著者

Dae Kyong Kim Yong Koo Kang Moo Yeol Lee Kwang-Gill Lee Joo-Hong Yeo Won Bok Lee Yong Sik Kim Sung Su Kim

出版者

The Pharmaceutical Society of Japan

雑誌

Journal of Health Science (ISSN:13449702)

巻号頁・発行日

vol.51, no.3, pp.317-324, 2005 (Released:2005-06-01)

参考文献数

43

被引用文献数

8 15

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This article was retracted. Please see the retraction notice.

著者

長谷中 利昭 李 文遠 藤巻 宏和 北風 嵐 宮本 毅 谷口 宏充 Toshiaki HASENAKA Moon-Won LEE Hirokazu FUJIMAKI Arashi KITAKAZE Tsuyoshi MIYAMOTO Hiromitsu TANIGUCHI 東北大学 東北アジア研究センター 江原大學校 師範大學 科学教育科 東北大学大学院 理学研究科 地学専攻 東北大学 東北アジア研究センター 東北大学 東北アジア研究センター 東北大学 東北アジア研究センター Center for Northeast Asian Studies Tohoku University Department of Science Education Collegge of Education Kangwon National University Graduate School of Science Tohoku University Center for Northeast Asian Studies Tohoku University Center for Northeast Asian Studies Tohoku University Center for Northeast Asian Studies Tohoku University

雑誌

東北アジア研究 = Northeast Asian studies (ISSN:13439332)

巻号頁・発行日

vol.2, pp.21-40, 1998-03-31

著者

Shih-Hu Ho Chia-Zong Lin Yu-Chih Chen Yen-Ling Song

出版者

The Japanese Society of Fish Pathology

雑誌

魚病研究 (ISSN:0388788X)

巻号頁・発行日

vol.37, no.1, pp.7-12, 2002-03-15 (Released:2009-10-26)

参考文献数

34

被引用文献数

1

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Vivrio hareyi など12種類のグラム陰性魚介類病原細菌およびオニテナガエビ寄生真菌1種類に対するセクロピンAとP1の抗菌性を調べた。 その結果, ほとんどの菌種に発育阻止効果を示し, セクロピンAの最小発育阻止濃度は0.98-7.81μM, 最小殺菌濃度(MBC)は3.90-15.59μmであった。 しかし塩分存在下(0.5M NaCl)では抗菌作用は低下した。 セクロピンAはウシエビの血球に対し, MBC値の3.2倍の濃度で細胞毒性を示した。 以上の結果から, セクロピンを海水飼育エビの細菌病に応用するのは難しいと考えられた。

著者

Khoirun NISA Sue Yee LIM Tatsuyuki OSUGA Nozomu YOKOYAMA Masahiro TAMURA Noriyuki NAGATA Kazuyoshi SASAOKA Angkhana DERMLIM Rommaneeya LEELA-ARPORN Tomoya MORITA Noboru SASAKI Keitaro MORISHITA Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0525, (Released:2018-02-02)

被引用文献数

6

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Quantitative contrast-enhanced ultrasonography (CEUS) enables non-invasive and objective evaluation of intestinal perfusion by quantifying the intensity of enhancement on the intestine after microbubble contrast administration. During CEUS scanning, sedation is sometimes necessary to maintain animal cooperation. Nevertheless, the effect of sedative administration on the canine intestinal CEUS is unknown. This study aimed to investigate the effect of sedation with a combination of butorphanol and midazolam on the duodenal CEUS-derived perfusion parameters of healthy dogs. For this purpose, duodenum was imaged following contrast administration (Sonazoid®, 0.01 ml/kg) in six healthy beagles before and after intravenous injection of a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg). Furthermore, hemodynamic parameters including blood pressure and heart rate were recorded during the procedure. Five CEUS derived perfusion parameters including time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), wash-in and wash-out rates (WiR and WoR, respectively) before and after sedation were statistically compared. The result showed that no significant change was detected in any of perfusion parameters. Systolic and mean arterial pressures significantly reduced after sedative administration, but diastolic arterial pressure and heart rate did not significantly change. Moreover, no significant partial correlation was observed between perfusion parameters and hemodynamic parameters. Thus, we concluded that the combination did not cause significant influence in duodenal CEUS perfusion parameters and could be a good option for sedation prior to duodenal CEUS in debilitated dogs.

