著者

Iida Atsuo Nishimaki Toshiyuki Sehara-Fujisawa Atsuko

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.5, 2015-01-19

被引用文献数

16

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魚類が「胎生」になるために獲得した仕組みの一端を解明 京都大学プレスリリース. 2015-01-20.

著者

Ju-hyeon Jung Je-myung Shim Hae-yeon Kwon Ha-roo Kim Bo-in Kim

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.1, pp.73-76, 2014 (Released:2014-02-06)

参考文献数

18

被引用文献数

11 28

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[Purpose] The purpose of the present study was to verify a new method for improving respiratory functions by applying both abdominal stimulation and inspiratory muscle training (IMT) to train the inspiratory muscle and the expiratory muscle simultaneously, to improve the efficiency of IMT of chronic stroke patients. [Subjects] Eighteen stroke patients were randomly assigned to an experimental group (n = 9) and a control group (n = 9). [Methods] The experimental group was administered IMT with abdominal stimulation, and the control group was administered only IMT. During the intervention period, the experimental group and control group received training 20 min/day, 3 times/wk, for 4 weeks. To examine the lung functions of the subjects, FVC, FEV1, PEF, and FEF25–75 were measured using an electronic spirometer. The diaphragm thickness ratio was calculated from measurements made with a 7.5-MHz linear probe ultrasonic imaging system. [Result] The experimental group and the control group showed significant increases in diaphragm thickness ratio on the paretic side, but not on the non-paretic side. With regard to lung function, the experimental group showed significant increases in FEV1, PEF, and FEF25–75. The changes between before and after the intervention in the two groups were compared with each other, and the results showed significant differences in FEV1 and PEF. [Conclusion] The present study identified that IMT accompanied by abdominal stimulation improved the pulmonary function of chronic stroke patients.

著者

Jung Eun-Yong Lee Beom-Jun Yun Young Won KANG Jong-Koo BAEK In-Jeoung MIN-YON Jung LEE Yoon-Bok SOHN Heon-Soo LEE Jae-Yong KIM Kang-Sung YU Wook-Joon DO Jae Cheul KIM Young Cheul NAM Sang-Yoon

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.66, no.11, pp.1347-1354, 2004-11-25

被引用文献数

1 16

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大豆由来イソフラボンであるゲニステインは栄養補助食品としてその効果が認められているが,同時にエストロゲン様作用が雄性生殖器の発達に及ぼす影響も懸念されている.そこで,本研究では,この点を明らかにする為に,妊娠および授乳期に大豆ベースの餌を食べさせた母親から生まれた21日齢のマウスに,ゲニステイン(2.5mg/kg/day)およびエストラジオール(7.5μg/kg/day)を5週間投与した.実験期間中,マウスはカゼインベースのAIN-76で飼育を行った.ゲニステイン投与とコントロール群(コーンオイル投与)との間に精子数や精子運動能に関して違いは見られなかった.エストラジオール投与群では前立腺重量や精巣上体精子数が,コントロール群に比べて顕著に減少していた.セレン依存性ペルオキシダーゼ・スーパーファミリーのひとつであるphospholipid hydroperoxide glutathione peroxidase (PHGPx)はゲニステインおよびエストラジオール投与群で,コントロールに比べて有意に増加していた.エストラジオール投与は精子変性やアポトーシス増加,精巣上体の変性や前立腺のhyperplasiaを引き起こしていたが,ゲニステイン投与マウスでは,これらに関し異常は見られなかった.従って,成長期のゲニステインの日常的な摂取は,生殖器の発達や機能には影響を与えないことが示唆された.

著者

Shin-ya Ohba

出版者

日本応用動物昆虫学会

雑誌

Applied Entomology and Zoology (ISSN:00036862)

巻号頁・発行日

vol.44, no.3, pp.447-453, 2009-08-25 (Released:2009-12-16)

参考文献数

29

被引用文献数

8 24 8

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A number of descriptive reports suggest that Cybister larvae feed on tadpoles, fish, and aquatic insects; however, no quantitative study on their feeding habits has been reported. In order to elucidate the feeding ecology of C. brevis larvae, field observations and laboratory experiments were carried out. In the field, all C. brevis larvae fed on invertebrates, such as insects and isopoda, but did not eat vertebrates, such as fish and anuran larvae. A rearing experiment demonstrated that all C. brevis larvae provided with tadpoles died. Larvae provided with Odonata nymphs had a longer total body length than larvae reared with a mixture of tadpoles and Odonata nymphs. In addition, larvae of C. brevis could search for and eat motionless Odonata nymphs, but all larvae died from starvation when they were supplied with motionless tadpoles. These results suggested that C. brevis larvae mainly preyed upon invertebrate animals and did not eat vertebrate animals, such as tadpoles and fish.

