著者

Emdadul Haque Eiji Yamamoto Kenta Shirasawa Hiroaki Tabuchi Ung-Han Yoon Sachiko Isobe Masaru Tanaka

出版者

Japanese Society for Root Research

雑誌

Plant Root (ISSN:18816754)

巻号頁・発行日

vol.14, pp.11-21, 2020 (Released:2020-10-09)

参考文献数

31

被引用文献数

6

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Genetic studies on the purple-fleshed sweetpotato (Ipomoea batatas L.), which is rich in anthocyanin (AN) in the storage root, were performed by polyploid GWAS based on the allele dosage probability using 59,675 SNPs obtained from 94 F1 progenies between the cultivars 'Konaishin' (which has a high yield but no AN) and 'Akemurasaki' (which has a high AN content but low to moderate yield). The distribution of relative AN content was highly biased, with 60% of clones showing a low to undetectable level (A530 < 0.5). Fifty-nine SNPs from six signals on homologous groups (HGs) 3, 5 (one major and one smaller signal), 7, 13, and 15 were strongly associated with the relative AN content. Twelve SNPs from the major signal and one from the smaller signal of HG 5 were further detected by QTL analysis. In a database search of the AN biosynthesis gene, transcription factors IbMYB1 and IbWD40 and AN structural genes IbF3H and IbDFR were located on HG 5, suggesting that an SNP marker or markers from HG 5 might be tightly linked to candidate gene(s) homologous to one of these transcription factors and AN structural genes as a major factor in determining AN accumulation in the storage roots. These results would enhance our understanding of the underlying genetic basis of AN accumulation in the storage roots of sweetpotatoes, and the SNP markers found here, especially 13 SNPs from HG 5, would be a potential platform for future marker-assisted selection for breeding high-AN sweetpotato varieties.

著者

Shuo Yan Hui Chen Ru-ming Xie Chun-shuang Guan Ming Xue Zhi-bin Lv Lian-gui Wei Yan Bai Bu-dong Chen

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2020.264, (Released:2020-06-30)

参考文献数

27

被引用文献数

2

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Eleven asymptomatic carriers who received nasal or throat swab test for SARS-CoV-2 after close contacts with patients who developed symptomatic 2019 coronavirus disease (COVID-19) were enrolled in this study. The chest CT images of enrolled patients were analyzed qualitatively and quantitatively. There were 3 (27.3%) patients had normal first chest CT, two of which were under age of 15 years. Lesions in 2 (18.2%) patients involved one lobe with unifocal presence. Subpleural lesions were seen in 7 (63.6%) patients. Ground glass opacity (GGO) was the most common sign observed in 7 (63.6%) patients. Crazy-paving pattern and consolidation were detected in 2 (18.2%) and 4 (36.4%) cases, respectively. Based on deep learning quantitative analysis, volume of intrapulmonary lesions on first CT scans was 85.73±84.46 cm3. In patients with positive findings on CT images, average interval days between positive real-time reverse transcriptase polymerase chain reaction assay and peak volume on CT images were 5.1±3.1 days. In conclusion, typical CT findings can be detected in over 70% of asymptomatic SARS-CoV-2 carriers. It mainly starts as GGO along subpleural regions and bronchi, and absorbs in nearly 5 days.

著者

Masamitsu Kamada Jun Kitayuguchi I-Min Lee Tsuyoshi Hamano Fumiaki Imamura Shigeru Inoue Motohiko Miyachi Kuninori Shiwaku

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.24, no.6, pp.474-483, 2014-11-05 (Released:2014-11-05)

参考文献数

56

被引用文献数

18 26

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Background: Both little and excessive physical activity (PA) may relate to chronic musculoskeletal pain. The primary objective of this study was to characterize the relationship of PA levels with chronic low back pain (CLBP) and chronic knee pain (CKP).Methods: We evaluated 4559 adults aged 40–79 years in a community-based cross-sectional survey conducted in 2009 in Shimane, Japan. We used self-administered questionnaires to assess sociodemographics and health status: PA was assessed by the International Physical Activity Questionnaire, and CLBP and CKP were assessed by a modified version of the Knee Pain Screening Tool. We examined relationships of PA with prevalence of CLBP and CKP using Poisson regression, controlling for potential confounders.Results: CLBP and CKP were both prevalent (14.1% and 10.7%, respectively) and associated with history of injury, medication use, and consultation with physicians. PA was not significantly related to CLBP or CKP (P > 0.05) before or after adjustment for potential confounders. For example, compared with adults reporting moderate PA (8.25–23.0 MET-hours/week), prevalence ratios for CKP adjusted for sex, age, education years, self-rated health, depressive symptom, smoking, chronic disease history, and body-mass index were 1.12 (95% confidential interval [CI] 0.84–1.50) among those with the lowest PA and 1.26 (95% CI 0.93–1.70) among those with the highest PA (P quadratic = 0.08). The prevalence ratios were further attenuated toward the null after additional adjustment for history of injury, medication use, and consultation (P quadratic = 0.17).Conclusions: This cross-sectional study showed that there were no significant linear or quadratic relationships of self-reported PA with CLBP and CKP. Future longitudinal study with objective measurements is needed.

