著者

大畑 耕一 KOH-ICHI OH-HATA 藤女子大学人間生活学部保育学科

出版者

藤女子大学

雑誌

藤女子大学紀要 第2部 (ISSN:13461389)

巻号頁・発行日

no.39, pp.97-104, 2002-02-14

著者

edited by Maike Sarah Reinerth and Jan-Noël Thon

出版者

Routledge

巻号頁・発行日

2017

著者

edited by Gabriele Fahr-Becker

出版者

Taschen

巻号頁・発行日

2007

著者

世界遺産・厳島-内海の歴史と文化プロジェクト研究センター [編]

出版者

世界遺産・厳島-内海の歴史と文化プロジェクト研究センター

巻号頁・発行日

2005

著者

Yayoi OTSUKA-YAMASAKI Osamu INANAMI Haruka SHINO Reeko SATO Masahiro YAMASAKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0390, (Released:2020-12-21)

被引用文献数

2

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Hereditary methemoglobinemia associated with nicotinamide adenine dinucleotide-cytochrome b5 reductase (b5R) deficiency is a rare autosomal recessive disorder in animals. Recently, nonsynonymous b5R gene (CYB5R3) variants have been reported to be associated with canine and feline hereditary methemoglobinemia. However, the underlying molecular mechanisms of canine and feline methemoglobinemia caused by these nonsynonymous variants have not yet been reported. Previously, we reported a Pomeranian dog family with hereditary methemoglobinemia, carrying CYB5R3 mutation of an A>C transition at codon 194 in exon 7, replacing an isoleucine residue with leucine (p.Ile194Leu). In this study, we investigated the enzymatic and structural properties of the soluble form of wild-type and Ile194Leu canine b5Rs to characterize the effects of this missense mutation. Our results showed that the kinetic properties of the mutant enzyme were not affected by this amino acid substitution. The secondary structure of the wild-type and Ile194Leu b5Rs detected by circular dichroism showed a similar pattern. However, the mutant enzyme exhibited decreased heat stability and increased susceptibility to trypsin hydrolysis. Moreover, the thermostability and unfolding measurements indicated that the mutant enzyme was more sensitive to temperature-dependent denaturation than the wild-type b5R. We conclude from these results that unstable mutant enzyme properties with normal enzymatic activity would be associated with hereditary methemoglobinemia in the Pomeranian dog family.

著者

土岐善麿 (Toki-Zenmaro) 著

出版者

日本のろーま字社

巻号頁・発行日

1911

著者

Keita Aida Kentaro Kamiya Nobuaki Hamazaki Ryota Matsuzawa Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Emi Maekawa Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.19-557, (Released:2020-05-15)

参考文献数

40

被引用文献数

10

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The simplified frailty scale is a simple frailty assessment tool modified from Fried's phenotypic frailty criteria, which is easy to administer in hospitalized patients. The applicability of the simplified frailty scale to indicate prognosis in elderly hospitalized patients with cardiovascular disease (CVD) was examined.This cohort study was performed in 895 admitted patients ≥ 65 years (interquartile range, 71.0-81.0, 541 men) with CVD. Patients were classified as robust, prefrail, or frail based on the five components of the simplified frailty scale: weakness, slowness, exhaustion, low activity, and weight loss. The primary endpoint was the composite outcome of all-cause mortality and unplanned readmission for CVD.Patients positive for greater numbers of frailty components showed higher risk of all-cause mortality or unplanned CVD-related readmission (P for trend < 0.001). Classification as both frail (adjusted HR: 3.27, 95% confidence interval [CI]: 1.49-7.21, P = 0.003) and prefrail (adjusted HR: 2.19, 95% CI: 1.00-4.79, P = 0.049) independently predicted the composite endpoint compared with robust after adjusting for potential confounding factors. The inclusion of prefrail, frail, and number of components of frailty increased both continuous net reclassification improvement (0.113, P = 0.049; 0.426, P < 0.001; and 0.321, P < 0.001) and integrated discrimination improvement (0.007, P = 0.037; 0.009, P = 0.038; and 0.018, P = 0.002) for the composite endpoint.Higher scores on the simplified frailty scale were associated with increased risk of mortality or readmission in elderly patients hospitalized for CVD.

