著者
Kazuaki Matsumoto Akari Shigemi Kazuro Ikawa Naoko Kanazawa Yuko Fujisaki Norifumi Morikawa Yasuo Takeda
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.38, no.2, pp.235-238, 2015-02-01 (Released:2015-02-01)
参考文献数
17
被引用文献数
5 22

Ganciclovir is a nucleoside guanosine analogue that exhibits therapeutic activity against human cytomegalovirus infection, and is primarily excreted via glomerular filtration and active tubular secretion. The adverse effects induced by ganciclovir therapy are generally of a hematological nature and include thrombocytopenia and leukopenia. Low marrow cellularity and elevated serum creatinine have been identified as risk factors for ganciclovir-induced neutropenia. However, the risk factors for thrombocytopenia have yet to be determined. Therefore, this study investigated patients administered ganciclovir to determine the risk factors for thrombocytopenia and leukopenia. Thrombocytopenia occurred in 41 of these patients (30.6%). Multivariate logistic regression analysis identified three independent risk factors for thrombocytopenia: cancer chemotherapy (odds ratio (OR)=3.1), creatinine clearance (<20 mL/min) (OR=12.8), and the ganciclovir dose (≥12 mg/kg/d) (OR=15.1). Leukopenia occurred in 36 patients (28.6%), and white blood cell count (<6000 cells/mm3) (OR=3.7) and the ganciclovir dose (≥12 mg/kg/d) (OR=7.8) were identified as risk factors. These results demonstrated that several factors influenced the occurrence of ganciclovir-induced thrombocytopenia and leukopenia, and suggest that special attention should be paid to patients receiving cancer chemotherapy with a low creatinine clearance (<20 mL/min) and high dose (≥12 mg/kg/d) in order to avoid ganciclovir-induced thrombocytopenia.
著者
鈴木, 良知
出版者
巻号頁・発行日
vol.[3],
著者
沢村 鶴松
出版者
The Japan Society of Naval Architects and Ocean Engineers
雑誌
造船協會論文集 (ISSN:18842062)
巻号頁・発行日
vol.1965, no.118, pp.337-347, 1965 (Released:2010-01-20)
参考文献数
2
被引用文献数
1

At the beginning of the initial design of ship, the breadth of ship has been determined by the formulas B=L/10+α (α=4.56), B=L/9+β (β_??_3.2) or L/B ratio (6.57.5 for cargo boat). But the above formulas have no connections with KG, GM and the freeboard. The author has delived the relation between B and D from the GM equation. The result is as following.[2Q/GM (d/D) D+1] 2-4QP/GM2 (d/D) 2B2=1whereP=Cw/Cb (0.0106+0.0727 Cw) =1/RQ=n (d/D) - (d/D) 2Cw/Cb+CwThe above equation is a hyperbola of B and D. So B can be put for an asymptote of this hyperbola.B=√RQ/L/Dratio·L+GM (d/D) √R/4Q where L=D×L/D ratio.The above equation can be expressed as following.B=L/const1+GM+ (d/D) const2 (1) Flush DK Shelter DK Three isl Well DK Oil Tanker(KG/D) (0.60) (0.60) (0.65) (0.52) Const1 8.38.7 7.78.2 8.48.8 12.513.2Const2 4.64.5 4.54.4 4.2 5.7Fore figure is U shape, aft figure is V.The const1 varies by the D/d ratio and KG/D, but the const2 varies very small.When the second term of the equation (1) is large in case of an oil tanker, a correction value [= (the second term of eq (1)) 2×1/2B] must be subtracted from B in the equation (1).The author has drawn the curves of R and Q for the general application.

1 0 0 0 OA 古刀 5巻

著者
菅原忠皎 [著]
巻号頁・発行日
vol.[4], 1794
著者
豊田秀樹編著
出版者
東京図書
巻号頁・発行日
2012
著者
坂井 隆
出版者
上智大学
雑誌
上智アジア学 (ISSN:02891417)
巻号頁・発行日
vol.23, pp.261-309, 2005-12-27

<特集>東南アジアの土器と施釉陶磁器(Technology and Chronology of Gazed Ceramics in Southeast Asia) 第3部:アジア・太平洋の海を繋ぐ肥前陶磁 (Part 3: Transpacific Trade of Hizen Ware: from Asia to the New World, Earthenware and Glazed Ceramics in Southeast Asia)
著者
加藤 茂 酒井 裕司 小島 紀徳
出版者
日本海水学会
雑誌
日本海水学会誌 = Bulletin of the Society of Sea Water Science, Japan (ISSN:03694550)
巻号頁・発行日
vol.67, no.6, pp.305-317, 2013-12-01
参考文献数
70

Vegetated coastal habitats - mangrove forests, salt-marshes and seagrass meadows - for blue carbon sink purposes are very important ecosystems. They provide valuable ecosystem functions, including a large carbon sink capacity and very rich biodiversity for human sustenance. Mangrove forests are considered bio indicators among marine-river estuary ecosystems in sub-tropical and tropical regions of the world. It is a unique habitat for several fresh and salt water species. The present research is aimed at studying the carbon accumulation and food cycle system in a rehabilitated mangrove site in southern Thailand. The rehabilitation of mangroves at abandoned shrimp ponds in Nakhon Si Thammarat, southern Thailand, has been taking place since 1998. Almost seven million mangrove trees have been planted over 1200 ha of abandoned shrimp ponds and new mud flats. It is observed that the mangrove plantation increases the population of species like crab, shellfish, shrimp and fish at the rehabilitated mangrove site. The food cycle system of the rehabilitated mangrove site and its surrounding mangrove forests is being studied. Stable isotopes such as &delta;<sup>15</sup>N and &delta;<sup>13</sup>C are monitored as a primary parameter to study the food cycle system in the mangrove forests and the coast around the mangrove forests. It has been found that the &delta;<sup>15</sup>N content in living organisms gradually accumulates from small phytoplankton to large fish in the food cycle system. The &delta;<sup>13</sup>C content in living organisms also gradually accumulates from phytoplankton to large fish in the food cycle system. The analysis data reveals that carnivorous fish enter the 12 to 13th stage of the food cycle system, which is triggered by the fall of mangrove leaves in the rehabilitated mangrove forest. Carbon portion of the soil also increased at the rehabilitated mangrove planting site. The rehabilitated mangrove forest will act as a sink source for atmospheric carbon and develop rich biodiversity of a marine-river estuary ecosystem.
著者
木村 照夫 井野 晴洋 西田 優一 青山 尚樹 柴田 勝司
出版者
一般社団法人 プラスチック成形加工学会
雑誌
成形加工 (ISSN:09154027)
巻号頁・発行日
vol.22, no.3, pp.153-159, 2010 (Released:2010-07-24)
参考文献数
5
被引用文献数
2 2

This study investigated a compression molding method of carbon fiber reinforced thermoplastics (CFRTP) made of carbon fiber extracted from CFRP waste. The short carbon fibers were mixed with polyester fibers using a papermaking method to make the preform sheet of compression molding. The waste obtained from a textile water jet loom was used as a matrix material. The setting speed of each fiber during the papermaking process was regulated by using a dispersing agent to obtain the good dispersion of each fiber. Laminated preform sheets combined with polyester fibers and carbon fibers were compressed with heating at 300 ℃ and then the polyester fiber was melted as a matrix material. It was cleared from the experimental results that the mechanical properties of molded CFRTP largely depends on both the fiber dispersion and the content of carbon fiber in the preform.