著者
相良 泰行
出版者
日本食品科学工学会
雑誌
日本食品科学工学会誌 (ISSN:1341027X)
巻号頁・発行日
vol.56, no.8, pp.429-443, 2009-08 (Released:2011-03-05)
著者
今留 謙一
出版者
日本臨床免疫学会
雑誌
日本臨床免疫学会会誌 (ISSN:09114300)
巻号頁・発行日
vol.36, no.6, pp.433-441, 2013 (Released:2013-12-31)
参考文献数
13

Epstein-Barr virus (EBV)はヒトヘルペスウイルスに属する腫瘍原性ウイルスとして1964年に世界で初めて報告されたウイルスである.しかし,世界の90%の成人が既に感染しており,死ぬまで何の疾患も引き起こさない場合がほとんどである.EBV感染細胞は多岐にわたり,B, T, NK細胞のいわゆるリンパ球系と上皮細胞系においてEBV感染が報告されている(Figure 1).EBV感染症の治療法・治療薬の研究はほとんどなされてこなかった.これはEBV感染モデル動物が存在していなかったことが大きな原因と言える.EBVはマウス・ラットなどの小動物には感染せず,霊長類にはわずかに感染するもののEBVに類似のサルヘルペスウイルスが既に感染していることで個別の解析が困難であることと高価なため研究に使用することが困難であった.適当なモデル動物が無かったためin vivoでの薬剤評価や感染実験ができず,感染直後のEBV特異的宿主免疫応答,EBV遺伝子発現,感染細胞動態などの研究の進展はゆるやかであった.今回我々はNOGマウスを使用しEBVがT/NK細胞感染モデルを作製し病態解明を試みた.その結果,モデルマウスはサイトカイン,感染細胞増殖,臓器への感染細胞浸潤など様々な患者病態を反映し再現していることが示された.また,これまでEBV感染T/NK細胞は白血病やリンパ腫の細胞と同様に腫瘍細胞であると考えられてきたが,このモデルマウスでの解析の結果感染初期は典型的な腫瘍細胞ではないことが明らかとなった.さらに,その応用として新規治療薬の評価,マイナー分画感染に対する感染細胞同定を紹介する.
著者
角田 史雄
出版者
地学団体研究会
雑誌
地学教育と科学運動 (ISSN:03893766)
巻号頁・発行日
no.62, pp.41-47, 2009-12-10
被引用文献数
2
著者
角田 史雄 堀口 万吉
出版者
日本地質学会
雑誌
地質学論集 (ISSN:03858545)
巻号頁・発行日
no.20, pp.21-45, 1981-03-30
被引用文献数
2

The writers and their collaborators have made study on the distribution of seismic intensity in Kanto district. They inquire of a few thousand persons the intensity who live in the wooden houses with second story. The data on the intensity are collected so on after an earthquake occurs. In this paper, following earthquakes are refferred, i.e. local earthquakes of western Tokyo (1979) and east-off Chiba Prefecture (1979); destructive ones of Kanto (1923) and Nishi-Saitama (1931). Approximate location and magnitude of those earthquakes are as follows; [Table] The distribution of seismic intensity of those earthquakes hows that straight, long and narrow zones are severe or sensitive to the earthquakes which are named the abnormalous seismic vibrated zones (F. Tsunoda, 1980). For instance, violent motion was felt along the margins of diluvial uplandand fault zones in the Kanto mountainland in case of the western Tokyo earthquake. Similar distribution was shown in the destructive Nishi-Saitama earthquake. Severe vibrated zone was found along the northeast coast of Tokyo Bay in case of the east-off Chiba Prefecture. Similar irregular distribution of intensity is found in the Kanto earthquake. Most of those anormalous seismic vibrated zones runs in northwest-southeast direction which is the general trend of the basement complex of Kanto Plain, and under some of them, faults of the basement complex are found, for instance, the Ayasegawa fault. So it must be intimately related with the faults developed in the basement. While some zones such as the Iwatsuki-Kasukabe abnormalous seismic vibrated zone run in northeast-southwest direction. The geological meaning of these zones is left to be solved in future. As already pointed out, the shock is also severe in the area where thick peat is deposited.
著者
角田 史雄
出版者
日本地質学会
雑誌
日本地質学会学術大会講演要旨
巻号頁・発行日
vol.100, 1993-03-25

