著者
松井 晋 Audrey STERNALSKI Christelle ADAM-GUILLERMIN 笠原 里恵 五十嵐 悟 横田 清美 渡辺 守 上田 恵介
出版者
日本鳥学会
雑誌
日本鳥学会誌 (ISSN:0913400X)
巻号頁・発行日
vol.64, no.2, pp.169-174, 2015 (Released:2015-12-13)
参考文献数
21
被引用文献数
2

福島第一原子力発電所事故から1年後の2012年に東京,長野,茨城,福島を含む地上から1 mの空間線量率が0.11-21.4(μGy/h)の地点で回収したカラ類(シジュウカラParus minorもしくはヤマガラPoecile varius)の主にコケ類を用いて作られた巣材の放射性セシウム[Cs-134+Cs-137]濃度は6.6-6,128.9(Bq/g dry weight, n=14)となり,空間線量率が高い場所で採集した巣材ほど,巣材の放射性セシウム濃度が高くなる傾向があった.これらの結果は,地上1 mの空間線量率は相対的な巣材の汚染レベルの指標になりうることを示唆し,空間線量率の高い地域ほど巣材に含まれる放射性物質から繁殖期に卵,雛,親が近接的に受ける外部被曝線量率が増加すると考えられた.
著者
Takashi Toyama Gi-Wook Hwang Akira Naganuma
出版者
一般社団法人日本毒性学会
雑誌
Fundamental Toxicological Sciences (ISSN:2189115X)
巻号頁・発行日
vol.2, no.5, pp.227-228, 2015-12-09 (Released:2015-12-09)
参考文献数
5
被引用文献数
1 1

This study attempted to identify substances that are driven out of HEK293 cells by methylmercury. Metabolomic analysis revealed that the levels of 3-phenylpropionic acid, citrulline, lactic acid, ornithine, proline and beta-alanine in the cell culture medium were increased by the treatment of cells with methylmercury. Address to the mechanism underlying the release of these substances will provide useful information to elucidate the toxicity mechanism of methylmercury.
著者
Kenji Nakatsuma Hiroki Shiomi Takeshi Morimoto Kenji Ando Kazushige Kadota Hiroki Watanabe Tomohiko Taniguchi Takashi Yamamoto Yutaka Furukawa Yoshihisa Nakagawa Minoru Horie Takeshi Kimura on behalf of the CREDO-Kyoto AMI investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-15-0870, (Released:2015-12-15)
参考文献数
19
被引用文献数
2 32

Background:In the setting of elective percutaneous coronary intervention (PCI), intravascular ultrasound (IVUS)-guided PCI is associated with a reduction in the incidence of target vessel revascularization (TVR), but the impact of IVUS on long-term clinical outcome in the setting of emergency PCI for ST-segment elevation acute myocardial infarction (STEMI) is still unclear.Methods and Results:The subjects consisted of 3,028 STEMI patients who underwent primary PCI within 24 h of symptom onset in the CREDO-Kyoto acute myocardial infarction registry. Of these, 932 patients (31%) underwent IVUS-guided PCI. Compared with the angiography-guided PCI without IVUS, IVUS-guided PCI was associated with significantly lower incidences of TVR (primary outcome measure; 22% vs. 27%, log-rank P<0.001) and definite stent thrombosis (ST; 1.2% vs. 3.1%, log-rank P=0.003). The cumulative incidence of all-cause death was not significantly different between the 2 groups. After adjusting for confounders, however, there were no significant differences between the 2 groups in risk for TVR (adjusted HR, 1.14; 95% CI: 0.86–1.51, P=0.38) and definite ST (adjusted HR, 0.58; 95% CI: 0.19–1.72, P=0.33).Conclusions:IVUS-guided PCI was not associated with a lower risk for TVR or ST in STEMI patients undergoing primary PCI.
著者
Ye-Won KIM Sangil SUH Ran CHOI Changbaig HYUN
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.15-0288, (Released:2015-11-09)
被引用文献数
4