著者

Tetsuo Minamino Shuichiro Higo Ryo Araki Shungo Hikoso Daisaku Nakatani Hiroshi Suzuki Takahisa Yamada Masaaki Okutsu Kouji Yamamoto Yasushi Fujio Yoshio Ishida Takuya Ozawa Kiminori Kato Ken Toba Yoshifusa Aizawa Issei Komuro EPO-AMI-II Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0889, (Released:2018-02-02)

参考文献数

21

被引用文献数

15

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Background:Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan. In total, 198 STEMI patients with low left ventricular ejection fraction (LVEF <50%) were randomly assigned to receive intravenous administration of EPO (6,000 or 12,000 IU) or placebo within 6 h of successful percutaneous coronary intervention. At 6 months, there was no significant dose-response relationship in LVEF improvement among the 3 groups tested (EPO 12,000 IU: 5.4±9.3%, EPO 6,000 IU: 7.3±7.7%, Placebo: 8.1±8.3%, P=0.862). Low-dose EPO also did not improve cardiac function, as evaluated by 99 mTc-MIBI SPECT or NT-proBNP at 6 months and did not increase adverse events.Conclusions:Administration of low-dose EPO did not improve LVEF at 6 months in STEMI patients (UMIN000005721).

著者

竹内 和彦 渡辺 裕司 Tran Quan-Kim 楊 軍 小菅 和仁 寺田 肇 大橋 京一

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.32, no.1, pp.27S-28S, 2001-01-31 (Released:2010-06-28)

著者

長谷中 利昭 李 文遠 谷口 宏充 北風 嵐 宮本 毅 藤巻 宏和 Toshiaki HASENAKA Moon-Won LEE Hiromitsu TANIGUCHI Arashi KITAKAZE Tsuyoshi MIYAMOTO Hirokazu FUJIMAKI 東北大学 東北アジア研究センター 江原大學校 師範大學科學教育科 東北大学 東北アジア研究センター 東北大学 東北アジア研究センター 東北大学 東北アジア研究センター 東北大学大学院 理学研究科 地学専攻 Center for Northeast Asian Studies Tohoku University Department of Science Education Collegge of Education Kangwon National University Center for Northeast Asian Studies Tohoku University Center for Northeast Asian Studies Tohoku University Center for Northeast Asian Studies Tohoku University Graduate School of Science Tohoku University

雑誌

東北アジア研究 = Northeast Asian studies (ISSN:13439332)

巻号頁・発行日

vol.2, pp.41-74, 1998-03-31

被引用文献数

1

著者

メストメッカー エルンスト-ヨアヒム 早川 勝[訳]

出版者

同志社大学

雑誌

同志社法學 (ISSN:03877612)

巻号頁・発行日

vol.63, no.2, pp.1426-1404, 2011-07

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万人の万人に対する競争(Bellum omnium contra omnes)? -自然状態における競争について 放牧地で時を過ごす羊の平穏は、比較的な自己愛と競争を欠いているひとの社会に関してカントが述べた比喩である。どうもうな狼の食欲は、市民社会における安全と安寧の自由をあきらめさせる自然状態におけるひとに対するホッブスが述べた比喩である。これらの見解は、自由と平等に関する正反対の原則を教える。カントにとっては、個人の自由は、対立する自由であって、この自由は、法の支配の下での平等な自由と共存することができる。これに対して、トーマス・ホッブスの明らかに反対の立場では、デヴィッド・ヒュームの法と社会の研究およびアダム・スミスの法と経済学の研究を意識しかつ考慮に入れた法と社会の諸原則が展開される。ホッブスは、法と経済を動かす力としての幸福に関するかれの功利主義の解釈と同じ様に、法実証主義に関するベンサムの基本的な説明を採り入れた。それは、法と幸福主義との同一視であり、競争と競争法に関するひとつの重要な論争に導く。つまり、個々人の競争的行為に対する貢献を結果として生じる幸福のプラスまたはマイナスの成果と同一視できるかという問題である。この論争は、ドイツでは、カルテルの禁止かまたはカルテルに対する濫用規制なのかという二者択一の問題を支配した。それに対して、米国では、成果に関する評価審査が有効競争理論のひとつの論点であった。つまり、この論争は、福利のマイナスの成果について特別な立証(specific proof of negative welfare effects)がなされない場合には、伝統的な反トラスト法違反を弁明することができないと主張する反トラストシカゴ学派によってもたらされた。欧州では、それは、もちろん、競争ルールに関する解釈についてより経済的なアプローチをするEU委員会の解釈によって、消費者に対する福利審査(consumer welfare test)の実行可能性に関する論争について終止符が打たれた。それは、デヴィッド・ヒュームの理論の伝統を引き継ぎながら、特別な競争行為の福利に関する成果審査では解明できない理由を説明する制度複合現象理論を展開したF.A.フォン・ハイエクの理論である。筆者は、本稿では、競争ルールが、契約の自由、個人の財産権に関する私法制度の一部であるとして、また、競争を発見手続きとして解している。競争の自由に関する個人の権利は、競争過程における公益とそれに対して適用できるルールを形成するのである。