著者

In-Hee Lee Sang-young Park

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.12, pp.1591-1593, 2013 (Released:2014-01-08)

参考文献数

24

被引用文献数

21 44

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[Purpose] Aging is associated with a progressive decline in overall muscle strength. Loss of lower limb strength leads to an increased risk of falls and a sedentary lifestyle. The purpose of this study was to investigate whether lower limb strengthening exercise leads to improved lower limb strength and balance function for the elderly. [Subjects] From a total of 74 respondents, 50 subjects were randomly assigned to either a training group (n = 30) or a control group (n = 20). The subjects ranged in age from 65 to 82 years. A randomized controlled trial compared the effects of strengthening exercise and balance function. [Methods] Leg extension and lower curl exercises were performed during the 12-week study. [Results] After training, the lower limb strength and balance of the individuals in the training group had significantly improved compared to the baseline. [Conclusion] Improvement in lower limb strength may lead to balance enhancement in neurologically intact older persons.

著者

ジャン=ピエール・ポティエ Jean-Pierre Potier 竹永 進 Takenaga Susumu 出雲 雅志 Izumo Masashi

出版者

神奈川大学

雑誌

神奈川大学史紀要 (ISSN:24240567)

巻号頁・発行日

vol.03, pp.92(39)-73(58), 2018-03-31

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神奈川大学図書館セミナー

著者

Yusif-zade Kenan

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2020-004, (Released:2020-10-10)

参考文献数

17

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Objectives: The most common method of removal of calculi (“stones”) from the common bile duct (CBD) is an endoscopic sphincterotomy. We wished to determine the role of an improved method of sphincterotomy in choledocholithiasis: “radial sphincterotomy”.Methods: From 2017 to 2018, 54 endoscopic retrograde cholangiopancreatography (ERCP) procedures were undertaken in patients diagnosed with choledocholithiasis. Group 1 (23 patients) received a standard “pull type” sphincterotomy. The sphincterotomy incision in group 1 was made at the 11, 12 or 1 ‘O’ clock directions of a conventional clock depending on the anatomy of the papilla and stone size. Group 2 (31 patients) received a radial sphincterotomy. In this case, several incisions were made in the 11, 12 or 1 ‘O’ clock directions. The main incision was applied to the transverse fold, and other radial incisions were made below the transverse fold, without going beyond the boundaries of the proposed course of the intramural part of the CBD.Results: Stone size (mm) was classified as ≤5, 5–10, 10–15, 15–20 and >20. In group 1, the stone size was <20 mm in 21 patients, and >20 mm in two patients. In group 2, stones >20 mm were detected in seven patients, and in other cases the size was 15–20 mm. In patients who underwent radial sphincterotomy, post-ERCP pancreatitis was noted in one patient, and bleeding and perforations were not observed .Conclusions: Our method showed promising results, and deserves more extensive research and worldwide application. We recommend that only experienced endoscopists should undertake this novel procedure.

著者

Ruijin ZHU Yu-an TAN Quanxin ZHANG Fei WU Jun ZHENG Yuan XUE

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E99.D, no.2, pp.351-359, 2016-02-01 (Released:2016-02-01)

参考文献数

14

被引用文献数

11 18

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Disassembly, as a principal reverse-engineering tool, is the process of recovering the equivalent assembly instructions of a program's machine code from its binary representation. However, when disassembling a firmware file, the disassembly process cannot be performed well if the image base is unknown. In this paper, we propose an innovative method to determine the image base of a firmware file with ARM/Thumb instruction set. First, based on the characteristics of the function entry table (FET) for an ARM processor, an algorithm called FIND-FET is proposed to identify the function entry tables. Second, by using the most common instructions of function prologue and FETs, the FIND-BASE algorithm is proposed to determine the candidate image base by counting the matched functions and then choose the one with maximal matched FETs as the final result. The algorithms are applied on some firmwares collected from the Internet, and results indicate that they can effectively find out the image base for the majority of example firmware files.

