著者

Zheng ZHANG Ru ZHANG Zhi-Zhen QIN Jia-Ping CHEN Jia-Ying XU Li-Qiang QIN

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.64, no.2, pp.143-150, 2018 (Released:2018-04-30)

参考文献数

42

被引用文献数

7 12

---

Whey protein is associated with improvement of metabolic syndrome. This study aimed to evaluate effects of whey protein on atherosclerosis in ApoE−/− mice. Male ApoE−/− mice were fed with a high-fat/cholesterol diet (HFCD), or HFCD supplemented with 10% or 20% whey protein for 18 wk. At the end of experiment, serum lipid profiles and inflammatory cytokines were assayed. Livers were examined using HE staining and Oil Red O staining. Aortas were used for en face and cryosection analyses to observe aortic lesions. Western blotting analysis was used to assess relative protein expression of cholesterol metabolism in the liver and aorta. No significant differences were observed in body weight or food intake among the three groups. Liver examination demonstrated decreased lipid droplets and cholesterol content in the whey-protein-supplemented groups. En face lesion of the aorta revealed a 21.51% and 31.78% lesion reduction in the HFCD supplemented with 10% and 20% whey groups, respectively. Decreased lesion was also observed in cryosection analysis. Whey protein significantly increased the serum high-density lipoprotein cholesterol level by 46.43% and 67.86%. The 20% whey protein significantly decreased serum IL-6 (a proinflammatory cytokine) by 70.99% and increased serum IL-10 (an anti-inflammatory cytokine) by 83.35%. Whey protein potently decreased lipogenic enzymes (ACC and FAS) in the liver and NF-κB expression in the liver and aorta. Whey protein significantly increased protein expression of two major cholesterol transporters (ABCA1 and ABCG1) in the liver and aorta. Thus, chronic whey protein supplementation can improve HFCD-induced atherosclerosis in ApoE null mice by regulating circulating lipid and inflammatory cytokines and increasing expressions of ABCA1 and ABCG1.

著者

Ken-ichi Okumura Naoki Koike Takafumi Nakano

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.66, no.2, pp.73-78, 2017 (Released:2017-12-31)

参考文献数

24

被引用文献数

4 5

---

Taxonomic accounts of two species belonging to the subfamily Coelotinae from Japan are reviewed. Iwogumoa portus Nishikawa 2009 originally described from Osaka, Japan and Coelotes plancyi Simon 1880 described from Beijing, China are considered to be conspecific. Therefore the former is synonymized with the latter, and C. plancyi is transferred to the genus Iwogumoa Kishida 1955. Coelotes inabaensis Arita 1974 described from Tottori, Japan is placed under the genus Dichodactylus Okumura 2017.

著者

Gyeongjin RA Su-hyun KIM Imyeong LEE

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E105-D, no.11, pp.1857-1871, 2022-11-01

---

Recently, the adoption of the industrial Internet of things (IIoT) has optimized many industrial sectors and promoted industry “smartization.” Smart factories and smart industries connect the real and virtual worlds through cyber-physical systems (CPS). However, these linkages will increase the cyber security danger surface to new levels, putting millions of dollars' worth of assets at risk if communications in big network systems like IIoT settings are left unsecured. To solve these problems, the fundamental method is security, such as authentication and confidentiality, and it should require the encryption key. However, it is challenging the security performance with the limited performance of the sensor. Blockchain-based identity management is emerging for lightweight, integrity and persistence. However, the key generation and management issues of blockchain face the same security performance issues. First, through blockchain smart contracts and hierarchical deterministic (HD) wallets, hierarchical key derivation efficiently distributes and manages keys by line and group in the IIoT environment. Second, the pairing verification value based on an elliptic curve single point called Root Signature performs efficient public key certificate registration and verification and improves the key storage space. Third, the identity log recorded through the blockchain is the global transparency of the key lifecycle, providing system reliability from various security attacks. Keyless Signature Infrastructure (KSI) is adopted to perform efficiently via hash-based scheme (hash calendar, hash tree etc.). We analyze our framework compared to hash-based state commitment methods. Accordingly, our method achieves a calculation efficiency of O(nlog N) and a storage space saving of 60% compared to the existing schemes.

