著者

坪井 聡 山縣 然太朗 大橋 靖雄 片野田 耕太 中村 好一 祖父江 友孝 上原 里程 小熊 妙子 古城 隆雄 ENKH-OYUN Tsogzolbaatar 小谷 和彦 青山 泰子 岡山 明 橋本 修二

出版者

日本公衆衛生学会

雑誌

日本公衆衛生雑誌 (ISSN:05461766)

巻号頁・発行日

vol.61, no.10, pp.613-624, 2014

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<b>目的</b> 糖尿病患者の病院への満足度に関する対策を政策的に推し進める科学的根拠を得るためには,一般化可能な知見が必要である。本研究の目的は,既存の公的統計を二次利用することで外来に通う糖尿病患者の病院への満足度の分布を示し,関連を持つ要因を詳細に検討することである。<br/><b>方法</b> 患者調査,医療施設調査および受療行動調査(いずれも平成20年)を連結させたデータセットを作成した。患者調査と医療施設調査の連結には,医療施設調査整理番号を,加えて,受療行動調査との連結には,性と生年月日の情報を用いた。外来に通う糖尿病患者の病院への満足度の分布を検討し,また,様々な要因との関連の有無を検討した。関連の検討に用いた項目は,受診状況(初診か再来か),診察までの待ち時間,医師による診察時間,受療状況(他の医療機関の利用の有無等),糖尿病性の合併症,その他の合併症,生活保護法による支払い,禁煙外来,糖尿病内科(代謝内科)の標ぼう,診療時間(土曜日,日曜日,祝日の診療),生活習慣病に関連する健診の実施である。<br/><b>結果</b> 糖尿病患者の62.3%は,病院への満足度において,やや満足,非常に満足と回答し,やや不満,非常に不満と回答した者は5.6%であった。受診状況,診察までの待ち時間,診察時間,受療状況,土曜日の診療の有無は,病院への満足度と統計学的に有意な関連を示した。一方,その他の項目は病院への満足度との間に明らかな関連を示さなかった。統計学的に有意な関連を示した要因を用いた多変量解析では,再診,短い待ち時間,他の医療機関にかかっていないこと,長い診察時間と高い満足度との間に統計学的に有意な関連が観察された。<br/><b>結論</b> 複数の公的統計を連結させることによって,外来に通う糖尿病患者の病院への満足度の分布を示し,関連を持つ要因を明らかにすることができた。糖尿病患者の病院への満足度を高めるために,待ち時間の短縮と診察時間の確保が重要である。今後,多くの公衆衛生施策の検討に際して,公的統計の更なる活用が望まれる。

著者

Chiho Ishida Kazuya Takahashi Yuko Kato-Motozaki Atsuro Tagami Kiyonobu Komai

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.4836-20, (Released:2020-09-19)

参考文献数

15

被引用文献数

7

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Objective To determine the clinicopathological features of levodopa or dopamine agonist (DA) responders with multiple system atrophy (MSA), an autopsy-confirmed diagnosis is vital due to concomitant cases of MSA and Parkinson's disease (PD). We therefore aimed to investigate the effectiveness of levodopa and DA in autopsy cases of MSA without PD and thereby clarify the clinical course, magnetic resonance imaging (MRI) findings, and pathological features of levodopa-responsive MSA cases. Patients and Methods The medical records (clinical data, MRI findings, and pathological findings) of 12 patients with MSA were obtained, and the patients were pathologically confirmed to not have PD. The clinical diagnoses of the patients were MSA with predominant parkinsonism (MSA-P) (n=7), MSA with predominant cerebellar ataxia (MSA-C) (n=4), and progressive supranuclear palsy (PSP) with a concomitant pathology of MSA (n=1). Results Nine patients received a maximum dose of 300-900 mg of levodopa as treatment, which was effective in two MSA-P patients and mildly effective in another two MSA-P patients. DA was mildly effective in one MSA-C patient. The levodopa responders showed marked autonomic dysfunction relatively late and became bedridden after 10 years. Additionally, they exhibited bilateral hyperintense putaminal rims in MRIs after six and nine years, respectively, after disease onset. One levodopa responder and one DA mild responder showed relatively mild neurodegeneration of the putamen. Conclusion Levodopa responders, despite having MSA-P, may show a relatively slow progression in putaminal neurodegeneration, and might maintain prolonged daily life activities in cases without an early occurrence of autonomic dysfunction.