著者

Anders JOHANNISSON Essraa M. AL-ESSAWE Anas Kh. AL-SAFFAR Saeid KARKEHABADI Isabel LIMA-VERDE Manuela WULF Christine AURICH Jane M. MORRELL

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.66, no.3, pp.215-221, 2020 (Released:2020-06-12)

参考文献数

30

被引用文献数

3 7

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The mechanism by which the content of the major groups of seminal plasma proteins in stallion semen changes between the breeding and non-breeding seasons remains unknown. Here, we investigated the proportions of non-heparin-binding, phosphorylcholine-binding, and heparin-binding proteins in seminal plasma with the aim of relating them to sperm quality and testosterone levels in good and bad freezer stallions. Only minor variations in the major protein groups were found between the breeding and non-breeding seasons. In the non-breeding season, a higher content of a subset of non-heparin binding proteins as well as of heparin-binding proteins was found. Analysis of semen characteristics revealed a somewhat contrasting picture. While only minor variations in sperm kinematics and sperm morphology were found between seasons, the flow-cytometric measurements of mitochondrial membrane potential and also, to some extent, reactive oxygen species production indicated lower sperm quality in the breeding season. Chromatin integrity and testosterone levels were unchanged between seasons. The results suggest that stallion ejaculates could be used year-round for freezing, since only minor differences in protein composition exist between the breeding and non-breeding seasons, as well as between good and bad freezers. In addition, sperm quality is not impaired during the non-breeding season.

著者

菅(七戸) 美弥 SUGA-SHICHINOHE Miya 菅(七戸) 美弥(東京学芸大学 人文科学講座 地域研究分野)

出版者

東京学芸大学学術情報委員会

雑誌

東京学芸大学紀要. 2. 人文社会科学系 (ISSN:18804322)

巻号頁・発行日

vol.68, pp.59-77, 2017-01

著者

Baek Ye-Seul Lee Jai-Young Park Kyung-Joo Park Ji-Hye Lee Hyun-Goo Oh Seung-Jin Kim Jong-Bin

出版者

一般社団法人 廃棄物資源循環学会

雑誌

廃棄物資源循環学会研究発表会講演集

巻号頁・発行日

vol.21, pp.321, 2010

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There is limitation for landfilling municipal solid waste(MSW) because of the narrow country and high population density in Korea. However, the generated quantity of the waste increased according to the population growth and mass production and consumption. So, Korea aims the waste minimization by recycling and reusing resources. If the waste dumps after incineration, it can use more long time.Whenever se design the incinerator, it has to know about waste using three components and heating value. Generally, there are three values such as combustible components, moisture, ash. In this study, the authors analyze by Korea Standard. The sampling points are Incheon, Gyeonggi, North part of Han river, South part of Han river, and there is mixed samples with each area. The authors sample from each point more than 100kg. And then the samples were measured bulk density and sorted 10 kinds of waste.The average bulk density of 5 sampling points is 94.86 kg/m3. The most of waste have large part of combustible components except the food waste and other combustible waste. As you know, the plastics have the highest heating value. The value of highest heating was calculated 8,094.96 kcal/kg and the value of lowest heating was calculated 7,686.31 kcal/kg by Dulong equation. Also the food waste has lowest heating value. The value of highest heating was calculated 3,963.69 kcal/kg and the value of lowest heating was calculated 3,192.46 kcal/kg by Dulong equation.

著者

Clercq Lucien-Laurent

出版者

北海道大学大学院文学研究科

雑誌

北海道大学大学院文学研究科研究論集 (ISSN:13470132)

巻号頁・発行日

no.10, pp.203-218, 2010

著者

Kenzo Hiraoka Osamu Ariyada Dilshadbek T. Usmanov Lee C. Chen Satoshi Ninomiya Kentaro Yoshimura Sen Takeda Zhang Yu Mridul K. Mandal Hiroshi Wada Stephanie Rankin-Turner Hiroshi Nonami

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.9, no.1, pp.A0092, 2020-12-04 (Released:2020-12-04)

参考文献数

61

被引用文献数

17

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In 2007, probe electrospray ionization/mass spectrometry (PESI/MS) was developed. In this technique, the needle is moved down along a vertical axis and the tip of the needle touched to the sample. After capturing the sample at the needle tip, the needle is then moved up and a high voltage is applied to the needle at the highest position to generate electrospray. Due to the discontinuous sampling followed by the generation of spontaneous electrospray, sequential and exhaustive electrospray takes place depending on the surface activity of the analytes. As modified versions of PESI, dipping PESI (dPESI), sheath-flow PESI (sfPESI) and adjustable sfPESI (ad-sfPESI) have been developed. These methods are complementary to each other and they can be applicable to surface and bulk analysis of various biological samples. In this article, the characteristics of these methods and their applications to real samples will be reviewed.