著者

Su-I Hou

出版者

Japan Society of Mixed Methods Research

雑誌

混合研究法 (ISSN:24368407)

巻号頁・発行日

vol.1, no.2, pp.61-67, 2022 (Released:2022-08-20)

---

This invited editorial article is based on my experience shared at the 2021 MMIRA Asia Regional / 7th JSMMR Annual Conference. The inaugural Asia Open Forum (AOF) was initiated by the Japan Society for Mixed Methods Research (JSMMR) and the Mixed Methods International Research Association (MMIRA) in 2019 at Hamamatsu, Shizuoka, Japan. The 2021 AOF was the 3rd panel which I have been honored and privileged to be a part of since it was established. The focus of the 2021 AOF was on “Mixed Methods Research Knowledge and Skills Acquired While Abroad.” The purpose was to capture the journey of panel speakers’ mixed methods learning outside of Asia and discuss the impact on their research career of their scholarly activities while abroad. I shared my mixed method research (MMR) learning in the U.S. and how I brought and shared what I leaned back to Taiwan. This article briefly discussed the following areas: (1) my background and my MMR dissertation, (2) my career path and the innovative Taiwan study abroad program, (3) my academic training abroad and continued professional development in mixed methods research, (4) my teaching of mixed methods research doctoral course, (5) my MMIRA and JSMMR encounters, and (6) my promotion of MMR in Taiwan, Asia, and abroad.

著者

Christian-Hendrik Heeger Kentaro Hayashi Karl-Heinz Kuck Feifan Ouyang

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.5, pp.1073-1086, 2016-04-25 (Released:2016-04-25)

参考文献数

53

被引用文献数

21 34

---

Ventricular arrhythmias (VA), like premature ventricular contractions (PVC) and ventricular tachycardia (VT) in patients without structural heart disease (idiopathic VA), mainly arise from the right and left ventricular outflow tracts (RVOT/LVOT). The prognosis for OT VA is generally good in the majority of patients, but there is potential for developing dilated cardiomyopathies from the high burden of VA, as well as a certain risk for sudden cardiac death because of fast monomorphic VT or polymorphic VT triggered by short-coupling PVC. Radiofrequency catheter ablation (RFCA) has evolved into a widely accepted treatment strategy for patients suffering from VAs. A detailed knowledge of surface ECGs and complex cardiac anatomy, especially within the ventricular OTs, is essential for the understanding of cardiac OT-VAs and highly related to safe and successful RFCA procedures. This review article focuses on RFCA of idiopathic VA arising from the cardiac OT as well as adjacent regions and will illustrate recent insights and technical issues. (Circ J 2016; 80: 1073–1086)

著者

Ryo Inuzuka Hisateru Tachimori Sung-Hae Kim Hikoro Matsui Tohru Kobayashi Atsuko Kato Takanari Fujii Mami Ho Hanako Morikawa Sara Takahashi Haruki Shirato Yuji Haishima Yoshihiro Okamoto Hideyuki Sakoda Hideshi Tomita

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0185, (Released:2022-09-01)

参考文献数

24

被引用文献数

2

---

Background: Balloon atrial septostomy (BAS) is an essential catheterization procedure for congenital heart lesions. Recently, a balloon catheter for static BAS was approved for the first time in Japan as an alternative to the conventional pull-through BAS. Despite the expected increase in the use of static BAS, reports on its safety are scarce worldwide.Methods and Results: Data on static and pull-through BAS registered in a national registry between 2016 and 2018 were collected. During the study period, 247 sessions of static BAS and 588 sessions of pull-through BAS were performed on a total of 674 patients. Patients who underwent static BAS were older (P<0.001). The incidence of serious adverse events (4.3% vs. 0.9%, P=0.03) and the overall incidence of adverse events (8.1% vs. 3.2%, P=0.03) were higher in static BAS than in pull-through BAS. Among patients who underwent static BAS, the risk factor for adverse events was a body weight <3 kg at the time of the procedure (odds ratio: 4.3 [confidence interval: 1.7–11], P=0.003).Conclusions: This nationwide study revealed differences in patient background between static and pull-through BAS, as well as a higher incidence of adverse events related to static BAS. Patients weighing <3 kg are at high risk for adverse events after static BAS and may require surgical and circulatory support backup.

