著者

Shotaro Ide Noriho Sakamoto Shintaro Hara Atsuko Hara Tomoyuki Kakugawa Yoichi Nakamura Yoji Futsuki Koichi Izumikawa Yuji Ishimatsu Katsunori Yanagihara Hiroshi Mukae

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.1, pp.79-83, 2017-01-01 (Released:2017-01-01)

参考文献数

20

被引用文献数

4

---

Although pneumothorax has been reported to be a major pulmonary adverse event in patients treated with pazopanib, a multikinase inhibitor, drug-induced interstitial lung disease (DILD) has not been reported. A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue. He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis. We diagnosed DILD due to pazopanib. The patient's pazopanib treatment was interrupted and a steroid was administered. The symptoms and GGO were improved with treatment. Physicians should be aware of DILD due to pazopanib in patients with pre-existing interstitial lung disease.

著者

前田 博 進士 五十八 Hiroshi MAEDA SHINJI Isoya

出版者

東京農業大学

雑誌

東京農業大学農学集報 (ISSN:03759202)

巻号頁・発行日

vol.53, no.3, pp.274-282, 2008-12

---

平成15年の地方自治法の改正によって公の施設に関して「指定管理者制度」が導入されることとなり、地方公共団体の所有する各種の施設と並んで都市公園もその対象となった。導入時のいきさつから招かれざるものとして公園管理者に受け止められた制度であるが、施行から2年を経過した現在比較的好印象で迎えられているように感じられる。そこで、都市公園管理史の観点から「指定管理者制度」の導入が都市公園の管理行政にどのような意味を持つかを検証した。考察の結果、「指定管理者制度」の導入は太政官布達第16号以来の都市公園管理史における転換期の特徴である外圧性と偶然性を持ち、近年の都市公園管理行政の閉塞感を打破する可能性、むしろ将来的に市民利用本位の公園管理のあり方を示唆する主要方策のひとつであることがわかった。具体的には(1)公園管理を再点検(2)正確な数量把握による予算確保(3)評価のための利用者意向把握等の動きが見られ、財政悪化時代を迎え危機的状況にあった公園管理行政の転換点となった。

著者

Ohtsuka Susumu El-Sherbiny Mohsen M. Ueda Hiroshi

出版者

日本甲殻類学会

雑誌

Crustacean research (ISSN:02873478)

巻号頁・発行日

no.29, pp.1-11, 2000-12

被引用文献数

3

---

Two new species of Tortanus (Atortus), T. (A.) ampliramus and T. (A.) nishidai, are described from the northern Red Sea and the Gulf of Aden, respectively. These new species evidently belong to the recticauda species group in the recticauda species complex. The species group has a distinct distribution in the western Indian Ocean, extending from South Africa. The functional morphology of spermatophores of Tortanus is also discussed. A semelparous reproductive strategy may be employed in some species of Tortanus, whereas others adopt an iteroparous strategy as do most of centropagoideans. The formation of swarms was found exclusively in the subgenus Atortus which inhabits clear waters. Swarms of T. (A.) erabuensis may utilize swarms of another small copepod, Oithona oculata as prey.

著者

Chikako Honda Hiroshi Iwanami Katsuki Naramoto Tsutomu Maejima Kyohei Kanamaru Yuki Moriya-Tanaka Toshio Hanada Masato Wada

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-010, (Released:2016-10-18)

