著者

He He Jun-Han Wang Shun Kojima Kazuki Maruta Chang-Jun Ahn

出版者

Research Institute of Signal Processing, Japan

雑誌

Journal of Signal Processing (ISSN:13426230)

巻号頁・発行日

vol.27, no.3, pp.49-57, 2023-05-01 (Released:2023-05-01)

参考文献数

16

被引用文献数

1

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In a high-speed moving mobile environment, the channel state information (CSI) in the last part of the packet is different from the actual channel in the beginning part. Therefore, the channel estimation accuracy is degraded, especially when a small number of pilot symbols are used to ensure transmission efficiency. For the above reasons, it is necessary to compensate for CSIs to achieve reliable communication. Decision feedback channel estimation (DFCE) has been widely considered to be one of the channel tracking methods. However, the presence of time and frequency selective fading environments still causes estimation errors due to the decision-making process. We focused on the time-frequency domain response of the CSIs, which can be represented as a two-dimensional image. This paper newly proposes a regression convolutional neural network (CNN) based channel tracking scheme using the time-frequency domain response of the CSIs by DFCE for training and prediction to solve these problems. Computer simulation results demonstrate that the proposed scheme can achieve higher BER performance than the conventional schemes.

著者

Haruka SAKAMOTO Genta ITO Yuko GOTO-KOSHINO Megumi SAKAMOTO Ryohei NISHIMURA Yasuyuki MOMOI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0439, (Released:2023-05-15)

被引用文献数

6

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The novel domestic cat hepadnavirus (DCH), a member of the Hepadnaviridae, was first detected in Australia and has recently been identified in more countries. In this study, we explored the DCH genome using next-generation sequencing of a plasma sample from a cat with a fever of unknown cause. Nucleotide sequence analysis showed the virus to be relatively genetically distant from the first reported DCH in Australia, showing 89% homology. Then we conducted an epidemiological survey by PCR of plasma samples collected from 203 cats that visited a veterinary hospital for diagnosis and treatment. Two of the 203 surveyed cats a were positive for DCH. One of the two positive cases had elevated liver enzymes of unknown etiology, and the other had hepatoma. Our study indicated that DCH infection was observed in domestic cats in the Tokyo area of Japan as well as other reported areas in the world. Further investigations are needed to define the clinical importance of DCH.

著者

Satoru OSHINO Naoki TANI Hui Ming KHOO Kuriko KAGITANI-SHIMONO Shin NABATAME Koji TOMINAGA Takufumi YANAGISAWA Masayuki HIRATA Haruhiko KISHIMA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2022-0300, (Released:2023-04-06)

参考文献数

11

被引用文献数

2

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Successful surgery for drug-resistant pediatric epilepsy can facilitate motor and cognitive development and improve quality of life by resolution or reduction of epileptic seizures. Therefore, surgery should be considered early in the disease course. However, in some cases, the estimated surgical outcomes are not achieved, and additional surgical treatments are considered. In this study, we investigated the clinical factors related with such unsatisfactory outcomes.We reviewed the clinical data of 92 patients who underwent 112 surgical procedures (69 resection and 53 palliation procedures). Surgical outcomes were assessed according to the postoperative disease status, which was classified as good, controlled, and poor. The following clinical factors were analyzed in relation to surgical outcome: sex, age at onset, etiology (malformation of cortical development, tumor, temporal lobe epilepsy, scar, inflammation, and non-lesional epilepsy), presence of genetic cause, and history of developmental epileptic encephalopathy. At a median of 59 (30-81.25) months after the initial surgery, the disease status was good in 38 (41%), controlled in 39 (42%), and poor in 15 (16%) patients. Among the evaluated factors, etiology exhibited the strongest correlation with surgical outcomes. Tumor-induced and temporal lobe epilepsy were correlated with good, whereas malformation of cortical development, early seizure onset, and presence of genetic cause were correlated with poor disease status. Although epilepsy surgery for the patients who present with the latter factors is challenging, these patients demonstrate a greater need for surgical treatment. Hence, development of more effective surgical options is warranted, including palliative procedures.