著者

Ogbomida Emmanuel Temiotan Nakayama Shouta M. M. Bortey-Sam Nesta Oroszlany Balazs Tongo Isioma Enuneku Alex Ajeh Ozekeke Ogbeide Ainerua Martins Oshioriamhe Fasipe Iriagbonse Priscillia Ezemonye Lawrence Ikechukwu Mizukawa Hazuki Ikenaka Yoshinori Ishizuka Mayumi Ogbomida Emmanuel Temiotan Nakayama Shouta M. M. Bortey-Sam Nesta Oroszlany Balazs Tongo Isioma Enuneku Alex Ajeh Ozekeke Ogbeide Ainerua Martins Oshioriamhe Fasipe Iriagbonse Priscillia Ezemonye Lawrence Ikechukwu Mizukawa Hazuki Ikenaka Yoshinori Ishizuka Mayumi Ogbomida Emmanuel Temiotan Nakayama Shouta M. M. Bortey-Sam Nesta Oroszlany Balazs Tongo Isioma Enuneku Alex Ajeh Ozekeke Ogbeide Ainerua Martins Oshioriamhe Fasipe Iriagbonse Priscillia Ezemonye Lawrence Ikechukwu Mizukawa Hazuki Ikenaka Yoshinori Ishizuka Mayumi

出版者

Elsevier

雑誌

Ecotoxicology and environmental safety (ISSN:01476513)

巻号頁・発行日

vol.151, pp.92-102, 2018-04-30

被引用文献数

48

---

The use of free range animals for monitoring environmental health offers opportunities to detect exposure and assess the toxicological effects of pollutants in terrestrial ecosystems. Potential human health risk of dietary intake of metals and metalloid via consumption of offal and muscle of free range chicken, cattle and goats by the urban population in Benin City was evaluated. Muscle, gizzard, liver and kidney samples were analyzed for Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, and Pb concentrations using inductively coupled plasma mass spectrometer (ICP-MS) while Hg was determined using Hg analyzer. Mean concentrations of metals (mg/kg ww) varied significantly depending upon the tissues and animal species. Human health risk estimations for children and adults showed estimated daily intake (EDI) values of tissues below oral reference dose (RfD) threshold for non essential metals Cd, As, Pb and Hg thus strongly indicating no possible health risk via consumption of animal based food. Calculated Hazard quotient (THQ) was less than 1 (&lt; 1) for all the metals analyzed for both adult and children. However, Cd and As had the highest value of THQ suggestive of possible health risk associated with continuous consumption of Cd and As contaminated animal based foods. Hazard Index (HI) for additive effect of metals was higher in chicken liver and gizzard for children and chicken liver for adults. Thus, HI indicated that chicken liver and gizzard may contribute significantly to adult and children dietary exposure to heavy metals. Principal component analysis (PCA) showed a clear species difference in metal accumulation between chickens and the ruminants. This study provides baseline data for future studies and also valuable evidence of anthropogenic impacts necessary to initiate national and international policies for control of heavy metal and metalloid content in food items.

著者

小林 寛 金 河守 Hiroshi Kobayashi Ha-soo Kim

雑誌

研究紀要 = Bulletin of Tsukuba International University (ISSN:13412382)

巻号頁・発行日

vol.20, pp.63-76, 2014

著者

Albert Youngwoo Jang Minsu Kim Pyung Chun Oh Soon Yong Suh Kyounghoon Lee Woong Chol Kang Ki Hong Choi Young Bin Song Hyeon-Cheol Gwon Hyo-Soo Kim Woo Jung Chun Seung-Ho Hur Seung-Woon Rha In-Ho Chae Jin-Ok Jeong Jung Ho Heo Junghan Yoon Soon Jun Hong Jong-Seon Park Myeong-Ki Hong Joon-Hyung Doh Kwang Soo Cha Doo-Il Kim Sang Yeub Lee Kiyuk Chang Byung-Hee Hwang So-Yeon Choi Myung Ho Jeong Chang-Wook Nam Bon-Kwon Koo Seung Hwan Han

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.86, no.9, pp.1365-1375, 2022-08-25 (Released:2022-08-25)