This study evaluated the quality of anesthesia, duration of analgesia, and changes in vital signs after intramuscular administration of a combination of butorphanol, medetomidine and alfaxalone in domestic cats. Ten healthy adult domestic cats (weighing 2.9 ± 0.5 kg) were used in this study. Rectal temperature (T), pulse rate (PR), respiratory rate (fR) and systolic arterial pressure (SAP) were measured and recorded prior to intramuscular (IM) administration of butorphanol (0.2 mg/kg), medetomidine (20 ug/kg) and alfaxalone (5 mg/kg) and then every 10 min until return of consciousness. Qualitative scores for induction of anesthesia and recovery were allocated, duration of anesthesia and recovery were calculated, and adverse events were recorded. A needle prick with a 22-gauge hypodermic needle was used to assess analgesia. Scores for induction and recovery quality were acceptable. No significant adverse events except nausea (7/10) and vomiting (5/10) were observed. The mean ± SD times from induction to extubation and to standing (full recovery) were 114 ± 8 and 125 ± 7 min, respectively. There were statistically significant changes in PR, fR and SAP after induction of anesthesia. The combination of butorphanol, medetomidine and alfaxalone provided acceptable quality of anesthesia and analgesia and exerted minimal cardiopulmonary effects in domestic cats.
著者
Marcelo M. Serra Bruno L. Ferreyro Oscar Peralta Ezequiel Levy Yeyati Natalia Causada Calo Teresa Garcia-Botta Diego Andresik Martín Rabellino Ricardo Garcia-Mónaco
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.54, no.21, pp.2745-2748, 2015 (Released:2015-11-01)
参考文献数
13
被引用文献数
4

Hereditary hemorrhagic telangiectasia (HHT) usually presents in association with pulmonary arteriovenous malformations (PAVMs). In addition, the incidence of venous thromboembolism tends to be increased in these patients. A 74-year-old female with HHT presented with cyanosis and hypoxemia. Contrast-enhanced multislice computed tomography (MSCT) revealed two left PAVMs and one in the right upper lobe. Both left PAVMs were treated with embolotherapy. Follow-up MSCT revealed an incidental pulmonary embolism in the right pulmonary branches. Deep venous thrombosis was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of thromboembolism. Finally, embolotherapy was performed. This case illustrates the chronic adaptation to hypoxemia and adds further evidence to the relative safety of anticoagulation treatment in these patients.
著者
Thanaa El-Kholy Enas Elsayed
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.7, pp.2039-2043, 2015 (Released:2015-07-22)
参考文献数
36
被引用文献数
9

[Purpose] The present study investigated the relationships of physical activity and healthiness with the intelligence quotients of high school students in Jeddah. [Subjects and Methods] A total of 135 male and female students were randomly drawn from public and private secondary schools in Jeddah. A self-designed questionnaire was distributed to the students that included demographic, physical activity, and health status sections. Body mass index measurement and an intelligence quotient test were carried out for all students. In addition, samples of blood were collected to estimate hemoglobin and serum iron. [Results] The highest proportions of males and females (39.1% and 51% respectively) had an intelligence quotient score of more than 75%. Moreover, the findings revealed that about 35% of the students were categorized as overweight obesity, and there was aninverse correlation between body mass index and physical activity. Students who shared physical education classes and exercising at and outside school showed a positive correlation with high IQ scores. Regarding hemoglobin and iron levels, there were significant correlations between their levels in blood and IQ. [Conclusion] The intelligence quotient of adolescent students is positively associated with physical activity and health status.
著者
Sumiko Yoshida Yasumasa Ikeda Ken-ichi Aihara
出版者
一般社団法人 日本動脈硬化学会
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
pp.31047, (Released:2015-10-30)
参考文献数
105
被引用文献数
1 19

Although many clinical studies have shown that a low testosterone level is associated with cardiovascular diseases, the role of androgens in cardiovascular physiology and pathophysiology remains controversial. Androgens exert various actions in their target organs, and the androgen receptor (AR) is widely distributed in several tissues, including endothelial cells, smooth muscle cells, and fibroblasts, in the vascular system. Biological activities of androgens are predominantly mediated through the AR by the transcriptional control of target genes and interaction with multiple signaling pathways. To clarify the molecular mechanisms of androgens in cardiovascular disease, we examined a pathological model using AR knockout mice and showed that the androgen–AR system has protective effects on cardiovascular remodeling against cardiovascular stress. In this review, we focus on the role of the androgen–AR system in angiogenesis after ischemic stress.
著者
Liang CONG Jing-Ting MA Zhen-Jing JIN Li-Wei DUAN Wei-Ping SU Jing ZHENG Ling-Juan ZHANG Jia XU Dong-Fu LI
出版者
Center for Academic Publications Japan
雑誌
Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日
vol.61, no.4, pp.326-331, 2015 (Released:2015-10-06)
参考文献数
12
被引用文献数
2

