著者
品川 高廣 河野 健二 益田 隆司 Takahiro Shinagawa Kenji Kono Takashi Masuda 東京農工大学工学部情報コミュニケーション工学科 電気通信大学情報工学科:科学技術振興事業団さきがけ21 電気通信大学情報工学科 Department of Computer Information and Communication Sciences Faculty of Engineering Tokyo University of Agriculture & Technology Department of Computer Science University of Electro-Communications:PRESTO Japan Science and Technology Corporation Department of Computer Science University of Electro-Communications
出版者
日本ソフトウェア科学会
雑誌
コンピュータソフトウェア (ISSN:02896540)
巻号頁・発行日
vol.21, no.2, pp.107-113, 2004-03-25
参考文献数
11
被引用文献数
1

本論文では,UNIXシステムにおけるsetuidプログラムのバグを利用したroot権限の不正取得に対処するために,setuidプログラム中のroot権限で動作するコードを最小化する手法について述べる.この手法では,我々が提案している細粒度保護ドメインを利用することでsetuidプログラム中の最小限必要なコードのみをroot権限で動作させ,root権限が不要なコードに含まれるバグによるroot権限の不正取得を防止することができる.
著者
Ui-Cheol Jeong Jae-Heon Sim Cheol-Yong Kim Gak Hwang-Bo Chan-Woo Nam
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.12, pp.3813-3816, 2015 (Released:2015-12-28)
参考文献数
20
被引用文献数
15 44

[Purpose] The aim of this study was to examine the effects of exercise to strengthen the muscles of the hip together with lumbar segmental stabilization exercise on the lumbar disability index, lumbar muscle strength, and balance. [Subjects and Methods] This study randomly and equally assigned 40 participants who provided written consent to participate in this study to a lumbar segmental stabilization exercise plus exercise to strengthen the muscles of the gluteus group (SMG + LES group) and a lumbar segmental stabilization exercise group. [Results] Each evaluation item showed a statistically significant effect. [Conclusion] Clinical application of exercise in this study showed that lumbar segmental stabilization exercise plus exercise to strengthen the muscles of the gluteus resulted in a greater decrease in low back pain disability index and increase in lumbar muscle strength and balance ability than lumbar segmental stabilization exercise in chronic low back pain patients receiving the exercise treatments during the same period.
著者
Yeunhwa Gu Chien-Sheng Huang Tota Inoue Takenori Yamashita Torao Ishida Ki-Mun Kang Atsunori Nakao
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌
Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日
vol.46, no.3, pp.269-276, 2010 (Released:2010-04-28)
参考文献数
26
被引用文献数
31 50

Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test and was associated with increased brain serotonin levels and elevated serum antioxidant activity. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of our results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.
著者
Hidetoshi Sugihara Koichi Kimura Keitaro Yamanouchi Naomi Teramoto Tomoko Okano Masao Daimon Hiroyuki Morita Katsu Takenaka Takanori Shiga Jun Tanihata Yoshitsugu Aoki Tokiko Inoue-Nagamura Hiroshi Yotsuyanagi Issei Komuro
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.20-372, (Released:2020-11-13)
参考文献数
25
被引用文献数
9

Duchenne muscular dystrophy (DMD) is X-linked recessive myopathy caused by mutations in the dystrophin gene. Although conventional treatments have improved their prognosis, inevitable progressive cardiomyopathy is still the leading cause of death in patients with DMD. To explore novel therapeutic options, a suitable animal model with heart involvement has been warranted.We have generated a rat model with an out-of-frame mutation in the dystrophin gene using CRISPR/Cas9 genome editing (DMD rats). The aim of this study was to evaluate their cardiac functions and pathologies to provide baseline data for future experiments developing treatment options for DMD.In comparison with age-matched wild rats, 6-month-old DMD rats showed no significant differences by echocardiographic evaluations. However, 10-month-old DMD rats showed significant deterioration in left ventricular (LV) fractional shortening (P = 0.024), and in tissue Doppler peak systolic velocity (Sa) at the LV lateral wall (P = 0.041) as well as at the right ventricular (RV) free-wall (P = 0.004). These functional findings were consistent with the fibrotic distributions by histological analysis.Although the cardiac phenotype was milder than anticipated, DMD rats showed similar distributions and progression of heart involvement to those of patients with DMD. This animal may be a useful model with which to develop effective drugs and to understand the underlying mechanisms of progressive heart failure in patients with DMD.
著者
Keita SATO Yumi SAKAMOTO Manabu SAKAI Chieko ISHIKAWA Megu NAKAZAWA Chieh-Jen CHENG Toshihiro WATARI Tomohiro NAKAYAMA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.82, no.10, pp.1421-1427, 2020 (Released:2020-10-20)
参考文献数
26
被引用文献数
5