参考文献数

17

被引用文献数

1 1

---

Background: Differences in the impact of the 1- or 2-stent strategy in similar coronary bifurcation lesion conditions are not well understood. This study investigated the clinical outcomes and its predictors between 1 or 2 stents in propensity score-matched (PSM) complex bifurcation lesions.Methods and Results: We analyzed the data of patients with bifurcation lesions, obtained from a multicenter registry of 2,648 patients (median follow up, 53 months). The patients were treated by second generation drug-eluting stents (DESs). The primary outcome was target lesion failure (TLF), composite of cardiac death, target vessel myocardial infarction (TVMI), and ischemia-driven target lesion revascularization (TLR). PSM was performed to balance baseline clinical and angiographic discrepancies between 1 and 2 stents. After PSM (N=333 from each group), the 2-stent group had more TLRs (hazard ratio [HR] 3.14, 95% confidence interval [CI] 1.42–6.97, P=0.005) and fewer hard endpoints (composite of cardiac death and TVMI; HR 0.44, 95% CI 0.19–1.01, P=0.054), which resulted in a similar TLF rate (HR 1.40, 95% CI 0.83–2.37, P=0.209) compared to the 1-stent group. Compared with 1-stent, the 2-stent technique was more frequently associated with less TLF in the presence of main vessel (pinteraction=0.008) and side branch calcification (pinteraction=0.010).Conclusions: The 2-stent strategy should be considered to reduce hard clinical endpoints in complex bifurcation lesions, particularly those with calcifications.

著者

Yoshiyuki KINOSE Yuji MASUTOMI Fumitaka SHIOTSU Keiichi HAYASHI Daikichi OGAWADA Martin GOMEZ-GARCIA Akiko MATSUMURA Kiyoshi TAKAHASHI Kensuke FUKUSHI

出版者

The Society of Agricultural Meteorology of Japan

雑誌

農業気象 (ISSN:00218588)

巻号頁・発行日

pp.D-19-00045, (Released:2019-12-19)

参考文献数

48

被引用文献数

7 14

---

In Asia, where rice is a major crop, there is high concern about the detrimental effects of climate change on rice productivity. Evaluating these effects, considering the country-specific cultivars’ responses to climate, is needed to effectively implement the national adaptation plans to maintain food security under climate change. However, to date, information on the effects of climate change on the local rice cultivars used in developing countries is extremely limited. In the present study, we used a process-based crop growth model, MATCRO-Rice, to predict the impact of climate change on yields of the major local rice cultivar Ciherang in Indonesia during the next 25 years (2018-2042). This model simulated the effects of current to future air temperature, precipitation, and atmospheric carbon dioxide concentration on rice yield. A total of 14 future climate scenarios, derived from a combination of four general circulation models and three or four representative concentration pathway scenarios in the Coupled Model Intercomparison Project Phase 5, were used to consider the uncertainty of the future climate. The results showed that the rice yield was reduced under all climate scenarios, mainly because of the higher air temperature, leading to reduced photosynthetic rates, increased respiration rates, and phenological changes such as acceleration of senescence. The mean yield reduction across the 14 future climate scenarios was 12.1% for all of Indonesia in 2039-2042. Therefore, to maintain yields in Indonesia, rice production needs to adapt to climate change, and especially to higher air temperatures, in the near future.

著者

Masaaki UNO Kenji YAGI Hiroyuki TAKAI Satoshi HIRAI Yukari MINAMI-OGAWA Yoshifumi TAO Yoshihiro SUNADA Shunji MATSUBARA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2022-0122, (Released:2022-10-13)

参考文献数

19

---

With the aging of the population, the number of people taking antithrombotic drugs is increasing. Few reports have described the clinical presentation, treatment, and outcomes of nontraumatic subarachnoid hemorrhage (SAH) in patients with preceding antithrombotic therapy. This study included 459 patients with nontraumatic SAH who had been treated between April 2009 and May 2021. Overall, 39 of the 459 patients with aneurysmal SAH were on antithrombotic therapy before ictus (8.5%). Therefore, we classified patients into two groups: Group A (n = 39), patients with preceding antithrombotic therapy and Group B (n = 420), patients without preceding antithrombotic therapy. Hunt and Kosnik (H&K) grade on admission was significantly higher in Group A than in Group B (p = 0.02). Patients in Group A more frequently received endovascular treatment. The rate of endovascular therapy for symptomatic vasospasm after SAH was significantly lower in Group A (2.6%) than in Group B (15.5%; p = 0.03). The outcomes at 3 months after onset were significantly poorer in Group A patients than in Group B patients (p = 0.03). Patients with preceding antithrombotic drugs tended to be at greater risk of unfavorable outcomes, but this difference was not significant in the univariate analysis. In the multivariate analysis, patient age, H&K grade ≥4, and subdural hematoma remained as risk factors for poor outcomes; however, preceding use of antithrombotic drugs was not a significant risk factor.