rights: 日本地質学会rights: 本文データは学協会の許諾に基づきCiNiiから複製したものであるrelation: IsVersionOf: http://ci.nii.ac.jp/naid/110003035197/
著者
角田 史雄
出版者
日本地質学会
雑誌
日本地質学会学術大会講演要旨
巻号頁・発行日
vol.83, 1976-03-25

rights: 日本地質学会rights: 本文データは学協会の許諾に基づきCiNiiから複製したものであるrelation: IsVersionOf: http://ci.nii.ac.jp/naid/110003033676/
著者
小坂 共栄 角田 史雄
出版者
一般社団法人 日本地質学会
雑誌
地質学雑誌 (ISSN:00167630)
巻号頁・発行日
vol.75, no.3, pp.127-140, 1969-03-25 (Released:2008-04-11)
参考文献数
15
被引用文献数
4 5
著者
角田 史雄
出版者
一般社団法人 日本地質学会
雑誌
地質学雑誌 (ISSN:00167630)
巻号頁・発行日
vol.108, no.8, pp.483-498, 2002-08-15 (Released:2008-04-11)
参考文献数
74
被引用文献数
1 1

伊豆半島とフォッサマグナ地域の境界部に位置する足柄地域の変形を広域の水平圧縮応力場での構造形成とする見解がよく知られている.しかし,足柄層群全体を変形させている足柄背斜の一般走行は,隣接する丹沢や箱根の変形構造のそれとは,形成時期も形成場も異なっている.また,足柄背斜を切って発達するより小規模な撓曲帯,背斜の西翼の小規模な褶曲,急傾斜帯などは,足柄地域が深成-火山活動の作用をうけつつ隆起していく過程で形成されている.以上のことから,足柄地域の褶曲を中心とする変形構造は,広域的で一様な古応力場のもとでの変形構造の一部ではなく,プリュームあるいはストック状のマグマの貫入やそれに起因する地塊の隆起という局地的な応力場によって形成されたものである.
著者
香川 孝三
出版者
JAPAN SOCIETY FOR GENDER STUDIES
雑誌
日本ジェンダー研究 (ISSN:18841619)
巻号頁・発行日
vol.2003, no.6, pp.27-40, 2003

There are important problems about the public pension paid to female persons. The Japan pension system is a three-tiered, national pension scheme, employees' pension insurance and corporate pension scheme. The former two public pensions will be discussed in this article.<BR>The basic pension benefit is paid by the national pension scheme, while the additional pension benefits are paid through the employees' pension insurance scheme. The insurance premimum for these schemes is decided by the amount of wages or salaries. So the public pension has a strong connection with the wage system in Japan. The amount of wages is determined to sustain a worker's family including husband, wife and some children. That is to say, the wage system is based on the family unit. Therefore the public pension scheme is also based on the family unit. But it should be based on the individual unit in the future. For these purposes the wage system should be designed on the individual job and work performances.<BR>The Japanese model unit of a household is based on a working husband and housewife. The housewife is not required to pay any insurance premium by herself if she gets less than 1.3 million yen as total income per a year. But she can get the basic pension benefit. It seems unfair for female persons who must pay the insurance premium by themselves. It is necessary for her to bear the cost of the insurance scheme. It is now considered at the Ministry of Health, Labour and Welfare whether to impose the burden on the housewife or her husband.<BR>When a housewife is divorced, she will be unable to maintain a living only with the basic pension benefit. She cannot use the additional pension benefit because it belongs to her ex-husband. So it is now planned to divide the additional pension benefits between husband and wife at the time of divorce.<BR>The limit of total income being less than 1.3 million yen per a year prevents female persons working in their full abilities.<BR>Female wages are in general lower than those of the male though wage discrimination on the basis of sex is subject to criminal penalties under Article 4 of the Fair Labour Standards Act providing that an employer shall not engage in discriminatory treatment of a woman as compared with a man with respect to wages by reason of the worker being a woman. On average female wages are about 60% of male wages. This brings about lower pension benefits for female persons.<BR>In Japan wages are composed of three parts: basic wages, various kinds of allowances and bonuses. Basic wages are decided on age, continuous service years, work ability, level of performance etc. There is no uniform level of wages according to the type of job or work. Therefore it is very difficult to apply the principle of "the same work, the same pay" to Japanese establishments. But proper proportionate wage differences should be kept between regular and part- time workers. This is a prerequisite for making a scheme of public pension based on the individual unit, not on the household unit.