Computed tomographic (CT) angiography, the gold standard for diagnosing portal vein thrombosis (PVT) in humans, is poorly documented in dogs. Therefore, we retrospectively reviewed dogs with PVT diagnosed by CT angiography. Medical records of 13 client-owned dogs diagnosed with PVT by CT angiography were reviewed. All dogs had chronic PVT, and the most frequent clinical sign was vomiting (5/13), with pancreatitis the most frequent concurrent disease (6/13). All dogs tested for plasma D-dimer concentration (12/12) revealed elevated levels. On CT angiography, a thrombus was detected as a non-contrast enhancement structure in the portal vessel of 13 dogs. There was no evidence of complete obstruction of the portal vein in any of the dogs. The median luminal filling of the portal vein was 60.4%. The thrombus extension was variable among dogs, with a median of 34.9 mm. CT angiography identified the thrombus in the main portal vein of 12/13 dogs and multiple thrombus formation other than the main portal vein in 9/13 dogs. CT angiography provided specific information such as detecting the presence, location, and number of PVT in dogs. Therefore, CT angiography might be useful for the diagnosis and follow-up evaluation of PVT in dogs.
著者
Hiroaki Abe Akira Michimata Kazuyoshi Sugawara Naoki Sugaya Shin-Ichi Izumi
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.218, no.3, pp.193-199, 2009 (Released:2009-06-27)
参考文献数
24
被引用文献数
41 66

Stroke is the leading cause of long-term disability, and many stroke patients have hemiparesis. Hemiparesis induces ankle-control disturbances and equinovarus deformity, leading to difficulty in walking and an increased risk for falling. Plastic ankle-foot orthosis (PAFO) is frequently prescribed to correct ankle joint alignment and increase walking speed and stride length during ambulation. While several studies have shown that PAFO improves gait parameters, such as stride length and walking speed, in hemiplegic patients, the effect of PAFO on gait stability remains unclear. We quantitatively assessed the effect of PAFO on gait stability in 16 hemiplegic stroke patients (mean age 55.9 ± 11.8 years; 5 female and 11 male subjects; and 11 hemorrhagic and 5 ischemic stroke) using an ink footprint record. Wearing PAFO significantly improved the stride length, step length on the unaffected and affected sides, step width, walking speed, step frequency and functional ambulation ability. The coefficient of variation (CV), as an index of stability of movement from trial to trial, provides a measure that defines motor skills for a given task. Unaffected-side step-length CV and step-width CV were significantly decreased, when using PAFO. Furthermore, the correlation was found only between unaffected-side step length and its CV. The decrease in CV indicates that PAFO improved gait stability. We concluded that in addition to providing a faster gait, PAFO improves gait stability during walking. Gait stability and gait efficiency need to be considered separately in evaluating the effects of ankle-foot orthosis on gait performance in hemiplegic patients.
著者
Kent MORI Satoshi SUZUKI Daisuke KOYABU Junpei KIMURA Sung-Yong HAN Hideki ENDO
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0534, (Released:2015-02-09)
被引用文献数
2 4

Although the sea otter (Enhydra lutris) is a complete aquatic species, spending its entire life in the ocean, it has been considered morphologically to be a semi-aquatic animal. This study aimed to clarify the unique hindlimb morphology and functional adaptations of E. lutris in comparison to other Mustelidae species. We compared muscle mass and bone measurements of five Mustelidae species: the sea otter, Eurasian river otter (Lutra lutra), American mink (Neovison vison), Japanese weasel (Mustela itatsi) and Siberian weasel (M. sibirica). In comparison with the other four species, E. lutris possessed significantly larger gluteus, popliteus and peroneus muscles, but smaller adductor and ischiopubic muscles. The popliteus muscle may act as a medial rotator of the crus, and the peroneus muscle may act as an abductor of the fifth toe and/or the pronator of the foot. The bundles of the gluteus superficialis muscle of E. lutris were fused with those of the tensor fasciae latae muscle, and gluteofemoralis muscles, and they may play a role in femur abduction. These results suggest that E. lutris uses the abducted femur, medially rotated crus, eversion of the ankle and abducted fifth digit or extended interdigital web as a powerful propulsion generator. Therefore, we conclude that E. lutris is a complete aquatic animal, possessing differences in the proportions of the hindlimb muscles compared with those in other semi-aquatic and terrestrial mustelids.
著者
Chao-Chieh CHEN Jane-Chi WU Bruno Andreas WALTHER Po-Jen CHIANG
出版者
The Ornithological Society of Japan
雑誌
ORNITHOLOGICAL SCIENCE (ISSN:13470558)
巻号頁・発行日
vol.19, no.2, pp.135-144, 2020 (Released:2020-07-29)
参考文献数
35
被引用文献数
2