被引用文献数

14

---

In common apple cultivars with white flesh and red skin, it is known that fruit overload lowers fruit quality, and that skin anthocyanin concentrations are reduced by bagging treatment and warmer climatic conditions. In this study, the effects of these factors on anthocyanin accumulation in the flesh of red-fleshed apples were investigated using ‘Geneva’ and ‘Pink Pearl’ apple cultivars. Excess fruiting resulted in decreased anthocyanin concentration in the flesh and the titration acidity of the fruit in both cultivars. Fruit bagging treatments using double-layer paper bags revealed that anthocyanin was synthesized to a certain extent in the flesh under dark conditions in both cultivars. The treatment significantly reduced anthocyanin accumulation in the flesh of bagged ‘Geneva’ apples compared with unbagged fruit, but no inhibitory effect was clear in ‘Pink Pearl’ apples. In both cultivars, the anthocyanin concentration in the flesh of unbagged apples grown in sunlight was higher than that in unbagged apples grown in shade, whereas there was no difference between positions for bagged fruit. In apples grown in either sunlight or shade, no significant difference was found between anthocyanin concentrations in the sun-exposed side and shaded side of fruits. These results indicate that sunlight irradiation partially promoted anthocyanin accumulation in the flesh of unbagged ‘Geneva’ and ‘Pink Pearl’ apples and accelerated its accumulation on both the sun-exposed and the shaded side. A comparison of the fruit quality of ‘Pink Pearl’ apples grown in different climatic regions showed that apples harvested at Suzaka, a warmer region, were lower in firmness, starch index, and titration acidity and higher in soluble solids concentration compared with those from Morioka, a cooler region. The anthocyanin concentration in the flesh of ‘Pink Pearl’ apples from the trees grown at Morioka was more than ten-fold higher than that in apples from the trees grown at Suzaka. Our results suggest that an appropriate fruit load, growth in sunlight, and growth under cooler climatic conditions, may redden the flesh of red-fleshed apples, as is the case for common apples.

著者

Makoto Nakao Hideki Muramatsu Tetsushi Takahashi Shunsuke Niwa Yusuke Kagawa Ryota Kurokawa Kazuki Sone Yuki Uozumi Misako Ohkusu Katsuhiko Kamei Hiroshi Koga

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.20, pp.3021-3024, 2016-10-15 (Released:2016-10-15)

参考文献数

17

被引用文献数

10

---

A 39-year-old man presented to our hospital with a four-week history of headache and a two-week history of low-grade fever. Chest X-rays showed a tumor of approximately 50 mm in size in the right lower field. A histopathological examination of a transbronchial lung biopsy specimen from the right S9/10 revealed numerous fungal elements that appeared as encapsulated yeast with clear halos. Gadolinium-enhanced brain magnetic resonance images showed multiple cerebral nodules. Cryptococcus gattii (Genotype VGIIa) was isolated from the bronchial lavage and cerebrospinal fluid specimens. The patient was an immunocompetent Japanese man who had not recently traveled to a C. gattii-endemic area.

著者

Dung VAN NGUYEN Junko SUZUKI Shohei MINAMI Kenzo YONEMITSU Nao NAGATA Ryusei KUWATA Hiroshi SHIMODA Chien Kim VU Thuy Quoc TRUONG Ken MAEDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0394, (Released:2016-10-14)

被引用文献数

8

---

Canine distemper virus (CDV) is one of the most serious pathogens found in many species of carnivores, including domestic dogs. In this study, hemagglutinin (H) genes were detected in five domestic Vietnamese dogs with diarrhea, and two CDVs were successfully isolated from dogs positive for H genes. The complete genome of one isolate, CDV/dog/HCM/33/140816, was determined. Phylogenetic analysis showed that all Vietnamese CDVs belonged to the Asia-1 genotype. In addition, the H proteins of Vietnamese CDV strains were the most homologous to those of Chinese CDVs (98.4% to 99.3% identity). These results indicated that the Asia-1 genotype of CDV was the predominant genotype circulating among the domestic dog population in Vietnam and that transboundary transmission of CDV has occurred between Vietnam and China.