We investigated the efficacy and safety of a new type of dietary fiber (high specific volume polysaccharide) for use in treating constipation of different etiologies. Functional constipation patients and irritable bowel syndrome-constipation (IBS-C) patients were administrated high specific volume polysaccharide (HSVP) three times daily for a period of 2 wk to relieve their symptoms. Scores on a stool form scale, and patient reports of straining during a bowel movement, having sensations of an incomplete bowel movement or a blocked anorectum, and abnormal defecation intervals were recorded, graded, and scored by a functional constipation sample group. Similarly, a cohort of IBS-C patients reported their occurrence of abdominal discomfort or pain, abnormal stool formation, defecation frequency, and straining during a bowel movement. Additionally, both groups reported any adverse reactions associated with taking HSVP. All patients in both groups returned for follow-up visits, and no adverse reactions to treatment with HSVP were reported. In the functional constipation group, HSVP was effective for treating symptoms of constipation in 81.46% and 93.17% of patients after 7 and 14 d of dosing, respectively (both p<0.05). In the IBS-C group, symptoms of constipation were relieved in 71.67% and 88.34% of patients after 7 and 14 d of dosing, respectively (both p<0.05). High specific volume polysaccharide was shown be effective for treatment of functional constipation and IBS-C, without causing significant adverse events.
著者
R. Iván Martínez-Lemos
出版者
(公社)日本産業衛生学会
雑誌
Journal of Occupational Health (ISSN:13419145)
巻号頁・発行日
pp.14-0217-RA, (Released:2015-04-10)
被引用文献数
7

Objectives: The purpose of this review is to summarize the current evidence on the economic impact of corporate wellness programs (CWPs) in Europe from the results of randomized controlled trials (RCTs) published up to 2013. Methods: A review was undertaken by searching for RCTs with key words in the following databases: PubMed, SPORTDiscus, and Business Source Premier. Only RCTs that evaluated the economic impact of CWPs, and included analyses performed in Europe with results converted into monetary values, were eligible for inclusion. An approach to economic analyses from both an employer’s perspective and a societal perspective was also undertaken. Results: Eleven RCTs were identified, and review of these studies determined that the economic impact of the majority of CWPs analyzed was mostly negative. We discuss a possible explanation for these discrepancies with regard to prior reviews in this area. Despite the fact that the RCT is the “gold standard” for investigating without bias, several limitations to the methodology may have influenced the results of the studies in this review and suggested the use of caution in the interpretation of the results. Conclusions: The findings of this review could be a “wake up call” for companies regarding the high probability of bias from non-RCT studies, the majority of which report a positive economic impact of these programs, and the risk of taking inappropriate decisions based on the results of such studies.
著者
Shinya Goto Chien-Hua Huang Seung-Jung Park Håkan Emanuelsson Takeshi Kimura
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-15-0112, (Released:2015-09-16)
参考文献数
37
被引用文献数
9 199

Background:Few data on the relative efficacy and safety of new P2Y12inhibitors such as prasugrel and ticagrelor in Japanese, Taiwanese and South Korean patients with acute coronary syndromes (ACS) exist.Methods and Results:The multicenter, double-blind, randomized PHILO trial compared the safety and efficacy of ticagrelor vs. clopidogrel in 801 patients with ACS (Japanese, n=721; Taiwanese, n=35; South Korean, n=44; unknown ethnicity, n=1). All were planned to undergo percutaneous coronary intervention and randomized within 24 h of symptom onset. Primary safety and efficacy endpoints were time to first occurrence of any major bleeding event and to any event from the composite of myocardial infarction, stroke or death from vascular causes, respectively.At 12 months, overall major bleeding occurred in 10.3% of ticagrelor-treated patients and in 6.8% of clopidogrel-treated patients (hazard ratio (HR), 1.54; 95% confidence interval (CI): 0.94–2.53); the composite primary efficacy endpoint occurred in 9.0% and in 6.3% of ticagrelor- and clopidogrel-treated patients, respectively (HR, 1.47; 95% CI: 0.88–2.44). For both analyses, the difference between groups was not statistically significant.Conclusions:In ACS patients from Japan, Taiwan and South Korea, event rates of primary safety and efficacy endpoints were higher, albeit not significantly, in ticagrelor-treated patients compared with clopidogrel-treated patients. This observation could be explained by the small sample size, imbalance in clinical characteristics and low number of events in the PHILO population.
著者
Nakamura Ikusei Aimoto Kohjiroh Fujimoto Kaoru Tominaga Hiro-o
出版者
The Chemical Society of Japan
雑誌
Chemistry Letters (ISSN:03667022)
巻号頁・発行日
no.3, pp.437-440, 1988
被引用文献数
2 2

A nickel supported on active carbon catalyst was found to exhibit an excellent activity for transfer hydrocracking of diphenylpropane with tetralin at 400 °C. It is demonstrated that the catalytic transfer hydrogenation is effected by the reverse spillover of hydrogen atom over the active carbon.
著者
Yong-Soo Kong Woo-Jin Lee Seol Park Gwon-Uk Jang
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.27, no.7, pp.2073-2076, 2015 (Released:2015-07-22)
参考文献数
28
被引用文献数
2 11