Detecting different bird species requires different and appropriate surveying methods. We tested a new detection method for the Tataka Area in Yushan National Park, Taiwan, which is an important alpine stopover site for migratory landbirds. Numerous migrant species have previously been reported from this area during bird counts and banding operations. However, these traditional survey methods are incapable of detecting nocturnal migrants. Therefore, we applied acoustic monitoring devices to survey the flight calls of nocturnal migrants in the Tataka Area in order to identify the species and estimate their detection rate. We set up acoustic recorders at five recording stations twice a month during September, October and November, and once in December 2014. We identified 18 nocturnal migrant taxa from 801 hours of recordings. The Black-crowned Night Heron Nycticorax nycticorax was the most frequently recorded species, followed by thrushes (Turdus spp.) and the Brown Shrike Lanius cristatus. Passages of nocturnal migrants occurred during every hour of the night, but with a significantly higher detection rate during the period from 2000 to 2300. Detection rates also varied significantly among months and recording stations. Significantly higher detection rates were recorded in September and October than in November and December. The recording station on a ridge detected significantly fewer birds than the other four recording stations situated in or near valleys. This suggests that nocturnal migrants use lower-lying stream valleys in order to pass over mountain ridges at the lowest possible point. This study provides the first evidence to demonstrate that, besides landbird migrants, many shorebird species and even kingfishers migrate through alpine areas at night when they pass over Taiwan Island during autumn migration.
著者
Takayuki Hoshiyama Tatsuhiko Wada Shin Nihonyanagi Ryo Kameda Minako Yamaoka-Tojo Michinari Fukuda Jyunya Ako Kunihiro Yamaoka Yoko Takayama
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.5601-20, (Released:2020-11-02)
参考文献数
42
被引用文献数
6

Objective To describe the clinical features and clinical course of individuals diagnosed with asymptomatic SARS-CoV-2 infection or mild COVID-19. Patients The study participants consisted of 7 crewmembers of the passenger cruise-liner, Diamond Princess, who were admitted to our hospital after becoming infected with SARS-CoV-2 aboard the ship. Methods The data on patient background and biochemical test results were obtained from the patients' medical records. All patients had a chest X-ray, and a throat swab and sputum samples were sent for culture on admission. Results The median age of the 7 patients, of whom 4 were male and 3 were female, was 39 years (range: 23-47 years). On admission, none of them had fever, but 4 (57%) had a cough. None of them showed any signs of organ damage on laboratory testing. Chest X-ray showed pneumonia in one individual, which resolved spontaneously, while the other 6 had normal chest X-ray findings. Culture of throat swabs and sputum samples revealed that 4 patients (57%) had bacterial upper respiratory infections (Haemophilus influenzae, Klebsiella pneumoniae, and Staphylococcus aureus). The period from a positive PCR test to negative conversion ranged from 5 to 13 days, with a median of 8 days. Conclusion Healthy young adults without risk factors who acquire SARS-CoV-2 infection may have an asymptomatic infection or may experience mild COVID-19. In addition to obesity, an older age, underlying illness, and being overweight can lead to a risk of exacerbation; thus, hospital management for such individuals may be desirable. Culturing respiratory samples may be useful for diagnosing secondary bacterial pneumonia.
著者
Yuko Nishina Shin-ichi Yoshioka
出版者
Tottori University Medical Press
雑誌
Yonago Acta Medica (ISSN:13468049)
巻号頁・発行日
vol.61, no.1, pp.019-026, 2018 (Released:2019-03-15)
参考文献数
23
被引用文献数
4 10

