著者

Josué DÍAZ-DELGADO Roy POOL Sharman HOPPES Argine CEREZO Óscar QUESADA-CANALES George STOICA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.5, pp.889-895, 2017 (Released:2017-05-18)

参考文献数

49

被引用文献数

14

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This report describes the clinical, macroscopic, histopathological and immunohistochemical features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum. Histologic, histochemical and immunohistochemical analyses supported a diagnosis of multicentric poorly differentiated spindle cell sarcoma with fibrosarcomatous, storiform and myxoid foci. The high incidence of neoplasia and cross similarities renders the African hedgehog a suitable species for comparative pathology studies.

著者

メナード-ウォーウィック ジュリアナ 堀田 碧

出版者

Barbara Summerhawk

雑誌

関係性の教育学 (ISSN:13490206)

巻号頁・発行日

vol.1, no.1, pp.65-75, 145-153, 2001

著者

Jin-Ok AHN Won-Joung JAUNG Sang-Heum WON Min-Ok RYU Woo-Jin SONG Kee-Ok JEON Jin-Young CHUNG Hwa-Young YOUN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0305, (Released:2017-11-14)

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Two dogs presented to the emergency service after accidental ingestion of afloqualone tablets, a muscle relaxant used for back pain in humans. Toxic effects of the drug in these dogs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria. Treatment consisted of fluid diuresis, furosemide, and propofol. Flumazenil, a gamma-amino butyric acid antagonist, was administered intravenously; however, it was not effective in stopping the seizures in these dogs. Both dogs recovered with supportive treatment. To the authors’ knowledge, this is the first documented report of afloqualone intoxication in dogs.

著者

Hee Tae Yu Pil-Sung Yang Hancheol Lee Seng Chan You Tae-Hoon Kim Jae-Sun Uhm Jong-Youn Kim Hui-Nam Pak Moon-Hyoung Lee Boyoung Joung

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0669, (Released:2017-11-14)

参考文献数

34

被引用文献数

13

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Background:Rate control is now a front-line therapy in the management of atrial fibrillation (AF). However, the survival benefits of different rate-control medications remain controversial, so we assessed the efficacy of rate-control medications in AF patients with concomitant heart failure (HF).Methods and Results:From January 2002 to December 2008, a total of 7,034 AF patients with a single type of rate-control drug or without rate-control treatment were enrolled from the Korea National Health Insurance Service database. The death rates over a mean follow-up of 4.5±1.2 years were 12.6% (580 of 4,593) and 29.0% (709 of 2,441) in non-HF and HF patients, respectively. Among the total subjects, the risk of death was lower in patients receiving β-blockers (adjusted hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.64–0.88) and calcium-channel blockers (adjusted HR 0.74, 95% CI 0.55–0.98) compared with those who did not receive rate-control medications. In patients without HF, use of rate-control medications did not affect the risk of death. In patients with HF, β-blockers significantly decreased the mortality risk (adjusted HR 0.63, 95% CI 0.50–0.79), whereas use of calcium-channel blockers or digoxin was not associated with death. The results were observed consistently among the cohorts after propensity matching.Conclusions:Use of β-blockers was associated with a reduced mortality rate for AF patient with HF but not for those without HF. These findings should be examined in a large randomized trial.

著者

KIRAKOSYAN Zara SAAKIAN David B. HU Chin-Kun

出版者

The Physical Society of Japan

雑誌

J Phys Soc Jpn (ISSN:00319015)

巻号頁・発行日

vol.81, no.11, pp.114801-114801-4, 2012-11-15

被引用文献数

8

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We consider the Eigen model with non-Poisson distribution of mutation number. We apply the Hamilton--Jacobi equation method to solve the model and calculate the mean fitness. We find that the error threshold depends on the correlation, and the suggested mechanism may give a simple solution to the error catastrophe paradox in the origin of life.

著者

Ju-hyun Lee Tae-ho Kim

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.9, pp.1578-1582, 2017 (Released:2017-09-15)

参考文献数

36

被引用文献数

10

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[Purpose] In this paper, hamstring stretching and nerve mobilization are conducted on patients with radicular lower back pain, and changes to pain levels, pressure thresholds, angles of knee joint extension, and disorder levels of lower back pain were studied. [Subjects and Methods] The subjects were divided into two groups: one group conducted hamstring stretches and was comprised of 6 male and 5 female subjects, and the other group received nerve mobilization treatment and was comprised of 5 male and 6 female subjects. [Results] Pain level and the disorder index of lower back pain were significantly alleviated after the intervention in both groups. Pressure threshold and angles of knee extension were significantly increased after the intervention in both groups. Comparing the two groups, the alleviation of pain was more significant in the nerve mobilization group. [Conclusion] Patients with radicular lower back pain showed significant differences in pain level, pressure threshold, knee extension angle, and disorder index of lower back pain for both the hamstring stretching group and nerve mobilization group after the treatment. Hamstring stretching and nerve mobilization can be usefully applied for the therapy of patients with radicular lower back pain.