著者

Dong-Kyu Lee Jae-Seop Oh

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.1, pp.116-118, 2018 (Released:2018-01-27)

参考文献数

15

被引用文献数

1

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[Purpose] This study assessed the relationship between hamstring length and gluteus maximus (GM) strength with and without normalization by body weight and height. [Subjects and Methods] In total, 34 healthy male subjects volunteered for this study. To measure GM strength, subjects performed maximal hip joint extension with the knee joints flexed to 90° in the prone position. GM strength was normalized for body weight and height. [Results] GM strength with normalization was positively correlated with hamstring length, whereas GM strength without normalization was negatively correlated with hamstring length. [Conclusion] The normalization of GM strength by body weight and height has the potential to lead to more appropriate conclusions and interpretations about its correlation with hamstring length. Hamstring length may be related to GM strength.

著者

Seok-Min Yun Sang-Kyoon Park Hee Sung Lim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.10, pp.1830-1835, 2017 (Released:2017-10-21)

参考文献数

49

被引用文献数

9

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[Purpose] This study was to observe the influence of Pilates training on the quality of life in chronic stoke patients. [Subjects and Methods] Forty chronic stroke patients participated in this study. They were divided into same number of experimental group (EG) and control group (CG). EG participated in a 60-min Pilates training program, twice a week for 12 weeks, while the CG did not participate in any exercise-related activities for the duration and participating in general occupational therapy without any exercise-related activities. Then the MMSE-K was performed before and after Pilates training to observe the influence of Pilates training on the quality of life in chronic stroke patients. [Results] Statistically significant improvement in the physical, social, and psychological domains was found in EG after the training. No statistically significant difference was found in all three quality of life domains for the CG. EG experienced a statistically significant improvement in all quality of life domains compared with that of CG. [Conclusion] Therefore, participation in Pilates training was found to effectively improve the quality of life in stroke patients. Pilates training involves low and intermediate intensity resistance and repetition that match the patient’s physical ability and can be a remedial exercise program that can improve physical ability and influence quality of life.

著者

Akihiro Nomura Hayato Tada Atsushi Nohara Masa-aki Kawashiri Masakazu Yamagishi

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.42960, (Released:2018-01-20)

参考文献数

27

被引用文献数

7

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Aim: Sitosterolemia is an extremely rare, autosomal recessive disease characterized by high plasma cholesterols and plant sterols because of increased absorption of dietary cholesterols and sterols from the intestine, and decreased excretion from biliary tract. Previous study indicated that sitosterolemic patients might be vulnerable to post-prandial hyperlipidemia, including high remnant-like lipoprotein particles (RLP) level. Here we evaluate whether a loading dietary fat increases a post-prandial RLP cholesterol level in sitosterolemic patients compared to heterozygous familial hypercholesterolemic patients (FH).Methods: We recruit total of 20 patients: 5 patients with homozygous sitosterolemia, 5 patients with heterozygous sitosterolemia, and 10 patients with heterozygous FH as controls from May 2015 to March 2018 at Kanazawa University Hospital, Japan. All patients receive Oral Fat Tolerance Test (OFTT) cream (50 g/body surface area square meter, orally only once, and the cream includes 34% of fat, 74 mg of cholesterol, and rich in palmitic and oleic acids. The primary endpoint is the change of a RLP cholesterol level after OFTT cream loading between sitosterolemia and FH. We measure them at baseline, and 2, 4, and 6 hours after the oral fat loading.Results: This is the first study to evaluate whether sitosterolemia patients have a higher post-prandial RLP cholesterol level compared to heterozygous FH patients.Conclusion: The result may become an additional evidence to restrict dietary cholesterols for sitosterolemia. This study is registered at University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000020330).