著者

齋藤 義文 小嶋 浩嗣 小川 泰信 SS-520-3観測ロケット実験PIチーム Saito Yoshifumi Kojima Hirotsugu Ogawa Yasunobu SS-520-3 PI Team

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第19回宇宙科学シンポジウム 講演集 = Proceedings of the 19th Space Science Symposium

巻号頁・発行日

2019-01

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第19回宇宙科学シンポジウム (2019年1月9日-10日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Doaa SALMAN Eiji OOHASHI Adel Elsayed Ahmed MOHAMED Abd El-Raheem ABD EL-MOTTELIB Tadashi OKADA Makoto IGARASHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.76, no.6, pp.855-862, 2014 (Released:2014-07-01)

参考文献数

42

被引用文献数

11 13

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The potential contamination of Toxoplasma gondii and Neospora caninum oocysts in the human environment is a concern from the public health viewpoint. However, estimation of their seroprevalences in humans cannot be performed in a manner that distinguishes between oocysts and tissue cysts as a source of infection. Rabbits are considered popular pet animals in Japan that can acquire natural infections by the aforementioned parasites only through the ingestion of oocysts. Therefore, this study was conducted to estimate the seroprevalences of T. gondii and N. caninum in pet rabbits in Japan as an indicator of the possible oocyst contamination in the environment surrounding human beings. Serum samples of 337 rabbits were examined by different serological methods. Enzyme-linked immunosorbent assays were performed to measure the titer of IgG and IgM antibodies. Samples revealed to be seropositive by ELISA were further analyzed by a latex agglutination test, Western blotting and an indirect immunofluorescence assay. The rates of seropositivity for T. gondii were 0.89% (3/337) and 0.29% (1/337) in IgG and IgM ELISA, respectively. SAG1 and SAG2 were detected as major antigens by the positive rabbit sera in Western blotting associated with strong staining observed by IFA in T. gondii tachyzoites. Regarding N. caninum, none of the serum samples showed a specific reaction in both Western blotting and the IFA. The results of this study indicate low seroprevalences of toxoplasmosis and neosporosis in pet rabbits in Japan, suggesting low oocyst contamination in the human environment.

著者

Tomo-o Watsuji Kaori Motoki Emi Hada Yukiko Nagai Yoshihiro Takaki Asami Yamamoto Kenji Ueda Takashi Toyofuku Hiroyuki Yamamoto Ken Takai

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.33, no.4, pp.348-356, 2018 (Released:2018-12-28)

参考文献数

46

被引用文献数

2 8

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The hydrothermal vent squat lobster Shinkaia crosnieri Baba & Williams harbors an epibiotic bacterial community, which is numerically and functionally dominated by methanotrophs affiliated with Methylococcaceae and thioautotrophs affiliated with Sulfurovum and Thiotrichaceae. In the present study, shifts in the phylogenetic composition and metabolic function of the epibiont community were investigated using S. crosnieri individuals, which were reared for one year in a tank fed with methane as the energy and carbon source. The results obtained indicated that indigenous predominant thioautotrophic populations, such as Sulfurovum and Thiotrichaceae members, became absent, possibly due to the lack of an energy source, and epibiotic communities were dominated by indigenous Methylococcaceae and betaproteobacterial methylotrophic members that adapted to the conditions present during rearing for 12 months with a supply of methane. Furthermore, the overall phylogenetic composition of the epibiotic community markedly changed from a composition dominated by chemolithotrophs to one enriched with cross-feeding heterotrophs in addition to methanotrophs and methylotrophs. Thus, the composition and function of the S. crosnieri epibiotic bacterial community were strongly affected by the balance between the energy and carbon sources supplied for chemosynthetic production as well as that between the production and consumption of organic compounds.

著者

Tamiko Suzuki-Nishimura Masayoshi Baba Shiori Otani Arisa Yamamoto Yasushi Kodama

出版者

Japanese Pharmacological Society

雑誌

日本薬理学会年会要旨集 (ISSN:24354953)

巻号頁・発行日

pp.PO3-4-11, 2018 (Released:2020-09-10)