著者

Hiroshi Tatano Hisami Yamanaka-Okumura Bei Zhou Chisaki Adachi Yuka Kawakami Takafumi Katayama Masashi Masuda Eiji Takeda Yutaka Taketani

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.3.4, pp.241-247, 2016 (Released:2016-09-17)

参考文献数

33

被引用文献数

6

---

Reducing dietary calorie density (CD) is useful in body weight management. This study investigates the association between dietary habits and preferences for different CDs. We conducted a randomized crossover study of 232 healthy subjects who consumed packed lunch boxes containing a control, high-meat and low-rice, low-vegetable, medium-fat and low-vegetable, high-fat, and high-fat and low-vegetable meals over six sessions. The subjective levels of sensory properties were assessed over time using a visual analog scale and the area under the curve. Subjects were assessed for dietary habits using a brief-type self-administered diet history questionnaire (BDHQ) and were divided into two groups based on a daily fat energy ratio ≥ 25% (high fat [HF], n=116) and < 25% (normal, n=116) that was matched for age, body mass index, and sex ratio. Our findings indicate that the desire for sweetness was higher in the HF group than in the normal group, regardless of the meals consumed. Particularly, among the 500-kcal low-CD meals, a high-protein meal provided greater fullness and satisfaction and lower prospective consumption in the HF group than in the normal group. Therefore, our study demonstrates that postprandial appetite sensation is associated with dietary habits of fat intake. J. Med. Invest. 63: 241-247, August, 2016

著者

Ichiro Furukawa Tomoe Ishihara Hiroshi Teranishi Shioko Saito Jun Yatsuyanagi Eriko Wada Yuko Kumagai Shiho Takahashi Takayuki Konno Hiroko Kashio Akihiko Kobayashi Naoki Kato Ken-ichi Hayashi Keisuke Fukushima Kazuhiko Ishikawa Kazumi Horikawa Akira Oishi Hidemasa Izumiya Takahiro Ohnishi Yoshiko Konishi Toshiro Kuroki

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2016.164, (Released:2016-08-31)

参考文献数

31

被引用文献数

25

---

This study was undertaken to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Salmonella enterica subsp. enterica and Campylobacter spp. in poultry meat, and to analyze the association of genetic types of these bacteria with their geographical distribution and antimicrobial resistance profiles. Fifty-four and 71 of 100 samples were found to be contaminated with Salmonella and Campylobacter, respectively. Nine Salmonella serotypes were found, including S. enterica subsp. enterica serovar Infantis (33%), Schwarzengrund (12%), Manhattan (9%), and others. Campylobacter jejuni and C. coli were detected from 64 (64%) and 14 (14%) samples, respectively. S. enterica subsp. enterica exhibited a high frequency of resistance against tetracycline (78.3%) and streptomycin (68.3%). C. jejuni and C. coli isolates were resistant to sulfamethoxazole/trimethoprim (90.5%), nalidixic acid (47.3%), ampicillin (45.9%), and ciprofloxacin (40.5%). Cluster analysis was performed for the Salmonella isolates using PFGE and for the Campylobacter isolates with PFGE as well as comparative genomic fingerprinting. which were combined with the drug-resistance data to analyze with respect to the locations in which the poultry meat was produced. This analysis revealed that C. jejuni strains with a particular genotype and antimicrobial resistance profile are spreading in specific areas in Japan.

著者

"ITONO Hiroshi"

出版者

鹿児島大学

雑誌

鹿児島大学水産学部紀要=Memoirs of Faculty of Fisheries Kagoshima University (ISSN:0453087X)

巻号頁・発行日

vol.20, no.1, pp.217-237,

---

"Some filamentous, minute red algae of the Callithamnieae and Compsothamnieae (Ceramiaceae, Rhodophyta) are described here. The species described are as follows : Callithamnion pedicellatum spec, nov., C. aglaothamnioides spec. nov. Aglaothamnion oosumiense spec, nov., A. cordatum, A. neglectum, Seirospora occidentalis, Pleonosporium japonicum spec, nov., P. polymorpha spec, nov., P. pusillum and Mesothamnion caribaeum."

