups. There were no differences in outcomes between the HAL and N-HAL groups. However, patients with right ICH in the HAL group exhibited a significant association with a functional independence measure (FIM) score of ≥ 110 compared with patients in the N-HAL group (HAL group: 81.8%, N-HAL group: 43.9%, P = 0.04). In patients with right ICH, HAL rehabilitation was associated with improved outcomes as evaluated by the FIM score. Thus, HAL rehabilitation may improve outcomes of acute ICH in appropriately selected patients.

著者

Ying WANG Noriaki KATAOKA Naoyuki KANDA Ryuta YAMADA Minami WATANABE Shogo MORITA Hiroshi IMAIZUMI Naoki KANO

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.64, no.9, pp.553-561, 2015-09-15 (Released:2015-09-29)

参考文献数

19

被引用文献数

1 5

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Hydrogen explosion occurred at Fukushima Dai-ichi nuclear power plants in Japan on 12―15th March, 2011. At the same time, lots of radioactive materials have been released including tritium(T), and caused serious environmental impacts. In order to investigate the effect of the accident of Fukushima Dai-ichi nuclear power plant on environment, we collected the short precipitation(hourly collected precipitation) and spring water for several years after the accident. As to the precipitation collected, T and radiocaesium were measured by using liquid scintillation counter and high-purity germanium detector, respectively. Furthermore, we also measured the concentration of ions(Na+, Cl-, Ca2+, and SO42-) in spring water. From the above-mentioned matters, the following points have been obtained:(1)The variation of T concentration in recent three years(2012, 2013 and 2014) can be clarified. (2)The effect of the accident on spring water in mountains around the Fukushima prefecture is so small. (3)As to the short precipitation on 15th March, 2011, the activity of radiocaesium was not detected, but the activity of T was detected significantly.

著者

Fumio MARUYAMA Kenji KAI Hiroshi MORIMOTO

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.93, no.3, pp.331-341, 2015 (Released:2015-07-10)

参考文献数

23

被引用文献数

1 4

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A climatic regime shift is characterized by an abrupt transition from one quasi-steady climatic state to another. We attempted to explain the change of multifractal behavior of climate indices when a regime shift occurred. We used the wavelet - transform method to analyze the multifractal behaviors of the El Niño/Southern Oscillation (ENSO) index (Niño3.4 index), Pacific Decadal Oscillation (PDO) index, North Pacific Index (NPI), Pacific/North American pattern (PNA) index, and West Pacific pattern (WP) index. We showed the change of multifractality of these climate indices. When the wavelet coherences between the Niño3.4 index and NPI, NPI and PDO index, and Niño3.4 and PDO indices became strong, changes from multifractal to monofractal behavior were observed at climatic regime shifts. It may be possible to explain the background of the change of fractality by regarding climate change as the consequence of mutual interactions of various climatic elements. A fluctuation increase is observed in a coupled chaotic system just before chaos synchronization, which is when fractality and states change. We expect that a similar mechanism possibly exists for a climatic regime shift. When fluctuations became large and multifractality became strong, a climatic regime shift occurred and a change from multifractal to monofractal behavior was observed. The strong interaction of climatic phenomena, such as the ENSO, PDO, and Aleutian Low, caused a climatic regime shift. The fractality change of the PDO index almost corresponded to the regime shifts. In terms of multifractal analysis, we conclude that a climatic regime shift corresponds to a change from multifractality to monofractality of the PDO index.

著者

二木 博史 フタキ ヒロシ FUTAKI Hiroshi

出版者

東京外国語大学

雑誌

東京外国語大学論集 (Area and Culture Studies) (ISSN:04934342)

巻号頁・発行日

no.89, pp.27-44, 2014-12-31

著者

Hiroshi UENO Osamu YAMATO Takeshi SUGIURA Moeko KOHYAMA Akira YABUKI Kenjiro MIYOSHI Kazuya MATSUDA Tsuyoshi UCHIDE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0281, (Released:2015-08-03)