著者

Daisuke Sueta Koichi Kaikita Nobukazu Okamoto Soichiro Yamabe Masanobu Ishii Yuichiro Arima Miwa Ito Yu Oimatsu Tatsuro Mitsuse Satomi Iwashita Eiichi Nakamura Seiji Hokimoto Hiroshi Mizuta Hisao Ogawa Kenichi Tsujita for the ESCORT-TKA Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0612, (Released:2017-09-16)

参考文献数

50

被引用文献数

4

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Background:The pharmacological advantage of combining physiotherapy with anticoagulants for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) is not fully known. Herein we investigated the potential benefit of this combination therapy in patients undergoing TKA.Methods and Results:The 38 patients were randomly assigned to a physiotherapy group (n=19) or a physiotherapy plus 30 mg/day edoxaban group (n=19). The occurrence of VTE was evaluated, as were serial changes in parameters measured by the Total Thrombus-formation Analysis System, a novel system for quantitatively analyzing thrombus formation using microchips with thrombogenic surfaces (collagen plus tissue factor, atheroma [AR]-chip). Combination therapy significantly reduced the incidence of VTE after TKA compared with monotherapy (P=0.038). The area under the curve (AUC) of thrombus formation for the AR-chip (AR10-AUC30) was significantly lower in the combination group (P=0.001) on Day 7 after TKA than before TKA, but no significant change was observed with monotherapy (P=0.809). In 13 VTE-positive patients, AR10-AUC30was significantly lower in the combination group (n=3) than in the monotherapy group (n=10) on Day 7 (P=0.045).Conclusions:The combination of physiotherapy and edoxaban significantly reduced the incidence of VTE after TKA compared with physiotherapy alone. However, it is possible that VTE occurrence after TKA is not only associated with thrombogenicity, but also rheological factors.

著者

William F. Smith-Vaniz 吉野 哲夫

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.32, no.1, pp.18-27, 1985-05-30 (Released:2010-06-28)

参考文献数

27

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日本産アゴアマダイ属魚類Opistognathusを再検討した結果, 既知の4種の他にイレズミアマダイO.decorusおよびセトアマダイO.liturusの2新種を確認した.前種は沖縄島, 後種は和歌山県白浜で採集されたものであり, いずれも頭部に顕著な斑点をもつことや背鰭軟条数が11~12と少ないことで, 他種とは明瞭に区別される.イレズミアマダイは鯉耙数が多いこと, 頭部感覚孔数が少ないこと, 両眼間隔が広いこと, 眼径が小さいこと, 眼下骨の形が異なることなどでセトアマダイと区別できる.従来用いられたGnathypopsやMerogymnusはOpistognathusのシノニムであり, 上記の2新種を含めた日本産本属魚類の検索表を作製した.

著者

Ilse Laude-Cirtautas

出版者

O. Harrassowitz

巻号頁・発行日

1980

著者

Shin-ya Nishizaki

出版者

Research Institute forMathematical Sciences

雑誌

Publications of the Research Institute for Mathematical Sciences (ISSN:00345318)

巻号頁・発行日

vol.30, no.6, pp.1055-1121, 1994 (Released:2009-04-24)

参考文献数

15

被引用文献数

11

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We propose a lambda calculus λenv→ where it is possible to handle first-class environments. This calculus is based on the idea of explicit substitution, that is; λσ-calculus. Syntax of λenv→ is obtained by merging the class of terms and the one of substitutions. Reduction is made from the weak reduction of λσ-calculus. Its type system also originates in the one of λσ-calculus. Confluence of λenv→ is proved by Hardin's interpretation method which is originally used for proving confluence of λσ-calculus. We proved strong normalizability of λenv→ by reducing it to strong normalizability of a simply typed record calculus. Finally, we propose a type inference algorithm which produced a principal typing for each typable term.