著者

サウェ-ンサック タヌ- 山本 順二

出版者

ぎょうせい

雑誌

文部時報 (ISSN:09169830)

巻号頁・発行日

no.1305, pp.p27-30, 1986-01

著者

Joo-Young Lee Hyo Hyum Lee

出版者

Japanese Society of Human-Environment System

雑誌

人間-生活環境系学会英文誌 (ISSN:13451324)

巻号頁・発行日

vol.17, no.1, pp.001-011, 2014 (Released:2014-12-08)

参考文献数

55

被引用文献数

8 11

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During the 1960~80s Korean breath-hold women divers (haenyeo) received attention from environmental physiologists, especially Professor Suk-Ki Hong and colleagues, due to their unique ability to resist cold water wearing only a thin cotton bathing suit (so-jung-ee). Eventually, Haenyeos began to wear wetsuits to avoid severe cold stress instead of the cotton bathing suit from the mid 1970’s.With advancing social industrialization, the number of haenyeos rapidly decreased and a total of 4,507 haenyeos works as of 2013. The average age of haenyeos is 70 years old and the oldest haenyeos currently diving is 92 years old. Today, some senior haenyeos over fifty years old share the diving experiences of their youth by wearing the classic cotton bathing suits. At present it is predicted that the tradition of haenyeos could cease to exist in 10-15 years because of their aging. At this point in time, it is worth reviewing the history of haenyeos’ diving practices and acclimatization/deacclimatization to cold. The present review described the diving practices and physiology of haenyeos related to cotton bathing suits and wetsuits. Finally, we suggest interdisciplinary research on haenyeos from the viewpoint of social-environmental physiology and intangible cultural heritage.

著者

Okakura-Kakuzo traduit de l'anglais par Gabriel Mourey illustrations de Loka-Hasegawa

出版者

A. Delpeuch

巻号頁・発行日

1927

著者

Yuri Yaguchi-Tanaka Takahiro Tabuchi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20200266, (Released:2020-07-11)

参考文献数

33

被引用文献数

8

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Background: Few longitudinal studies have examined the association between skipping breakfast and overweight/obesity in pre-elementary school children. Furthermore, this association may differ between boys and girls. The main objective of this study was to assess whether skipping breakfast in early childhood was associated with later incidence of overweight/obesity with stratification by gender, using data on children aged 2.5 to 13 years old in The Longitudinal Survey of Newborns in the 21st century.Methods: We examined the associations between skipping breakfast at 2.5 years old and overweight/obesity at 2.5 (n=34,649), 4.5 (n=35,472), 7 (n=31,266), 10 (n=31,211), and 13 (n=28,772) years old. To estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of overweight/obesity by each age (2.5, 4.5, 7, 10, 13 years), a multivariate logistic regression was used adjusting for time-invariant and time-varying covariates.Results: At the age of 2.5 years, 11.0% of boys and 12.2% of girls were skipping breakfast. In fully adjusted models, skipping breakfast at 2.5 years old was not significantly associated with overweight/obesity at 2.5 and 4.5 years old, but was significantly associated with overweight/obesity at 7 and 10 years old, in both sexes. Skipping breakfast at 2.5 years old was significantly associated with overweight/obesity at 13 years old in boys (OR=1.38, 95% CI=1.17-1.62), but not in girls (OR=1.21, 95% CI=0.98-1.49).Conclusions: Skipping breakfast in early childhood increased overweight/obesity in later childhood, but there may be gender differences in the association.