著者

Lo Huei-Wen

出版者

京都大学経済学会

雑誌

調査と研究 (ISSN:09175393)

巻号頁・発行日

no.26, pp.41-61, 2003-04

著者

Keiko Sumimoto Hidekazu Tanaka Jun Mukai Kentaro Yamashita Yusuke Tanaka Ayu Shono Makiko Suzuki Shun Yokota Kensuke Matsumoto Yu Taniguchi Noriaki Emoto Ken-ichi Hirata

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.10, pp.625-629, 2020-10-09 (Released:2020-10-09)

参考文献数

9

被引用文献数

3

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Background:The 6th World Symposium on Pulmonary Hypertension proposed that precapillary pulmonary hypertension (PH) be defined as mean pulmonary arterial pressure (mPAP) >20 mmHg instead of mPAP ≥25 mmHg. Peak tricuspid regurgitation velocity (TRV) >3.4 m/s is widely used to predict PH, but it is unclear whether this value remains reliable for the new definition of PH.Methods and Results:We found that the optimal cut-off value of peak TRV for 511 PH patients was >2.8 m/s, with a sensitivity of 89.5%, specificity of 73.4%, and area under the curve of 0.89 (P<0.001).Conclusions:Based on the new definition of PH, TRV >2.8 m/s can be considered to indicate a high probability of PH.

著者

坂田 完三 CHO Jeong-Yong CHO Jeong-Young

出版者

京都大学

雑誌

特別研究員奨励費

巻号頁・発行日

2004

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台湾烏龍茶(東方美人)は、他の烏龍茶と異なりウンカに吸汁されたチャ葉を摘採して作られ、独特な香気を生み出す。こでまでに東方美人茶の独特な香気成分として2,6-dimethylocta-3,7-diene-2,6-diol(diol)とhotrienolが検出された。本研究では、東方美人茶の原料であるウンカ加害チャ葉でdiolとhotrienolの生合成に関与する酵素遺伝子を明らかにすることを目指した。ウンカ加害チャ葉でモノテルペン酸化酵素活性を有するシトクロムP450がlinaloolを酸化してdiolやhotrienolを生成すると考えられ、様々なP450遺伝子の探索を行った。昨年度、烏龍茶製造工程中のチャ葉についてdifferential screening分析の結果から得られた P450ホモログ(TOBA)はモノテルペン水酸化に関与するP450と比較的高い相同性を示し、diol及びhotrienolの生合成に関与する可能性が高いと考えられた。そこで、ウンカ加害チャ葉で3_-RACEおよび5_-RACEを行い、TOBAの全長cDNAを単離した。RT-PCRによりウンカ無加害チャ葉に比べてウンカ加害チャ葉でTOBAの転写量は増加していた。一方、他の植物でモノテルペン水酸化に関与することが知られているP450遺伝子から作成したプライマーを用いて、RT-PCRに行い、ウンカ加害新鮮チャ葉からTOBAと異なる8種のP450ホモログ遺伝子を見出した。これらのP450ホモログについてRT-PCRを行った結果、3種のP450(候補P450)の発現が無加害チャ葉に比べてウンカ加害チャ葉で増加していた。また、見出した8種のうち3種の候補P450はモノテルペン水酸化に関与するP450と比較的高い相同性を示し、diolおよびhotrienolの生合成に関与する可能性が高いと考えられた。現在、候補P450遺伝子の全長cDNAを取得するため、ウンカ加害チャ葉を用いて、cDNA libraryを構築し、候補P450の全長cDNAの単離を行っている。さらに、TOBAと候補P450遺伝子を昆虫細胞あるいは大腸菌を用いて大量発現し、得られた酵素のlinaloolに対する酸化反応を検討する。

著者

Lulin Dai Jun-ya Okamura Gang Wang

出版者

Japanese Society for Medical and Biological Engineering

雑誌

Advanced Biomedical Engineering (ISSN:21875219)

巻号頁・発行日

vol.9, pp.93-99, 2020 (Released:2020-05-15)

