著者

川村康文

出版者

「フォーラム理科教育」研究会

雑誌

フォーラム理科教育

巻号頁・発行日

vol.5, pp.52-52, 2003-11-14

著者

一松 信

出版者

The Mathematical Society of Japan

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.39, no.3, pp.276-281, 1987

著者

小林 昭七

出版者

The Mathematical Society of Japan

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.39, no.4, pp.348-354, 1987

著者

林 美貴子

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.141, no.3, pp.169-174, 2013 (Released:2013-03-08)

参考文献数

16

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デスモプレシン酢酸塩水和物の口腔内崩壊錠(ミニリンメルト®OD錠120 μg,240 μg)は,本邦初の経口夜尿症用剤として,2012年3月に承認を取得した.本剤は,アルギニンバソプレシン(AVP)の誘導体で,AVPの1位のアミノ酸を脱アミノ化し,さらに8位のL-アルギニンをD-アルギニンに置換した合成ペプチドである.また,腎集合管細胞に分布するV2受容体を活性化して水の再吸収を促進する薬理学的作用(抗利尿作用)をもつ選択的V2受容体アゴニストである.デスモプレシンのラットにおけるバソプレシンV1,V2受容体およびオキシトシン受容体に対する結合親和性(Ki)はそれぞれ1748,1.04,81 nmol/L であり,バソプレシンV2受容体に選択的な結合親和性を示した.デスモプレシンは,バソプレシンV1受容体に比べV2受容体に対して高い選択性を有し,昇圧作用をほとんど有さず,用量に依存して抗利尿作用が長時間持続する特徴を有している.夜尿症患者を対象とした国内第III相試験では,本剤投与3~4週の14日間あたりの,ベースラインからの夜尿日数減少量は,本剤が3.3日,プラセボが1.5日で,本剤はプラセボに比べ有意に夜尿日数を減少させることが確認された.また,安全性においても特に問題となる有害事象は認められなかった.これらの結果より,夜尿症患者に対する本剤の安全性,忍容性が確認された.デスモプレシン製剤は,海外で40年にわたる臨床使用経験がある.経鼻製剤では,アレルギー性鼻炎等による,鼻腔粘膜からの吸収障害による薬効への影響等が認められていた.経口製剤の開発により,そのような課題が克服された.夜尿症治療に重要とされる水分摂取管理において,水なしで服用できる本OD錠は安定した臨床効果が期待できる.投与の簡便性も加わり,夜尿症で悩む患者のQOLの向上に貢献しうる薬剤であると考えられる.

著者

中田 晋

出版者

仙台市科学館

雑誌

仙台市科学館研究報告 (ISSN:13450859)

巻号頁・発行日

no.25, 2016-01-13

著者

藤川 正毅 石川 清貴 真壁 朝敏 田中 真人 笹川 崇 表 竜二

出版者

The Japan Society of Mechanical Engineers

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

2016

被引用文献数

5

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This paper proposes a novel implementation scheme of geometrically nonlinear finite element programs, which automatically compute exact internal force vectors and element stiffness matrices by numerically differentiating a strain energy function at each element. This method can significantly simplify the complex implementation procedure which is often observed in conventional finite element implementations, since it never requires B matrices, stress tensors, and elastic tensors by hand. The proposed method is based on a highly accurate numerical derivatives which use hyper-dual numbers and never suffer from any round-off and truncation errors. Several numerical examples are performed to demonstrate the effectiveness and robustness of the proposed method.

著者

武藤 世良

出版者

The Japanese Psychological Association

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

2016

被引用文献数

6

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This study examined the action tendencies of respect-related emotions in Japanese university students. Participants (<i>n</i> = 405) randomly received a questionnaire about one of six respect-related emotions: (a) <i>keiai</i> (respect mingled with mild love); (b) <i>shinsui</i> (idolatry, worship, and adoration); (c) <i>ifu</i> (awe mingled with fear); (d) <i>kanshin</i> (admiration); (e) <i>kyotan</i> (wonder); and (f) <i>sonkei</i> (respect proper) and were asked to recall a situation they felt the emotion. Next, they rated how much they felt like doing the respect-related (intrapersonal or interpersonal) actions in the situation. Statistical analysis revealed several action tendencies of respect-related emotions, however, the degree of each differed between the prototypical episodes of the emotions (a)–(e). The action tendency pattern of <i>sonkei</i> was most similar to that of <i>keiai</i>, therefore <i>keiai</i> could be considered as the prototypical feeling of <i>sonkei</i> in university students. Furthermore, almost all the respect-related emotions tended to strongly motivate willingness for self-correction and improvement. These findings suggest that respect-related emotions play an important role in self-improvement and building good relationships with superiors, at least in late adolescence.

著者

武藤 世良

出版者

The Japanese Psychological Association

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

2016

被引用文献数

5

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This study examined the reproducibility of the hierarchical semantic structure of respect-related emotions and the prototypical meaning of <i>sonkei</i> (respect) in modern Japanese people. Participants, ages 20–79, rated the semantic similarity of 153 pairs of 18 respect-related words used in previously published work. Hierarchical cluster analysis (<i>n</i> = 515) showed almost the same semantic organization as the previous study. The highest level of abstraction consisted of "person-focus respect, emotional attitude" and "action-focus respect, emotional state." The basic level consisted of (a) respect mingled with mild love; (b) ought-respect (respect as moral duty); (c) idolatry (worship and adoration); (d) awe mingled with fear; (e) admiration; and (f) wonder. The word <i>sonkei</i> was included in category (a). Additional analyses were conducted according to age. The results revealed that the basic categories seen in adults ages 60–79 differed from those in the whole sample and that <i>sonkei</i> was included in the category which could be considered as ought-respect. These findings suggest that the semantic organization of respect-related emotions is gradually changing under the influence of modern culture.

著者

川瀬 光義

出版者

京都大學經濟學會

雑誌

經濟論叢 (ISSN:00130273)

巻号頁・発行日

vol.136, no.5-6, pp.557-578, 1985-11

著者

Michel Komajda

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.5, pp.948-953, 2015-04-24 (Released:2015-04-24)

参考文献数

53

被引用文献数

13 24 3

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The management of chronic heart failure (HF) with low ejection fraction (EF) has changed considerably over the past 30 years: the introduction of angiotensin-converting enzyme inhibitors (ACEIs), β-blockers, angiotensin-receptor blockers, mineralocorticoid-receptor antagonists and recently, the Ifblocker, ivabradine, has led to a significant reduction in overall mortality and HF mortality. Recently, a trial testing a dual inhibitor blocking the angiotensin-II receptor and neprylisin, the enzyme responsible for B-type natriuretic peptide degradation, showed that this complex molecule improved clinical outcomes compared with the ACEI enalapril. However, challenges remain in the management of HF, with suboptimal implementation of guideline-recommended therapies, a changing profile of patients who are older and have multiple comorbidities and a high rate of early rehospitalization for HF. Use of devices such as implantable cardiac defibrillators and cardiac resynchronization therapy are also associated with an improvement in outcomes in this condition. HF with preserved EF (HFpEF), a growing fraction of the HF population, remains a clinical dilemma: no pharmacological intervention has so far demonstrated any convincing benefit on outcome. Heterogeneity of the populations tested, role of comorbidities, difficulties in identifying patients with HFpEF, as well as a mismatch between the clinical phenotypes and the treatments tested, can explain the failure to find beneficial interventions. Overall, the management of HF after discharge remains fragmented and concerted action by all professionals concerned is needed. (Circ J 2015; 79: 948–953)

出版者

共立出版