著者

Dong-In KIM Hakhyun KIM Purum SON Ji-Houn KANG Byeong-Teck KANG Mhan-Pyo YANG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0647, (Released:2017-06-29)

被引用文献数

17

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The present study aimed to determine whether circulating serum concentrations of 25-hydroxyvitamin D [25-(OH)D] differed between healthy dogs and dogs with acute pancreatitis (AP). Twenty-two healthy dogs and twenty client-owned dogs with AP were enrolled in the study. Serum concentrations of 25-(OH)D, blood ionized calcium (iCa), and serum C-reactive protein (CRP) were measured. Concentrations of serum 25-(OH)D and blood iCa in dogs with AP were significantly lower than those of healthy dogs, and serum concentrations of CRP in dogs with AP were significantly higher than those of healthy dogs. A significant difference in 25-(OH)D serum concentrations was observed between survivor and non-survivor dogs with AP. After resolution of clinical signs, concentrations of serum 25-(OH)D, blood iCa, and serum CRP did not differ compared to those before treatment. This study shows that dogs with AP exhibit decreased 25-(OH)D levels, which might be associated with calcium imbalances and mortality rate in canine AP.

著者

Yoshihiro Higuchi Toyoki Maeda Jing-Zhi Guan Junichi Oyama Masahiro Sugano Naoki Makino

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.73, no.2, pp.274-279, 2009 (Released:2009-01-23)

参考文献数

36

被引用文献数

12 41

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Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis. Methods and Results The mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age- and risk-factor-matched MetS patients without ELC (7.6±1.1 kbp vs 8.6±1.2 kbp; P<0.05). ELC were present in 13 patients in the AVD group (n=18), but only 4 patients in the non-AVD group (n=16) had ELC (72.2% and 25% respectively; P<0.05). Conclusions These findings suggest that ELC is a useful dermatological indicator of an accelerated aging process, as suggested by excessive telomere loss, and might be a useful indirect marker of high-risk patients. (Circ J 2009; 73: 274 - 279)

著者

Hee Jeong YU Seung Heon LEE Seungwoo LEE Yu Jung CHOI Dayoung OH Ki-Hoan NAM YoungMin YUN Doug-Young RYU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0192, (Released:2017-06-24)

被引用文献数

2

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Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2. Compared with Sap1, Sap2 had a Trp50Leu substitution. The biochemical characteristics of the variants were comparatively analyzed using heterologous expression in Escherichia coli. The membrane fraction of E. coli expressing Sap2 exhibited higher CYP holoprotein and heme contents than the Sap1-containing membranes, although the level of total CYP1A1 protein (i.e., apoprotein + holoprotein) was comparable between the groups. As normalized to holo-CYP content, the Sap2-expressing membranes showed lower CYP1A1-specific enzyme activities, such as 7-ethoxyresorufin O-dealkylation (EROD), than the Sap1 group. In single substitution variants of residue 50, proteins with hydrophobic residues having mass similar to Leu exhibited lower EROD activities than those with hydrophobic residues having larger mass than Leu. In addition, variants with polar or charged residues having mass similar to Leu showed activities that were comparable to those of Sap2. Taken together, these findings suggest that the Trp50Leu substitution leads to an enhancement of holo-CYP1A1 formation, but diminishes the enzyme activity because of the small size of Leu compared with Trp.

著者

Eun-Joo Shin Jae-Hyung Bach Sung Youl Lee Jeong Min Kim Jinhwa Lee Jau-Shyong Hong Toshitaka Nabeshima Hyoung-Chun Kim

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.116, no.2, pp.137-148, 2011 (Released:2011-06-16)

参考文献数

100

被引用文献数

11 28

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Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

著者

Nanako USHIO James K. CHAMBERS Kennichi WATANABE Takuya E. KISHIMOTO Jun-You LI Hiroyuki NAKAYAMA Kazuyuki UCHIDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.78, no.8, pp.1373-1375, 2016 (Released:2016-09-01)