著者

Jyh-Cherng JONG En-Fu CHANG

出版者

Eastern Asia Society for Transportation Studies

雑誌

Journal of the Eastern Asia Society for Transportation Studies (ISSN:18811124)

巻号頁・発行日

vol.6, pp.278-291, 2005 (Released:2008-03-14)

参考文献数

13

被引用文献数

21

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Railway operators are heavy users of electric energy. To implement energy saving programs and to study economical operation strategies, an energy estimating model is required. In this paper, two models for estimating energy consumption of single train operation are presented. To verify the proposed models, a real railway link and an electric train from Taiwan Railway Administration (TRA) are selected for the experiment. The energy consumption estimated from the proposed model is then compared with that estimated by other commercial software. It is found that the difference is only 0.22%, demonstrating that the proposed models are accurate enough in practice for estimating energy consumption. The models can be further extended to develop models and algorithms for estimating power demand of multiple-train operation and minimizing energy consumption through different driving strategies.

著者

Tanaka Yukari Fukushima Hirokata Okanoya Kazuo Myowa-Yamakoshi Masako

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-10-17

被引用文献数

4

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「子どもが育つ、親も育つ」-養育経験が脳の働きに与える影響-. 京都大学プレスリリース. 2014-10-20.

著者

レ-ル ヨ-ガン 松浦 寿夫 田村 恵子

出版者

青土社

雑誌

ユリイカ (ISSN:13425641)

巻号頁・発行日

vol.18, no.3, pp.p120-125, 1986-03

著者

Gotoh Shimpei Ito Isao Nagasaki Tadao Yamamoto Yuki Konishi Satoshi Korogi Yohei Matsumoto Hisako Muro Shigeo Hirai Toyohiro Funato Michinori Mae Shin-Ichi Toyoda Taro Sato-Otsubo Aiko Ogawa Seishi Osafune Kenji Mishima Michiaki

出版者

Elsevier Inc.

雑誌

Stem cell reports (ISSN:00928674)

巻号頁・発行日

vol.3, no.3, pp.394-403, 2014-09-09

被引用文献数

255

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ヒトiPS細胞から肺胞上皮細胞を分化誘導し、単離する方法を確立 -肺の再生/創薬研究につながる大きな一歩-. 京都大学プレスリリース. 2014-08-22.

著者

Muneo TAKAOKI Sachiko YANO Naomi MATHERS Fenny DWIVANY Rizkita ESYANTI Thomas DJAMALUDDIN Mhd Fairos ASILLAM Farahana KAMARUDIN Mohammed Selamat MADOM Sawat TANTIPHANWADI Nguyen Vu GIANG Kibo-ABC

出版者

(一社)日本航空宇宙学会

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.12, no.ists29, pp.Tp_1-Tp_5, 2014 (Released:2014-10-01)

被引用文献数

1

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The “Space Seeds for Asian Future (SSAF)” program is one of the activities of the “Kibo-ABC” initiative under the Asia-Pacific Regional Space Agency Forum (APRSAF). The program intends to promote understanding, and to give regional space agencies experience in the utilization of the Japanese Experiment Module, “Kibo”, of the International Space Station (ISS). It also aims to provide young people in the Asia-Pacific region with opportunities to learn about leading edge sciences through their participations in experiments under peculiar space conditions, including microgravity. Students from Indonesia, Malaysia, Thailand and Vietnam participated in the SSAF2010-2011 program. As part of this program seeds from each of these nations were flown to the ISS and kept in the Kibo Module. These seeds were then returned to Earth where they were germinated and compared to control seed not flown in space. This experiment involved researchers, students and the general public. In the SSAF2013 program, there are plans to cultivate seeds indigenous to Asia in the Kibo/ISS facilities. The plan is to send Azuki bean (Vigna angularis) to Kibo, and observe the growth of their seedlings under dark conditions. Members of the Kibo-ABC initiative are collaborating in the preparation of the seed germination testing procedures, following which many people, including children, students and researchers, are expected to participate in the program.