著者

Xun CHEN Xue-nong DUAN Li-min WANG Yi-ping CHEN Dun-dun WANG

出版者

The Japan Society of Mechanical Engineers

雑誌

Proceedings of the International Conference on Power Engineering : ICOPE (ISSN:24242942)

巻号頁・発行日

pp._ICOPE-15--_ICOPE-15-, 2015-11-30 (Released:2017-06-19)

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Under the circumstances of different inlet air heating modes for thermal units with rotary air preheaters using flue gas denitrification, in order to perform the comparison and analysis on the outlet gas and air temperatures, the wall temperature of the heat storage element, and the influencing trend and variation patterns of acid corrosion area and ammonium bisulfate deposition area, the thermodynamic properties of the air pre-heater are calculated. Based on the thermodynamic model, the calculation are done on the air pre-heater of a 600MW power plant, with hot air recirculation mode and inlet air heating mode respectively. The results show that in the hot air recirculation mode, with the hot air recirculation ratio increasing, the average outlet wall temperature of the cold-section goes up, while that of the hot-section goes down. Meanwhile, with the acid corrosion area in the cold-section shrinking, the ammonium bisulfate deposition area ascends, which intensifies ash clogging in the air pre-heater. In the steam air heating mode, the average outlet wall temperature of the heat storage elements at both the hot and cold section increase, and the acid corrosion and ammonium bisulfate buildup areas descend simultaneously. Thus, for the air heater of thermal power units using flue gas denitrification technology and high-sulphur coal, the calculations for thermal check should be conducted for winter peak load scenarios, and the inlet air heating by steam air heater is more preferable to be applied in practice.

著者

Xun CHEN Xue-nong DUAN Li-min WANG

出版者

The Japan Society of Mechanical Engineers

雑誌

Proceedings of the International Conference on Power Engineering : ICOPE (ISSN:24242942)

巻号頁・発行日

pp._ICOPE-15--_ICOPE-15-, 2015-11-30 (Released:2017-06-19)

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The heat transfer performance of a tri-sector rotary air pre-heater was comprehensively investigated considering the influences of coal quality, flue gas flow rate, ambient temperature and load variation. By applying the standard of ASME PTC 4.3 with actual characteristics of the tri-sector rotary air preheater, an applicable index evaluation system for the tri-sector rotary air preheater was established. Combining the energy conservation principle and the parameters matching relationship of thermal systems, test methods of the corresponding key parameters were introduced. Finally, a typical application of the index evaluation system in the analysis and evaluation of the thermal performance and heat transfer effect of a retrofitted tri-sector rotary air preheater for a 300 MW unit was introduced.

著者

ハンス-ゲオルク・ガーダマー著 中村志朗訳

出版者

未來社

巻号頁・発行日

1996

著者

Ying-kit Chan

出版者

Center for Southeast Asian Studies, Kyoto University

雑誌

Southeast Asian Studies (ISSN:21867275)

巻号頁・発行日

vol.5, no.2, pp.305-329, 2016 (Released:2016-08-25)

参考文献数

124

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Since Singapore’s independence in 1965, the People’s Action Party government has launched an extensive urban planning program to transform the island into a modern metropolis. This paper discusses human-animal relations and the management of stray cats in postcolonial Singapore. In exploring the perceptions and handling of stray cats in Singapore, I argue that stray cats became an urban “problem” as a result of the government’s public-health regime, urban renewal projects, and attempts to fashion itself and Singapore for international tastes, and that cat activists are the main agents of rebuilding connections between animals and everyday urban life. In particular, I analyze how cat-welfare associations and individual citizens assume functions that the government has been loath to perform unless absolutely necessary.

