著者

Alan R. Tang Anthony M. Steinle Hani Chanbour Godwin Emeka-Ibe Byron F. Stephens Scott L. Zuckerman Amir M. Abtahi

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

pp.2022-0076, (Released:2022-06-28)

被引用文献数

2

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Introduction: Posterior cervical spine approaches have been associated with increased rates of wound complications compared to anterior approaches. While barbed suture wound closure for lumbar spine surgery has been shown to be safe and efficacious, there is no literature regarding its use in posterior cervical spine surgery. In a cohort of patients undergoing elective posterior cervical spine surgery, we sought to compare postoperative complication rates between barbed and traditional interrupted suture closure.Methods: A retrospective review of demographics, past medical history, and operative and postoperative variables collected from a prospective registry between July 1, 2016, and June 30, 2020 was undertaken. All patients 18 years old and above undergoing elective posterior cervical fusion were included. The primary outcome of interest was wound complications, including surgical site infection (SSI), dehiscence, or hematoma. In addition, numerical rating scale (NRS) neck pain (NP), NRS arm pain (AP), Neck Disability Index (NDI), and operative time were collected. A variety of statistical tests were used to compare the two suture groups.Results: Of 117 patients undergoing posterior cervical fusion, 89 (76%) were closed with interrupted suture and 28 (24%) with barbed suture. The interrupted cohort were more likely to have >1 comorbidity (p < 0.001), diabetes mellitus (p = 0.013), and coronary artery disease (p = 0.002). No difference in postoperative wound complications between interrupted/barbed sutures was observed after univariate (OR 1.07, 95% CI: 0.27–4.25, p = 0.927) and multivariable logistic regression analysis (OR 0.77, 95% CI: 0.15–4.00, p = 0.756). Univariate logistic regression revealed no differences in achieving minimal clinically important difference (MCID) NRS-NP (OR 0.73, 95% CI: 0.28–1.88, p = 0.508) or NRS-AP (OR 0.68, 95% CI: 0.25–1.90, p = 0.464) at 3 months between suture groups. The interrupted suture group was less likely to achieve MCID NDI at 3 months (OR 0.29, 95% CI: 0.11–0.80, p = 0.016)Conclusions: Barbed suture closure in posterior cervical spine surgery does not lead to higher rates of postoperative wound complications/SSI compared to traditional interrupted fascial closure.

著者

Yu Ito Nobuyasu Awano Fumiya Uchiyama Minoru Inomata Naoyuki Kuse Mari Tone Kohei Takada Kazushi Fujimoto Yutaka Muto Shogo Sagisaka Kenro Maki Ryuta Yamashita Akinori Harada Jun-ichi Nishimura Munehiro Hayashi Takehiro Izumo

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.7422-21, (Released:2021-08-24)

参考文献数

20

被引用文献数

1 4

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In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed under therapeutic anticoagulation with unfractionated heparin. Although the activated partial prothrombin time was within the optimal range, contrast-enhanced computed tomography (CECT) revealed SMH in the bilateral iliopsoas muscles in both cases, which required emergent transcatheter embolization. Close monitoring of the coagulation system and the early diagnosis of bleeding complications through CECT are needed in severe COVID-19 patients treated with anticoagulants.

著者

HSIEH Min-Ken CHEN Yu-Wen CHEN Yi-Chun WU Chien-Ming

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-028, (Released:2022-03-10)

被引用文献数

3

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We applied tracer transport simulations using Taiwan vector vorticity equation cloud-resolving model (TaiwanVVM) to evaluate the effects of the local circulation associated with the lee vortex and the planetary boundary layer development on the transport and accumulation of the pollutants on a diurnal time scale in central Taiwan. The wind directions of crucial synoptic northeast monsoon are idealized as the initial conditions of the simulations to examine the impact of the lee vortex on the pollutants transport. The primary local non-traffic emission sources are taken as the tracer emission sites so that the experiment results could be a good proxy of the realistic scenarios. With the local circulation over complex topography being resolved explicitly, the impact of the boundary layer development on the tracer transport of the Puli basin is discussed. The simulation results clarify the contribution of the sea breeze and the lee vortex to the tracer transport in central Taiwan. We conclude that high tracer concentration at Puli at night is due to the tracer being trapped by the thinning of the mixed layer depth in the evening. The sensitivity of the local tracer transport to the change of the synoptic wind direction shows that under northeasterly due east (due north) environment, the pollutant transports from the southern source (northern source) of central Taiwan are most likely to induce high concentration in Puli at night. This is the first study to distinguish the contribution of the sea breeze and the lee vortex in pollutants transport in Taiwan. The results obtained from idealized experiments provide the possible mechanism of pollutants transport, which could be taken as an insight to interpret the observations and guide the design of field experiment to further establish the fundamental principles of the pollution transports in central Taiwan.