著者

Takeshi Yamashita Yukihiro Koretsune Yuejin Yang Shih-Ann Chen Namsik Chung Yuichi J. Shimada Tetsuya Kimura Koichi Miyazaki Kenji Abe Michele Mercuri Christian T. Ruff Robert P. Giugliano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.4, pp.860-869, 2016-03-25 (Released:2016-03-25)

参考文献数

23

被引用文献数

48 75

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Background:In the multinational, double-blind, double-dummy ENGAGE AF-TIMI 48 phase 3 study, once-daily edoxaban was non-inferior to warfarin for prevention of stroke or systemic embolism event (SEE) in patients with non-valvular atrial fibrillation (AF). Here, we evaluated the efficacy and safety of edoxaban in patients from East Asia.Methods and Results:Patients aged ≥21 years with documented AF and CHADS score ≥2 were randomized to receive once-daily edoxaban higher-dose (60 mg) or lower-dose (30 mg) regimen or warfarin dose-adjusted to an international normalized ratio of 2.0–3.0. Patients with a creatinine clearance of 30–50 ml/min, weighing ≤60 kg, or receiving strong p-glycoprotein inhibitors at randomization or during the study received a 50% dose reduction of edoxaban or matched placebo. This prespecified subanalysis included 1,943 patients from Japan, China, Taiwan, and South Korea. The annualized rate of stroke/SEE for higher-dose edoxaban was 1.34% vs. 2.62% for warfarin (hazard ratio [HR], 0.53; 95% confidence interval [CI]: 0.31–0.90, P=0.02) and 2.52% for lower-dose edoxaban (HR, 0.98; 95% CI: 0.63–1.54, P=0.93). Compared with warfarin (4.80%), major bleeding was significantly reduced for the higher-dose (2.86%; HR, 0.61; 95% CI: 0.41–0.89, P=0.011) and lower-dose regimens (1.59%; HR, 0.34; 95% CI: 0.21–0.54, P<0.001).Conclusions:Once-daily edoxaban provided similar efficacy to warfarin while reducing major bleeding risk in the East Asian population. (Circ J 2016; 80: 860–869)

著者

長野 真紀 今村 文彦 黄 國賓 Maki NAGANO Fumihiko IMAMURA Kuo-pin HUANG

出版者

神戸芸術工科大学

雑誌

芸術工学2016

巻号頁・発行日

2016-11-25

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本研究では、福佬(Ho-lo)人の移住文化を対象に、その歴史と暮らしの変遷、居住環境について分析・考察した。研究対象地は周囲を海に囲まれた環境下にあり、独自の伝統文化や習俗、空間構造を継承している。このような地理的・文化的環境の中で、東アジアの結節点となる台湾領域中国福建省金門島及び八重山諸島石垣島を主対象に捉え、研究を展開した。 金門島では、血縁による結びつきが重視され、同一氏族により形成された宗族的つながりを強く持つ単姓村と、多数の氏により形成される複姓村に分類される。対象集落は、海岸線に沿った緩やかな台地に立地し、1315 年頃に福建省厦門からの移住者が開墾した農漁村集落である。住居は四合院で構成され、一定の領域内で中規模な空間を形成しているが、宗族ごとに住居の向きが異なり、それぞれに方向軸を持っているため各時代の空間形成の発展性を読み取ることができる。 また、集落は明確な境界域を定めず、人口増加に対応しながら空間を拡張している。これは、島に福佬人しか居住していないこと、地形条件に対する制限が少ないことが要因として考えられる。台湾本島や石垣島では、住居の周囲は自然地形や植栽などにより空間を補っている場合が多い。

著者

Tomoko FUKUUCHI Shun-suke MORIYA Toru SUGIYAMA Hidetsugu TABATA Kiyoko KANEKO

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.20P252, (Released:2020-09-11)

被引用文献数

1

著者

Yu-Feng Hu Wen-Han Cheng Yuan Hung Wen-Yu Lin Tze-Fan Chao Jo-Nan Liao Yenn-Jiang Lin Wei-Shiang Lin Yi-Jen Chen Shih-Ann Chen

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0566, (Released:2020-09-09)

参考文献数

64

被引用文献数

17

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The health crisis due to coronavirus disease 2019 (COVID-19) has shocked the world, with more than 1 million infections and casualties. COVID-19 can present from mild illness to multi-organ involvement, but especially acute respiratory distress syndrome. Cardiac injury and arrhythmias, including atrial fibrillation (AF), are not uncommon in COVID-19. COVID-19 is highly contagious, and therapy against the virus remains premature and largely unknown, which makes the management of AF patients during the pandemic particularly challenging. We describe a possible pathophysiological link between COVID-19 and AF, and therapeutic considerations for AF patients during this pandemic.