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The manic depression drug lithium carbonate has many mechanisms of action. As one of these mechanisms is the inhibition of amine release from the end of synapses, we examined the effects of lithium carbonate on the IgE-independent histamine release from rat peritoneal mast cells. In the presence of 0.3 mM CaCl2, at concentrations from 0.3 to 3.0 mM, lithium carbonate inhibited the histamine release induced by bradykinin (BK) (10 μM), substance P (SP) (10 μM) or compound 48/80 (48/80) (1 μg/mL). The histamine release induced by 1 μg/mL of 48/80 was inhibited by lithium carbonate, but that by 5 μg/ml of 48/80 was not. The IgE independent activator GlcNAc-specific Datura stramonium agglutinin (DSA) releases histamine from rat mast cells similar with 48/80, and lithium carbonate also inhibited the histamine release induced by DSA at 100 μg/mL. BK, SP and 48/80 are well-known activators against MRGPR. Mouse MrgprB2 and human MRGPRX2 on mast cells are possible targets of the pseudo-allergic drug reactions involving mast cell activation. Rat peritoneal mast cells have similar MRGPR calcium-dependent and calcium-independent pathways for mast cell activation. Inhibition of BK- or SP-induced histamine release by lithium carbonate did not recover after increasing the extracellular calcium concentration, suggesting that MRGPR in rat mast cells may be a calcium-independent, G-protein dependent receptor. The effects of lithium carbonate suggested that lithium carbonate inhibited downstream of the common signal transduction pathway, following MRGPR activation induced by BK, SP, 48/80 or DSA. The clinical dose of lithium carbonate is from 0.5 to 1 mM, and addiction occurs from 1.8 to 2.5 mM. The inhibitory effects of lithium carbonate on the IgE-independent histamine release were observed at both the clinical and addictive doses in humans, suggesting that lithium carbonate similarly inhibits both histamine release from mast cells and brain amine release from synapses.

著者

Hayato Tada Mika Hori Kota Matsuki Masatsune Ogura Atsushi Nohara Masa-aki Kawashiri Mariko Harada-Shiba

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.29, no.6, pp.816-824, 2022-06-01 (Released:2022-06-01)

参考文献数

25

被引用文献数

5 18

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Aim: The 2017 Japan Atherosclerosis Society (JAS) familial hypercholesterolemia (FH) criteria adopt a cut-off value of ≥ 9 mm of Achilles tendon thickness (ATT) detected by X-ray as one of the three key items. This threshold was determined based on an old data evaluating the ATT of 36 non-FH individuals that was published in 1977. Although the specificity of these clinical criteria is extremely high due to a strict threshold, there are a significant number of patients with FH whose ATT <9 mm. We aimed to determine a cut-off value of ATT detected by X-ray to differentiate FH and non-FH based on genetic diagnosis.Methods: The individuals (male/female=486/501) with full assessments of genetic analyses for FH-genes (LDLR and PCSK9), serum lipids, and ATT detected by X-ray at the Kanazawa University Hospital and National Cerebral and Cardiovascular Center Research Institute were included in this study. Receiver operating characteristic (ROC) analyses were conducted to determine a better cut-off value of ATT that predicts the pathogenic mutation of FH. Results: The ROC analyses revealed that the best cut-off values of ATT are 7.6 mm for male and 7.0 mm for female, with the sensitivities/specificities of 0.83/0.83 for male and 0.86/0.85 for female, respectively. If the thresholds of ATT of 8.0/7.5 mm and 7.5/7.0 mm were applied to the diagnosis of male/female FH, the sensitivities/specificities predicting the pathogenic mutation of FH by the 2017 JAS FH clinical criteria would be 0.82/0.90 and 0.85/0.88, respectively.Conclusions: These results suggest that the cut-off value of ATT detected by X-ray is obviously lower than 9.0 mm, which was adopted by the 2017 JAS FH clinical criteria.

著者

Naoko Takeo Masashi Nakamura Satoshi Nakayama Osamu Okamoto Naoki Sugimoto Shinichi Sugiura Nayu Sato Susumu Harada Masao Yamaguchi Naoya Mitsui Yumiko Kubota Kayoko Suzuki Makoto Terada Akiyo Nagai Junko Sowa-Osako Yutaka Hatano Hiroshi Akiyama Akiko Yagami Sakuhei Fujiwara Kayoko Matsunaga

出版者

Japanese Society of Allergology

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.67, no.4, pp.496-505, 2018 (Released:2018-10-18)

参考文献数

48

被引用文献数

33

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Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart.Methods: All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen.Results: Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins.Conclusions: SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.