著者

Akira Sezai Masayoshi Soma Kin-ichi Nakata Mitsumasa Hata Isamu Yoshitake Shinji Wakui Hiroaki Hata Motomi Shiono

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.8, pp.2043-2049, 2013 (Released:2013-07-25)

参考文献数

25

被引用文献数

29 85

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Background: Febuxostat has been reported to have a stronger effect on hyperuricemia than allopurinol. Methods and Results: Cardiac surgery patients with hyperuricemia (n=141) were randomized to a febuxostat group or an allopurinol group. The study was single-blind, so the treatment was not known by the investigators. The primary endpoint was serum uric acid (UA) level. Secondary endpoints included serum creatinine, urinary albumin, cystatin-C, oxidized low-density lipoprotein (LDL), eicosapentaenoic acid/arachidonic acid ratio, total cholesterol, triglycerides, LDL, high-density lipoprotein, high-sensitivity C-reactive protein, blood pressure, heart rate, pulse wave velocity (PWV), ejection fraction, left ventricular mass index (LVMI), and adverse reactions. UA level was significantly lower in the febuxostat group than the allopurinol group from 1 month of treatment onward. Serum creatinine, urinary albumin, cystatin-C and oxidized LDL were also significantly lower in the febuxostat group. There were no significant changes in systolic blood pressure, PWV, and LVMI in the allopurinol group, but these parameters all had a significant decrease in the febuxostat group. Conclusions: Febuxostat was effective for high-risk cardiac surgery patients with hyperuricemia because it reduced UA more markedly than allopurinol. Febuxostat also had a renoprotective effect, inhibited oxidative stress, showed anti-atherogenic activity, reduced blood pressure, and decreased PWV and LVMI.  (Circ J 2013; 77: 2043–2049)

著者

亀井 輝彦 Li Yan Lee Seungpil 大和田 健 Nguyen Hao Nguyen Qui Mokhlesi Nima Hsu Cynthia Li Jason Ramachandra Venky 東谷 政昭 Pham Tuan 渡邉 光恭 本間 充祥 渡辺 慶久 井納 和美 Le Binh Woo Byungki Htoo Khin Tseng Tai-Yuan Pham Long Kim Kwang-ho Chen Yi-Chieh She Min Yuh Jong Chu Alex Chen Chen Puri Ruchi Lin Hung-Szu Chen Yi-Fang Mak William Huynh Jonathan Chan Jim Yang Daniel Shah Grishma Souriraj Pavithra Tadepalli Dinesh Tenugu Suman Gao Ray Popuri Viski Azarbayjani Behdad Madpur Ravindra Lan James Yero Emilio Pan Feng Hong Patrick Kang Jang Yong Moogat Farookh Fong Yupin Cernea Raul Huynh Sharon Trinh Cuong Mofidi Mehrdad Shrivastava Ritu Quader Khandker QUADER Khandker

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. ICD, 集積回路 (ISSN:09135685)

巻号頁・発行日

vol.112, no.15, pp.7-12, 2012-04-16

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19nm製造プロセスを用い、シングルチップとしては最大容量となる128Gb 3-bit/cell NAND型フラッシュメモリを開発した。NAND型フラッシュメモリとしては最大のGb/mm^2である、チップサイズ170mm^2を実現した。3-bit per cellでありながら、All Bit-Line(ABL)アーキテクチャ、Air Gap技術、400MbpsトグルモードI/Oインターフェースの採用により、標準BCH ECCにおいても18MB/sの書き込みスループットを実現した。

著者

樋笠 勝士 荻野 弘之 佐藤 直子 長町 裕司 O'LEARY Joseph 川村 信三 児嶋 由枝 竹内 修一 HOLLERICH Jean-c 村井 則夫

出版者

上智大学

雑誌

基盤研究(B)

巻号頁・発行日

2006

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本研究は、平成18年度から21年度にわたる4年間の研究計画により、西洋中世における「美」の概念を、とくに新プラトン主義の受容と変容という課題に絞って、歴史研究を行うものである。本研究の独創性は「美」の概念について、古代末期思想家プロティノスに始まる新プラトン主義美学思想が、西洋中世キリスト教思想にどのような影響を与えたのかを解明する点にある。その思想の影響系列は、「美」を「光」と関係づけるキリスト教の伝統的な形而上学思想の原型をつくりだし、また典礼芸術等の芸術現象に展開する文化的基礎となる概念形成にも展開している。さらに中世の神学思想における超越概念にも影響を与える基本思想にもなっていることから、美学研究のみならず西洋中世思想研究の基礎研究にとって、本研究課題は思想史研究上の大きな意義を有するものとなる。

著者

Ryoji Nagai Jun-ichi Shirakawa Yukio Fujiwara Rei-ichi Ohno Narumi Moroishi Noriyuki Sakata Mime Nagai

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.55, no.1, pp.1-6, 2014 (Released:2014-07-01)

