著者

Motoko Tanaka Shigeyuki Miyamura Tadashi Imafuku Yuna Tominaga Hitoshi Maeda Makoto Anraku Keishi Yamasaki Daisuke Kadowaki Yu Ishima Hiroshi Watanabe Tomoko Okuda Kazuko Itoh Kazutaka Matsushita Masafumi Fukagawa Masaki Otagiri Toru Maruyama

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.39, no.6, pp.1000-1006, 2016-06-01 (Released:2016-06-01)

参考文献数

29

被引用文献数

9

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A ferric citrate formulation for treating hyperphosphatemia is a new therapeutic that not only suppresses the accumulation of phosphorus in patients with chronic kidney disease-mineral bone disorders (CKD-MBD), but also ameliorates anemia caused by iron deficiency. In contrast, it has been demonstrated that intravenous iron injection markedly increases oxidative stress. This study was designed to investigate the effect of a ferric citrate formulation on oxidative stress in CKD-MBD patients receiving hemodialysis therapy. Fifteen CKD-MBD patients undergoing dialysis were enrolled in this study. The patients were orally administered a ferric citrate formulation for 6 months. Their plasma phosphorus concentrations remained unchanged with the switch from other phosphorus adsorbents to the ferric citrate formulation. In addition, the ferric citrate formulation generally allowed for dose reduction of an erythropoiesis stimulating agent with an increased hematopoietic effect. The average values of plasma ferritin level increased after the introduction of a ferric citrate formulation, but did not exceed 100 (ng/mL). Interestingly, oxidative stress markers did not increase significantly, and anti-oxidative capacity was not significantly decreased at 6 months after the drug administration. Similarly, no change was observed in any inflammation markers. The ferric citrate formulation induces negligible oxidative stress in CKD-MBD patients receiving dialysis under the present clinical condition.

著者

Tamagawa Toru Hayato Asami Nakamura Satoshi TERADA Yukikatsu BAMBA Aya HIRAGA Junko S. HUGHES John P. HWANG Una KATAOKA Jun KINUGASA Kenzo KUNIEDA Hideyo TANAKA Takaaki TSUNEMI Hiroshi UENO Masaru HOLT Stephen S. KOKUBUN Motohide MIYATA Emi SZYMKOWIAK Andrew TAKAHASHI Tadayuki TAMURA Keisuke UENO Daisuke MAKISHIMA Kazuo

出版者

社団法人日本天文学会

雑誌

PASJ : publications of the Astronomical Society of Japan (ISSN:00046264)

巻号頁・発行日

vol.61, no.1, pp.S167-S174, 2009-01-30

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Tycho's supernova remnant was observed by the XIS and HXD instruments onboard the Suzaku satellite on 2006 June 26-29 for 92 ks. The spectrum up to 30 keV was well fitted with a two-component model, consisting of a power-law with photon index of 2.7 and a thermal bremsstrahlung model with temperature of 4.7 keV. The former component can alternatively be modeled as synchrotron emission from a population of relativistic electrons with an estimated roll-off energy of around 1 keV. In the XIS spectra, in addition to the prominent Fe K_alpha line (6.445 keV), we observe for the first time significant K_alpha line emission from the trace species Cr and Mn at energies of 5.48 keV and 5.95 keV, respectively. Faint K_beta lines from Ca (4.56 keV) and Fe (7.11 keV) are also seen. The ionization states of Cr and Mn, based on their line centroids, are estimated to be similar to that of Fe K_alpha (Fe XV or XVI).

