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1 0 0 0 OA 日本人の無機ヒ素摂取量の確率論的手法による推計

著者: 小栗朋子吉永淳
出版者: 日本衛生学会
雑誌: 日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日: vol.69, no.3, pp.177-186, 2014 (Released:2014-09-24)
参考文献数: 33
被引用文献数: 8

Objective: The objective was to estimate the inorganic arsenic (iAs) intake of the general Japanese adult population by a probabilistic approach. Methods: Bioaccessible iAs concentrations in rice (n=56) and hijiki (n=32), the two food items that are the major iAs sources for the Japanese, were measured by liquid chromatography-ICP mass spectrometry. The concentration in cooked rice was estimated from the measured concentration in a raw rice sample while taking into consideration the loss of iAs during cooking. The iAs concentration in hijiki was measured using soaked hijiki samples. The daily consumption of cooked rice and soaked hijiki was taken from published data. The distribution profile of daily iAs intake was estimated by multiplying the bioaccesible iAs concentration in cooked rice and soaked hijiki samples by the amount of these samples consumed daily, which were randomly extracted according to the respective distributions. This process was repeated 10,000 times. Results: The distribution profiles of iAs concentration in rice and hijiki were normal and log-normal, respectively, and those of the amount of cooked rice and soaked hijiki consumed were beta and log-normal, respectively. The daily bioaccessible iAs intake values were estimated to be 19 and 59 μg/day at 50 and 95 percentile. At 50 percentile iAs intake, the contributions from rice and hijiki were estimated to be equal, whereas the contribution from hijiki increased with the estimated total daily iAs intake. Conclusions: The iAs intakes of Japanese subjects estimated in previous duplicated portion studies were fairly consistent with the present estimation. Moreover, it was confirmed that the cancer risk derived from dietary iAs intake of the general Japanese population was not negligible.

2015-10-01 10:01:42
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1 0 0 0 IR Hepatic toxicity and prognosis in HCV-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens : a Japanese multicenter analysis

著者: 遠西大輔
出版者: 岡山大学
巻号頁・発行日: 2011

博士論文

2015-10-01 07:35:21
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https://ci.nii.ac.jp/naid/500000545381

1 0 0 0 OA ヘーゲルにおける絶対的否定と限定的否定 : 『精神現象学』における主と奴の弁証法についての一考察

著者: 石崎嘉彦イシザキヨシヒコ Ishizaki Yoshihiko
出版者: 大阪大学文学部
雑誌: 待兼山論叢. 哲学篇 (ISSN:03874818)
巻号頁・発行日: vol.14, pp.53-69, 1980-12

2015-10-01 07:33:59
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http://hdl.handle.net/11094/4290

1 0 0 0 http://jairo.nii.ac.jp/0205/000

2015-10-01 07:02:54
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http://jairo.nii.ac.jp/0205/000

1 0 0 0 OA 低出力レーザー照射による骨芽細胞の遺伝子発現の変動

著者: 山本雅久河原三明安孫子宜光
出版者: 公益社団法人日本口腔インプラント学会
雑誌: 日本口腔インプラント学会誌 (ISSN:09146695)
巻号頁・発行日: vol.15, no.3, pp.323-329, 2002-09-30 (Released:2015-08-20)
参考文献数: 27
被引用文献数: 1

The recent advent of improved low-level laser irradiation (LLLI) therapy has promoted interest in clinical implantology. It has been reported that LLLI on bony implant sites might have positive effects on the integration of implants. The biostimulatory effect of cell proliferation and bone formation by LLLI has been investigated, but little is known about the molecular basis of biostimulatory mechanisms. Since LLLI will be useful to support implant therapy, it is important to elucidate the mechanism of the biostimulatory effect of LLLI on bone formation. We previously constructed the cDNA library of mouse osteoblastic cells (MC 3 T 3-E 1), which enhanced gene expression by LLLI using a subtracted gene cloning technology. In the present study, we further analyzed the DNA nucleotide sequence of gene clones, and focused on a gene clone designated MCL-174. The nucleotide sequence of MCL-174 insert was determined and assessed in the standard nucleotide-nucleotide BLAST (blastn) homology-search using NCBI DNA databases. DNA nucleotide sequences of clone MCL-174 inserted DNA exhibited 99% homology with Mus musculus annexin Ⅲ gene. Reverse-transcription PCR analysis showed that the mRNA level was enhanced by LLLI. These findings suggest that LLLI may enhance mRNA transcription and play a role in stimulating proliferation of osteoblasts through the enhancement of annexin Ⅲ gene expression. Annexin Ⅲ was detected in secretory ameloblasts and odontoblasts, and it was thought to be involved in the regulation of cell calcium. These findings suggest that the biostimulatory effect of LLLI on bone formation may relate through gene expression of annexin Ⅲ.