著者

Shota Kurushima Yoshiro Horai Ayuko Takatani Ayako Nishino Shin-ya Kawashiri Kunihiro Ichinose Hideki Nakamura Atsushi Kawakami

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9195-17, (Released:2017-10-11)

参考文献数

8

被引用文献数

3

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We herein report a woman in her 50s with systemic lupus erythematosus (SLE) who developed swelling and pain in her fingers; the symptoms were more prominent in winter. Magnetic resonance imaging (MRI) revealed bone edema in the phalanges of both hands, which was compatible with phalangeal microgeodic syndrome (PMS). This is the first reported case of PMS in a patient with SLE and suggests that performing MRI should be considered for patients with SLE in order to assess the nature of finger symptoms and signs more precisely.

著者

Shun TAKEO Daichi SATO Koji KIMURA Yasunori MONJI Takehito KUWAYAMA Ryoka KAWAHARA-MIKI Hisataka IWATA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.60, no.2, pp.92-99, 2014 (Released:2014-04-24)

参考文献数

38

被引用文献数

17 65

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The aim of the present study was to address the effect of resveratrol-mediated upregulation of sirtuin 1 (SIRT1) during oocyte maturation on mitochondrial function, the developmental ability of oocytes and on mechanisms responsible for blockage of polyspermic fertilization. Oocytes collected from slaughterhouse-derived ovaries were cultured in TCM-199 medium supplemented with 10% FCS and 0 or 20 µM resveratrol (Res). We examined the effect of Res on SIRT1 expression in in vitro-matured oocytes (Exp 1); fertilization and developmental ability (Exp 2); mitochondrial DNA copy number (Mt number), ATP content and mitochondrial membrane potential in matured oocytes (Exp 3); and the time required for proteinase to dissolve the zona pellucida following in vitro fertilization (as a marker of zona pellucida hardening), as well as on the distribution of cortical granules before and after fertilization (Exp 4). In Exp 1, the 20 µM Res treatment upregulated protein expression of SIRT1 in oocytes. In Exp 2, Res treatment improved the ratio of normal fertilization and the total cell number of blastocysts. In Exp 3, Res treatment significantly increased the ATP content in matured oocytes. Additionally, Res increased the overall Mt number and mitochondrial membrane potential, but the effect was donor-dependent. In Exp 4, Res-induced zona hardening improved the distribution and exocytosis of cortical granules after in vitro fertilization. In conclusion, Res improved the quality of oocytes by improving mitochondrial quantity and quality. In addition, Res added to the maturation medium enhanced SIRT1 protein expression in oocytes and improved fertilization via reinforcement of the mechanisms responsible for blockage of polyspermic fertilization.

著者

Ken-ichi Takayama

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.64, no.10, pp.933-946, 2017 (Released:2017-10-28)

参考文献数

99

被引用文献数

12

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Hormonal alterations with aging contribute to the pathogenesis of several diseases. Androgens mediate their effects predominantly through binding to the androgen receptor (AR), a member of the ligand-dependent nuclear receptor superfamily. By androgen treatment, AR is recruited to specific genomic loci dependent on tissue specific pioneer factors to regulate target gene expression. Recent studies have revealed the epigenetic modulation by AR-associated histone modifiers and the roles of non-coding RNAs in AR signaling. Androgens are male sex hormone to induce differentiation of the male reproductive system required for the establishment of adult sexual function. As shown by several reports using AR knockout mouse models, androgens also have anabolic functions in several tissues such as bone, muscle and central nervous systems. Notably, AR has a central role in prostate cancer progression. Prostate cancer is the most frequently diagnosed cancer in men. Androgen-deprivation therapy for cancer patients and decline of serum androgen with aging promote several diseases associated with aging and quality of life of older men such as osteoporosis, sarcopenia and dementia. Thus, androgen replacement therapy for treating late onset hypogonadism (LOH) or new epigenetic regulators have the potential to overcome the symptoms caused by the low androgen, although adverse effects for cardiovascular diseases have been reported. Given the increasing longevity and consequent rise of age-related diseases and prostate cancer patients, a more understanding of the AR actions in male health remains a high research priority.

著者

Katsuhiro Otomo translation and English-language adaptation Yoko Umezawa Linda M. York Jo Duffy

出版者

Kodansha Comics

巻号頁・発行日

2009

著者

寺本 明子 Akiko TERAMOTO 東京農業大学応用生物科学部教養分野 Foreign language studies(English) Faculty of Applied Bio-Science Tokyo University of Agriculture

出版者

東京農業大学

雑誌

東京農業大学農学集報 (ISSN:03759202)