著者

Hiroshi Narazaki Shoko Tani Jun Ishizaki Kazuo Nakazawa Hiroshi Inada Haruhiko Nishimura

出版者

一般社団法人日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.51, no.Supplement, pp.R-303-R-303, 2013 (Released:2013-09-06)

著者

豊田 弘司 豊田 弘司 TOYOTA Hiroshi

出版者

奈良教育大学教育学部附属教育実践総合センター

雑誌

教育実践総合センター研究紀要 (ISSN:13476971)

巻号頁・発行日

no.11, pp.19-22, 2002-03

著者

永井 浩 Hiroshi Nagai

出版者

神田外語大学グローバル・コミュニケーション研究所

雑誌

Global communication studies = グローバル・コミュニケーション研究 (ISSN:21882223)

巻号頁・発行日

no.1, pp.1-18, 2014

著者

Hiroshi Mine Taku Shimosawa Soki Sakurai Tadashi Takeuchi

雑誌

研究報告システムソフトウェアとオペレーティング・システム(OS) (ISSN:21888795)

巻号頁・発行日

vol.2016-OS-137, no.14, pp.1-8, 2016-05-23

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With online video editing systems, file servers supporting standard file sharing protocol and achieving high I/O performance with real-timeness are required to reduce the overall system cost. AVFS is a file system optimized for the efficient storing and access of video files. Samba is a widely used file server application and enables client terminals to access files via a network. Since Samba is not adapted to efficiently process accesses to video files using features provided by AVFS, modifications of Samba such as the addition of deadline information to I/O requests are required to benefit from AVFS. In this paper, we propose rt-Samba, the Samba-AVFS cooperation method composed of a Samba VFS module and an I/O surrogate daemon using real-time features provided by AVFS. Using this method, I/O access performance is improved while keeping the amount of modifications in Samba low. Furthermore, the standard CIFS protocol is preserved, allowing the use of unmodified editing stations for accessing files. Evaluation results of a Linux file server implementation of our proposed method show that rt-Samba achieves 3 times higher read throughput and 1.1 times higher write throughput keeping the storage I/O stability compared to an original Samba server accessing files on Ext4.

著者

Norifumi Takeda Hiroki Yagi Hironori Hara Takayuki Fujiwara Daishi Fujita Kan Nawata Ryo Inuzuka Yuki Taniguchi Mutsuo Harada Haruhiro Toko Hiroshi Akazawa Issei Komuro

出版者

一般社団法人 インターナショナル・ハート・ジャーナル刊行会

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.16-094, (Released:2016-05-13)

被引用文献数

1 50

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Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective tissue that affects the cardiovascular, skeletal, ocular, pulmonary, and nervous systems and is usually caused by mutations in the FBN1 gene, which encodes fibrillin-1. MFS is traditionally considered to result from the structural weakness of connective tissue. However, recent investigations on molecular mechanisms indicate that increased transforming growth factor-β (TGF-β) activity plays a crucial role in the pathogenesis of MFS and related disorders, such as Loeys–Dietz syndrome (LDS), which is caused by mutation in TGF-β signaling-related genes. In addition, recent studies show that angiotensin II type 1 receptor (AT1R) signaling enhances cardiovascular pathologies in MFS, and the angiotensin II receptor blocker losartan has the potential to inhibit aortic aneurysm formation. However, the relationship between TGF-β and AT1R signaling pathways remains poorly characterized. In this review, we discuss the recent studies on the molecular mechanisms underlying cardiovascular manifestations of MFS and LDS and the ensuing strategies for management.

著者

Ichiro Honda Hiroshi Matsunaga Kaori Kikuchi Satoshi Matuo Machiko Fukuda Shunsuke Imanishi

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-120, (Released:2016-04-26)

被引用文献数

12

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The roles of plant hormones in the early growth of pepper fruit (Capsicum annuum L.) were investigated. An exogenous hormone treatment study indicated that cytokinin (CK) was more effective at stimulating early fruit growth in two lines than auxin or gibberellin (GA). Endogenous levels of CKs, 3-indole-acetic acid (IAA), and GAs in young pollinated and unpollinated fruit of four lines (two with medium-sized and two with small fruit) were also investigated. In pollinated fruit, the level of trans-zeatin riboside (tZR) increased with fruit size. In unpollinated fruit, tZR did not increase in any lines. IAA levels decreased gradually after flowering and did not differ between pollinated and unpollinated fruit in any lines. Levels of GA1 in unpollinated fruit of the lines in which unpollinated fruit were relatively well enlarged were slightly higher. In the line in which unpollinated fruit could not enlarge, GA1 levels of all samples were lower than the others. These results indicate that tZR is important in the early enlargement of pollinated pepper fruit, and that GA1 is involved in early fruit enlargement, especially in unpollinated pepper.

