著者
佐々木 崇裕 原田 要之助
雑誌
情報処理学会論文誌 (ISSN:18827764)
巻号頁・発行日
vol.56, no.12, pp.2337-2345, 2015-12-15

近年,情報システムは組織にとって欠かせないものとなり,それへの依存も高まっている.その結果,情報システムの事故や情報漏えいが社会に大きな影響を与えるようになった.これらの事故・トラブルの中には,ヒューマンエラーや規則違反といった人の行動に起因しているものがある.人の行動に起因する事故を減らすために航空や医療の分野では,事故という結果に至らなかったヒヤリ・ハット情報を収集・分析・公表する取り組みが行われており,安全に貢献している.本研究では,そのような取り組みが情報セキュリティ分野に導入できないか,取り組みの必要性,事例収集の形態について考察を行った.また,アンケート調査を通じて,その取り組みの導入を実現する可能性があること,情報を収集する際は収集目的を明確に示すことが重要であることが分かった.最後に,情報セキュリティ分野におけるヒヤリ・ハット情報収集の具体的な方法を提案する.

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1915年04月23日, 1915-04-23

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1913年06月03日, 1913-06-03

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1913年05月16日, 1913-05-16

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1933年04月12日, 1933-04-12

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1911年08月19日, 1911-08-19

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1916年08月23日, 1916-08-23

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1952年01月23日, 1952-01-23
著者
ばね文化財調査委員会
出版者
日本ばね学会
雑誌
ばね論文集 (ISSN:03856917)
巻号頁・発行日
vol.2012, no.57, pp.41-57, 2012-05-30 (Released:2012-12-03)

This report provides the survey of Japanese spring technological heritage in the 20th century which was conducted by a JSSE designated committee from 2009 to 2012. The 115 proposed items include coiling machines, spring testing machines, books and papers on spring design & spring manufacturing. Their whereabouts and technical significance are listed in this report. The existing historical coiling machines are listed in chronological manner. The development of spring manufacturing technology is also explained in this table.
著者
Seong Soo Joo Yeong Min Yoo Byung Woo Ahn Sang Yun Nam Yun-Bae Kim Kwang Woo Hwang Do Ik Lee
出版者
公益社団法人日本薬学会
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.31, no.7, pp.1392-1396, 2008-07-01 (Released:2008-07-01)
参考文献数
26
被引用文献数
26 77

Considering the importance of inflammation and apoptosis in neurodegenerative conditions, the potential suppressive effects of the Rg3, a by-product obtained during the steaming of red ginseng, may indicate that Rg3 could provide a beneficial therapeutic approach to treating or preventing neurodegenerative disease. We investigated the effect of Rg3 on Aβ42-mediated microglial activation and inflammation-mediated neurotoxicity in murine BV-2 microglial and Neuro-2a neuroblastoma cells, respectively. Rg3 effectively reduced inflammatory cytokine expression in Aβ42-treated BV-2, and inhibited the binding of NF-κB p65 to its DNA consensus sequences, and significantly reduced the expression of TNF-α in activated microglia. Pretreatment with Rg3 increased the survival rate of Neuro-2a exposed to TNF-α. These observations suggest that Rg3 reduced neurotoxicity by inhibiting chronic inflammation through the suppression of activated microglia. In addition, the expression of pro-inflammatory cytokines in BV-2 stimulated by Aβ42 was decreased but not eliminated by Rg3 when binding to the macrophage scavenger receptor type A (MSRA) was blocked with fucoidan. This implies that the inflammatory response may not be exclusively triggered via MSRA. More interestingly, iNOS was almost completely inhibited in the presence of Rg3 when MSRA binding was blocked with fucoidan. Moreover, Rg3 increased the expression of MSRA in BV-2 transfected with siRNA targeting MSRA mRNA, and this increased MSRA expression may play a role in the phagocytosis of Aβ42 peptides. Our results indicate that inhibition of the inflammatory repertoire of microglia, neuroprotection, and increased MSRA expression induced by Rg3 may at least partly explain its therapeutic effects in chronic neurodegenerative diseases.

1 0 0 0 OA 官報

著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1899年10月21日, 1899-10-21

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著者
大蔵省印刷局 [編]
出版者
日本マイクロ写真
巻号頁・発行日
vol.1904年08月08日, 1904-08-08
著者
Kawasaki Ichiya
出版者
Kinokuniya Co.
雑誌
Japanese Journal of Experimental Medicine (ISSN:00215031)
巻号頁・発行日
vol.42, no.4, pp.327-340, 1972-08
被引用文献数
24
著者
本田 実信
出版者
北海道大学
雑誌
北方文化研究 (ISSN:03856046)
巻号頁・発行日
no.2, pp.89-110, 1967-03
被引用文献数
2
著者
北川 誠一
出版者
学術雑誌目次速報データベース由来
雑誌
オリエント (ISSN:00305219)
巻号頁・発行日
vol.40, no.2, pp.69-84, 1998

In 1236, the <i>tamachi</i> army of Chormaghan Noyan began to conquer the Georgian Kingdom. Starting at their traditonal winter encampment in Arran, they proceeded to the North West. Their first victims were the cities and districts of the western branches of the Middle Kur. In the Kazakh canton of the present Republic of Azerbaijan, their course was divided into three directions. The Nothern course led them to the central and eastern provinces of Georgia. To the south they advanced and conquered the cities of Ani, Kars and Surb Mari, and third course overran the territories of South-West Georgia. In this way almost all the territories of the Georgian Kingdom were conquered.<br>In about 1240, the conquerd part of Georgia was divided among the six Georgian generals, called the generals of ten thousands ("<i>tmanis mtavari</i>" in Georgian) by the Mongols.<br>After the coronation of Emperor Monke, the conquered part of Georgia was put under the physical administration of Arghun-Aqa who made a census in 1254, and Georgia's population was counted and the area was divided into nine <i>tümens</i>. Each of these <i>tümens</i> could afford ten thousand soldiers. It was after this census that a new tax system was introduced by Arghun-Aqa.