著者

BLÁZQUEZ-SALOM Macià

出版者

THE JAPANESE SOCIETY FOR GEOGRAPHICAL SCIENCES

雑誌

地理科学 (ISSN:02864886)

巻号頁・発行日

vol.76, no.3, pp.157-177, 2022-03-28 (Released:2022-03-28)

参考文献数

93

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Tourism development in the Balearic Islands underlines intense regional and local debate. The archipelago's strong specialization in tourism, in what is essentially a tourism monoculture, has led to tensions and converging political interests in its territorial protection. As a result, spatial and tourism planning regulations have been developed to safeguard the Balearics' natural spaces and to limit building development, tourist beds, extensions to infrastructure and the commodification of housing as holiday rentals. The hypothesis posed in this paper is that Balearic tourism is moving from a mass tourism model to a gentrified safe haven for investors and for the affluent. Based on a case study of the archipelago, a presentation is given of the geographical characteristics and socioenvironmental conflicts that might explain how calls for the islands' protection have been instrumental in bringing about processes of social segregation. The paper concludes by considering the challenges to be faced and possible alternative opportunities.

著者

Yuki Kataoka Tomohisa Baba Tatsuyoshi Ikenoue Yoshinori Matsuoka Junichi Matsumoto Junji Kumasawa Kentaro Tochitani Hiraku Funakoshi Tomohiro Hosoda Aiko Kugimiya Michinori Shirano Fumiko Hamabe Sachiyo Iwata Yoshiro Kitamura Tsubasa Goto Tomohiro Handa Shoji Kido Shingo Fukuma Noriyuki Tomiyama Toyohiro Hirai Takashi Ogura Japan COVID-19 AI team

出版者

Society for Clinical Epidemiology

雑誌

Annals of Clinical Epidemiology (ISSN:24344338)

巻号頁・発行日

pp.22014, (Released:2022-07-08)

被引用文献数

2

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Background: We aimed to develop and externally validate a novel machine learning model that can classify CT image findings as positive or negative for SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR).Methods: We used 2,928 images from a wide variety of case-control type data sources for the development and internal validation of the machine learning model. A total of 633 COVID-19 cases and 2,295 non-COVID-19 cases were included in the study. We randomly divided cases into training and tuning sets at a ratio of 8:2. For external validation, we used 893 images from 740 consecutive patients at 11 acute care hospitals suspected of having COVID-19 at the time of diagnosis. The dataset included 343 COVID-19 patients. The reference standard was RT-PCR.Results: In external validation, the sensitivity and specificity of the model were 0.869 and 0.432, at the low-level cutoff, 0.724 and 0.721, at the high-level cutoff. Area under the receiver operating characteristic was 0.76.Conclusions: Our machine learning model exhibited a high sensitivity in external validation datasets and may assist physicians to rule out COVID-19 diagnosis in a timely manner at emergency departments. Further studies are warranted to improve model specificity.

著者

Abubakr Ahmed Abdullah Al-shoaibi Yuanying Li Zean Song Chifa Chiang Yoshihisa Hirakawa KM Saif-Ur-Rahman Masako Shimoda Yoshihisa Nakano Masaaki Matsunaga Atsuko Aoyama Koji Tamakoshi Atsuhiko Ota Hiroshi Yatsuya

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63519, (Released:2022-07-13)

参考文献数

48

被引用文献数

4

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Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

著者

Tai-YanWu Ching-NungLin Shi-JimYen

雑誌

ゲームプログラミングワークショップ2013論文集

巻号頁・発行日

pp.15-18, 2013-11-01

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Minesweeper is a Partially Observable Markov Decision Process(POMDP) problem.How to gain more information from current situation affects future decision making significantly.This paper proposes a heuristic solver which outperforms all present minesweeper solvers includingpure heuristic and hybrid single player MCTS with heuristic approaches. With our methodology,more hidden information can be extracted from the same situation than previous methods. Fur-thermore, this solver is practical with efficient performance.