著者

Eri Katsuyama Ken-ei Sada Noriko Tatebe Haruki Watanabe Takayuki Katsuyama Mariko Narazaki Koichi Sugiyama Katsue S. Watanabe Hiroshi Wakabayashi Tomoko Kawabata Jun Wada Hirofumi Makino

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.8, pp.991-994, 2016 (Released:2016-04-15)

参考文献数

16

被引用文献数

8

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Idiopathic intracranial hypertension (IIH) is a syndrome of increased intracranial pressure and presents as an intractable headache, vomiting, and ophthalmologic manifestations. We herein report the case of a young girl who presented with bilateral abducens nerve palsy due to IIH as the onset of systemic lupus erythematosus (SLE). The patient was successfully treated with corticosteroid therapy. Our case lacked the typical symptoms of IIH, such as headache or nausea; therefore, it is necessary to carefully determine the cause of bilateral abducens nerve palsies. The development of IIH in SLE patients is a rare occurrence, but this manifestation should not be overlooked.

著者

Orikasa Yuki Masese Titus Koyama Yukinori Mori Takuya Hattori Masashi Yamamoto Kentaro Okado Tetsuya Huang Zhen-Dong Minato Taketoshi Tassel Cédric Kim Jungeun Kobayashi Yoji Abe Takeshi Kageyama Hiroshi Uchimoto Yoshiharu

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-07-11

被引用文献数

288

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高エネルギー密度・高安全性・低コスト二次電池の開発に成功 -リチウムからマグネシウム金属へ-. 京都大学プレスリリース. 2014-07-11.

著者

Hiroshi Kobayashi Masaru Yamaoka Makoto Hayashi Bunnai Ogiso

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.1, pp.93-99, 2016 (Released:2016-03-26)

参考文献数

27

被引用文献数

1 5

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A non-contact electromagnetic vibration device (NEVD) was previously developed to monitor the condition of periodontal tissues by assessing mechanical parameters. This system requires placement of an accelerometer on the target tooth, to detect vibration. Using experimental tooth models, we evaluated the performance of an NEVD system with a laser displacement sensor (LDS), which does not need an accelerometer. Simulated teeth (polyacetal rods) were submerged at various depths in simulated bone (polyurethane or polyurethane foam) containing simulated periodontal ligament (tissue conditioner). Then, mechanical parameters (resonant frequency, elastic modulus, and viscosity coefficient) were assessed using the NEVD with the following detection methods: Group 1, measurement with an accelerometer; Group 2, measurement with an LDS in the presence of the accelerometer; and Group 3, measurement with an LDS in the absence of the accelerometer. Statistical analyses were performed using nonparametric methods (n = 5) (P < 0.05). The three mechanical parameters significantly increased with increasing depth. In addition, the mechanical parameters significantly differed between the polyurethane and polyurethane foam models. Although Groups 1 and 2 did not significantly differ, most all mechanical parameters in Group 3 were significantly larger and more distinguishable than those in Groups 1 and 2. The LDS was more accurate in measuring mechanical parameters and better able to differentiate periodontal tissue conditions. (J Oral Sci 58, 93-99, 2016)

著者

Chuwa Tei Teruhiko Imamura Koichiro Kinugawa Teruo Inoue Tohru Masuyama Hiroshi Inoue Hirofumi Noike Toshihiro Muramatsu Yasuchika Takeishi Keijiro Saku Kazumasa Harada Hiroyuki Daida Youichi Kobayashi Nobuhisa Hagiwara Masatoshi Nagayama Shinichi Momomura Kazuya Yonezawa Hiroshi Ito Satoshi Gojo Makoto Akaishi Masaaki Miyata Mitsuru Ohishi WAON-CHF Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.4, pp.827-834, 2016-03-25 (Released:2016-03-25)