著者

Yoshimitsu OHGIYA Hiroshi NOBUSAWA Noritaka SEINO Osamu MIYAGAMI Naomi YAGI Sasamori HIROTO Jiro MUNECHIKA Masanori HIROSE Nobuyuki TAKEYAMA Nobuyuki OHIKE Ryu MATSUOKA Akihiko SEKIZAWA Takehiko GOKAN

出版者

日本磁気共鳴医学会

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

vol.15, no.2, pp.212-219, 2016 (Released:2016-04-11)

参考文献数

23

被引用文献数

15

---

Purpose: To evaluate morphological and signal intensity (SI) changes of placental insufficiency on magnetic resonance imaging (MRI) and to assess morphological changes and decreased flow voids (FVs) on T2-weighted rapid acquisition with relaxation enhancement (RARE) images for diagnosing placental insufficiency.Methods: Fifty singleton fetuses underwent MRI using a 1.5-T MR scanner. Placental thickness, area, volume, SI, amniotic fluid SI, and size of FVs between the uterus and the placenta were measured on MR images. Two radiologists reviewed T2-weighted RARE images for globular appearance of the placenta and FVs between the uterus and the placenta. Data were analyzed using t-tests, McNemar’s tests, and areas under the receiver operating characteristic curve (AUCs) at 5% level of significance.Results: Twenty-five of the 50 pregnancies were categorized as having an insufficient placenta. Significant differences were observed between insufficient and normal placentas in mean placental thickness, area, volume, placenta to amniotic fluid SI ratio, and size of FVs (49.0 mm vs. 36.9 mm, 1.62 × 104 mm2 vs. 2.67 × 104 mm2, 5.13 × 105 mm3 vs. 6.56 × 105 mm3, 0.549 vs. 0.685, and 3.4 mm vs. 4.3 mm, respectively). The sensitivity and accuracy using globular appearance plus decreased FVs were greater than those using decreased FVs (P < 0.01). There was no significant difference among AUCs using globular appearance and decreased FVs, and globular appearance plus decreased FVs.Conclusions: Placental insufficiency was associated with placental thickness, area, volume, placenta to amniotic fluid SI ratio, and size of FVs. Evaluating FVs on T2-weighted RARE images can be useful for detecting placental insufficiency, particularly in placentas without globular appearance on MR images.

著者

片山 寛 カタヤマ ヒロシ KATAYAMA HIROSHI

出版者

西南学院大学学術研究所

雑誌

西南学院大学神学論集 (ISSN:03874109)

巻号頁・発行日

vol.73, no.1, pp.29-40, 2016-03

---

1933年から1945年までのいわゆるナチズムの時代のドイツのキリスト教会について,以前は,告白教会を善玉とし,ドイツ的キリスト者を悪玉とする単純な対立図式だけで論ずる傾向が強かった。しかし近年はむしろ,この時代を生きたもっと多様な教会像を検討する論考が多く見られるようになった。たとえば,Philipp Thull (Hrsg.), Christen im Dritten Reich)においては,これまでにもよく見られた,DEK(ドイツ福音主義教会)内部の上記の闘争と,カトリック教会内の諸問題の検討の他に,いくつかの教派Neuapostolische Kirche,Mennoniten, Pfingstbewegung, alt-katholische Kirche におけるナチズム時代が,それぞれの著者によって論じられている。そしてその最後に,Karl Heinz Voigt)は,「自由教会」と総称で呼ばれる15の小教派(上記とも重なるが,メノナイト,バプテスト,バプテスト系の兄弟団,エリム教会,メソジスト,福音主義共同体,ヘルンフート兄弟団,自由福音教会,セブンスデイ・アドヴェンティスト,古ルター派教会,古カトリック教会,救世軍,ミュールハイム連盟,神の教会,(ペンテコステ系の)フォルクスミッシオン)について,それらがDEKの告白教会運動から疎外された状況を論じている。自由教会はナチズムと闘うことができなかったことを批判されることが多く,自由教会自身がそれについて苦い後味を抱いているのであるが,それは彼らのせいだけではなかったというのである。この発表で特に取り上げたいのは,ドイツのバプテスト同盟Bund der Baptistengemeinden(1942年にいくつかの小教派を統合して,福音主義自由教会同盟Bund Evangelisch-Freikirchlicher Gemeindenに改称した。現代もバプテストはこの名称を使用している)がナチズムの時代をどのように生きのびたのかについてである。それを私は,Günter Balders の論文「ドイツ・バプテスト小史」の第5章「第三帝国と第二次世界大戦の時代(1933-1945)」)にもとづいて紹介したい。その上で,自由教会としてのバプテストが,どのようなものであり,どのような点で優れ,またどのような点で限界を持っていたかを考察したいと思う。