被引用文献数

1 3

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A male Japanese domestic cat with retarded growth in Hokkaido, Japan, showed progressive motor dysfunction, such as ataxia starting at 3 months of age and tremors, visual disorder and seizure after 4 months of age. Finally, the cat died of neurological deterioration at 9 months of age. Approximately half of the peripheral blood lymphocytes had multiple abnormal vacuoles. Magnetic resonance imaging showed bisymmetrical hyperintensity in the white matter of the parietal and occipital lobes in the forebrain on T2-weighted and fluid-attenuated inversion recovery images, and mild encephalatrophy of the olfactory bulbs and temporal lobes. The activity of lysosomal acid β-galactosidase in leukocytes was negligible, resulting in the biochemical diagnosis of GM1 gangliosidosis. Histologically, swollen neurons characterized by accumulation of pale, slightly granular cytoplasmic materials were observed throughout the central nervous system. Dysmyelination or demyelination and gemistocytic astrocytosis were observed in the white matter. Ultrastructually, membranous cytoplasmic bodies were detected in the lysosomes of neurons. However, genetic analysis did not identify the c.1448G>C mutation, which is the single known mutation of feline GM1 gangliosidosis, suggesting that the cat was affected with a new variant of the feline disease.

著者

Yuki Atsumu Otsuka Rei Kozakai Rumi Kitamura Itsuko Okura Tomohiro Ando Fujiko Shimokata Hiroshi

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.3, pp.1818, 2013-05

被引用文献数

51 7

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We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. Data were collected from community-dwelling 957 adult men who participated in a longitudinal study of ageing biennially from 1997–2010. Appendicular muscle mass (AMM) was measured with dual-energy X-ray absorptiometry at baseline and follow-up examinations. The cut-off point of sarcopenia was defined as a skeletal muscle index (AMM/height2) < 6.87 kg/m2. Total testosterone (TT) and free testosterone (FT) were measured with a radioimmunoassay. The calculated FT (cFT) was determined with a formula using albumin, TT, and sex hormone-binding globulin levels. We analyzed 4,187 or 2,010 cumulative data points using generalized estimating equations. Low TT was not associated with sarcopenia. Low cFT (odds ratio = 2.14, 95% confidence interval: 1.06–4.33) and FT (odds ratio = 1.83, 95% confidence interval: 1.04–3.22) were associated with sarcopenia. Low FT may be a predictor of risk for muscle loss in Japanese men.

著者

Hiroshi Akiyama Hideki Matsuoka Takanori Okuyama Kyohei Higashi Toshihiko Toida Hiroyuki Komatsu Yoshiko Sugita-Konishi Satomi Kobori Yukio Kodama Midori Yoshida Hitoshi Endou

出版者

内閣府食品安全委員会

雑誌

Food Safety (ISSN:21878404)

巻号頁・発行日

vol.3, no.1, pp.16-29, 2015 (Released:2015-03-30)

参考文献数

37

被引用文献数

6

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A novel type of encephalopathy associated with the ingestion of Sugihiratake mushroom (Pleurocybella porrigens) occurred in patients with chronic renal failure treated on hemodialysis in fall, 2004 in Japan. To clarify the mechanism of encephalopathy onset, we, for the first time, purified the cyanogen glycoside fraction (CG) from Sugihiratake mushroom using reversed phase high-performance liquid chromatography and hydrophilic interaction chromatography. Furthermore, we investigated single dose toxicity of the CG in an adenine-induced rat model of chronic renal damage (CRD). Pathological examination of kidneys indicates the development of CRD. Oral administration of the CG induces the accumulation of thiocyanate in the hemolyzed blood and brain in CRD rats, although no morphological changes were found in the brain. No further enhancement of kidney damage is observed after the oral administration of the CG in CRD rats. This is the first experimental report to suggest that acute encephalopathy, induced by Sugihiratake mushroom intake in the patients with chronic renal failure, is associated with intoxication of cyanide and thiocyanate, presumably produced metabolically produced after the ingestion of Sugihiratake mushroom.

著者

Junji Kobayashi Kazuya Miyashita Katsuyuki Nakajima Hiroshi Mabuchi

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.31617, (Released:2015-07-21)

参考文献数

87

被引用文献数

3 66

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Hepatic lipase (HL) is a key enzyme catalyzing the hydrolysis of triglycerides (TG) and phospholipids (PLs) in several lipoproteins. It is generally recognized that HL is involved in the remodeling of remnant, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and the production of small, dense low-density lipoproteins (sd-LDLs).On the other hand, it is unclear whether HL accelerates or retards atherosclerosis. From the clinical point of view, HL deficiency may provide useful information on answering this question, but the rarity of this disease makes it impossible to conduct epidemiological study.In this review, we describe a comprehensive and updated view of the clinical significance of HL on lipid and lipoprotein metabolism.