[Purpose] This study aimed to investigate the effects of prone bridge exercise on trunk muscle thickness. [Subjects and Methods] Thirty-seven chronic low back pain patients participated in this study. Each participant was randomly assigned to one of three exercise groups, namely, a prone bridge exercise group, supine bridge exercise on a Swiss ball group, and supine bridge exercise group. The thicknesses of the transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) were measured using ultrasound. [Results] After eight weeks of training, the three groups showed significant increases in the thicknesses of the TrA, IO, and EO. Among the groups, TrA and IO showed significantly different muscle thicknesses. [Conclusion] The prone bridge exercise significantly affected the thicknesses of the TrA, IO, and EO unlike the supine bridge exercises. Based on the results of this study, the prone bridge exercise is a more effective method to improve trunk stability than conventional supine bridge exercises.
著者
Hassadin BOONSRIROJ Daria Llenaresas MANALO Kazunori KIMITSUKI Taichi SIHMATSU Nozomi SHIWA Harumi SHINOZAKI Yurika TAKAHASHI Naoto TANAKA Satoshi INOUE Chun-Ho PARK
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.15-0308, (Released:2015-08-14)
被引用文献数
3 13

Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands are important as exit and propagation sites for the rabies virus, the mechanisms of rabies excretion remain unclear. Here, we investigated the histopathology of the salivary glands of rabid dogs and analyzed the mechanism of excretion into the oral cavity. Mandibular and parotid glands of 22 rabid dogs and three control dogs were used. Mild to moderate non-suppurative sialadenitis was observed in the mandibular glands of 19 of the 22 dogs, characterized by loss of acinar epithelium and infiltration by lymphoplasmacytic cells. Viral antigens were detected in the mucous acinar epithelium, ganglion neurons and myoepithelium. Acinar epithelium and lymphocytes were positive for anti-caspase-3 antibodies and TUNEL staining. In contrast, no notable findings were observed in the ductal epithelial cells and serous demilune. In the parotid gland, the acinar cells, myoepithelium and ductal epithelium all tested negative. These findings confirmed the path through which the rabies virus descends along the facial nerve after proliferation in the brain to reach the ganglion neurons of the mandibular gland, subsequently traveling to the acinar epithelium via the salivary gland myoepithelium. Furthermore, the observation that nerve endings passing through the myoepithelium were absent from the ductal system suggested that viral proliferation and cytotoxicity could not occur there, ensuring that secretions containing the virus are efficiently excreted into the oral cavity.
著者
劉 海宇 Liu Hai-yu
出版者
国立大学法人岩手大学平泉文化研究センター
雑誌
岩手大学「平泉文化研究センター年報」 = Hiraizumi studies (ISSN:21877904)
巻号頁・発行日
vol.2, pp.85-93, 2014

中国古代の庭園を分類する場合、一般的には皇帝直属の大規模な皇家苑囿と貴族・富豪の私邸庭園とに大別される。『史記』秦始皇本紀によれば、秦の始皇帝は戦国諸侯を滅ぼすたびに、その宮室を模して首都咸陽の北の山麓に宮殿を建てたという。天下を統一すると、さらに渭水を中心に、離宮別館・苑囿台池を造営し、中でも蘭池宮・上林苑・阿房宮等は現在においても有名である。ところで、始皇帝の贅を尽くして造営した苑囿に対して、秦代の官僚や富豪の私邸庭園については、将軍王翦の「美しき田宅園池を請ふこと甚だ衆し」を除けば、史書にほとんど記録を確認できない。いわんや秦代の庶民の私邸庭園においておやである。もとより資料の制限により、従来の研究では秦代の宮廷苑囿に関する議論は多く見えるが、秦代の私邸園池については研究が少ないのが現状である。 幸いにも、近年、中国各地から秦代の簡牘資料が相次いで出土しており、秦代の研究ではこれらの簡牘の利用なくして進展は考えられないと言えよう。秦代の簡牘資料では、「数術」と分類される一群がある。「数術」とは、『漢書』芸文志では「太史令の尹咸をして数術を校せしむ」の顔師古注に「占卜の書なり」とか、「凡そ数術百九十家、二千五百二十八巻。数術は、みな明堂・羲和・史卜の職なり」とあるように、古代の天文・暦法・占卜等に関する学問のことである。「数術」の書籍には天文・暦譜・五行・蓍亀・雑占・刑法の分野が含まれており、出土した「数術」簡牘にもこうしたすべての分野が包括されている。それでは、秦代の「数術」簡牘文献に官僚や庶民の私邸園池に関する資料があるのだろうか。 本稿では、出土した秦代の「数術」簡牘に見える池を中心とする私邸庭園について、関係資料を収集・分析することによって、秦代の私邸庭園の地割や池の性格を明らかにし、あわせて成立年代が平安時代末期とされる東アジアの最古の造園書『作庭記』における造園の禁忌思想と比較してみたい。
著者
瀧口 吉郎 大川 裕司 宮川 和典 小杉 美津男 鈴木 四郎 久保田 節 加藤 務 設楽 圭一 谷岡 健吉 Park Wug-Dong 小林 昭 平井 忠明
出版者
一般社団法人映像情報メディア学会
雑誌
映像情報メディア学会技術報告 (ISSN:13426893)
巻号頁・発行日
vol.22, no.57, pp.13-18, 1998-10-22
被引用文献数
1