著者

Yamashita Yumi Ogura-Tsujita Yuki Tokuda Makoto Yukawa Tomohisa

出版者

National Museum of Nature and Science

雑誌

Bulletin of the National Museum of Nature and Science. Series B, Botany (ISSN:18819060)

巻号頁・発行日

vol.46, no.3, pp.119-127, 2020-08

著者

徐 賢燮 SEO Hyun-seop

出版者

長崎県立大学

雑誌

研究紀要 (ISSN:13466372)

巻号頁・発行日

no.9, pp.215-228, 2008-12-22

著者

Yu ZHANG Shao-hua CHEN

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.19, no.1, pp.1-6, 2013 (Released:2013-03-09)

参考文献数

37

被引用文献数

4

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Coffee is the most popular drink in the world and coffee intake may be a risk factor for gastroesophageal reflux disease (GERD), which is a common disorder and its worldwide prevalence is increasing. However, the effect of coffee on GERD remains to be fully elucidated. The relationship between GERD and coffee consumption is not clear given the existing literature, whose results are diverse and contradictory. Existing systematic investigations are not adequate and further well-designed prospective studies are needed to clarify the effect of coffee on GERD.

著者

今西 順一 Jun-ichi Imanishi

出版者

京都府立大学福祉社会学部福祉社会研究会

雑誌

福祉社会研究 (ISSN:13471457)

巻号頁・発行日

no.2, pp.50-63, 2001

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本論文は、現行法制度の原則である民刑分離の下で、どのような制度が最も効果的に、犯罪被害者の財産的損害の回復を行うことが可能なのかを考察したものである。1章では、被害回復の方法の基本となる、民事手続においての被害回復について述べる。この方法は被害者が加害者に対して、(1)民事裁判を提起するか、(2)示談を成立させることが考えられる。しかし、これらの方法は損害回復の実効性に乏しいものである。というのも、加害者が無資力の場合、被害者は為す術がなく、泣き寝入りせざるを得ないからである。2章では、わが国の「犯罪被害者等給付金支給法」について述べる。この制度は犯罪被害者に対して、国家が見舞金を支給するというものである。ただ、この制度はその性格上、被害者の損害を補填するものではない上に、財源を税金によっているため、被害者救済の範囲も自ずと限界がある。3章では、実効性の高い損害回復制度として、犯罪者からの没収・追徴財産、罰金等を基とした、被害者救済基金のわが国への導入の可否について述べる。この制度はわが国でも実行が容易で、かつ効果的な被害者救済を行うことが可能と考える。

著者

Hayato Tada Hirofumi Okada Akihiro Nomura Soichiro Usui Kenji Sakata Atsushi Nohara Masakazu Yamagishi Masayuki Takamura Masa-aki Kawashiri

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0901, (Released:2020-12-03)

参考文献数

21

被引用文献数

11

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Background:This study is aimed to compare the efficacy of the 2017 Japan Atherosclerosis Society (JAS) familial hypercholesterolemia (FH) criteria, which focuses on only 3 essential clinical manifestations, with that of Dutch Lipid Clinic Network (DLCN) FH criteria, which adopts a scoring system of multiple elements.Methods and Results:A total of 680 Japanese dyslipidemic participants (51% men) were enrolled between 2006 and 2018, all of whom had full evaluations of low-density lipoprotein (LDL) cholesterol, Achilles tendon X-rays, family history records, and genetic analysis of FH-associated genes (LDLR,APOB, andPCSK9). Predictive values for the existence of FH mutations by both clinical criteria were evaluated. Overall, 173 FH patients were clinically diagnosed by using the 2017 JAS criteria and 100, 57, 156, and 367 subjects were also diagnosed as having definite, probable, possible, and unlikely FH by the DLCN FH criteria, respectively. The positive and negative likelihood ratio predicting the presence of FH mutations by using the 2017 JAS FH criteria were 19.8 and 0.143, respectively; whereas, using the DLCN criteria of definite, probable, and possible FH, the ratios were 29.2 and 0.489, 9.70 and 0.332, and 3.43 and 0.040, respectively.Conclusions:Among Japanese patients, the JAS 2017 FH criteria is considered superior to diagnose FH mutation-positive patients and simultaneously rule out FH mutation-negative patients compared with the DLCN FH criteria.

著者

Yuko HASEGAWA Chiharu TSUTSUMI Fusako MITSUHASHI Noriyuki KIMURA Yoshitaka IWABUCHI Shu SAKAMOTO Kazuko ISHIKAWA-TAKATA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.66, no.5, pp.441-448, 2020-10-31 (Released:2020-10-31)