参考文献数

15

被引用文献数

1

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A 7-year-old Duroc sow exhibited emaciation, loss of appetite and rapid breathing, and was euthanized. Histopathological examination revealed mild to moderate fibrosis of the heart, cystic kidneys and ulcerative enteritis associated with Balantidium infection. Additionally, a small nodule was incidentally found in the peripancreatic fat tissue. The nodule consisted of disarranged cellular components: pancreatic islet cells (either insulin-, glucagon- or somatostatin-positive), pancreatic acinar cells, hepatocytes (human hepatocyte-positive) and ductal cells (cytokeratin 19-positive). Some of the human hepatocyte-positive cells were also positive for chromogranin A and cytokeratin 7, indicating that they were hepatic progenitor cells. The nodule was therefore diagnosed as hamartoma, probably originating from a fragment of the caudal verge of the liver bud, which contains hepatic and pancreatic progenitors.

著者

Shinzo Tsuda Yuko Fukui Noriko Nakamura Yukihisa Katsumoto Keiko Yonekura-Sakakibara Masako Fukuchi-Mizutani Kazuyuki Ohira Yukiko Ueyama Hideo Ohkawa Timothy A. Holton Takaaki Kusumi Yoshikazu Tanaka

出版者

日本植物細胞分子生物学会

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.21, no.5, pp.377-386, 2004 (Released:2005-06-03)

参考文献数

34

被引用文献数

35 76

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Petunia flower colors are mainly due to flavonoids. The flower color of commercial varieties of Petunia hybrida was successfully modified by the suppression of endogenous flavonoid biosynthetic genes, the expression of a hetelorogous flavonoid biosynthetic gene, and the combination of both. Flower color changed from purple to almost white or from purple to red by the suppression of the endogenous gene expression, from red to orange by the down-regulation of the flavonoid 3′-hydroxylase gene and the expression of the rose dihydroflavonol 4-reductase gene, and from violet to pale violet by the expression of the flavonol synthase or flavone synthase gene. These results clearly indicate the usefulness of metabolic engineering of the flavonoid biosynthetic pathway to modify flower color. Only a few of the transgenic petunia exhibited phenotypic stability. For commercialisation, it is necessary to generate many independent transgenic lines, select elite lines with stable phenotypes and maintain them in tissue culture.

著者

Ayano Kudo Marika Sato Haruna Sawaguchi Jun-ichi Hotta Hiroyuki Mayama Yoshimune Nonomura

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.65, no.11, pp.909-912, 2016 (Released:2016-11-01)

参考文献数

12

被引用文献数

3

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In the present study, mechanical phenomena on fractal agar gel were analyzed to understand the interfacial properties of hydrophilic biosurfaces. The evaluation of adhesion strength between the fractal agar gel surfaces showed that the fractal structure inhibits the adhesion between the agar gel surfaces. In addition, when the disintegration behavior of an agar gel block was observed between fractal agar gel substrates, the rough structure prevented the sliding of an agar gel block. These findings are useful for understanding the biological significance of rough structure on the biological surfaces.

著者

新開 潤一 Jun-ichi Shinkai

雑誌

国際学研究 (ISSN:21868360)

巻号頁・発行日

vol.6, no.3, pp.115-124, 2017-03-30

著者

Juri OTA-KUROKI Keiichi KUROKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0251, (Released:2017-06-15)

被引用文献数

1

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A 10-year-old female spayed American Pitt Bull Terrier was presented with a slow growing mass on the temporal limbus area of the right eye. Canine nodular granulomatous episclerokeratitis was suspected, and the affected eye was treated with 1% prednisolone acetate ophthalmic suspension and 0.03% Tacrolimus ophthalmic solution. As the lesion did not respond to the medical treatments and continued to grow, the mass was excised by lamellar sclerokeratectomy. Microscopically, the mass was composed of granulomatous inflammation with intrahistiocytic lipids and lakes of acicular cholesterol clefts, histopathology findings consistent with xanthogranuloma. To the authors’ knowledge, this is the first canine report of limbal xanthogranuloma.

