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[Introduction] Many antidepressants are indicated for the treatment of major depression. Two network meta-analyses have provided the most comprehensive assessments to date, accounting for both direct and indirect comparisons; however, these reported conflicting interpretation of results. Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. [Methods and analysis] We will include all randomised controlled trials reported as double-blind and comparing one active drug with another or with placebo in the acute phase treatment of major depression in adults. We are interested in comparing the following active agents: agomelatine, amitriptyline, bupropion, citalopram, clomipramine, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, levomilnacipran, milnacipran, mirtazapine, nefazodone, paroxetine, reboxetine, sertraline, trazodone, venlafaxine, vilazodone and vortioxetine. The main outcomes will be the proportion of patients who responded to or dropped out of the allocated treatment. Published and unpublished studies will be sought through relevant database searches, trial registries and websites; all reference selection and data extraction will be conducted by at least two independent reviewers. We will conduct a random effects network meta-analysis to synthesise all evidence for each outcome and obtain a comprehensive ranking of all treatments. To rank the various treatments for each outcome, we will use the surface under the cumulative ranking curve and the mean ranks. We will employ local as well as global methods to evaluate consistency. We will fit our model in a Bayesian framework using OpenBUGS, and produce results and various checks in Stata and R. We will also assess the quality of evidence contributing to network estimates of the main outcomes with the GRADE framewor

2016-08-30 10:20:42
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1 0 0 0 OA マルクス学位論文の検討 (Uberlegungen zur Marxschen Dissertation)

著者: 宮本十蔵
出版者: 信州大学人文学部
雑誌: 信州大学人文科学論集
巻号頁・発行日: vol.3, pp.1-10, 1968-12-15

2016-08-29 15:11:00
1 レファ協

http://hdl.handle.net/10091/11167

1 0 0 0 OA 超伝導と電子相関(第44回物性若手夏の学校(1999年度),講義ノート)

著者: 小形正男
出版者: 物性研究刊行会
雑誌: 物性研究 (ISSN:07272997)
巻号頁・発行日: vol.73, no.2, pp.309-317, 1999-11-20

この論文は国立情報学研究所の電子図書館事業により電子化されました。

2016-08-29 00:29:28
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http://hdl.handle.net/2433/96738

1 0 0 0 OA <研究ノート>実業専門学校経営論に関する史的考察ノート : 渡邊龍聖『乾甫式辞集』に見られる商業専門教育論

著者: 中村治人 NAKAMURA Haruhito
出版者: 名古屋大学史編集室
雑誌: 名古屋大学史紀要 (ISSN:09155848)
巻号頁・発行日: vol.5, pp.3-25, 1997-03 (Released:2006-01-06)

国立情報学研究所で電子化したコンテンツを使用している。

2016-08-28 23:34:08
1 + 1 Wikipedia

http://hdl.handle.net/2237/5264

1 0 0 0 OA 一般労働組合の成立過程 - ロンドン・ドック・ストライキ(一八八九年)を中心にして -

著者: 前川嘉一
出版者: 京都大學經濟學會
雑誌: 經濟論叢 (ISSN:00130273)
巻号頁・発行日: vol.79, no.1, pp.43-67, 1957-01

2016-08-28 14:41:00
1 はてなブックマーク

1 0 0 0 OA 場の制御と再生技術による機械加工工具の長寿命化に関する研究

著者: 柳原聖
出版者: 東京大学工学系研究科産業機械工学専攻
巻号頁・発行日: 2006-11-16

報告番号: 乙16649 ; 学位授与年月日: 2006-11-16 ; 学位の種別: 論文博士 ; 学位の種類: 博士(工学) ; 学位記番号: 第16649号 ; 研究科・専攻: 工学系研究科産業機械工学専攻

2016-08-28 14:24:26
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http://hdl.handle.net/2261/38176

1 0 0 0 OA Augmented expression of neuronal nitric oxide synthase in the atria parasympathetically decreases heart rate during acute myoccardial infarction in rats

著者: Takimoto Yoshihito
出版者: Kyoto University
巻号頁・発行日: 2003-01-23

新制・論文博士

2016-08-27 12:59:28
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http://hdl.handle.net/2433/149374

1 0 0 0 OA 少年犯罪報道と専門職倫理 : 成長発達権を手がかりとして

著者: 塚本晴二朗
出版者: 北海道大学大学院文学研究科応用倫理研究教育センター
雑誌: 応用倫理 (ISSN:18830110)
巻号頁・発行日: vol.7, pp.3-15, 2013-10-01

The ideal behind the Juvenile Law is the “nurturing of sound and healthy juveniles.” Following this ideal, Article 61 of the Juvenile Law forbids the reporting of “rulings that pertain to judgments concerning juvenile offenders in family court or crimes committed when the individual prosecuted is a juvenile.” However, starting from Article 21 of the Constitution which honors freedom of expression as central, Article 61 of the Juvenile Law becomes an ethical standard. Article 21 of the Constitution starts from the idea of respecting freedom of expression, granting autonomy to the press. In this article, I draw attention this. In this article, I argue that juvenile crime reporting is not only a legal but also an ethical issue. Firstly, I provide a brief overview on a logic which approves of such reporting that the juveniles who committed a crime can be guessed. Secondly, I consider “the rights to grow and develop for the juveniles” in the light of an anonymous reporting on a juvenile crime. This idea is based on ethics of rights, which I criticize in the rest of the article. Thirdly, I explore Clifford Christians's ethics of the “common good” in order to critically to examine the rights-based rationale of juvenile crime reporting. Lastly, I examine the interrelations of juvenile crime reporting, journalists as professionals, and professional ethics.