Background Comprehensive care is necessary for people with epilepsy (PWE) to lead a fulfilling life at home and in the community. The purpose of this study was to determine the epilepsy-related knowledge, attitudes and practices of home healthcare nurses (HHNs) in the San-in region of Japan.Methods A questionnaire survey was conducted by mail of 546 HHNs working in Tottori and Shimane Prefectures. The questionnaire assessed the epilepsy-related knowledge, attitudes and practices of HHNs. For the analysis, simple and cross tabulation of questionnaire responses were conducted, and the chi-squared test was used for statistical testing.Results A total of 285 HHNs participated in the study. Of the respondents, 43.9% had experience taking care of PWE in a home healthcare nursing setting. Regarding the cause of epilepsy, in descending order the percentage of correct responses were 86.7% for stroke, 85.3% for head injury, and only 13.3% for dementia. Concerning how to respond to an epileptic seizure, almost all respondents answered correctly, but 29.8% gave the incorrect answer of “place something inside the mouth.” Regarding the practices of HHNs in relation to caring for PWE, nurses scored 52.0% for collaborating with the attending physician, indicating the need for improvement. The score for “provide information about social resources” was low at 18.4%. Of the respondents, 95.8% answered that epilepsy-related knowledge and technical skills were necessary for home healthcare nursing practice, and 87.7% were interested in participating in a workshop on epilepsy.Conclusion The study revealed an inadequate level of knowledge of epilepsy with dementia and corresponding epileptic seizures, a low awareness of nursing care in collaboration with physicians, and the importance of providing information about social resources. There is a need to offer information and education on the latest knowledge about epilepsy to HHNs.
著者
Jiyoung PARK Hae-Beom LEE Seong Mok JEONG
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.82, no.11, pp.1602-1606, 2020 (Released:2020-11-12)
参考文献数
14

A 13-year-old, 5.6-kg castrated-male Maltese was presented for reverse sneezing. A dome-shaped round mass abutting diaphragm was incidentally found ventral to caudal vena cava, which had the same echogenicity and density as that of the liver during ultrasonography and computed tomography, showing isoattenuation with a contrast study. Vascular distribution was identified throughout the mass. A caval foramen hernia (CFH) was diagnosed tentatively, followed by a herniorrhaphy and splenectomy of the chronically congested spleen. The patient had been doing well for 5-month postoperative but died because of aspiration pneumonia. CFH is an extremely rare condition, requiring surgery due to compression of the vena cava. It should be considered as a differential diagnosis when intrathoracic, mass-like lesions are identified near the diaphragm.
著者
Meng-Huan Lei Yu-Lin Wu Sheng-Liang Chung Chao-Chin Chen Wei-Cheng Chen Yu-Chen Hsu
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.59386, (Released:2020-11-07)
参考文献数
43
被引用文献数
10

Aims: Type 2 diabetes mellitus (T2DM) is no longer regarded as a coronary risk equivalent, and heterogeneity of cardiovascular risk exists, suggesting that further risk stratification should be mandatory. This study aimed to determine the prevalence and clinical predictors of coronary artery calcium (CAC) score, and evaluate the CAC score as a predictor of cardiovascular outcome in a large asymptomatic T2DM cohort. Methods: A total of 2,162 T2DM patients were recruited from a Diabetes Shared Care Network and the CAC score was measured. Cardiovascular outcomes were obtained for 1,928 patients after a follow-up of 8.4 years. Multiple regression analysis and Cox proportional hazard regression were applied to identify clinical predictors of CAC and calculate the incidence and hazard ratios (HRs) for all-cause mortality and cardiovascular events by CAC category. Results: Of the recruited patients, 96.8% had one or more risk factors. The distribution of CAC scores was as follows: CAC=0 in 24.2% of the patients, 0 <CAC ≤ 100 in 41.5%, 100 <CAC ≤ 400 in 20.3%, CAC >400 in 14.7%. The multivariable predictor of increased CAC included age (years) (odds ratio, 1.07; 95% confidence interval, 1.06–1.08), male sex (1.82; 1.54–2.17), duration (years) of T2DM (1.07; 1.05–1.09), and multiple risk factors (1.94; 1.28–2.95). Increasing severity of CAC was associated with higher all-cause or cardiac mortality and higher incident cardiovascular events. The HRs for cardiac death or major cardiac events in CAC >400 vs CAC=0 were 8.67 and 10.52, respectively (p<0.001) Conclusion: CAC scoring provides better prognostication of cardiovascular outcome than traditional risk factors in asymptomatic T2DM patients, and may allow identifying a high-risk subset for enhancing primary prevention.
著者
Roman-Liu DANUTA Joanna KAMIŃSKA Tomasz TOKARSKI
出版者
National Institute of Occupational Safety and Health
雑誌
Industrial Health (ISSN:00198366)
巻号頁・発行日
pp.2020-0130, (Released:2020-09-24)
被引用文献数
7

