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1 0 0 0 2. ストレス及び運動の成長ホルモン分泌に及ぼす影響

著者: 岩坪治雄宮井潔岡田義昭
出版者: 一般社団法人日本内分泌学会
雑誌: 日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日: vol.44, no.9, pp.987-992,963, 1968
被引用文献数: 1

The effects of stress, exercise and other factors on human growth hormone (HGH) secretion were investigated in normal subjects and various disorders. Plasma HGH was measured by chromatoelectrophoretic radioimmunoassay. 1) Exercise : Exercise by double two step test of Master was associated with a slight increase of HGH secretion only in female, but successively 6 times of the test with a remarkable increase both in female and in male. This rise of plasma HGH level was accelerated by arginine infusion or beef ingestion. 2) Operation : Major abdominal surgery under general anaesthesia with Fluothane and nitrous oxide was followed by a remarkable elevation of plasma HGH with a peak at 60-90 minutes after the operation started. On the other hand, brain operation under the same anaesthesia but with hypothermia did not lead to significant changes or rather led to decrease in plasma HGH while cooling, but to a remarkable increase as rewarming commenced. 3) Cold Exposure : No increase in plasma HGH level was found during exposure of normal subjects to 4°C for 1-2 hours but a significant elevation of plasma HGH level was observed following recovery to room temperature (23°C). 4) Drugs : Intravenous injection of 35 mg of histamine caused a moderate increase in plasma HGH. In 6 of 8 normal subjects, simultaneous injection of aminophylline enhanced the increased response of plasma HGH by insulin-induced hypoglycemia. 5) HGH secretion in primary hypothyroidism : Plasma HGH response to hypoglycemia and exercise (two step test) was significantly lower in patients with untreated primary hypothyroidism than in normal subjects. 6) HGH secretion in hypopituitarism : Studies on secretion of trophic hormones in hypopituitarism showed that, of 12 patients, panhypopituitarism was found in 3 cases, partial deficiency in 8 and selective ACTH deficiency in 1. Of 9 subjects with pituitary dwarfism, panhypopituitarism was found in 1 case, partial deficiency in 5 and isolated GH deficiency in 3, of which two cases were siblings. Some cases, of which basal HGH secretion was detectable at overnight fast and suppressed by glucose administration, showed a dissociative response to various stimuli : a significant elevation of HGH level by arginine infusion despite no responses to insulin or pyrogen injection. Others showed parallel responses to such various stimuli as insulin induced hypoglycemia, arginine infusion and or exercise.

2017-01-21 01:57:29
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1 0 0 0 ラット脳内セロトニン神経活動への拘束ストレスの影響に関する研究 : In vivo Microdialysis による検討

著者: 天野裕治
出版者: 九州歯科学会
雑誌: 九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi (ISSN:03686833)
巻号頁・発行日: vol.46, no.1, pp.319-328, 1992-02-25
被引用文献数: 1

Using the technique of in vivo microdialysis, extracellular concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA) were determined in the striatum, thalamus, dentate gyrus and prefrontal cortex while Sprague-Dawley rats underwent immobilization stress for twenty minutes. Microdialysis probes had semipermeable cellulose tubes (molecular weight cutoff 50, 000 ; O.D. 0.22 mm). Perfusion was started at 12 or 36 hours after implantation of the microdialysis probe under a freely-moving condition. Measurements of the extracellular concentration of serotonin and 5-HIAA were made at twenty minute intervals, which were started 120 minutes after the onset of the perfusion. Serotonin and 5-HIAA were quantified by a high-performance liquid chromatography coupled with an electrochemical detector. Extracellular serotonin levels increased following twenty minute immobilization stress in all four regions of the rat brain. The immobilization stress relatively increased the extracellular serotonin levels in the prefrontal cortex and dentate gyrus. These results suggest that twenty minute immobilization stress induces the activation of serotonin release in rat brain regions concerning the induction of anxiety.

2017-01-21 01:47:05
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https://ci.nii.ac.jp/naid/110003004828

1 0 0 0 ビーチライフ創生プロジェクト「砂浜の図書館」実施の報告と考察

著者: 高市慎太郎
出版者: 東海大学
雑誌: 研究資料集 (ISSN:09193480)
巻号頁・発行日: vol.19, pp.153-162, 2011

2017-01-21 01:23:29
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https://ci.nii.ac.jp/naid/110008918555

1 0 0 0 夏季海浜図書館運営の概況

出版者: 高田教育研究会
雑誌: 教育創造 (ISSN:09109846)
巻号頁・発行日: vol.6, no.7, 1953-07

2017-01-21 01:22:06
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https://ci.nii.ac.jp/naid/40000705895

1 0 0 0 IR 高齢期における芸術創造の特性について

著者: 古瀬徳雄
出版者: 関西福祉大学社会福祉学部研究会
雑誌: 関西福祉大学社会福祉学部研究紀要 (ISSN:1883566X)
巻号頁・発行日: no.12, pp.35-44, 2009-03

幾多の作曲家が〈アヴェ・マリア〉を作曲している.ヴェルディ(1813~1901)もその一人である.彼の《アヴェ・マリア》は高齢期の76歳の作品であり,雑誌に投稿された謎の音階に基づいた定旋律で創られている.その後,オペラの大作《ファルスタッフ》を作曲し,82歳の彼は宗教的作品《スタバート・マーテル》《テ・デウム》を完成させ,《聖歌4篇》として世に発表する.一般的には,超高齢期には枯淡の境地に入る場合も多いが,彼は落日の太陽のごとく燃え続けている.さらに造形・絵画の巨匠達にも,高齢期になって,絶妙な作品を開拓した創作家たちが存在することも判明した.そこで音楽界と美術界の高齢期における作品を抽出し,対比させ,芸術創造の特徴や共通点を考察すると,「滑稽性」「肥満性」「グループ性」「宗教性」を捉えることが考えられた.