著者

岡村 和子 藤田 悟郎 小菅 律 サンドラ シュミット-アーント

出版者

日本交通心理学会

雑誌

交通心理学研究 (ISSN:09109749)

巻号頁・発行日

vol.30, no.1, pp.1-25, 2014 (Released:2020-04-18)

参考文献数

87

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In many motorized countries, concern has been growing about driving under the influence of substances other than alcohol, i.e. illicit drugs such as cannabis and amphetamine, as well as medicinal drugs such as sedatives and antihistamine. These drugs affect central nervous system, thus may impair driving performance and pose danger to traffic safety. The nature of the problem and the current scientific evidence is yet unknown in Japan. This report aimed to overview the issue of drug driving by way of systematic literature search of studies published between 2000 and 2012. A total of 62 peer-reviewed articles and relevant reports have been identified that include meta-analyses, systematic/narrative reviews, or original investigations into the risk of traffic accident or impairment caused by drug driving. The present work attempted to summarize epidemiological research estimating accident risk of drug driving, experimental research investigating effects of drug impairment on driving performance, and finally, current interventions aiming at efficient detection of drug driving. Further research needs, future research direction in traffic psychology, and implication to traffic safety in Japan is discussed.

著者

Masaharu Akao Yeong-Hwa Chun Masahiro Esato Mitsuru Abe Hikari Tsuji Hiromichi Wada Koji Hasegawa on behalf of the Fushimi AF Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.78, no.9, pp.2166-2172, 2014-08-25 (Released:2014-08-25)

参考文献数

20

被引用文献数

99 116

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Background:Atrial fibrillation (AF) is a common arrhythmic disorder among the elderly, and increases the risk of stroke. Oral anticoagulants (OAC) are highly effective in preventing stroke, and there are evidence-based guidelines for the optimal use of OAC in patients with AF.Methods and Results:The Fushimi AF Registry is a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto, a typical urban community in Japan with a total population of 283,000. Of the 3,282 patients enrolled by October 2012, 1-year follow-up was completed for 2,914 patients. OAC, mainly warfarin, were given to 1,546 patients (53.1%); overused for low-risk patients, and underused for patients at risk, based on the guidelines. Moreover, warfarin was sometimes given at a sub-therapeutic dose; only 54.4% of patients were within the optimal therapeutic range. The 1-year outcomes revealed that the incidences of both stroke and major bleeding were equivalent between patients taking OAC and those without; major clinical events were as follows: (OAC vs. non-OAC) stroke 2.7% vs. 2.8%, ischemic stroke 2.1% vs. 2.0% and major bleeding 1.4% vs. 1.5% (NS for all).Conclusions:The Fushimi AF Registry provides a unique snapshot of current AF management in an urban community in Japan. The present study reveals inappropriate use of OAC for patients with AF, indicating discordance between guideline recommendations and real-world clinical practice. (Circ J2014;78:2166–2172)

著者

Rojeet Shrestha Hitoshi Chiba Shu-Ping Hui

出版者

Japanese Society for Biomedical Mass Spectrometry

雑誌

Medical Mass Spectrometry (ISSN:24327441)

巻号頁・発行日

vol.4, no.1, pp.2-23, 2020-06-25 (Released:2020-09-08)