著者

Moon-Hwan Kim Chung-Hwi Yi Jong-Hyuck Weon Heon-Seock Cynn Do-Young Jung Oh-Yun Kwon

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.4, pp.1019-1022, 2015 (Released:2015-04-30)

参考文献数

23

被引用文献数

32 44

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[Purpose] This study investigated whether the toe-spread-out exercise affects the hallux valgus angle, the cross-sectional area of the abductor hallucis muscle, and the hallux valgus angle during active abduction. [Subjects and Methods] Twenty-four subjects with hallux valgus were randomly assigned to orthosis and orthosis plus toe-spread-out exercise groups. The orthosis group wore the orthosis for 8 weeks, while the orthosis plus toe-spread-out group also performed the toe-spread-out exercise. The hallux valgus angle, the cross-sectional area of the abductor hallucis muscle, and the hallux valgus angle during active abduction were measured initially and after 8 weeks by radiography and ultrasonography. [Results] While there were no significant changes in the three parameters in the orthosis group, there were significant differences in the orthosis plus toe-spread-out exercise group after 8 weeks. In addition there were significant differences in the three measures between the two groups. [Conclusion] The toe-spread-out exercise reduces the hallux valgus angle and hallux valgus angle during active abduction, and increases the cross-sectional area of the abductor hallucis muscle. The toe-spread-out exercise is recommended for patients with mild to moderate hallux valgus.

著者

Aeo Yeun-Kyung

出版者

国学院大学大学院

雑誌

国学院大学大学院紀要 文学研究科 (ISSN:03889629)

巻号頁・発行日

vol.36, pp.249-263, 2004

著者

Ali Abd El-Monsif Thabet Ahmed Mohamed Elsodany Kadrya H Battecha Mansour Abdullah Alshehri Bassem Refaat

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.10, pp.1742-1748, 2017 (Released:2017-10-21)

参考文献数

44

被引用文献数

7 15

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[Purpose] To determine the efficacy of high intensity laser therapy (HILT) versus pulsed electromagnetic field (PEMF) in the treatment of primary dysmenorrhea. [Subjects and Methods] This was a randomized clinical trial that included 52 girls diagnosed with primary dysmenorrhea and who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles where group (A) included those participants treated with HILT 15 min/session and group (B) those who were treated with PEMF 30 min/session. All patients were evaluated before starting the treatment as well as after the end of treatment by present pain intensity scale and the prostaglandin level in blood and pain relief scale at the end of treatment for both groups. [Results] The results showed a significant decrease in the severity of pain, statistically significant decrease in prostaglandin level in blood, and a statistically significant pain alleviation in both groups. With comparison between both groups there was a statistically significant decrease in the severity of pain, significant decrease in the blood levels of PGF2α, in group (A) than group (B). [Conclusion] Both HILT and PEMF are effective in the treatment of primary dysmenorrhea with HILT being superior to PEMF.

著者

Seira Nishibe-Toyosato Yosuke Ando Nayu Nakasuji Takahiro Hayashi Kaori Ito Hidezo Matsuda Naho Tsujii Masahiro Tsuge Kazuyoshi Imaizumi Kenji Kawada Shigeki Yamada

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.3, pp.505-510, 2023-03-01 (Released:2023-03-01)

参考文献数

25

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Pharmaceutical consultation targeting outpatients at the Fujita Health University Hospital (Japan) provides support to patients undergoing anticancer drug treatment. This study aimed to explore factors that affect the comprehension of cancer chemotherapy among outpatients who received cancer treatment at our hospital. A questionnaire survey was conducted, and comprehension was scored on a scale of 1–5 (1, no comprehension; 5, full comprehension). When factors other than age and sex [the influence of which on comprehension has been reported in previous reports] were noted, differences in comprehension between the questionnaire items were comparatively analyzed according to the presence/absence of the relevant factors. Overall, 536 patients were included. Age (<70 years) and pharmacist interventions were identified as factors contributing to a comprehension score. The levels of comprehension regarding the name of the cancer chemotherapy, content/schedule of the treatment, purposes of the prescribed drugs, and objectives of blood tests were significantly higher in the group that received the pharmaceutical interventions; conversely, the level of comprehension for the self-management of adverse events was significantly lower in this group than in the group that did not receive any pharmaceutical interventions. Age and interventions by the pharmacist affected the comprehension of cancer chemotherapy by patients.

著者

カリ- G.