著者

Won-gyu Yoo

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.12, pp.1997-1998, 2014 (Released:2014-12-18)

参考文献数

11

被引用文献数

2

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[Purpose] This study examined the effects of the intrinsic foot muscle exercise combined with interphalangeal flexion exercise on metatarsalgia with Morton’s toe. [Subject] A 38-year-old male with Morton’s toe, who complained of pain in his left metatarsophalangeal joints was the subject. [Methods] The pressure pain threshold, peak contact pressure of the metatarsophalangeal region during gait, and the navicular drop were measured before and after the intrinsic foot muscles exercises combined with interphalangeal flexion exercise. [Results] After exercising for 2 weeks, the pressure pain threshold increased from 1 to 1.5 kg, while the peak contact pressure decreased from 0.63 to 0.50 kg/cm2, and the navicular drop improved from 5 to 8 mm. [Conclusion] The results show that the combined exercises alleviated the pain while walking by reducing the excessive pressure on the metatarsophalangeal region, and the improvement of gait with Morton’s toe.

著者

NAO-AKI WATANABE KANEMASA KATSU

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.45, no.8, pp.1335-1345, 1992-08-25 (Released:2006-04-19)

参考文献数

33

被引用文献数

1 1

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The bactericidal activity of cefclidin (E1040), a new cephalosporin, against a clinical strain of Citrobacter freundii was compared with that of ceftazidime in a two-compartment in vitro pharmacokinetic model system designed to simulate plasma concentrations in humans for 12 hours after intravenous administration of a 1 g dose. Both cefclidin and ceftazidime showed rapid bactericidal activity against C. freundii. However, during the simulation of ceftazidime treatment, regrowth was observed after two hours and a subpopulation emerged which was resistant to ceftazidime. Neither regrowth nor the emergence of resistant mutants was observed with cefclidin during the 12-hour simulation. The ceftazidime-resistant mutants constitutively overproduced β-lactamase at levels which were about 500-fold higher than that of the parent wild-type strain. Against this β-lactamase overproducing mutant, no bactericidal activity of ceftazidime was observed in the in vitro model system, whereas the bactericidal activity of cefclidin was observed during the 12-hour period. The emergence of Enterobacter cloacae mutants derepressed for β-lactamase production was also observed with ceftazidime but not cefclidin. The affinity of cefclidin for the β-lactamase isolated from these mutants was lower than that of ceftazidime, and the kinetic parameters of enzymatic hydrolysis showed that cefclidin was hydrolyzed more slowly at a low concentration (0.2μM) than was ceftazidime. It is suggested that the high activity of cefclidin against strains derepressed for β-lactamase plays a major role in the absence of emergence of resistant mutants.

著者

М-во здравоохранения Союза ССР

出版者

Медгиз

巻号頁・発行日

1957

著者

Kaori Kuroda Hiroki Kato Song-Ju Kim Makoto Naruse Mikio Hasegawa

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)

巻号頁・発行日

vol.9, no.1, pp.74-81, 2018 (Released:2018-01-01)

参考文献数

10

被引用文献数

23

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Recently, various mobile communication systems have been widely deployed, and mobile traffic is increasing. However, the bandwidth available for mobile communications is limited, hence the scarcity of radio resources in mobile communications is a serious problem. As an approach to solve this problem, cognitive wireless communication models have been proposed. These model search for vacant time slots in multi-channel wireless communication systems. Although previous studies have shown that frequency utilization efficiency can be improved by multi-armed bandit algorithms, channels are assumed to be independent. However, channels used in 2.4 GHz wireless LANs (such as IEEE802.11b or IEEE802.11g) are not independent because these channels overlap with adjacent channels. In this paper, we propose an extended multi-armed bandit algorithm that uses continuous-valued rewards, which is applicable to wireless communication systems with overlapping channels. We show the effectiveness of the proposed method by experimental demonstrations.

著者

Syozo OSAWA Zhi-Hui SU Masaaki NISHIKAWA Osamu TOMINAGA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.92, no.9, pp.455-461, 2016-11-11 (Released:2016-11-11)

参考文献数

16

被引用文献数

1

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Phylogenetic analyses using mitochondrial DNA sequences of several kinds of beetles have shown that their evolution included a silent stage in which no morphological changes took place. We thus propose a new category of evolutionary process called “silent evolution”.