The aim of this study was to identify effective work place intervention strategies for the prevention of low back pain (LBP). The study focused on interventions to two major groups: personal interventions and technical interventions. Data basis were searched for with inclusion criteria: study design based on randomised controlled trial; outcome measures including non-specific LBP occurrence expressed by prevalence or intensity; intervention met the definition of the technical and/or personal (physical exercises, behavioural training, educational) intervention programme. Eighteen papers were selected for full analysis. The diversification of quantitative indicators of differences between control and intervention groups were carried out using Cohen’s d index. The results of analysis showed strong differences in effects among intervention strategies, as well as among different cases within similar intervention strategies. LBP severity before intervention and the length of intervention were discussed as potentially influencing factors. The results of the analysis suggest that the most effective strategies for LBP prevention include technical modifications of the workstand and education based on practical training. Behavioural and physical training seems to be of lesser importance. LBP severity before intervention and the time when the measurements of outcome measures take place play an important role in the effectiveness of intervention.
著者
Shigenori MITSUSHIMA Yuki KOIZUMI Ken-ichiro OTA Nobuyuki KAMIYA
出版者
The Electrochemical Society of Japan
雑誌
Electrochemistry (ISSN:13443542)
巻号頁・発行日
vol.75, no.2, pp.155-158, 2007-02-05 (Released:2012-03-20)
参考文献数
19
被引用文献数
7 13

Platinum depositions have been observed in the electrolyte membrane of polymer electrolyte fuel cells (PEFCs) as in other types of fuel cells; PEFCs, MCFCs. The platinum solubility in the membrane must be a key issue to improve and guarantee the durability of PEFCs. In this basic study, the platinum solubility has been determined in an acidic medium as a function of temperature, pH, and potential which was controlled by the oxygen partial pressure. The solubility was 3.0×10−6 mol dm−3 at 23°C in 1 mol dm−3 H2SO4 under air, and increased with temperature and the decrease in pH. The platinum solubility slightly increased with the oxygen partial pressure in oxygen–nitrogen mixtures. However, the solubility in nitrogen was much smaller than the mixtures. Based on these results, the dissolution of platinum in an acidic medium would follow the acidic dissolution mechanism.
著者
モンスリムアンディ ブーンティダ 大原 直也 田中 美菜子 山本 福壽 Boontida Moungsrimuangdee Naoya O-hara Minako Tanaka Fukuju Yamamoto 鳥取大学大学院連合農学研究科 鳥取大学農学部 鳥取大学農学部 鳥取大学農学部 The United Graduate School of Agricultural Sciences Tottori University Faculty of Agriculture Tottori University Faculty of Agriculture Tottori University Faculty of Agriculture Tottori University
出版者
樹木医学会
雑誌
樹木医学研究 = Journal of tree health (ISSN:13440268)
巻号頁・発行日
vol.15, no.3, pp.89-96, 2011-07-31
参考文献数
25
被引用文献数
1

カシノナガキクイムシ(Platypus quercivorus)の加害を受けたコナラ(Quercus serrata)成木,および健全な個体の木部におけるエチレン生成と道管内のチロース形成を比較した.カシノナガキクイムシの加害にはナラ菌(Raffaelea quercivora)の感染がともなっていた.加害を受けた後も生存していた個体では,当年生の木部からの多量のエチレン放出が確認された.これに対し健全な個体,および加害後に枯死した個体からのエチレン生成量は少なかった.昆虫の加害は,多くが樹幹の基部に集中していた.加害後に生存していた個体の道管の多くはチロースによって閉塞されていた.エチレン生成は当年生の木部で顕著であったが,内部の辺材部位,あるいは心材外周の移行材の部位では少なかった.エチレン生成の多かった生存個体では,道管内にナラ菌の菌糸の蔓延も確認した.当年生木部における活発なエチレンの生成は,コナラのナラ菌感染に対する防御反応に関係しているものと予想された.