巻号頁・発行日

vol.53, no.4, pp.368-377,

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英国が,進歩と繁栄の時代として誇るヴィクトリア朝は,一方で,工場の生産性至上主義,子供の奴隷,貧困者からの搾取の時代でもあった。そして当然のことながら,次の四半世紀にかけて,良い面を伝えるだけでなく,暗い影も落とした。当時の英国の知識人達は,社会にとって有害なこうした負の性質に恐れを抱いたが,そのうちの一人が,同郷のオスカー・ワイルドより2歳下の,ダブリン出身のジョージ・バーナード・ショーであった。ショーは,彼のやり方,つまり劇作を通して,社会を改良したいと強く願っていた。彼がギリシャ神話から題材を取り,1912年に書いた『ピグマリオン』は,そうした作品の一つである。主人公は,ロンドンの花売り娘イライザ・ドゥーリトルで,音声学者ヒギンズ教授の指導で,上品なレディーに変身する。この劇は,英国の階級社会への風刺であるように言われるが,私は,男女の性質の差に関するショーの見方を表すものと考える。『ピグマリオン』の登場人物を分析し,彼等を二つのタイプに分けることにする。一つは,ヒギンズ教授(敵役),ピッカリング大佐,アルフレッド・ドゥーリトル(イライザの父親)を含む男性のグループで,もう一つは,イライザ,ヒギンズ夫人,ピアス夫人(家政婦)を含む女性グループである。前者は,仕事や階級を表し,競争や独立独行を象徴する。後者は,協力的でありながら,それぞれ個を確立している。ショーは何を我々に教えているのだろうか。彼は,「偉大な芸術は,社会改良の情熱を持ち教訓的でなくてはならない」と考えていた。この論文では,ドラマツルギーの一つの要素である演繹法を解明することによって,『ピグマリオン』におけるショーのメッセージに迫った。The Victorian Age in England, so often boasted of as an age of progress and prosperity, was also an age of factories, of child slavery, and of exploitation of the poor, which was naturally followed not just by positive phases but by negative ones in the country over the first quarter of the next century. In those days the English intelligentsia was afraid of negative qualities which were harmful to society. Among them was George Bernard SHAW from Dublin, two years junior to Oscar WILDE. SHAW strongly desired to reform society in his own way, through his ability as a dramatist. One of his best examples was Pygmalion, written in 1912, whose title was taken from an old Greek myth. Its protagonist is Eliza Doolittle, who is transformed from a London street vendor who hawks flowers into a charming lady by Professor Higgins, a phonetician. Many have said that the play presents a satirical view of the English class system ; however, I see the play as an expression of SHAW's view of the gender gap. Analyzing the characters of Pygmalion, I divide them into two types : the male group which includes Professor Higgins (an antagonist), Colonel Pickering and Alfred Doolittle (Eliza's father), and the female group which includes Eliza, Mrs Higgins and Mrs Pearce (housekeeper). The male group represents a profession or class and symbolizes competition and self-dependence. The female group indicates individuality combined with a cooperative nature. What does SHAW teach us? He says that great art must be didactic with a passion for reforming the world. I clarify his messages in Pygmalion by elucidating his deductive style, an element of dramaturgy.

著者

Karin LUNDGREN-KOWNACKI Mats DAHL Chuansi GAO Kristina JAKOBSSON Caroline LINNINGE Danping SONG Kalev KUKLANE

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2017-0030, (Released:2017-10-20)

被引用文献数

8

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It is common practice in India to consume the dairy drink buttermilk as a way of mitigating occupational heat strain. This paper explores the thermoregulatory and hydration benefits of drinking buttermilk but also the impacts of work in a hot environment on the gut microbiota, renal and cognitive function. Twelve healthy participants were subjected to a 3-hour period of medium load physical intermittent work in a climatic chamber (34°C, 60 % RH). The subjects were given water, buttermilk (700 ml) or no rehydration at random. Mean body temperatures when no rehydration was given were significantly higher (P≤0.001). When subjects drank water or buttermilk they had a lower sweat rate than with no rehydration (P≤0.05) and the perception of feeling hot, uncomfortable, thirsty and physically exerted was significantly reduced (P≤0.05). A hormonal stress response at the end of the exposure was seen when not drinking (P≤0.05). No differences in cognitive abilities and gut microbiota were found. The exposure lowered the renal blood flow suggesting an acute impact of short term heat exposure. It was also found that buttermilk has a protective effect on this impact. Our results demonstrated that keeping hydrated by water/buttermilk consumption mitigates heat strain in well-nourished subjects.