参考文献数

176

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Lipids are ubiquitous in the human body, playing diverse biochemical and physiological functions. Unfortunately, lipids are susceptible to oxidation in vivo by free radicals. Lipid hydroperoxides (LOOH) are one of the primary products of lipid peroxidation which play a crucial role in the pathogenesis of oxidative stress, inflammation, and atherosclerosis. Understanding the underlying molecular mechanism of these diseases is critically important for risk stratification, prevention, and therapeutic intervention. Despite its importance in the atherosclerotic process, the qualitative and quantitative evaluations of LOOH in the biological samples have been largely limited, because of structural variability, instability and rapid clearance from circulation. Application of liquid chromatography/mass spectrometry (LC/MS) has revolutionized the study of lipidomic and eased the identification and quantification of hundreds of molecular species of oxidized lipids derived from fatty acids, cholesteryl esters, triacylglycerol and phospholipids in various biological samples. In this review, we will be discussing oxidized lipid species in human lipoproteins, its analytical consideration and significance. An overview of lipids and its oxidative products in lipoproteins, technological advances its identification and quantification using mass spectrometry, and its possible linkage to disorders of lipid metabolism will be discussed.

著者

Shin-ichiro SASAHARA Yuichi OI Shotaro DOKI Daisuke HORI Yuh OHTAKI Christina-Sylvia ANDREA Tsukasa TAKAHASHI Nagisa SHIRAKI Yu IKEDA Tomohiko IKEDA Ryutaro IZUMI Tamaki SAITO Ichiyo MATSUZAKI

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.18, no.5, pp.180-185, 2020 (Released:2020-09-04)

参考文献数

32

被引用文献数

1

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Over the past few years, the number of Japanese astronauts recruited for a long-term stay in the International Space Station (ISS) has increased. Being on a prolonged mission with the same people, in the same room, should impose psychosocial stress on the astronauts, possibly causing feelings of “psychological suffocation”. Several confinement studies have been conducted to simulate the conditions of the ISS, the Mir space station, and potential habitats on Mars, and to survey psychological interpersonal communication between the crew in a confined environment, including the Isolation Study for European Manned Space Infrastructure, Experimental Campaign for the European Manned Space Infrastructure, Simulation of Flight of International Crew on Space Station, Human Behavior in Extended Spaceflight, Mars-500, and Hawaii Space Exploration Analog and Simulation. Here, the findings from these studies were integrated into a structured review according to an evidence-based set of items for reporting in systematic reviews and meta-analyses. The results indicated that metaanalyses would not always be appropriate because it is difficult to design a research protocol with a high level of evidence in this field. Therefore, future research in this field should be focused on the following three points: 1) developing more accurate parameters for monitoring stress levels in long-term confinement environments; 2) analyzing stress levels in such situations with higher precision; and 3) accumulating and assembling existing and future data from long-term confinement environments.

著者

Yoshitaka Hirasawa Atsushi Fujiwara Kazuya Tabata Kenji Yoshida Tsutomu Negama Takayuki Anzai Shin-ichi Sato

出版者

The Japanese Society of Toxicology

雑誌

Fundamental Toxicological Sciences (ISSN:2189115X)

巻号頁・発行日

vol.7, no.2, pp.105-114, 2020 (Released:2020-03-27)

参考文献数

33

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The purpose of this study was to profile cytokine storms (cytokine release syndrome) in the LPS-induced disseminated intravascular coagulation (DIC)-cynomolgus monkey model by measuring changes in 22 cytokines using Luminex. In this study, increases were noted in 20 cytokines, excluding IL-4 and IL-17A. Specifically, IL-6, IL-8, G-CSF and TNF-α, pro-inflammatory cytokines, and IL-10, an anti-inflammatory cytokine, as well as MCP-1, markedly increased by 10,000 pg/mL or more. In addition to the marked increases in the pro-inflammatory cytokines IL-6 and G-CSF, the concentrations of IL-5, IL-18, IFN-γ, VEGF and IL-15 increased continuously. Also, in addition to the marked increases in the pro-inflammatory cytokine IL-8 as well as in MCP-1, the concentrations of IL-1ra, IL-2, IL-1β, IL-12/23 (p40), GM-CSF and TGF-α gradually decreased after initially increasing. On the other hand, in addition to the marked increases in the pro-inflammatory cytokine TNF-α and anti-inflammatory cytokine IL-10, MIP-1β and MIP-1α transiently increased and then rapidly disappeared from serum. IL-13 increased at 6 hr after administration only. Since the behavior of cytokines in this monkey model was similar to those noted in DIC in humans, this model will be useful for evaluating the efficacy of anti-DIC drugs. In addition, this model will also be useful for assessing the risk of cytokine storm development, which is a serious adverse effect of certain types of antibody drugs and CAR-T cell-based therapies.