著者

Yudai Tamura Yuichi Tamura Yu Taniguchi Ichizo Tsujino Takumi Inami Hiromi Matsubara Ayako Shigeta Yoichi Sugiyama Shiro Adachi Kohtaro Abe Yuichi Baba Masaru Hatano Satoshi Ikeda Kenya Kusunose Koichiro Sugimura Soichiro Usui Yasuchika Takeishi Kaoru Dohi Saki Hasegawa-Tamba Koshin Horimoto Noriko Kikuchi Hiraku Kumamaru Koichiro Tatsumi on behalf of the Japan Pulmonary Hypertension Registry Network

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-22-0098, (Released:2022-10-08)

参考文献数

21

被引用文献数

3

---

Background: Portopulmonary hypertension (PoPH) is one of the major underlying causes of pulmonary arterial hypertension (PAH). However, PoPH, especially treatment strategies, has been poorly studied. Therefore, this study evaluated current treatments for PoPH, their efficacy, and clinical outcomes of patients with PoPH.Methods and Results: Clinical data were collected for patients with PoPH who were enrolled in the Japan Pulmonary Hypertension Registry between 2008 and 2021. Hemodynamic changes, functional class, and clinical outcomes were compared between patients with PoPH treated with monotherapy and those treated with combination therapies. Clinical data were analyzed for 62 patients with PoPH, including 25 treatment-naïve patients, from 21 centers in Japan. In more than half the patients, PAH-specific therapy improved the New York Heart Association functional class by at least one class. The 3- and 5-year survival rates of these patients were 88.5% (95% confidence interval [CI] 76.0–94.7) and 80.2% (95% CI 64.8–89.3), respectively. Forty-one (66.1%) patients received combination therapy. Compared with patients who had received monotherapy, the mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac index were significantly improved in patients who had undergone combination therapies.Conclusions: Combination therapy was commonly used in patients with PoPH with a favorable prognosis. Combination therapies resulted in significant hemodynamic improvement without an increased risk of side effects.

著者

Ji-Hoon KANG Seoung-Yob AHN Hun-Young YOON

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0370, (Released:2022-10-04)

---

A 14-year-old spayed female Shih-Tzu was referred to the Veterinary Medical Teaching Hospital of Konkuk University for evaluation of an abdominal mass. In diagnostic imaging, two large cystic masses were identified. The affected liver lobes were surgically resected, and the specimens were submitted for histopathological evaluation and immunohistochemical staining. The two cystic lesions were diagnosed as biliary cystadenocarcinoma (BCAC). Recurrence and regional invasion were identified on ultrasonography 36 days postoperatively. The patient died on postoperative day 271. To the best of our knowledge, previously reported case studies of BCAC in dogs presented limited clinical information. In this report, we present a detailed picture comprising a range of clinical information and histopathological examination of BCAC in a dog.

著者

Mayumi Nakanishi-Matsui Naomi Matsumoto

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.10, pp.1426-1431, 2022-10-01 (Released:2022-10-01)

参考文献数

54

被引用文献数

7

---

Vacuolar-type ATPase (V-ATPase) shares its structure and rotational catalysis with F-type ATPase (F-ATPase, ATP synthase). However, unlike subunits of F-ATPase, those of V-ATPase have tissue- and/or organelle-specific isoforms. Structural diversity of V-ATPase generated by different combinations of subunit isoforms enables it to play diverse physiological roles in mammalian cells. Among these various roles, this review focuses on the functions of lysosome-specific V-ATPase in bone resorption by osteoclasts. Lysosomes remain in the cytoplasm in most cell types, but in osteoclasts, secretory lysosomes move toward and fuse with the plasma membrane to secrete lysosomal enzymes, which is essential for bone resorption. Through this process, lysosomal V-ATPase harboring the a3 isoform of the a subunit is relocated to the plasma membrane, where it transports protons from the cytosol to the cell exterior to generate the acidic extracellular conditions required for secreted lysosomal enzymes. In addition to this role as a proton pump, we recently found that the lysosomal a3 subunit of V-ATPase is essential for anterograde trafficking of secretory lysosomes. Specifically, a3 interacts with Rab7, a member of the Rab guanosine 5ʹ-triphosphatase (GTPase) family that regulates organelle trafficking, and recruits it to the lysosomal membrane. These findings revealed the multifunctionality of lysosomal V-ATPase in osteoclasts; V-ATPase is responsible not only for the formation of the acidic environment by transporting protons, but also for intracellular trafficking of secretory lysosomes by recruiting organelle trafficking factors. Herein, we summarize the molecular mechanism underlying secretory lysosome trafficking in osteoclasts, and discuss the possible regulatory role of V-ATPase in organelle trafficking.