著者

Mei Gao-Takai Zen Lin Yuta Sugiyama Takane Katayama Ai Shinmura Hikaru Naito Ayako Katayama-Ikegami

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.UTD-371, (Released:2022-07-05)

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This study investigated anthocyanin accumulation, sugar contents, and endogenous hormone contents in the berry skin, as well as the expression of genes related to anthocyanin and abscisic acid (ABA) synthesis and metabolism, using grafted ‘Ruby Roman’ berries on the rootstocks of ‘Kober 5BB’ [5BB(2x), a semidwarf rootstock], ‘Hybrid Franc’ [HF(2x), a vigorous rootstock], and their colchicine-induced autotetraploids [5BB(4x) and HF(4x)]. Rootstock had significant effects on the total content, but not on the composition, of anthocyanins. The berries on 5BB(4x) rootstock, where the grapevine showed less vegetative growth, had higher anthocyanin content during the ripening process, and also had higher sugar and ABA contents around véraison. ABA, indole acetic acid (IAA), and cytokinins showed synchronous changes during berry development: they had the lowest levels at pre-véraison, and their metabolic pathways were accelerated after véraison. Furthermore, they all tended to be higher on 5BB(4x) than on the other rootstocks. Since the expression levels of most of the ABA biosynthesis-related genes did not show a corresponding increase with the contents of ABA and ABA-glucosyl ester (ABA-GE), it is considered that the increase in ABA content after véraison may be mainly due to the decrease in catabolism and/or exogenous import from other organs. This study provides an overview showing the dynamic changes and relationship of three phytohormones during the ripening of grape berries grafted on different rootstocks, and explores the mechanisms regulating ripening.

著者

橋本 博文 横堀 伸一 三田 肇 高橋 昭久 吉田 由香里 高橋 和生 稲富 裕光 Hashimoto Hirofumi Yokobori Shin-ichi Mita Hajime Takahashi Akihisa Yoshida Yukari Takahashi Kazuo Inatomi Yuko

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

観測ロケットシンポジウム2018 講演集 = Proceedings of Sounding Rocket Symposium 2018

巻号頁・発行日

2018-07

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第1回観測ロケットシンポジウム(2018年7月17日-18日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)), 相模原市, 神奈川県

著者

Jeong-Eun Song Yong-Shik Kim Jang-Yeul Sohn

出版者

Japan Society of Physiological Anthropology

雑誌

Journal of PHYSIOLOGICAL ANTHROPOLOGY (ISSN:18806791)

巻号頁・発行日

vol.26, no.6, pp.599-603, 2007-11-30 (Released:2007-12-30)

参考文献数

5

被引用文献数

5 8

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This study aims at examining the reduction of indoor air contaminants by plants placed in an indoor space. Field measurements were performed using Aglaonema brevispathum, Pachira aquatica, and Ficus benjamiana, which were verified as air-purifying plants by NASA. Three conditions for the amount of plants and positions were used in two separate rooms whose dimensions are identical. The concentration of Volatile Organic Compounds (VOCs) was monitored three hours after the plants were placed and three days after the plants were placed. The variations of concentration of Benzene, Toluene, Etylbenzene, and Xylene (BTEX), as well as Formaldehyde, which are all known as the major elements of Volatile Organic Compounds were monitored. The amount of reduction in concentration of Toluene and Formaldehyde was monitored 3 hours and 3 days after the plants were placed in the space. The reduction in the concentration of Benzene, Toluene, Etylbenzene, Xylene, and Formaldehyde was significantly greater when plants were present. When plants were placed near a window, the reduction of concentration was greater. The more plants were used, the more a reduction of indoor air contaminants occurred. The effect of reducing the concentration of air contaminants increased when the amount of plants increased, and when the plants were placed in sunny area. The concentration of Toluene was reduced by 45.6 μg/m3 when 10% of the model space was occupied by Aglaonema brevispathum.