参考文献数

15

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Neuroscientists usually investigate stimulus selectivity by using a stimulus set and identifying the stimulus that evokes the largest electrophysiological responses averaged over a certain time period. However, the visual environment, and hence the brain activity, changes all the time. A method with sufficiently high temporal resolution for the investigation of dynamic changes in stimulus selectivity is desired. Here, we propose a method by dividing the usual time window for spike rate calculation into multiple smaller time windows. We applied this method to the analysis of temporal change in stimulus selectivity of inferotemporal (IT) cells in macaque monkey recorded previously using microelectrode while they were performing an object discrimination task, in which one object had to be discriminated from others regardless of change in viewing angle. The IT cortex is located at the last stage of the ventral cortical pathway, and is important for object recognition and discrimination. The proposed method theoretically possesses temporal resolution in millisecond order. We demonstrated its ability by following the changes in stimulus selectivity with temporal resolution as high as 20 ms. Furthermore, we divided the response time window into early phase and late phase. In each phase, single cell responses to images (4 objects × 4 views; 16 images in each of the stimulus set) were compared to identify the stimulus evoking the largest response. When comparing the early and late phases, 40% of the cells showed the largest response to the same stimulus (same object and same viewing angle); 13% of the cells showed the largest response to the same object but at different viewing angles; 20% of the cells showed the largest response to different objects at the same viewing angle; and 20% of the cells showed the largest response to different objects at different viewing angles. The dynamic change of stimulus selectivity from early phase to late phase may provide important information about the underlying neuronal mechanism for object recognition. Successful application of the proposed method to the analysis of IT cell activity demonstrates the validity and usefulness of the method.

著者

Eri Oguro Shiro Ohshima Akie Kikuchi-Taura Atsuko Murata Kentaro Kuzuya Yasutaka Okita Hidetoshi Matsuoka Satoru Teshigawara Maiko Yoshimura Yuji Yoshida Kentaro Isoda Eriko Kudo-Tanaka Yoshinori Harada Toshio Kaminou Yukihiko Saeki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.9, pp.1355-1360, 2019-05-01 (Released:2019-05-01)

参考文献数

17

被引用文献数

3 9

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A 26-year-old woman with Takayasu's arteritis (TAK) experienced back and neck pain during tocilizumab (TCZ) treatment. The levels of C-reactive protein were normal, and ultrasonography revealed no significant changes. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) showed signal enhancement in the walls of several arteries. Contrast computed tomography showed arterial inflammation in the same lesion. After increasing the dose of prednisolone and TCZ, all signal enhancements decreased and continued to decrease, as observed on days 76 and 132. Thus, DWIBS may be a novel imaging modality for assessing the disease activity of TAK, particularly during follow-up.

著者

HUNG Tzu-Chieh

出版者

一般財団法人 アジア政経学会

雑誌

アジア研究 (ISSN:00449237)

巻号頁・発行日

vol.63, no.3, pp.1-11, 2017-07-31 (Released:2017-09-05)

参考文献数

15

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During Kuomintang’s (KMT) administration from 2008 to 2016, China’s influence in Taiwan expanded enormously through increasing mutual communication and exchanges between the two countries, thus giving China leverage to install its proxy agent framework to achieve its political interests. This paper argues that by using Taiwanese elites, China advanced its political agenda, and strengthened its proxy agent framework during this process. China has implanted a softer strategy in connecting with proxy agents. The paper first discusses China’s goals and strategy of further communication and cooperation with Taiwan to elucidate the foundation upon which proxy agent frameworks have been implemented. Next, specific cases of proxy agents providing different degrees of evidence are examined. The cases discussed include the Want Want China Times Group and other business tycoons, Taipei Whampoa Military Academy Alumni Association, the True Enlightenment Education Foundation, and certain Taiwanese political elites. These cases focus on the characteristics of these people’s and entities’ relationships with China that helped China influence or acquire interests in Taiwan. Finally, the paper illustrates the relationship among China, its proxy agents and the Taiwanese as well as the impact of proxy agents. The paper concludes that China’s proxy agent framework is an ecology system of interest that involves quid pro quo. Fieldwork indicates that economic attraction, subsidies and Chinese identity are the major strategies used to attract proxy agents. Although certain cases concerning the connections between China and Taiwan groups and individuals remain unverified, a coincident win-win situation between China and certain Taiwan groups and individuals are revealed periodically. China’s large market and its promise of economic rewards have indeed influenced the actions of Taiwanese elites. China is buying “the hearts and minds” not of the general Taiwanese but of Taiwanese elites, who may serve as proxy agents. After Tsai yin-wen won the presidential election in 2016, China has continued to increase its number of proxy agents to influence Taiwan. It is thus very likely that the number of Taiwanese who devote themselves to the proxy agents “industry” will increase.