著者

戸谷 洋志 トヤ ヒロシ Toya Hiroshi

出版者

大阪大学大学院文学研究科哲学講座

雑誌

メタフュシカ (ISSN:13426508)

巻号頁・発行日

vol.44, pp.133-139, 2013-12-25

著者

Izumi ANDO Kaoru KARASAWA Hiroshi MATSUDA Akane TANAKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0258, (Released:2016-07-22)

被引用文献数

8

---

Serum nerve growth factor (NGF) levels are increased by the external stress in mice, humans and horses; however, similar variations have been unclear in dogs. Since dogs are usually subjected to conditions of work, exercise and activity as important partners of humans, we measured serum NGF levels post-exercise and compared them with serum cortisol levels, as a biomarker of physical stress. Serum cortisol levels were immediately elevated post-exercise and returned to basal levels within 1 hr. On the other hand, serum NGF levels were significantly increased 1 hr post-exercise and gradually returned to basal levels. Further research is necessary; nevertheless, we have demonstrated for the first time that serum NGF levels respond to exercise stress in dogs.

著者

山森 宙史 Hiroshi Yamamori

出版者

関西学院大学先端社会研究所

雑誌

関西学院大学先端社会研究所紀要 (ISSN:18837042)

巻号頁・発行日

no.13, pp.105-120, 2016-03

著者

Masashi Yamanouchi Yuki Uehara Hirohide Yokokawa Tomohiro Hosoda Yukiko Watanabe Takayoshi Shiga Akihiro Inui Yukiko Otsuki Kazutoshi Fujibayashi Hiroshi Isonuma Toshio Naito

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.21, pp.2471-2475, 2014 (Released:2014-11-01)

参考文献数

26

被引用文献数

4 24

---

Objective The causes of fever of unknown origin (FUO) vary depending on the region and time period. We herein present a study of patients with classic FUO where we investigated differences based on patient background factors, such as age and causative diseases, and changes that have occurred over time. Methods We extracted and analyzed data from the medical records of 256 patients ≥18 years old who met the criteria for classic FUO and were hospitalized between August, 1994 and December, 2012. Results The median age of the patients was 55 years (range: 18-94 years). The cause of FUO was infection in 27.7% of the patients (n=71), non-infectious inflammatory disease (NIID) in 18.4% (47), malignancy in 10.2% (26), other in 14.8% (38), and unknown in 28.9% (74). The most common single cause was human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (n=17). NIID and malignancy were more common in patients ≥65 years old than in patients <65 years old. During 2004-2012, compared to 1994-2003, infections and "other" causes were decreased, whereas NIID, malignancy, and unknown causes were increased. Conclusion FUO associated with HIV/AIDS is increasing in Japan. In addition, as in previous studies in Japan and overseas, our study showed that the number of patients in whom the cause of FUO remains unknown is increasing and exceeds 20% of all cases. The present study identified diseases that should be considered in the differential diagnosis of FUO, providing useful information for the future diagnosis and treatment of FUO.