著者

Hiroko Takumi Kazuko Kato Hiroki Nakanishi Maiko Tamura Takayo Ohto-N Saeko Nagao Junko Hirose

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

pp.ess21449, (Released:2022-06-10)

被引用文献数

10

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Precision nutrition, also referred to as personalized nutrition, focuses on the individual to determine the individual’s most effective eating plan to prevent or treat disease. A precision nutrition for infants requires the determination of the profile of human milk. We compared the lipid profiles of the foremilk (i.e., the initial milk of a breastfeed) and hindmilk (the last milk) of six Japanese subjects and evaluated whether a human milk lipid profile is useful for precision nutrition even though the fat concentration fluctuates during lactation. We detected and quantified 527 species with a lipidome analysis by liquid chromatography-tandem mass spectrometry. The fat concentration in hindmilk (120.6 ± 66.7 μmol/mL) was significantly higher than that in foremilk (68.6 ± 33.3 μmol/mL). While the total carbon number of fatty acids in triglyceride (TG) was highest in C52 for all subjects, the second or third number differed among the subjects. Both the distribution of total carbon number of fatty acids included in TG and the distribution of fatty acids in TG classified by the number of double bonds were almost the same in the foremilk and hindmilk in each subject. The lipids levels containing docosahexaenoic acid and arachidonic acid in total lipids of the foremilk and the hindmilk were almost the same in each subject. Among the sphingolipids and glycerophospholipids, the level of sphingomyelin was the highest in four subjects’ milk, and phosphatidylcholine was the highest in the other two subjects’ milk. The order of their major species was the same in each foremilk and hindmilk. A clustering heatmap revealed the differences between foremilk and hindmilk in the same subject were smaller than the differences among individuals. Our analyses indicate that a human-milk lipid profile reflects individual characteristics and is a worthwhile focus for precision nutrition.

著者

DATT Ishan CAMARGO Suzana J. SOBEL Adam H. MCTAGGART-COWAN Ron WANG Zhuo

出版者

公益社団法人 日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-037, (Released:2022-05-13)

被引用文献数

3

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A significant fraction of tropical cyclones develop in baroclinic environments, following tropical cyclogenesis “pathways” that are characterized by dynamical processes often associated with higher latitudes. This study investigates whether such storms are more likely to undergo subsequent extratropical transition than those that develop in more typical, non-baroclinic environments. We consider tropical cyclones globally in the period 1979-2011 using best-track datasets, and define the genesis pathway of each storm using McTaggart-Cowan's classification: non-baroclinic, low-level baroclinic, trough-induced, weak and strong tropical transition. In each basin, we analyze the total number and the fraction of storms that underwent extratropical transition, their seasonality, and storm tracks, according to their genesis pathways. The relationship between the pathways and extratropical transition is statistically significant in the North Atlantic and Western North Pacific, where the strong tropical transition and the trough-induced pathways have a significantly greater extratropical fraction compared to all other pathways, respectively. Latitude, longitude and environmental factors such as sea surface temperature and vertical shear were further analyzed to explore whether storms in these pathways happen to be in environments conducive to extratropical transition, or whether a “memory” of the genesis pathway persists throughout the storm life cycle. After controlling for genesis latitude, the relationship between the strong tropical transition and trough induced pathways, and extratropical transition occurrence remains statistically significant, implying a lasting effect from the pathway on the probability of an eventual extratropical transition.

著者

HSU Wei-Ching KIKUCHI Kazuyoshi ANNAMALAI H. RICHARDS Kelvin J.