参考文献数

32

被引用文献数

42

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Background:Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain.Methods and Results:In 19 institutes, we prospectively enrolled hospitalized patients with advanced HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission and BNP >300 pg/ml regardless of more than 1 week of medical therapy. Enrolled patients were randomized into Waon therapy or control groups. Waon therapy was performed once daily for 10 days with a far infrared-ray dry sauna maintained at 60℃ for 15 min, followed by bed rest for 30 min covered with a blanket. The primary endpoint was the ratio of BNP before and after treatment. In total, 76 Waon therapy and 73 control patients (mean age 66 years, men 61%, mean plasma BNP 777 pg/ml) were studied. The groups differed only in body mass index and the frequency of diabetes. The plasma BNP, NYHA classification, 6-min walk distance (6MWD), and cardiothoracic ratio significantly improved only in the Waon therapy group. Improvements in NYHA classification, 6MWD, and cardiothoracic ratio were significant in the Waon therapy group, although the change in plasma BNP did not reach statistical significance. No serious adverse events were observed in either group.Conclusions:Waon therapy, a holistic soothing warmth therapy, showed clinical advantages in safety and efficacy among patients with advanced HF. (Circ J 2016; 80: 827–834)

著者

田中 弘 Tanaka Hiroshi

出版者

神奈川大学経済学会

雑誌

商経論叢 = Review of economics and commerce (ISSN:02868342)

巻号頁・発行日

vol.50, no.2, pp.81-162, 2015-03

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論説

著者

S. Maninang John C. Lizada Ma. Concepcion Gemma Hiroshi

出版者

Elsevier Ltd

雑誌

Food chemistry (ISSN:03088146)

巻号頁・発行日

vol.117, no.2, pp.352-355, 2009-11

被引用文献数

18 8

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The scientific basis of the adverse, or at times lethal, effect of ingesting durian (Durio zibethinus Murray) while imbibing alcohol has not been established. Symptoms are reminiscent of the disulfiram–ethanol reaction (DER) arising from the inhibition of aldehyde dehydrogenase (ALDH). Cognizant of the inhibitory effect of sulphur compounds like disulfiram on ALDH and the rich sulphur content of durian, the influence of durian fruit extract on the ALDH-mediated oxidative metabolism of acetaldehyde was investigated. We report a dose-dependent inhibition of yeast ALDH (yALDH), at most 70% at 0.33 ppm (mg extract/l assay mix), by dichloromethane:pentane extracts. Sulphur-rich TLC fruit extract fractions that eluted farthest from the origin effected the greatest inhibitory action. yALDH assay using diethyl disulfide as internal standard further supports the role of durian’s sulfury constituents in the fruit’s ALDH-inhibiting property. Insight into the etiology of DER-like symptoms felt upon simultaneous durian and alcohol consumption is hereby presented.

著者

太郎丸 博 田中 重人 タロウマル ヒロシ タナカ シゲト Tarohmaru Hiroshi Tanaka Sigeto

出版者

大阪大学人間科学部

雑誌

大阪大学人間科学部紀要 (ISSN:03874427)

巻号頁・発行日

vol.23, pp.167-183, 1997-03

著者

Morino Hiroshi Miyamoto Hisashi

出版者

National Museum of Nature and Science

雑誌

Bulletin of the National Museum of Nature and Science. Series A, Zoology (ISSN:18819052)

巻号頁・発行日

vol.41, no.1, pp.1-13, 2015-02

著者

Morino Hiroshi Miyamoto Hisashi

出版者

National Museum of Nature and Science

雑誌

Bulletin of the National Museum of Nature and Science. Series A, Zoology (ISSN:18819052)

巻号頁・発行日

vol.41, no.2, pp.105-121, 2015-05

著者

Yanagawa,Hiroshi

出版者

Japanese Society of Plant Physiologists

雑誌

Plant and cell physiology

巻号頁・発行日

vol.14, no.4, 1973-08

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Plant growth inhibitors I, II, III, VII, VIII, which occur in asparagus, promoted growth and pyruvate oxidation in Streptococcus faecalis 10Cl. Activities were compared with those obtained withα-lipoic acid and several structurally related synthetic sulfur containing compounds.