著者

Ryota HAGIHARA Makoto ISOZAKI Masamune KIDOGUCHI Hidetaka ARISHIMA Ken-ichiro KIKUTA

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.319-322, 2022-12-31 (Released:2022-09-23)

参考文献数

8

---

A 38-year-old woman presented with impaired consciousness and anisocoria due to a subarachnoid hemorrhage and an intracerebral hemorrhage of the left temporal lobe. Examination revealed severe tortuosity in the left middle cerebral artery and three sequential bead-like aneurysms. She underwent a craniotomy in the acute phase to stop rebleeding at the rupture site and remove the intracerebral hematoma. During the chronic phase, endovascular treatment with superselective balloon test occlusion (ssBTO) was performed for the remaining aneurysms. Preoperative ssBTO was useful in evaluating collateral circulation and assessing the curability of the treatment.

著者

EL-BARBARY Mohamed N. IKEDA Mariko UEKITA Yasufumi

出版者

The Association of Japanese Geographers

雑誌

Geographical review of Japan series B (ISSN:18834396)

巻号頁・発行日

vol.94, no.2, pp.65-80, 2021-12-25 (Released:2021-12-25)

参考文献数

52

被引用文献数

1

---

Historic Cairo, in Egypt, is a living urban entity that was registered by the UNESCO as a World Cultural Heritage Site in 1979. Its historic urban core is crowded with outstanding medieval buildings which overlap with the city’s modern architecture and local people’s daily life activities. Unfortunately, despite receiving several conservation interventions, since the mid-20th century, most of the historic buildings in Cairo are in constant deterioration. Therefore, the study aimed at identifying the reasons behind this controversial situation, based on theoretical and practical methodologies. Through critical review of related literature and field survey, the study identified the shortcomings in the main conservation practices, implemented in Historic Cairo after the mid-20th century, and the current challenges for its effective conservation. The research findings clarified that no significant conservation effort was made in Historic Cairo during the 1950s and 1960s. While, since the early 1970s, about 17 mega conservation projects have been conducted, by national and international organizations, most of these projects adopted inappropriate conservation approaches which ignored the living nature of Historic Cairo and undermined the active participation and needs of the local community. The ‘top-down’ strategy prevailed in most conservation projects, in which the historic buildings were either ‘restored then closed’ without adaptive reuse or conserved for ‘touristic’ purposes without monitoring after conservation. Finally, the study concluded that the ‘local community’ oriented approach is the most appropriate for the effective conservation of Historic Cairo.

著者

Makoto Ando Tomota Suminaka Noriaki Shimada Kenichiro Asano Jun-ichi Ono Kazuaki Jikuya Seiichi Mochizuki

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.32, no.2, pp.46-55, 2018 (Released:2018-12-22)

参考文献数

34

被引用文献数

4 4

---

The ratio of the volumes of extracellular water to total body water (ECW/TBW) obtained by multi-frequency bioelectrical impedance analysis (MF-BIA) indicates body water balance. However, the characteristics of ECW/TBW in hemodialysis (HD) patients have not been fully investigated yet. We evaluated correlations of ECW/TBW with body composition, circulatory and body fluid status, and nutritional status in 60 stable maintenance HD patients using MF-BIA. ECW/TBW increased with increasing age and showed significant positive correlations with volume index (VI), cardiothoracic ratio, and brain natriuretic peptide, all of which are indices of circulatory and body fluid status. Furthermore, there were significant negative correlations between ECW/TBW and serum albumin (Alb), the geriatric nutritional risk index, and the normalized protein catabolic rate, all of which indicate nutritional status. Following multiple regression analysis, the independently related factors for total subjects were age, VI, and Alb. In obese HD patients, ECW/TBW tended to decrease, indicating intravascular dehydration. In conclusion, ECW/TBW in HD patients was shown to increase with age and can reflect circulatory, body fluid, and nutritional status, as well as the difference between predetermined dry weight and “optimal body weight” which may change along with a patient’s nutritional status.