著者

Takao Sato Tomoki Kameyama Takashi Ohori Akira Matsuki Hiroshi Inoue

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.21, no.10, pp.1031-1043, 2014-10-24 (Released:2014-10-24)

参考文献数

53

被引用文献数

1 15

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Aim: Epicardial adipose tissue (EAT) is a pathogenic fat depot that may be associated with coronary atherosclerosis and cardiovascular events. Because eicosapentaenoic acid (EPA) has been reported to exert cardiovascular protective effects, we aimed to assess the effects of EPA on the volume of visceral adipose tissue, including EAT and abdominal visceral adipose tissue (AVAT), using multislice computed tomography (CT). Methods: In 30 patients with coronary artery diseases (9 women; mean age, 67.2±5.4 years), EAT and AVAT volumes were compared between the control group (n=15, conventional therapy) and the EPA group (n=15, conventional therapy plus purified EPA 1800 mg/day) during a six-month period. EAT was defined as any pixel that had CT attenuation of -150 to -30 Hounsfield units (HU) within the pericardial sac. Results: After the six-month follow-up, the serum EPA level increased from 59.9±18.8 to 177.2± 3.3 μg/mL in the EPA group (p<0.01), but no increase was noted in the control group. Similarly, the EPA/arachidonic acid (AA) ratio increased from 0.39±0.12 to 1.22±0.28 in the EPA group (p<0.01), with no significant increase in the control group. The AVAT and EAT volumes decreased in the EPA group but were unchanged in the control group (AVAT, −11.6±17.0 vs. +8.8±13.6 cm2, p<0.01; EAT, −7.3±8.3 vs. +8.7±8.8 cm3, p<0.01). Moreover, the change in the AVAT volume negatively correlated with the change in EPA (r=−0.58, p<0.01) and EPA/AA levels (r=−0.53, p<0.01). A similar negative correlation in these parameters was also observed for the EAT volume. Conclusions: Oral intake of purified EPA appears to be associated with reductions in EAT and AVAT volumes.

著者

中谷 拓士 Hiroshi Nakatani

雑誌

人文論究 (ISSN:02866773)

巻号頁・発行日

vol.56, no.1, pp.102-117, 2006-05-25

著者

加藤 浩 Kato Hiroshi

出版者

大阪大学大学院文学研究科

雑誌

待兼山論叢. 美学篇 (ISSN:03874818)

巻号頁・発行日

vol.44, pp.1-28, 2010-12-24

著者

杉山 洋 すぎやま ひろし Sugiyama Hiroshi

出版者

独立行政法人国立文化財機構奈良文化財研究所

巻号頁・発行日

pp.1-4, 2015-03-31

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本書は文化庁伝統文化課所管、平成22 年度から24 年度文化遺産国際貢献事業(文化遺産国際協力拠点交流事業)、カンボジア・ウドン遺跡及びロンヴェック遺跡等の保存に関する拠点交流事業の報告書である。

著者

Hironori Nakagami Hiroshi Koriyama Ryuichi Morishita

出版者

一般社団法人 インターナショナル・ハート・ジャーナル刊行会

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.55, no.2, pp.96-100, 2014 (Released:2014-03-28)

参考文献数

38

被引用文献数

2 13

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Vaccines are commonly used as a preventive medicine for infectious diseases worldwide, however, clinical trials on an amyloid beta vaccine for Alzheimer’s disease represents a new concept in the field of vaccinations. Several recent studies indicate the potential of therapeutic vaccines as well as classical vaccines as preventive medicines. A number of therapeutic vaccines for cancer have been developed as novel immunotherapies. Their targets are usually specifi c antigens in cancer cells, allowing activated cytotoxic T cells (CTLs) to attach and remove the antigen-presenting cancer cells. Recently, we and others have attempted to develop a therapeutic vaccine against hypertension. The vaccine target is angiotensin II (AngII), and induced anti-AngII antibodies could efficiently ameliorate high blood pressure. However, because AngII is an endogenous hormone, we must avoid the induction of autoimmune diseases by administration of an AngII vaccine. Therefore, our system was used to design a therapeutic vaccine that elicits anti-AngII antibodies without CTL activation against AngII. Because the target antigen itself does not include T cell epitopes, the immunogenic molecule (ie, KLH) provides antigen that supports the activation of T cells. In particular, helper T cells may activate B cells that produce antibodies against our specific antigen. In this review, we will explain our concept of therapeutic vaccines based on our recent data.