著者

Miyawaki Shingo Kawamura Yoshimi Oiwa Yuki Shimizu Atsushi Hachiya Tsuyoshi Bono Hidemasa Koya Ikuko Okada Yohei Kimura Tokuhiro Tsuchiya Yoshihiro Suzuki Sadafumi Onishi Nobuyuki Kuzumaki Naoko Matsuzaki Yumi Narita Minoru Ikeda Eiji Okanoya Kazuo Seino Ken-ichiro Saya Hideyuki Okano Hideyuki Miura Kyoko

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

no.7, 2016-05-10

著者

René-Charles Guilbert de Pixerécourt sous la direction de Roxane Martin édition critique par Michelle Cheyne ...

出版者

Classiques Garnier

巻号頁・発行日

2013

著者

Susanna JÄRVELIN-PASANEN Sanna SINIKALLIO Mika P. TARVAINEN

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.56, no.6, pp.500-511, 2018 (Released:2018-11-21)

参考文献数

63

被引用文献数

11 130

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The aim of this systematic review was to explore studies regarding association between occupational stress and heart rate variability (HRV) during work. We searched PubMed, Web of Science, Scopus, Cinahl and PsycINFO for peer-reviewed articles published in English between January 2005 and September 2017. A total of 10 articles met the inclusion criteria. The included articles were analyzed in terms of study design, study population, assessment of occupational stress and HRV, and the study limitations. Among the studies there were cross-sectional (n=9) studies and one longitudinal study design. Sample size varied from 19 to 653 participants and both females and males were included. The most common assessment methods of occupational stress were the Job Content Questionnaire (JCQ) and the Effort-Reward Imbalance (ERI) questionnaire. HRV was assessed using 24 h or longer Holter ECG or HR monitoring and analyzed mostly using standard time-domain and frequency-domain parameters. The main finding was that heightened occupational stress was found associated with lowered HRV, specifically with reduced parasympathetic activation. Reduced parasympathetic activation was seen as decreases in RMSSD and HF power, and increase in LF/HF ratio. The assessment and analysis methods of occupational stress and HRV were diverse.

著者

Akito Tsuchiya Aki Nishihara Ayumi Saeki Yuki Teru Takashi Aoki Tomoya Kono Masahiro Sakai Jun-ichi Hikima

出版者

The Japanese Society of Fish Pathology

雑誌

魚病研究 (ISSN:0388788X)

巻号頁・発行日

vol.55, no.1, pp.18-21, 2020-03-15 (Released:2020-04-02)

参考文献数

25

被引用文献数

1

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Pseudotuberculosis pathogen, Photobacterium damselae subsp. piscicida (Pdp) shows some differences in virulence between Japanese and US strains. ​In this study, we analyzed plasmid DNAs derived from Japanese and US strains of Pdp, and found two homologous regions in these plasmids, pOT-51443-4/p91-197-1 and pOT-51443-1/p91-197-2. ​All genes in the p91-197-1 from US strain were observed in the pOT-51443-4 from Japanese strain. ​This event might have occurred during transmission of the US plasmid to Japanese strain. ​Inhibitor of vertebrate lysozyme (ivy), a known pathogenicity factor was encoded in the homologous region of pOT-51443-1/p91-197-2. ​Thus, the genomic region containing ivy may have been horizontally transmitted between the two Pdp strains.

著者

Sinclair, Catherine, 1800-1864

出版者

Blackie & Son

巻号頁・発行日

1976

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A Victorian tale in which two children seek adventure while under the watchful eye of their nanny. A reprint of the first children's book to show the amusing side of misconduct