ランキング (合計) - Ceek.jp Altmetrics

1 0 0 0 OA Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride

著者: 宮崎正三有田隆一堀了平伊藤圭二
出版者: The Pharmaceutical Society of Japan
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: vol.22, no.3, pp.638-642, 1974-03-25 (Released:2008-03-31)
被引用文献数: 13 21

The existence of the two crystalline forms of chlortetracycline hydrochloride (CTC-HCI) was confirmed by infrared spectroscopy and X-ray diffraction. From the dissolution studies with crystalline powder and compressed disk, an appreciable difference in the dissolution behavior in water was detected between the two forms. In order to determine the effect of polymorphism on the gastrointestinal absorption of CTC-HCl, blood plasma levels obtained in rabbits after intraduodenal administration and cumulative amounts excreted in human subjects after oral administration of the two forms were compared. The results indicated that polymorphic state of CTC-HCl significantly influences bioavailability of the CTC-HCl.

2017-12-27 04:13:43
1 + 0 Twitter

1 0 0 0 OA 没落と芸術批評の交叉するところ : ヘーゲル美学における造形芸術への現実主義的な眼差しについて

著者: 馬場浩平
出版者: 東京都立大学大学院独文研究会
雑誌: METROPOLE (ISSN:13412515)
巻号頁・発行日: no.27, pp.1-42, 2004

2017-12-27 03:50:57
1 + 0 Twitter

http://hdl.handle.net/10748/4964

1 0 0 0 OA 古今六義諸説

著者: 小沢, 蘆庵
出版者: 写

2017-12-27 03:23:07
1 + 0 Twitter

1 0 0 0 IR 多孔性粉体との混合物中における医薬品の特異な性質について

著者: 市川順一
出版者: 千葉大学
巻号頁・発行日: 1985

学位:千大院薬博甲第17号

2017-12-27 02:59:56
1 + 0 Twitter

https://ci.nii.ac.jp/naid/500000013019

1 0 0 0 医薬品粉体のメカノケミカル効果 : 環境温度の影響を中心に

著者: 松本崇弘
出版者: 昭和大学
巻号頁・発行日: 1990

博士論文

2017-12-27 02:58:04
1 + 0 Twitter

1 0 0 0 OA 分子探針を用いる走査型トンネル顕微鏡

著者: 西野智昭梅澤喜夫
出版者: 公益社団法人日本分析化学会
雑誌: 分析化学 (ISSN:05251931)
巻号頁・発行日: vol.54, no.6, pp.417-426, 2005 (Released:2005-08-31)
参考文献数: 16

分子探針を用いた走査型トンネル顕微鏡(STM)について,これまで行われた研究を概説した.分子探針を用いることにより,探針-試料間の水素結合,配位結合及び電荷移動相互作用の各々に基づき,化学選択的なSTM観察が可能となる.これは,上記3種の相互作用に伴う電子波動関数の重なりを通じてトンネル電流が促進されるためである.分子探針を用いることによって得られる化学選択性は,探針分子に含まれる官能基を設計することにより制御できる.また,多くの分子探針は自己組織化単分子膜により下地金探針を修飾することによって作製されたが,導電性ポリマー又はカーボンナノチューブを探針として用いても化学選択性が得られる.更に分子探針によって配座解析,単分子-単分子間の電子移動の測定も可能となる.

2017-12-27 02:57:42
1 + 1 Wikipedia

1 0 0 0 OA Preparation of Phenylbutazone Polymorphs and Their Transformation in Solution

著者: 金庭延慶市川順一松本崇弘
出版者: The Pharmaceutical Society of Japan
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: vol.36, no.3, pp.1063-1073, 1988-03-25 (Released:2008-03-31)
参考文献数: 12
被引用文献数: 5 8

Polymorphism of phenylbutazone was investigated in detail. Pure α form of phenylbutazone could not be obtained by conventional methods, but it was found that the β form was transformed to the stable α form in ethanol solution at 4°C. At 15 and 25°C, the β form was transformed to a mixture of the α and δ forms, while at 35°C, tha α form in the mixture was converted to the δ form. These results showed that the preparation of a pure polymorphic form by means of recrystallization in solution is not necessarily straightforward. The dissolution bethavior of each form in buffer solution was examined next. The transition temperatures of the pairs of α and δ forms and of α and β forms were 29.0 and 61.6°C, respectively, in buffer solution as determined by means of the non linear van't Hoff model proposed by Grant et al. The heats of fusion of the α, β and δ forms were 8.74, 6.48 and 6.85 kcal/mol, and their melting points were 91.2, 93.3 and 101.4°C, respectively. These results suggested that the pair of β and δ forms is in a monotropic relation and the pairs of a α and β forms and of α and β forms are in enantiotropic relationships.

2017-12-27 02:57:30
1 + 0 Twitter

1 0 0 0 IR 社会事業教育における社会科学の視点 : 戦前・戦後のつながりに注目して

著者: 阿部敦渡邊かおり
出版者: 奈良女子大学
雑誌: 奈良女子大学社会学論集 (ISSN:13404032)
巻号頁・発行日: vol.20, pp.53-64, 2013

This study aims to comprehend the treatment of social science subjects in the social welfare curriculum of Japan. As a result of the study, the following points became clear:(1) The social science subjects occupied an important place in the curriculum before WWII.(2) This trend was still applicable to the first few years after the end of WWII.(3) After 1948, many social science subjects were excluded from the curriculum by the influence of Florence Brugger (Chief of Social Work Training Branch, Welfare Div., Public Health and Welfare Sec., GHQ/SCAP).(4) A complete revision of the curriculum for certified social workers in 1987 has further ingrained this trend.