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-020, (Released:2021-12-21)

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Previous studies suggest the nature of the air-sea interaction of the tropical intraseasonal oscillation (ISO) can strongly influence our understanding and simulation of the ISO characteristics. In this study we assess the representation of the surface components in three of the most up-to-date reanalyses, including ERA5, ERA-interim (ERAi), and JRA55, to identify which reanalysis dataset is more suitable for investigating air-sea interaction associated with the ISO, and to quantify the intraseasonal biases of related variables for simulating the ocean responses. All three reanalyses well capture the ISO convective characteristics in terms of the spatial patterns and the propagation features, although the amplitude of the outgoing longwave radiation is severely underestimated (by ∼40 to 60 %, depending on region and season) in JRA55. Out of the two ERA reanalysis datasets, our results indicate the ERA5 may serve as a better ocean forcing dataset, as the ERAi largely underestimates the magnitudes of the ISO-related precipitation and 10-meter winds (of summer ISO, or BSISO) while overestimates the latent heat flux (of winter ISO, or MJO). JRA55, while having comparable amplitude biases to ERA5 in variables except precipitation, generally shows larger phase biases than the two ERA renalyses.

著者

TAO Wei-Kuo LANG Stephen IGUCHI Takamichi SONG Yi

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-015, (Released:2021-12-13)

被引用文献数

5

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The Goddard Convective-Stratiform Heating (CSH) algorithm has been used to retrieve latent heating (LH) associated with clouds and cloud systems in support of the Tropical Rainfall Measuring Mission (TRMM) and Global Precipitation Measurement (GPM) mission. The CSH algorithm requires the use of a cloud-resolving model (CRM) to simulate LH profiles to build look-up tables. This paper describes the current V6 CSH and its differences/similarities versus the previous V5 CSH. Long-term CRM simulations are conducted to identify the impact of CRM resolution and the convective-stratiform separation method on LH structure/profiles. The TRMM and GPM Combined radar-radiometer algorithm derived surface rain rates and their associated precipitation properties are the input to the CSH algorithm. CSH V6 retrieved regional LH profiles in the tropics and subtropics display the classic signatures of heating in the convective region and heating over cooling in the stratiform region. Since there is no direct measurement of LH structure, the performance of the CSH V6 algorithm is examined by comparing its vertically-integrated heating (or equivalent surface rain rate) against the surface rain rate derived from the TRMM/GPM Combined algorithm. The CSH three-month and zonal mean equivalent surface rain rates are in good agreement with the Combined rain rates over the ITCZ region; the agreement is best over ocean. CSH three-month and zonal mean equivalent surface rain rates are larger than the Combined rain rates over land in both the tropics and sub-tropics. CSH three-month mean equivalent surface rain rates also have local differences with the Combined rain rates that can be smoothed by area averaging to larger horizontal resolutions (from the CSH standard grid of 0.25° × 0.25° to 0.5° × 0.5° or 1.0° × 1.0°). CSH equivalent surface rain rates have more light rain rates but less larger rates compared to the GPM Combined surface rain rates.

著者

Kunihiro Nishimura Kuniaki Ogasawara Takanari Kitazono Koji Iihara on behalf of the J-ASPECT Study Collaborators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-1214, (Released:2021-08-13)

参考文献数

27

被引用文献数

2

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Background:The degree of association between mortality and case volume/physician volume is well known for many surgical procedures and medical conditions. However, the link between physician volume and death rate in patients hospitalized for stroke remains unclear. This study analyzed the correlation between in-hospital stroke mortality and physician volume per hospital, considering board certification status.Methods and Results:For this retrospective registry-based cohort study, data were obtained from the Japanese nationwide registry on patients hospitalized for ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) between 2010 and 2016. The number of stroke care physicians and relevant board-certified physicians was also obtained. Odd ratios (ORs) of 30-day in-hospital mortality were estimated after adjusting for institutional and patient differences using generalized mixed logistic regression. From 295,150 (ischemic stroke), 98,657 (ICH), and 36,174 (SAH) patients, 30-day in-hospital mortality rates were 4.4%, 16.0%, and 26.6%, respectively. There was a correlation between case volume and physician volume. A higher number of stroke care physicians was associated with a reduction in 30-day mortality after adjusting for stroke case volume and comorbidities for all stroke types (all P for trend<0.05).Conclusions:An increased number of stroke care physicians was associated with reduced in-hospital mortality for all types of stroke. The volume threshold of board-certified physicians depends on the specialty and stroke type.