著者

キム ヒョンジン ハン ソンヨン 佐々木 浩 安藤 元一 Kim Hyeonjin Sungyong Han Hiroshi Sasaki Motokazu Ando 東京農業大学大学院農学研究科畜産学専攻 Korean Otter Research Center 筑紫女学園大学短期大学部幼児教育科 東京農業大学農学部バイオセラピー学科 Department of Animal Science Graduate School of Agriculture Tokyo University of Agriculture Korean Otter Research Center Department of Early Childhood Education Chikushi Jogakuen University Junior College Department of Human and Animal-Plant Relationships Faculty of Agriculture Tokyo University of Agriculture

巻号頁・発行日

vol.59, no.1, pp.29-38,

---

ユーラシアカワウソLutra lutraが経済成長に伴う環境変化からどのような影響を受けるのか調べることを目的に,工業集積の進む韓国慶尚南道の海岸における本種の生息痕を1982年,1991-94年,2002年および2009年にわたってモニタリングした。慶尚南道馬山地域における糞密度は,1990年代には減少傾向を示したが,2000年代後半には回復傾向に転じた。回復傾向は釜山市などでも見られた。本種が安定的に生息する海域のCODは約4mg/L以下のレベルであった。糞が多く見られたのは,岬の湾口にある磯海岸,海岸近くの小島,河川の人工湖などであり,これらは餌資源の多いことや,隠れ場所として適していることが共通していた。本種は人工護岸のわずかな隙間や,沖合の水産養殖イカダの上をサインポストとして利用しており,人工環境への適応力も備えていた。調査期間中に調査地の陸域における各種経済指標は高い伸びを示したが,湾奥部におけるカワウソが生息しない地域が若干広がったことを除くと,陸域における経済発展や開発は本種の生息に直接的な影響は与えないことがわかった。

著者

白沢 ナベ 中川 裕 NAKAGAWA Hiroshi

出版者

千葉大学ユーラシア言語文化論講座

雑誌

千葉大学ユーラシア言語文化論集 (ISSN:21857148)

巻号頁・発行日

no.10, pp.291-313, 2008-03

---

採録・訳・註 中川裕This text was recited by Nabe Shirasawa (1905・93)on Aug 29, 1988, who was born in Chitose. The Ainu heroic epics are usually known as verses sung on melodies. In Chitose (and several other areas), however, women can't sing them but must recite them in prose. Whether there are differences in stories between the epics in verse and in prose has never studied but this text would be one of the examples which suggests the existence of some differences.

著者

佐藤 英雄 / 萩谷 正教 / 小林 博 サトウ ヒデオ / ハギヤ マサノリ / コバヤシ ヒロシ SATO hideo / HAGIYA masanori / KOBAYASHI hiroshi

出版者

茨城大学教育学部

雑誌

茨城大学教育実践研究

巻号頁・発行日

no.19, pp.25-34, 2000

著者

Yoshitaka NAKAO Hiroshi NAGAMOCHI

出版者

一般社団法人 日本機械学会

雑誌

Journal of Advanced Mechanical Design, Systems, and Manufacturing (ISSN:18813054)

巻号頁・発行日

vol.1, no.2, pp.217-226, 2007 (Released:2007-04-27)

参考文献数

12

被引用文献数

2 13

---

We consider a discrete-type split delivery vehicle routing problem, in which delivery goods for a customer consist of a set of items, each item is required to be serviced by exactly one vehicle, and each customer is allowed to be visited more than once. In this paper, we propose a fast algorithm that constructs a set of routes one by one without any improvement procedures. The algorithm generates routes by dynamic programming based on an elaborate route evaluation function that estimates the total travel cost required to service all the remaining items by vehicles. Experimental results on real-world instances are reported.

著者

Kurata Hiroshi Nomura Ryoichi Suga Nobuhito

出版者

Graduate School of Economics &amp; Business Administration, Hokkaido University

雑誌

Discussion Paper, Series A

巻号頁・発行日

vol.288, pp.1-32, 2015-09

---

This study clarifies how a reduction in trade costs affects location and economic welfare in an economy with a vertically-linked industry. We focus on location in upstream and downstream sectors and economic welfare for a reduction in trade costs for intermediate goods. We show that the reduction in trade costs makes upstream and downstream production in the North move to the South, and further liberalization makes some of the upstream productions remove back to the North. We also demonstrate that such reduction in trade costs improves world welfare but does not necessarily benefit for each country.