著者

Shota Fukuda Hiroyuki Watanabe Masao Daimon Yukio Abe Akihiro Hirashiki Kumiko Hirata Hiroshi Ito Masumi Iwai-Takano Katsuomi Iwakura Chisato Izumi Takayuki Hidaka Toshinori Yuasa Kazuya Murata Satoshi Nakatani Kazuaki Negishi Kazuhiro Nishigami Tomoko Nishikage Takahiro Ota Akihiro Hayashida Konomi Sakata Nobuhiro Tanaka Satoshi Yamada Kazuhiro Yamamoto Junichi Yoshikawa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.5, pp.1177-1181, 2012 (Released:2012-04-25)

参考文献数

27

被引用文献数

27 67

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Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50±12ml/m2 and 46±9ml/m2 for left ventricular (LV) end-diastolic volume index, 19±5ml/m2 and 17±4ml/m2 for end-systolic volume index, 61±4% and 63±4% for ejection fraction, 64±12g/m2 and 56±11g/m2 for mass index, 23±6ml/m2 and 24±6ml/m2 for left atrial (LA) maximum volume index, 10±3ml/m2 and 10±3ml/m2 for minimum volume index, and 58±6% and 58±6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age. Conclusions: This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease. (Circ J 2012; 76: 1177-1181)

著者

木下(小室) 友香理 門倉 利守 数岡 孝幸 穂坂 賢 中田 久保 KOMURO Yukari KINOSHITA KADOKURA Toshimori KAZUOKA Takayuki HOSAKA Masaru NAKATA Hisayasu 東京農業大学短期大学部醸造学科 東京農業大学応用生物科学部醸造科学科 東京農業大学短期大学部醸造学科 東京農業大学短期大学部醸造学科 東京農業大学短期大学部醸造学科 Department of Brewing and Fermentation Junior College of Tokyo University of Agriculture Department of Fermentation Science Faculty of Applied Bio-Science Tokyo University of Agriculture Department of Brewing and Fermentation Junior College of Tokyo University of Agriculture Department of Brewing and Fermentation Junior College of Tokyo University of Agriculture Department of Brewing and Fermentation Junior College of Tokyo University of Agriculture

巻号頁・発行日

vol.53, no.2, pp.100-106,

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花から分離した酵母(以下,花酵母)の分類学的性質を調べる目的で,生理学的試験と染色体DNA電気泳動を行った。また,各花酵母の醸造特性を知るため,清酒小仕込み試験を行ない,製成酒の一般成分と香気成分分析を行った。その結果,花酵母13株は,清酒酵母K-9株と同様に,メレジトースおよび硝酸塩を資化せず,クエン酸塩無添加のビタミン欠培地で増殖し,イーストサイジンに対する抵抗性を有した。TTC染色は赤色,アルシアンブルー染色は白色~淡青色であった。染色体DNA電気泳動パターンは,第VI染色体が長く,第III染色体と接近した清酒酵母K-9株と同じ泳動パターンを示した。また,高泡形成試験では全株が高泡を形成しなかったことより,花酵母13株は高泡を形成しない清酒酵母タイプであった。清酒小仕込み試験の結果,花酵母はカプロン酸エチル生成タイプ(ND-4株,AB-2株),酢酸イソアミル生成タイプ(BK-1株,MR-4株,SN-3株,GE-1株,KAF-2株,KS-3株,ST-4株,SUNF-5株),双方をバランスよく生成するタイプ(HNG-5株,NI-2株,CAR-1株)に大別できた。また,有機酸組成分析の結果,前報4)のAB-2株,KS-3株,MR-4株に加え,CAR-1株,GE-1株,KAF-2株,ST-4株,SUNF-5株による製成酒はリンゴ酸含有量が高いことが明らかとなった。花酵母による製成酒は吟醸香成分であるカプロン酸エチルおよび酢酸イソアミル生成量が多く,リンゴ酸の割合が高い有機酸組成を持つことから,多様化する消費者嗜好に対応する清酒開発を可能にすると思われる。