著者

Kei KONDOH Ayman ATIBA Kiyoshi NAGASE Shizuko OGAWA Takashi MIWA Teruya KATSUMATA Hiroshi UENO Yuji UZUKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0279, (Released:2015-04-04)

被引用文献数

1

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In the present study, we compare a new carbon dioxide (CO2) absorbent, Yabashi lime® with a conventional CO2 absorbent, Sodasorb® as a control CO2 absorbent for Compound A (CA) and Carbon monoxide (CO) productions. Four dogs were anesthetized with sevoflurane. Each dog was anesthetized with four preparations, Yabashi lime® with high or low-flow rate of oxygen and control CO2 absorbent with high or low-flow rate. CA and CO concentrations in the anesthetic circuit, canister temperature, and carbooxyhemoglobin (COHb) concentration in the blood were measured. Yabashi lime® did not produce CA. Control CO2 absorbent generated CA and its concentration was significantly higher in low-flow rate than a high-flow rate. CO was generated only in low-flow rate groups, but there was no significance between Yabashi lime® groups and control CO2 absorbent groups. However, the CO concentration in the circuit could not be detected (≤5 ppm) and no change was found in COHb level. Canister temperature was significantly higher in low-flow rate groups than high-flow rate groups. Furthermore, in low-flow rate groups, the lower layer of canister temperature in control CO2 absorbent group was significantly higher than Yabashi lime® group. CA and CO productions are thought to be related to the composition of CO2 absorbent, flow rate, and canister temperature. Though CO concentration is equal, it might be safer to use Yabashi lime® with sevoflurane anesthesia in dogs than conventional CO2 absorbent at the point of CA production.

著者

Hiroshi Arima Yutaka Oiso

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.49, no.19, pp.2043-2047, 2010 (Released:2010-10-01)

参考文献数

17

被引用文献数

4 20 8

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Background and objective We previously reported that baclofen, a GABAB agonist, reduces body weight in obese mice. In this clinical study, we examined the possibility that baclofen might serve as an effective therapeutic agent for obesity in humans. Methods Seven women and three men ranging from 25-51 years of age and 31.3-41.0 kg/m2 body mass index were included in the study. Baclofen, which was started at a dose of 15 mg/day and increased to 30 mg/day in 10 days, was administered for 12 weeks. Results Administration of baclofen for 12 weeks significantly decreased both body weight (baseline: 93.30 ± 9.80 kg, 12 weeks: 91.70 ± 10.30 kg) and waist circumference (baseline: 107.9 ± 9.0 cm, 12 weeks: 105.6 ± 10.0 cm). Serum leptin levels, which possibly reflect the amount of adipose stores, were also decreased significantly by the treatment. On the other hand, there were no significant changes in the blood pressure or metabolism of glucose and lipid. No adverse effects were observed. Conclusion Although the anti-obesity effects of baclofen in the present study were mild, this pilot study suggests the possibility that baclofen might serve as a new anti-obesity drug in humans.

著者

Hiroshi Yoshikura

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2014.039, (Released:2014-11-25)

参考文献数

12

被引用文献数

3 8

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This article reviews Japanese HIV/AIDS surveillance data from 1985 to 2011. It revealed that heterosexual males are more prone to be detected as “AIDS case”, while male homosexuals and females are detected more as “HIV case” irrespectively of sex, age, infection route, residential area and nationality; and probability of detection as “AIDS case” increased with advance of age irrespective of sex and infection route. Interpretation of the data requires further information on clinical latency of AIDS that could be different depending on the infection routes, different sex, and different ages; nature of the acute phase syndrome; and factors that enhance it, such as, route and dose of infection; and mucosal immunity involved in sexually transmitted HIV/AIDS infection and influence of aging and sex on it.