著者

Junji Ikeda Akira Matsushima Wataru Ishii Tetuya Goto Kenta Takahashi Kazuo Nakamichi Masayuki Saijo Yoshiki Sekijima Shu-ichi Ikeda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.10, pp.1231-1234, 2017-05-15 (Released:2017-05-15)

参考文献数

22

被引用文献数

17

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The current standard diagnostic approach for progressive multifocal leukoencephalopathy (PML) is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5-year history of systemic lupus erythematosus developed right hemiplegia and motor aphasia. MRI revealed a large white matter lesion in the left frontal lobe. JC virus DNA was undetectable in the CSF, but a brain biopsy showed typical histopathology and a high DNA load of the JC virus. The patient was treated with mefloquine and mirtazapine, and is currently alive at 24 months after onset. An early brain biopsy may therefore be important for making a timely diagnosis of PML.

著者

Tadatsugu Gamou Kenji Sakata Hayato Tada Tetsuo Konno Kenshi Hayashi Hidekazu Ino Masakazu Yamagishi Masa-aki Kawashiri on behalf of the MILLION Study Group

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.10, pp.1490-1495, 2017-09-25 (Released:2017-09-25)

参考文献数

31

被引用文献数

4

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Background:The MILLION study, a prospective randomized multicenter study, revealed that lipid and blood pressure (BP)-lowering therapy resulted in regression of coronary plaque as determined by intravascular ultrasound (IVUS). In the present study we performed additional analysis to investigate the associated factors with regression of coronary plaque.Methods and Results:We investigated serial 3D IVUS images from 68 patients in the MILLION study. Standard IVUS parameters were assessed at both baseline and follow-up (18–24 months). Volumetric data were standardized by length as normalized volume. In patients with plaque regression (n=52), plaque volumenormalizedsignificantly decreased from 64.8 to 55.8 mm3(P<0.0001) and vessel volumenormalizedsignificantly decreased from 135.0 to 127.5 mm3(P=0.0008). There was no difference in lumen volumenormalizedfrom 70.1 to 71.8 mm3(P=0.27). There were no correlations between % changes in vessel volume and cholesterol or BP. On the other hand, negative correlations between % change in vessel volume and vessel volumenormalizedat baseline (r=−0.352, P=0.009) or plaque volumenormalizedat baseline (r=−0.336, P=0.01) were observed.Conclusions:The current data demonstrated that in patients with plaque regression treated by aggressive lipid and BP-lowering therapy, the plaque regression was derived from reverse vessel remodeling determined by vessel volume and plaque burden at baseline irrespective of decreases in lipids and BP.

著者

日経マグロウヒル社 = Nikkei artificial intelligence / Nikkei Mcgraw-hill Inc.

出版者

日経マグロウヒル社

巻号頁・発行日

1986

著者

Chiung-Huei Peng Yi-Sun Yang Kuei-Chuan Chan Edy Kornelius Jeng-Yuan Chiou Chien-Ning Huang

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.9, pp.1015-1021, 2017-05-01 (Released:2017-05-01)

参考文献数

28

被引用文献数

39

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Objective Periodontal disease may predispose individuals to cardiovascular disease (CVD). Diabetes mellitus, especially in patients with severe periodontitis, increases the risk of CVD mortality. However, the outcomes of periodontal therapy vary among the different treatment modalities. We aim to investigate whether periodontal treatment could influence the occurrence of CVD in patients with type 2 diabetes and periodontal problems. Methods A retrospective cohort study was conducted based on a dataset released by Taiwan National Health Insurance (NHI). The dataset was composed of randomly sampled, newly diagnosed diabetic patients who received insurance benefits from 1999 to 2001; patients who were younger than 18 years of age or who already had CVD before 1999 were excluded. The NHI code was used to identify the treatments, including subgingival curettage and flap operations. The patients' demographic variables were matched using a 1:4 propensity score. All of the subjects were followed up until the onset of CVD, or December 31, 2011. A Cox proportional hazards regression analysis was performed to evaluate the effects of periodontal treatment on the rates of myocardial infarction, heart failure and stroke. Results Three thousand thirty-nine and 12,156 diabetic subjects were classified into the advanced periodontal treatment group and the non-advanced periodontal treatment group, respectively. The Cox proportional hazards analysis revealed that although the overall incidence of CVD was not significantly improved (Hazard ratio, HR 0.95; 95% CI 0.90-1.01), advanced periodontal treatment reduced the rates of myocardial infarction (HR 0.92; 95% CI 0.85-0.99) and heart failure (HR 0.60; 95% CI 0.45-0.80). There was no significance difference in the incidence of stroke (HR 0.95; 95% CI 0.85-1.06). Conclusion Advanced periodontal therapy lowers the rate of CVD, especially myocardial infarction and heart failure. Dental management has a beneficial effect on the health of patients with type 2 diabetes.