著者

Buck-Morss Susan 高橋 明史

出版者

青土社

雑誌

現代思想

巻号頁・発行日

vol.35, no.9, pp.144-183, 2007-07

著者

editor Bente Scavenius translated by Barbara Haveland and Jean Lundsk̄r-Nielsen

出版者

Gyldendal

巻号頁・発行日

1996

著者

CHEN Stacey H. CHEN Yu-Kuan WU Huey-Min

出版者

GRIPS Policy Research Center

雑誌

GRIPS Discussion Papers

巻号頁・発行日

vol.17-03, 2017-05

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Datasets of schools or hospitals often include an urban.rural divide drawn by government. Such partition is typically determined by subjective thresholds for a few variables, such as access to transportation and local population size, leaving aside relevant factors despite data availability. We propose to measure ‘remoteness’ by mapping a comprehensive set of covariates onto a scalar, and define an objective score of remoteness using a standard selection model. We apply the proposed method to data from Taiwanese public elementary schools. Our method replaces 35% and 47% respectively of the current official list of ‘remote’ and ‘extra-remote’ campuses, shifting the remoteness designation to those furthest from train stations, having the highest teacher vacancy percentages, and located in the least populous areas with the least well-educated populations. The campus- and district-level variables used are publicly available and periodically updated in most advanced economies, and the statistical model can be easily implemented.

著者

edited by Nicholas Sims-Williams

出版者

Published for the British Academy by Oxford University Press

巻号頁・発行日

2002

著者

Sung-Bum Ju Gi Duck Park

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.2, pp.278-281, 2017 (Released:2017-02-24)

参考文献数

24

被引用文献数

4

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[Purpose] This study was conducted to investigate the effects of ankle functional rehabilitation exercise on ankle joint functional movement screen results and isokinetic muscular function in patients with chronic ankle sprain patients. [Subjects and Methods] In this study, 16 patients with chronic ankle sprain were randomized to an ankle functional rehabilitation exercise group (n=8) and a control group (n=8). The ankle functional rehabilitation exercise centered on a proprioceptive sense exercise program, which was applied 12 times for 2 weeks. To verify changes after the application, ankle joint functional movement screen scores and isokinetic muscular function were measured and analyzed. [Results] The ankle functional rehabilitation exercise group showed significant improvements in all items of the ankle joint functional movement screen and in isokinetic muscular function after the exercise, whereas the control group showed no difference after the application. [Conclusion] The ankle functional rehabilitation exercise program can be effectively applied in patients with chronic ankle sprain for the improvement of ankle joint functional movement screen score and isokinetic muscular function.

著者

佐藤 慶 山本 信次 広田 純一 Kei Sato Shinji Yamamoto Jun-ichi Hirota 岩手大学大学院農学研究科 岩手大学農学部 岩手大学農学部 Graduate School of Agriculture Iwate Univ. Faculty of Agriculture Iwate Univ. Faculty of Agriculture Iwate Univ

出版者

農村計画学会

雑誌

農村計画論文集 = Transactions of rural planning (ISSN:09129731)

巻号頁・発行日

vol.3, pp.241-246, 2001-12-07

参考文献数

5

被引用文献数

3

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本研究では、地域づくりの優良事例の内容をミクロに分析し「住民主導」の内実を明らかにすることを目的とした。本事例からは、地区住民から出された要望を地域リーダーが具体化し、それを自治会役員会が承認し、地区全体の活動として実施するという、活動における地域リーダー層の役割を明らかにすることができた。こうした地域リーダー層以外の一般住民の意識と活動に対する関与の実態を明らかにすることを目的としたアンケート調査を行った。その結果、地区住民の中には「地域づくりを支持はするが、自ら積極的にかかわりたいとまでは思わない」といういわば「消極的支持層」が存在することが明らかになった。In J area in Murone village, Iwate Prefecture, several community activities have been found to contribute to revitalization of the rural community and people's exchange with visitors. This study is to analyze the involvement of local people in the development process of those activities, to discuss how the activities became possible and to analyze the consciousness of local people about those activities. The result of the questionnaire are summarized as follows : 1) a half or more local people agreed to do those activities, 2) though some of them had intention of leaving up those activities to someone else.