出版者

世紀編集室

雑誌

世紀

巻号頁・発行日

no.302, pp.p28-36, 1975-07

著者

Hai-Bo Wang Zi-Mei Mo Guang-Wei Yuan Xiang-Dong Dai Song-Yu Zhou Hock Eng Khoo Changbao Li

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

pp.ess22354, (Released:2023-03-10)

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This study aimed to determine the efficiency of ultraviolet (UV)-LED cold light treatment on the degradation of aflatoxin (AF)B1 in peanut oils. The peanut oil samples obtained from different places in China and abroad were determined for AFB1 degradation efficiency of the UV-LED cold-light irradiation method. The degradation products were analyzed by ultra-high performance liquid chromatography coupled to quadrupole orbitrap high-resolution mass spectrometry (UPLC-Q-Exactive MS). The results indicated that the AFB1 content in all peanut oil samples decreased rapidly after 5 min of irradiation. Four main photodegradation products (C18H16O7, C17H14O7, C17H14O7, and C17H14O8) were identified using the established LC-MS method. Their chemical structures were postulated based on the LC-MS data. Also, the degradation pathways were proposed based on the data obtained. Oxidation and reduction reactions were mainly responsible for AFB1 decomposition. The reactions occurred at the furan and lactone rings. These findings demonstrated that UV-LED cold-light irradiation was an effective method for treating AFB1-contaminated peanut oil.

著者

Ladawan Lerslerwong Chompoonut Buapuean Adirek Rugkong Kanokporn Bunya-Atichart

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.QH-033, (Released:2023-03-10)

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Limes (Citrus aurantifolia Swingle) have a short postharvest life. Therefore, effective treatments increasing storage life to lengthen the time that produce remains fresh is desirable. This study evaluated the effects of postharvest treatments of 1-methylcyclopropene (1-MCP), gibberellic acid (GA3), and Aloe vera on lime storage life and fruit quality. The optimum individual treatments of 50% Aloe vera coating, 300 mL·L−1 GA3, and 750 nL·L−1 1-MCP were identified as most effective in extending lime postharvest life. Under ambient conditions (26.4 ± 1.0°C, 64.4 ± 7.4% RH), 1-MCP fumigation was the best treatment, increasing lime postharvest life to 28.2 days. The 1-MCP-treated fruit had a higher juice content than the control fruit. Also, soluble solid contents and titratable acidity were not significantly different, while ascorbic acid was lower than the control. Under cold room conditions (10.0 ± 0.3°C, 68.9 ± 12.4% RH), 1-MCP fumigation followed by Aloe vera coating was the best treatment, increasing lime storage life by 38.7 days. The longer storage time did reduce juice content in treated limes compared to untreated fruit. However, the treatment did not affect the soluble solid contents, titratable acidity, or ascorbic acid level. In conclusion, for optimum postharvest life in limes stored under ambient conditions, fumigation with 1-MCP is best. While for limes stored in cold rooms, a cotreatment of 1-MCP fumigation followed by Aloe vera coating maximizes postharvest life.

著者

Tsuyoshi Takara Kazuo Yamamoto Naoko Suzuki Shin-ichiro Iio Hayata Noguchi Toshihiro Kakinuma Asami Baba Wakana Yamada Masafumi Nagata Hiroshi Shimoda

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.9, no.3, pp.158-169, 2022-10-20 (Released:2022-10-26)

参考文献数

52

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Background and objective: Plant-derived glucosylceramides (GlcCer) have been clinically reported to enhance skin barrier functions. GlcCer and ceramides (Cer) interact with immune-stimulating receptors on antigen-presenting cells, such as c-type lectin receptors and toll-like receptor 4. However, the clinical and immunological efficacies of orally ingested GlcCer remain unknown. Therefore, we herein conducted a clinical trial on the effects of rice-derived GlcCer (Oryza Ceramide®: OC) on cold symptoms, immune parameters, and SF-36 scores. Methods: OC (type PCD, 60 mg daily) containing 1.8 mg of GlcCer and 0.09 mg of Cer [t18:0/24:0] was used as the active sample. We enrolled 44 healthy Japanese individuals who are prone to catching colds and a low immune score. All subjects were randomly allocated to an active group (n = 22) or placebo group (n = 22). Capsules containing OC or the placebo were administered for 8 weeks. Cold symptom scores during the intervention were the primary outcome, while immune parameters and SF-36 scores measured after the 8-week intervention were the secondary outcomes. Results: Forty subjects completed the trial, and the per protocol set comprised 19 and 21 in the active and placebo groups, respectively. Regarding the primary outcome, cumulative days with cold symptoms, such as nasal congestion, throat irritation, a cough, headache, muscle pain, and diarrhea, was lower in the OC group. Among the secondary outcomes, physical functioning in SF-36 scores was improved in the OC group. Regarding immune parameters, a negative correlation was observed between changes in blood T-lymphocytes and cumulative days with cold symptoms. Laboratory tests revealed no abnormalities to suggest adverse effects of OC. Conclusions: OC consisting of GlcCer attenuated typical cold symptoms, such as nasal congestion, throat irritation, a cough, headache, muscle pain, and diarrhea, and improved physical conditions. Changes in T-lymphocytes may be one of the mechanisms by which OC ameliorates cold symptoms.