著者

Yasuhiro Abe Eiichi Yamamoto Hiroyuki Yoshida Akiko Usui Naomi Tomita Hitomi Kanno Sayaka Masada Hidetomo Yokoo Genichiro Tsuji Nahoko Uchiyama Takashi Hakamatsuka Yosuke Demizu Ken-ichi Izutsu Yukihiro Goda Haruhiro Okuda

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c20-00431, (Released:2020-08-08)

参考文献数

28

被引用文献数

20

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The purpose of this study was to elucidate the effect of high-temperature storage on the stability of ranitidine, specifically with respect to the potential formation of N-nitrosodimethylamine (NDMA), which is classified as a probable human carcinogen. Commercially available ranitidine reagent powders and formulations were stored under various conditions, and subjected to LC-MS/MS analysis. When ranitidine tablets from two different brands (designated as tablet A and tablet B) were stored under accelerated condition (40°C with 75% relative humidity), following the drug stability guidelines issued by the International Conference on Harmonisation (ICH-Q1A), for up to 8 weeks, the amount of NDMA in them substantially increased from 0.19 to 116 ppm and from 2.89 to 18 ppm, respectively. The formation of NDMA that exceeded the acceptable daily intake limit (0.32 ppm) at the temperature used under accelerated storage conditions clearly highlights the risk of NDMA formation in ranitidine formulations when extrapolated to storage under ambient conditions. A forced-degradation study under the stress condition (60°C for 1 week) strongly suggested that environmental factors such as moisture and oxygen are involved in the formation of NDMA in ranitidine formulations. Storage of ranitidine tablets and reagent powders at the high temperatures also increased the amount of nitrite, which is considered one of the factors influencing NDMA formation. These data indicate the necessity of controlling/monitoring stability-related factors, in addition to controlling impurities during the manufacturing process, in order to mitigate nitrosamine-related health risks of certain pharmaceuticals.

著者

ハン-オラルメエル-ヒスセル 著

出版者

写

巻号頁・発行日

vol.二,

著者

ハン-オラルメエル-ヒスセル 著

出版者

写

巻号頁・発行日

vol.一,

著者

ハン-オラルメエル-ヒスセル 著

出版者

写

巻号頁・発行日

vol.三,

著者

Taiji Ogawa Mariko Honda-Ogawa Kazunori Ikebe Shigetada Kawabata Yoshinobu Maeda

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.59, no.3, pp.391-395, 2017 (Released:2017-09-14)

参考文献数

13

被引用文献数

1 3

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Dry mouth occurs frequently in aged individuals, as well as in patients who are hospitalized, receiving multiple drugs, undergoing radiation treatment to the head and neck, or wearing a removable denture prosthesis, use of mouth rinse being often an option for relief. In the present study, we performed microbiological assessments of subjects given three different commercially available mouth rinses commonly employed in clinical practice (Peptisal, Biotène, ConCool) to determine their effects. For bacterial clearance in vitro, Peptisal showed the highest level of suppression of oral indigenous bacteria found in both planktonic formations and biofilm. Furthermore, the inhibitory effects of these agents on biofilm formation on acrylic resin plates were examined using scanning electron microscopy. Again, Peptisal proved superior, because acquisition of resistance to antimicrobial peptides by a sensitive microbial strain was rarely observed. We conclude that Peptisal is an effective mouth rinse for clearance of planktonic and biofilm microorganisms present in the oral cavity.

著者

Ryusei Nishigori Yoko Warabi Yukiko Shishido-Hara Kazuo Nakamichi Yasuhiro Nakata Takashi Komori Eiji Isozaki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.3038-19, (Released:2019-07-31)

参考文献数

15

被引用文献数

5 9

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The patient was a 74-year-old woman with rheumatoid arthritis who developed ataxia. MRI revealed T2-hyperintense lesions predominantly in the left middle cerebellar peduncle. Punctate or linear Gd enhancement was also observed on T1-weighted images. A brain biopsy was conducted and the pathology revealed a mild demyelinated lesion. PCR of biopsied brain tissues revealed the presence of JCV DNA, but JCV-infected oligodendroglia-like cells were not apparent on immunohistochemistry. Sensitive in-situ hybridization, however, detected three JCV-positive cells and the infiltration of CD4+ and CD8+ T cells and plasma cells was also observed. Immunosuppressants were tapered off and mirtazapine and mefloquine administered, resulting in a favorable outcome.

著者

Shinya - Imai Takuya - Hamada Masaya - Hamada Takanori - Shirokura Iriya - Muneta Kuniyuki - Kakushima Tetsuya - Tatsumi Shigetaka - Tomiya Kazuo - Tsutsui Hitoshi Wakabayashi

雑誌

2020 International Conference on Solid State Devices and Materials

巻号頁・発行日

2020-08-31