著者

Issei Tokimatsu Katsumi Shigemura Tomohiro Kotaki Hiroki Yoshikawa Fukashi Yamamichi Tadashi Tomo Soichi Arakawa Masato Fujisawa Jun-ichi Kadota

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.11, pp.1315-1319, 2017-06-01 (Released:2017-06-01)

参考文献数

19

被引用文献数

4

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Objectives To investigate the efficacy of oral moxifloxacin (MFLX) as a treatment for pneumonia in hemodialysis (HD) patients and the pharmacokinetic (PK) profile of MFLX after oral administration. Methods Thirteen adult patients who required HD due to chronic renal failure were enrolled in the present study, which was performed to investigate the treatment of community-acquired pneumonia in HD patients. A standard dose of MFLX (400 mg, once daily) was administered. The therapy was continued, discontinued, or switched to another antibiotic depending on the response of the pneumonia to MFLX. A population PK model was developed using the post-hoc method. Results In total, 13 HD patients with pneumonia (male, n=7; female, n=6) were enrolled in the present study. The evaluation on the 3rd day showed that treatment was successful in 11 patients (84.6%) and that 10 patients were cured (76.9%). In the one case in which MFLX treatment failed, the patient was cured by switching to ceftriaxone (CTRX) (2 g, intravenously) plus levofloxacin (LVFX) (250 mg, orally). The causative bacterium in this male patient was P. aeruginosa. It did not display resistance to fluoroquinolones. One patient had liver dysfunction due to MFLX. The estimated PK parameters of MFLX were as follows: AUC0→24, 61.04±17.74 μg h/mL; Cmax, 5.25±1.12 μg/mL; and Ctrough, 1.15±0.45 μg/mL. The PK parameters of MFLX among the patients in whom adverse events occurred or in whom a cure was not achieved did not differ from those of the other patients to a statistically significant extent. Conclusion MFLX showed good efficacy and safety in HD patients with community-acquired pneumonia and the results of the PK analysis were favorable. Further prospective studies with larger numbers of patients will be needed to draw definitive conclusions.

著者

Jun Tamogami Takashi Kikukawa Toshifumi Nara Makoto Demura Tomomi Kimura-Someya Mikako Shirouzu Shigeyuki Yokoyama Seiji Miyauchi Kazumi Shimono Naoki Kamo

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.14, pp.49-55, 2017 (Released:2017-03-18)

参考文献数

25

被引用文献数

7

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A spectrally silent change is often observed in the photocycle of microbial rhodopsins. Here, we suggest the presence of two O intermediates in the photocycle of Acetabularia rhodopsin II (ARII or also called Ace2), a light-driven algal proton pump from Acetabularia acetabulum. ARII exhibits a photocycle including a quasi-equilibrium state of M, N, and O (M<=>N<=>O→) at near neutral and above pH values. However, acidification of the medium below pH ~5.5 causes no accumulation of N, resulting in that the photocycle of ARII can be described as an irreversible scheme (M→O→). This may facilitate the investigation of the latter part of the photocycle, especially the rise and decay of O, during which molecular events have not been sufficiently understood. Thus we analyzed the photocycle under acidic conditions (pH ≤ 5.5). Analysis of the absorbance change at 610 nm, which mainly monitors the fractional concentration changes of K and O, was performed and revealed a photocycle scheme containing two sequential O-states with the different molar extinction coefficients. These photoproducts, termed O1 and O2, may be even produced at physiological pH, although they are not clearly observed under this condition due to the existence of a long M-N-O equilibrium.

著者

Yoko Tanemura Hisami Yamanaka-Okumura Masae Sakuma Yoshitaka Nii Yutaka Taketani Eiji Takeda

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.3.4, pp.291-297, 2014 (Released:2014-09-27)

参考文献数

28

被引用文献数

2 24

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Long-term suppression of postprandial glucose concentration is an important dietary strategy for the prevention and treatment of type 2 diabetes. Because previous reports have suggested that seaweed may exert anti-diabetic effects in animals, the effects of Wakame or Mekabu intake with 200 g white rice, 50 g boiled soybeans, 60 g potatoes, and 40 g broccoli on postprandial glucose, insulin and free fatty acid levels were investigated in healthy subjects. Plasma glucose levels at 30 min and glucose area under the curve (AUC) at 0-30 min after the Mekabu meal were significantly lower than that after the control meal. Plasma glucose and glucose AUC were not different between the Wakame and control meals. Postprandial serum insulin and its AUC and free fatty acid concentration were not different among the three meals. In addition, fullness, satisfaction, and wellness scores were not different among the three meals. Thus, consumption of 70 g Mekabu with a white rice-based breakfast reduces postprandial glucose concentration. J. Med. Invest. 61: 291-297, August, 2014