著者

Yasushi Ueki Shoichi Kuramitsu Tatsuya Saigusa Keisuke Senda Hitoshi Matsuo Kazunori Horie Hiroaki Takashima Hidenobu Terai Yuetsu Kikuta Takayuki Ishihara Tomohiro Sakamoto Nobuhiro Suematsu Yasutsugu Shiono Taku Asano Kenichi Tsujita Katsuhiko Masamura Tatsuki Doijiri Yohei Sasaki Manabu Ogita Tairo Kurita Akiko Matsuo Ken Harada Kenji Yaginuma Noriyoshi Kanemura Shinjo Sonoda Hiroyoshi Yokoi Nobuhiro Tanaka on behalf of the J-CONFIRM Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-1024, (Released:2022-03-12)

参考文献数

19

被引用文献数

1

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Background:Little evidence is available regarding the long-term outcome in elderly patients after deferral of revascularization based on fractional flow reserve (FFR).Methods and Results:From the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on fractional flow reserve in multicenter registry), 1,262 patients were divided into 2 groups according to age: elderly and younger patients (aged ≥75 or <75 years, respectively). The primary endpoint was the cumulative 5-year incidence of target vessel failure (TVF), defined as a composite of cardiac death, target vessel-related myocardial infarction (TVMI), and clinically driven target vessel revascularization (CDTVR). Cumulative 5-year incidence of TVF was not significantly different between elderly and younger patients (14.3% vs. 10.8%, P=0.12). Cardiac death occurred more frequently in elderly patients than younger patients (4.4% vs. 0.8%, P<0.001), whereas TVMI and CDTVR did not differ between groups (1.3% vs. 0.9%, P=0.80; 10.7% vs. 10.1%, P=0.80, respectively). FFR values in lesions with diameter stenosis <50% were significantly higher in elderly patients than in younger patients (0.88±0.07 vs. 0.85±0.07, P=0.01), whereas this relationship was not observed in those with diameter stenosis ≥50%.Conclusions:Elderly patients had no excess risk of ischemic events related to the deferred coronary lesions by FFR, although FFR values in mild coronary artery stenosis were modestly different between elderly and younger patients.

著者

Karen E. JOHNSON Li-Chen LIN Shalonda Estelle Brazzell HORTON Ana TODD Nancy GUILLET Stephanie MORGAN

出版者

Disaster Nursing Group

雑誌

Health Emergency and Disaster Nursing (ISSN:21882053)

巻号頁・発行日

vol.9, no.1, pp.23-30, 2022-03-25 (Released:2022-03-25)

参考文献数

37

被引用文献数

2

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Aim: This paper examines nurse-led interdisciplinary efforts to address COVID-19 vaccine inequities in Texas, United States (US) through the founding of a two-pronged community-based vaccination program, VAMOS-VaxNOW.Methods: Using state/federal reports and guidelines, local/national news sources, and volunteers’ voices, we frame our efforts within the sociopolitical and historical contexts that contributed to the need for VAMOS-VaxNOW.Results: Like most states, Texas distributed most of its vaccine supply to mass hubs that could efficiently serve large amounts of people. Nursing faculty at The University of Texas at Austin quickly recognized the need to expend effort into mobile clinics to reach populations who were likely to face barriers to accessing mass hubs (e.g., language barriers, transportation/mobility limitations, institutional mistrust). Leveraging long-standing relationships with community partners, we launched our first mobile vaccine clinic (VAMOS) with a historically Black church in March, 2021. From there we partnered with other community organizations serving populations experiencing vaccine inequities (e.g., Spanish-speaking churches, apartment complexes) to host mobile clinics. We also began a home visit program (VaxNow) for those facing mobility challenges or other barriers to accessing mass hubs. Our “hub-and-spoke” model was the first of its kind in our community and served as a model for others launching similar efforts.Conclusions: VAMOS-VaxNOW highlights the importance of nurse-led, interdisciplinary disaster response. Early mobilization planning guided by a deep understanding of how present-day and historical inequities shape disaster outcomes, thoughtful leaders collaborating with community partners, compassionate volunteers, and building trust were key factors in leading the successful operation.