高感度固体撮像素子を目指して、a-Seのアバランシェ増倍現象を利用したHARP光電変換膜とMOS型トランジスタからなる固体走査部とを多数のInの柱で接合した固体HARP撮像素子の研究が進められている。この固体撮像素子では走査回路の耐圧が60Vであることから、HARP膜の印加電圧が60V以下に、すなわち使用できる膜の厚さが制限される。そこで、この条件下においてもっとも良好な特性の得られるHARP膜の膜厚についての検討を行った。その結果、0.4μmの膜厚とすることで、印加電圧60Vにおいて目標とする4倍の増倍率を暗電流が抑制された状態で実現できることが明らかになった。また、HARP膜のさらなる感度向上を目的として、Te添加による光電変換効率の改善を検討し、シミュレーションと試作の両面からTe添加により緑色光に対する光電変換効率を従来の2倍以上に向上できることを確認した。
著者
Hiroshi Akiyama Hideki Matsuoka Takanori Okuyama Kyohei Higashi Toshihiko Toida Hiroyuki Komatsu Yoshiko Sugita-Konishi Satomi Kobori Yukio Kodama Midori Yoshida Hitoshi Endou
出版者
内閣府食品安全委員会
雑誌
Food Safety (ISSN:21878404)
巻号頁・発行日
vol.3, no.1, pp.16-29, 2015 (Released:2015-03-30)
参考文献数
37
被引用文献数
6

A novel type of encephalopathy associated with the ingestion of Sugihiratake mushroom (Pleurocybella porrigens) occurred in patients with chronic renal failure treated on hemodialysis in fall, 2004 in Japan. To clarify the mechanism of encephalopathy onset, we, for the first time, purified the cyanogen glycoside fraction (CG) from Sugihiratake mushroom using reversed phase high-performance liquid chromatography and hydrophilic interaction chromatography. Furthermore, we investigated single dose toxicity of the CG in an adenine-induced rat model of chronic renal damage (CRD). Pathological examination of kidneys indicates the development of CRD. Oral administration of the CG induces the accumulation of thiocyanate in the hemolyzed blood and brain in CRD rats, although no morphological changes were found in the brain. No further enhancement of kidney damage is observed after the oral administration of the CG in CRD rats. This is the first experimental report to suggest that acute encephalopathy, induced by Sugihiratake mushroom intake in the patients with chronic renal failure, is associated with intoxication of cyanide and thiocyanate, presumably produced metabolically produced after the ingestion of Sugihiratake mushroom.
著者
Sung-Jin Choi Won-Seob Shin Bok-Kyun Oh Jae-Kwang Shim Dae-Hyouk Bang
出版者
理学療法科学学会
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.26, no.9, pp.1411-1414, 2014 (Released:2014-09-17)
参考文献数
26
被引用文献数
9 22

[Purpose] The purpose of this study was to determine the effects of task-oriented training with whole body vibration (WBV) on the sitting balance of stroke patients. [Subjects] The subjects were 30 stroke patients who were randomly divided into experimental (n1=15) and control (n2=15) groups. [Methods] Subjects in both groups received general training five times per week. Subjects in the experimental group practiced an additional task-oriented training program with WBV, which was performed for 15 minutes, five times per week, for four weeks. The center of pressure (COP) path length and average velocity were used to assess subjects static sitting balance, and the Modified Functional Reach Test (MFRT) was used to assess their dynamic sitting balance. The paired t-test was performed to test the significance of differences between before and after the intervention. The independent t-test was conducted to test the significance of differences between the groups. [Results] Following the intervention, the experimental group showed a significant change in MFRT. [Conclusion] The results of this study suggest that task-oriented training with WBV is feasible and efficacious for stroke patients.