著者

Chisato Tomoda Yuna Ogimi Fumi Saito Chie Masaki Junko Akaishi Kenichi Matsuzu Akifumi Suzuki Takashi Uruno Keiko Ohkuwa Hiroshi Shibuya Wataru Kitagawa Mitsuji Nagahama Kiminori Sugino Koichi Ito

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ15-0631, (Released:2015-12-10)

被引用文献数

1 6

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Metastatic differentiated thyroid carcinoma (DTC) is an uncommon cause of malignant pleural effusion (MPE) and the characteristics and clinical course have been rarely described. Herein, we report a retrospective review of the clinical course of 18 patients (15 women and 3 men) with MPE from DTC who underwent treatment at our institution between January 2005 and December 2014. MPE from DTC was diagnosed based on cytology and/or level of thyroglobulin in the pleural fluid. Pathologically, papillary carcinoma was found in 16 patients and follicular carcinoma in 2 patients. Median ages at initial diagnosis of DTC and MPE were 64 years (range, 22-79) and 74 years (range, 39-86), respectively. All patients showed radiologically apparent lung metastases, with MPE developing after 0-212 months (median, 25). In 16 patients (88.9%), other coexistent distant metastases at the time of MPE diagnosis were found in the bone (n = 10), brain (n = 5), and skin (n = 2). All patients were treated conservatively with palliative thoracentesis or chest tube drainage with or without pleurodesis. Recurrent MPE after treatment was seen in 9 patients; discharge to home health care after treatment for MPE was possible for 14 patients. The overall survival after initial diagnosis varied considerably from 14 months to 37 years, but the median survival after appearance of MPE was 10 months (range, 1-28). Systemic therapy for iodine-resistant recurrent thyroid disease may need to be considered as a treatment option for patients with MPE.

著者

Ryo Naito Katsumi Miyauchi Hirokazu Konishi Shuta Tsuboi Manabu Ogita Tomotaka Dohi Takatoshi Kasai Hiroshi Tamura Shinya Okazaki Kikuo Isoda Hiroyuki Daida

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.32284, (Released:2015-11-11)

参考文献数

16

被引用文献数

1 5

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Aim: Current Japanese guidelines state the target level of low-density lipoprotein cholesterol (LDL-C) of <100mg/dL for secondary prevention of coronary artery disease (CAD). However, this level was set considering the results of trials mainly conducted in Western countries. In addition, the effect of achieving target LDL-C on secondary prevention is unknown. Methods: We examined the effects of achieving target LDL-C on clinical outcomes. Patients who underwent percutaneous coronary intervention at Juntendo University Hospital (Tokyo, Japan) from 2004 to 2010 and received follow-up coronary angiography (CAG) were analyzed. The study population was divided into two groups based on the follow-up LDL-C. The incidence of major adverse cardiovascular events within 3 years after the follow-up CAG was examined. Results: A total of 1321 consecutive patients were enrolled. Sixty-three percent of the patients achieved the target LDL-C. The rate of 3-year events was lower in the group that achieved the target LDL-C (achieved group). The adjusted relative risk reduction in the achieved group was 26% (p=0.02). In the sub-analysis among the four groups stratified by baseline LDL-C of 140 and follow-up LDL-C of 100, the adjusted hazard ratio for 3-year events was 1.84 (95% confidence interval; 1.10-3.24)in Group 3 (baseline <140, follow-up ≥100) and 2.05 (1.18-3.74) Group 4 (baseline ≥140, follow-up ≥100) [Group 2 (baseline ≥140, follow-up <100) as reference]. Conclusions: Our data suggested that follow-up LDL-C <100mg/dL was appropriate for secondary prevention of CAD in Japanese population.