著者

Chigusa Shimizu-Okabe Shigeki Okada Shiki Okamoto Hiroaki Masuzaki Chitoshi Takayama

出版者

JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

雑誌

ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)

巻号頁・発行日

vol.55, no.1, pp.47-56, 2022-02-26 (Released:2022-02-26)

参考文献数

50

被引用文献数

3

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Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the mature brain; however, it acts excitatory during development. This difference in action depends on the intra­cellular chloride ion concentration, primarily regulated by potassium chloride co-transporter2 (KCC2). Sufficient KCC2 expression results in its inhibitory action. GABA is also abundant in pancreatic islets, where it acts differentially on the islet cells, and is involved in carbohydrate metabolism. However, the mechanisms underlying the differential action remain unknown. We performed immunohistochemistry for glutamic acid decarboxylase (GAD), a synthetic enzyme for GABA, and KCC2 in normal adult islets. GAD was co-localized with insulin in β cells, whereas KCC2 was expressed in glucagon-positive α cells. These results are in line with previous observations that GABA decreases glucagon release but increases insulin release, and suggest that GABA and insulin may work together in reducing blood glucose levels under hyperglycemia. Next, we examined the streptozotocin-induced type1 diabetes mellitus mouse model. GAD and insulin expression levels were markedly decreased. KCC2 was expressed in glucagon-positive cells, whereas insulin- and somatostatin-positive cells were KCC2-negative. These findings suggest that in diabetes model, reduced GABA release may cause disinhibition of glucagon release, resulting in increased blood sugar levels and the maintenance of hyperglycemic state.

著者

Ho-Yin CHAN Jiangping ZHOU

出版者

Eastern Asia Society for Transportation Studies

雑誌

Journal of the Eastern Asia Society for Transportation Studies (ISSN:18811124)

巻号頁・発行日

vol.14, pp.50-70, 2022-03-11 (Released:2022-03-22)

参考文献数

68

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Transportation infrastructures, as both enablers and victims of social movements, often become major political arenas of cities. In this article, we unravel the understudied role that social movements play in the formation of grassroots transport initiatives. We illustrate this role by synthesizing how grassroots efforts have created, diversified, and networked social innovations in urban transport systems in the 2019 Anti-Extradition Law Amendment Bill Movement in Hong Kong. We document the timeline of the movement and related solidarity activities, which led to various grassroots transport initiatives. We identify three lines of research that appear to be decisively informative to transport literature: 1) emergency experiences, community capacities and mobility reselience, 2) grassroots engagement in transport disruption management and 3) community-oriented governance for a participatory smart city. These issues require particular attention in future research to guide transport policy on grassroots initiatives toward sustainable transport systems.

著者

SUZUKI Yasuhiro ISHII Shoko INAMURA Tetsuya NARA Yumiko TAKAHASHI Hirofumi BATTULGA Sukhee ENKHTAIVAN Dangaa NARANGEREL Serd-Yanjiv ARIUNAA Chadraabal SERJMYADAG Dalai ALTANBADRALT Batsukh BADRAL Tuvshin

出版者

The Association of Japanese Geographers

雑誌

Geographical review of Japan series B (ISSN:18834396)

巻号頁・発行日

vol.92, no.1, pp.1-9, 2019-12-27 (Released:2019-12-27)

参考文献数

23

被引用文献数

1

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As emphasized in the Sendai Framework for Disaster Risk Reduction (DRR) 2015–2030, an important key for enhancing citizens’ resilience is cooperation, in which universities and academic organizations may bear the burden of connecting people. Recently, some universities have conducted various DRR education programs together with local governments and citizens in Japan. In this report, we introduce the progress of our three international cooperative projects between Japan and Mongolia conducted between 2014 and 2018: 1) establishment of the Cooperative Center for Resilience Research (CCRR) by the National University of Mongolia and Nagoya University; 2) the Public Symposium for Earthquake DRR with the Mongolian Government; and 3) the Grass-Roots Joint Project of the Japan International Cooperation Agency (JICA) for disaster awareness in Khovd Province (Aimag), Mongolia. Through these transdisciplinary research projects, we intended to identify the essential conditions for an effective enhancement of citizens’ resilience. As a result, we found the following key aspects to be considered in international DRR cooperation flamework: 1) transfer the spirit of DRR rather than simply its components, 2) customize DRR to match the climate and residents’ temperament in the target area, 3) consider whether the project is consistent with the public policy of the target area, and 4) involve regional organizations and residents to ensure continuity for DRR activity.