著者

Harukazu Kanehira Akinori Agariguchi Hisashi Kato Shigeki Yoshimine Hiroshi Inoue

出版者

Japan Prosthodontic Society

雑誌

日本補綴歯科学会雑誌 (ISSN:03895386)

巻号頁・発行日

vol.52, no.3, pp.375-380, 2008-07-10 (Released:2008-10-10)

参考文献数

49

被引用文献数

17 31

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Purpose: To evaluate the causes of temporomandibular disorder (TMD) by examining the relationships between 3 major TMD symptoms, parafunction, and stress, a questionnaire survey was performed during dental examinations in corporations.Methods: The survey was performed using 6 questions on the following topics: 1. Trismus; 2. Joint noise; 3. Pain; 4. Clenching in the daytime; 5. Nocturnal bruxism; and 6. Stress.There were 3,225 subjects, 2,809 males and 416 females and the mean age of the subjects was 40.12 years. The relationships between questions 1 to 5 and question 6 were examined by the chi-square test.Results: There were significant correlations (question 1, p=0.001; questions 2-5, p<0.001).Conclusion: Clearly, there was an influence of psychological factors, such as stress, on TMD, and such factors were considered to play important roles in its etiology, progression, and treatment. The results of this study suggest that well-controlled studies of TMD are necessary.

著者

Shinya Suzuki Takeshi Yamashita Ken Okumura Hirotsugu Atarashi Masaharu Akao Hisashi Ogawa Hiroshi Inoue

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-14-1131, (Released:2014-12-11)

参考文献数

26

被引用文献数

16 97

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Background:The incidence rate of ischemic stroke in Japanese non-valvular atrial fibrillation (NVAF) patients without anticoagulation therapy remains unclear.Methods and Results:We performed a pooled analysis of 3,588 patients from the Shinken Database (n=1,099), J-RHYTHM Registry (n=1,002), and Fushimi AF Registry (n=1,487) to determine the incidence rate of ischemic stroke in Japanese NVAF patients without anticoagulation therapy. Average patient age was 68.1 years. During the follow-up period (total, 5,188 person-years; average, 1.4 years), 69 patients suffered from ischemic stroke (13.3 per 1,000 person-years; 95% confidence intervals [CI]: 10.5–16.8). The incidence rates of ischemic stroke were 5.4, 9.3, and 24.7 per 1,000 person-years and 5.3, 5.5, and 18.4 per 1,000 person-years in patients with low (0), intermediate (1), and high (≥2) CHADS2 and CHA2DS2-VASc scores, respectively. History of ischemic stroke or transient ischemic attack (hazard ratio [HR], 3.25; 95% CI: 1.86–5.67), age ≥75 years (HR, 2.31; 95% CI: 1.18–4.52), and hypertension (HR, 1.69; 95% CI: 1.01–2.86) were independent risk factors for ischemic stroke.Conclusions:A low incidence rate of ischemic stroke was observed in Japanese NVAF patients except for those with CHADS2 score ≥2. In this pooled analysis, history of ischemic stroke or transient ischemic attack, advanced age, and hypertension were identified as independent risk factors for ischemic stroke.

著者

Hiroshi Ito

出版者

一般社団法人 インターナショナル・ハート・ジャーナル刊行会

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.55, no.3, pp.185-189, 2014 (Released:2014-05-26)

参考文献数

41

被引用文献数

8 24 2

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In patients with acute myocardial infarction (MI), coronary microvasculatures are often damaged irreversibly due to myocardial ischemia and reperfusion, and flow to the previously ischemic myocardium is markedly reduced, a phenomenon known as the “no-reflow phenomenon”. Percutaneous coronary intervention (PCI) may accelerate embolization of plaque gruels and microthrombi to the microvessels, which further reduces tissue perfusion. The extent of the no-refl ow zone correlates with infarct size, and it has additional prognostic information. Recent advances in imaging modalities have enabled us to diagnose the no-reflow phenomenon and to assess the mechanisms of the no-refl ow phenomenon. Pharmacological interventions and catheter-based devices to retrieve embolic materials have been proposed, and some of them are associated with improvement in clinical outcomes. Thus, we should keep in mind that only the achievement of complete microvascular perfusion is associated with better functional and clinical outcomes in patients with acute MI.