著者

Jong-Ho Koh Jin-Man Kim Un-Jae Chang Hyung-Joo Suh

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.26, no.1, pp.84-87, 2003 (Released:2003-01-01)

参考文献数

22

被引用文献数

50 77

---

This study was conducted to investigate the hypocholesterolemic effect of the hot-water fraction (HW) from cultured mycelia of Cordyceps sinensis in a 5 l fermenter. The composition of HW was mainly carbohydrate (83.9%) and protein (11.8%) on a dry basis, and the carbohydrate of HW consisted of glucose, mannose, galactose, and arabinose in the molecular ratio of 1.0 : 0.8 : 0.5 : 0.1, respectively. In mice fed a cholesterol-free diet and those fed a cholesterol-enriched diet, body and liver weights were not significantly different from those of the controls. The serum total cholesterol (TC) of all mice groups administered HW (150 and 300 mg/kg/d, respectively) with the cholesterol-enriched diet decreased more than in the control group. Among the mice fed the cholesterol-enriched diet, HW also increased the high-density lipoprotein (HDL) cholesterol level, but decreased the very low-density lipoprotein plus low-density lipoprotein (VLDL+LDL) cholesterol level. The changes in HDL- and VLDL+LDL-cholesterol levels consequently decreased the atherogenic value. The results indicate that HW in rats administered a cholesterol-enriched diet decreased the plasma cholesterol level. The 300 mg/kg dose had a significant effect on the serum TC level.

著者

Dah-Renn FU Tsuyoshi KADOSAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.9, pp.1237-1243, 2022 (Released:2022-09-05)

参考文献数

35

---

The expression of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) has been reported in human nasopharyngeal and canine nasal carcinomas. The present study measured EGFR and COX-2 expression and calculated correlations between these proteins and clinical variables and outcomes in dogs with nasal carcinoma treated with radiation therapy. Before treatment, the immunohistochemistry of EGFR and COX-2 was performed in 67 biopsied tissues from canine nasal carcinomas. The correlations between these protein levels, clinical variables, and outcomes were evaluated. EGFR and COX-2 were detected in 88.1% and 82.1% of our samples, respectively. Neither EGFR nor COX-2 was associated with T stage and cribriform plate destruction. Dogs with low EGFR levels had a significantly longer survival time than dogs with high EGFR expression (P=0.043). The COX-2 expression level was not significantly associated with survival times after radiation therapy (P=0.653). Overexpression of EGFR is negatively correlated with survival in dogs with nasal carcinoma. Future studies should identify tumor biomarkers to develop therapeutic targets for effective treatments for canine nasal carcinomas.

著者

Hayato TAKEUCHI Yoshinobu TAKAHASHI Seisuke TANIGAWA Takanari OKAMOTO Yoshinori KODAMA Yukiko SHISHIDO-HARA Ema YOSHIOKA Tomoko SHOFUDA Yonehiro KANEMURA Eiichi KONISHI Naoya HASHIMOTO

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.199-208, 2022-12-31 (Released:2022-07-08)

参考文献数

26

---

Despite recent signs of progress in diagnostic radiology, it is quite rare that a glioblastoma (GBM) is detected asymptomatically. We describe two patients with asymptomatic nonenhancing GBMs that were not diagnosed with neoplasia at first. The patients had brain scans as medical checkups, and incidentally lesions were detected. In both cases, surgical specimens histopathologically showed no evidence of neoplasia, whereas molecular genetic findings were isocitrate dehydrogenase (IDH) -wildtype, O6-methylguanine-DNA methyltransferase promoter (pMGMT) unmethylated, and telomerase reverse transcriptase (TERT) promoter mutated, which matched to GBM. One patient was observed without adjuvant therapy and the tumor recurred 7 months later. Reoperation was performed, and histopathologically GBM was confirmed with the same molecular diagnosis as the first surgical specimen. Another patient was carefully observed, and chemoradiotherapy was begun 6 months after the operation following the extension of the lesion. Eventually, because of disease progression, both patients deceased. We postulate that in each case, the tumor was not lower-grade glioma but corresponded to the early growth phase of GBM cells. Thus far, cases of malignant transformation from lower-grade glioma or asymptomatic GBM with typical histologic features are reported. Nevertheless, to the best of our knowledge, no such case of nonenhancing, nonhistologically confirmed GBM was reported. We conjecture these cases shed light on the yet unknown natural history of GBM. GBM can take the form of radiological nonenhancing and histological nonneoplastic fashion before typical morphology. Molecular genetic analysis can diagnose atypical preceding GBM, and we recommend early surgical removal and adjuvant treatment.