著者

Hon-Kan Yip Pei-wen Wang Li-Teh Chang Ali A. Youssef Jiunn-Jye Sheu Fan-Yen Lee Chiung-Jen Wu

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.71, no.8, pp.1213-1218, 2007 (Released:2007-07-25)

参考文献数

43

被引用文献数

8 9

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Background Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production. The purpose of the present study was to determine the frequency distribution of an A/G single nucleotide polymorphism at position 49 in exon 1 of the CTLA-4 gene, which may be a functional related-genetic risk marker for the development of ST-segment elevation (ST-se) acute myocardial infarction (AMI). Methods and Results A total of 503 consecutive patients, consisting of 250 ST-se AMI patients undergoing primary coronary angioplasty (group 1), 203 angina pectoris patients undergoing elective coronary angioplasty (group 2) and 50 patients with chest pain and normal coronary angiographic findings (group 3), were enrolled in the present study. The frequency of the G/G genotype was significantly higher in group 1 (53.2%) than in groups 2 (33.0%) and 3 (36.0%) (p=0.0005). In group 1, patients with a G/G genotype had significantly higher levels of high-sensitivity C-reactive protein and white blood cell counts, and much higher incidences of multi-vessel disease, greater lesion lengths, advanced congestive heart failure (≥ class 3) and 30-day mortality, than patients with G/A or A/A genotypes (p values<0.05 in all cases). Multivariate analysis of the enrolled baseline variables (age, gender, diabetes mellitus, smoking, hypertension and hypercholesterolemia) and the genotypes (G/G, A/G and A/A) demonstrated that G/G genotype is the only independent predictor of development of AMI (p<0.0001). Conclusion The G/G genotype polymorphism of the CTLA-4 gene is associated with increased risk of AMI. (Circ J 2007; 71: 1213 - 1218)

著者

Natteewan Udomsil Sumeth Imsoonthornruksa Chotika Gosalawit Mariena Ketudat-Cairns

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.25, no.4, pp.597-605, 2019 (Released:2019-09-26)

参考文献数

25

被引用文献数

32 78

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The used of insects as protein sources is growing rapidly for a variety of reasons, including global food security, sustainability, nutritional value and animal welfare. The nutritional composition and functional properties of extracted proteins from two cricket species (A. domesticus and G. bimaculatus) were investigated. Both cricket species contained high amounts of proteins (60–70% dry weight) with all essential amino acids and 10–23% lipids. The amount of omega-3 and omega-6 fatty acids and several minerals, such as P, Na and Ca were also high. Proteins were isolated from both cricket species by solubilisation at pH 11.0–12.0, followed by pH 4.0 isoelectric precipitation. The cricket proteins have high water capacity, moderate foaming capacity and stability with high emulsion activity. Therefore, they certainly could be further utilized as ingredients in various food types that could be an alternative nutritional source for both direct consumption and processing for protein extracts.

著者

Migyeong Kim Jeong Hoon Cho Sang-Boom Ryoo

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.19, pp.26-32, 2023 (Released:2023-02-18)

参考文献数

22

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Forecasts of discrete events, such as precipitation, dust storms, and typhoons, can be deterministic, categorical, or probabilistic. Ensemble-based probabilistic predictions generate more consistent forecasts than individual deterministic models. We introduce and evaluate the Ensemble Prediction System of Asian Dust Aerosol Model 3, which generates probability forecasts of Asian dust. Probability forecasts were produced for 300 μgm−3 PM10 mass concentrations, according to the air-quality standards of the Ministry of Environment of South Korea and Korea Meteorological Administration. Crisis-level information was produced to categorize the dust risk level for Asia, using a risk matrix. The model's performance was evaluated using a 2 × 2 contingency table, the Brier skill score, and a reliability diagram. For skill score evaluation via the contingency table, the average hit rate and threat score were 0.46 and 0.34 for the best three sites, Jurihe, Erenhot, and Wulatezhongqi. The Brier skill score was positive for approximately 60% of stations, with the highest (0.410) and lowest (−2.038) values in Erenhot and Yanan, respectively. The reliability diagram revealed overestimated Asian dust frequencies for all stations. Although the stations were located within the same regions, their skill scores differed. Regional characteristics of skill scores should be further investigated in the future.