参考文献数

23

被引用文献数

2

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The official testing methods for establishing nutritive values are accurate but relatively costly and time-consuming. Near infrared spectroscopy (NIRS) is potentially an alternative method that can analyze several components in a few minutes using an exclusively electronic instrument with no need for a laboratory expert. However, the accuracy of commercial NIRS spectroscopic food analyzers is not sufficient for Japanese food labeling, because of interference from moisture contained in the foods. This study aims to assess the effect of a freeze-drying pretreatment on the accuracy of NIRS food analysis. Thirty-four samples, consisting of six food items habitually consumed in Japan and cooked by different cooking methods were treated by milling then freeze-drying. They were analyzed by a commercial NIRS instrument (Calorie AnswerTM) with calibration curves developed based on other freeze-dried samples. The obtained nutritive values (energy, protein, lipid, carbohydrate and moisture) were corrected to the values before freeze-drying using the vaporized moisture content. The same samples before freeze-drying were also analyzed using the official testing methods to assess the analytical accuracy using NIRS after freeze-drying, and further analyzed using the same NIRS with the commercial calibration curves to assess the effect of freeze-drying. The accuracies were better for the freeze-dried samples than for the wet samples. The magnitude of the error in energy and carbohydrate was significantly associated with the retained moisture content in the freeze-dried sample. In conclusion, freeze-drying was an effective pretreatment for improving the accuracy of NIRS analyses of Japanese cooked foods, although it is still time-consuming and needs additional investment.

著者

Hiroto Takenaka Tatsunori Ikemoto Junya Suzuki Masayuki Inoue Young-Chang Arai Takahiro Ushida Masataka Deie Mitsuhiro Kamiya

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

pp.2019-0083, (Released:2019-12-03)

被引用文献数

4

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BackgroundThe present study aimed to investigate the association between trunk muscle strength, lumbar spine bone mineral density (BMD), lumbar scoliosis angle (LSA), and appendicular skeletal muscle mass index (ASMI) and the severity locomotive syndrome (LS) using dual-energy X-ray absorptiometry (DXA) technology in elderly individuals.MethodsIn this cross-sectional study, we enrolled 168 individuals aged >60 years. We measured their trunk muscle strength (flexion and extension) and BMD, LSA, and ASMI using DXA. We defined degenerative lumbar scoliosis (DLS) as LSA ≥ 10° by the Cobb method using the DXA image. The locomotor function was evaluated using the timed up-and-go (TUG) test and the 25-question Geriatric Locomotive Function Scale (GLFS-25) score. Normal locomotor function, LS-1, and LS-2 were defined as a GLFS-25 score of <7, ≥7 and <16, and ≥16, respectively. We compared the three groups, analyzing the associations between all variables and the locomotor function using univariate and multivariate analyses.ResultsAlthough there was no significant difference in sex ratio, BMD, ASMI, and trunk-flexor strength, significant differences were observed in age (p < 0.01), the prevalence of DLS (p = 0.02), trunk-extensor strength (p < 0.01), and trunk-extensor/flexor strength ratio (p < 0.01) among the three groups. In multiple regression analyses, the significant risk factors of the TUG test were age (β = 0.26), body mass index (β = 0.36), LSA (β = 0.15), ASMI (β = −0.30), and trunk-extensor strength (β = −0.19), whereas the significant factor of the GLFS-25 score was trunk-extensor strength (β = −0.31).ConclusionsThe results indicate that it is clinically important for LS to pay careful attention not only to BMD but also to lumbar scoliosis when DXA examination of the lumbar spine is routinely conducted. Moreover, it is essential to note that trunk-extensor strength is more important than trunk-flexor strength in maintaining locomotor function in elderly individuals.

著者

Wataru Aoki Maiko Watanabe Masaki Watanabe Naoki Kobayashi Jun Terajima Yoshiko Sugita-Konishi Kazunari Kondo Yukiko Hara-kudo

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

vol.95, no.3, pp.133-139, 2020-06-01 (Released:2020-08-27)

参考文献数

22

被引用文献数

3

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Entoloma sarcopum is widely known as an edible mushroom but appears morphologically similar to the poisonous mushrooms E. rhodopolium sensu lato (s. l.) and E. sinuatum s. l. Many cases of food poisoning caused by eating these poisonous mushrooms occur each year in Japan. Therefore, they were recently reclassified based on both morphological and molecular characteristics as sensu stricto species. In this study, we analyzed the nucleotide sequences of the rRNA gene (rDNA) cluster region, mainly including the internal transcribed spacer regions and mitochondrial cytochrome oxidase 1 (CO1) gene, in E. sarcopum and its related species, to evaluate performances of these genes as genetic markers for identification and molecular phylogenetic analysis. We found that the CO1 gene contained lineage-specific insertion/deletion sequences, and our CO1 tree yielded phylogenetic information that was not supported by analysis of the rDNA cluster region sequence. Our results suggested that the CO1 gene is a better genetic marker than the rDNA cluster region, which is the most widely used marker for fungal identification and classification, for discrimination between edible and poisonous mushrooms among Japanese E. sarcopum and related species. Our study thus reports a new genetic marker that is useful for detection of Japanese poisonous mushrooms, Entoloma.