参考文献数

29

被引用文献数

15 39

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Approximately 100 years have passed since the Maillard reaction was first reported in the field of food chemistry as a condensation reaction between reducing sugars and amino acids. This reaction is thought to progress slowly primarily from glucose with proteins in vivo. An early-stage product, called the ”Amadori product”, is converted into advanced glycation end products. Those accumulate in the body in accordance with age, with such accumulation being enhanced by lifestyle-related diseases that result in the denaturation of proteins. Recent studies have demonstrated that intermediate carbonyls are generated by several pathways, and rapidly generate many glycation products. However, accurate quantification of glycation products in vivo is difficult due to instability and differences in physicochemical properties. In this connection, little is known about the relationship between the structure of glycation products and pathology. Furthermore, the interaction between proteins modified by glycation and receptors for advanced glycation end products is also known to induce the production of several inflammatory cytokines. Therefore, those inhibitors have been developed over the world to prevent lifestyle-related diseases. In this review, we describe the process of protein denaturation induced by glycation and discuss the possibility of using the process as a marker of age-related diseases.

著者

Hae-Won JUNG Hee-Chun LEE Ji-Hyun KIM Hyo-Mi JANG Jong-Hyun MOON Jung-Hyang SUR Jeongim HA Dong-In JUNG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0001, (Released:2014-08-13)

被引用文献数

3 12

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An 8-year-old intact male Belgian Malinois, weighing 37.2 kg, was referred for evaluation due to right side facial paresis, ataxia and a two-month history of decreased cognitive ability. Physical and neurological examinations revealed mild depression, left-sided head tilt, right-sided facial paresis and ataxia. A well-demarcated, broad-based cerebellar mass and hyperostosis were found on CT imaging of the brain. Based on these CT findings, a cerebellar meningioma was strongly suspected. Hydroxyurea and prednisolone were administered; after 4 weeks, there was reduction in mass size as compared to initial CT results. However, the mass size was found to have grown 6 weeks after hydroxyurea treatment. We then prescribed a combination of imatinib mesylate and hydroxyurea. Two weeks following combination treatment, the mass size had reduced significantly. The mass continuously decreased in size until the patient died during anesthesia. Cerebellar transitional meningioma was confirmed by histopathologic examination. To the author’s knowledge, this is the first reported case of imatinib mesylate plus hydroxyurea therapy for the treatment of meningioma in veterinary medicine.

著者

大塚 攻 長澤 和也 Ho Ju-Shey GRYGIER MARK J.

出版者

日本プランクトン学会

雑誌

日本プランクトン学会報 (ISSN:03878961)

巻号頁・発行日

vol.51, no.1, pp.13-24, 2004-02-25

参考文献数

100

被引用文献数

6

著者

Eun-Woo LEE Seong-Kyoon CHOI Gil-Jae CHO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0189, (Released:2014-07-15)

被引用文献数

1 8

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The present study was conducted to analyze the genetic characteristics of the Donggyeong dog and establish parentage conservation systems for it by using 10 microsatellite markers recommended by the International Society for Animal Genetics (ISAG). A total of 369 dogs from 12 dog breeds including the Donggyeong dog were genotyped using 10 microsatellite loci. The number of alleles per locus varied from 5 to 10 with a mean value of 7.6 in the Donggyeong dog. The observed heterozygosity and expected heterozygosity ranged from 0.4706 to 0.9020 (mean 0.7657) and from 0.4303 to 0.8394 (mean 0.7266), respectively. The total exclusion probability of 10 microsatellite loci was 0.99955. Of the 10 microsatellite markers, the AHT121, AHTh260 and CXX279 markers had relatively high PIC values (≥0.7). This study found that there were specific alleles, 116 allele at AHT121 in the Donggyeong dog when compared with other dog breeds. Also, the results showed two (Korean native dogs and the foreign dog breeds) distinct clusters. The closest distance (0.1184) was observed between the Donggyeong dog and Jindo dog, and the longest distance (0.3435) was observed between the Donggyeong dog and Bulgae. The Korean native dog breeds have comparatively near genetic distances between each other.

著者

Mari Maeda-Yamamoto Kaori Ema Manami Monobe Ikuo Shibuichi Yuki Shinoda Tomohiro Yamamoto Takao Fujisawa

出版者

一般社団法人日本アレルギー学会

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.58, no.3, pp.437-444, 2009 (Released:2009-09-11)

参考文献数

20

被引用文献数

28

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Background: We previously reported that 'benifuuki' green tea containing O-methylated catechin significantly relieved the symptoms of perennial or seasonal rhinitis compared with a placebo green tea that did not contain O-methylated catechin in randomized double-blind clinical trials. In this study we assessed the effects of 'benifuuki' green tea on clinical symptoms of seasonal allergic rhinitis. Methods: An open-label, single-dose, randomized, parallel-group study was performed on 38 subjects with Japanese cedar pollinosis. The subjects were randomly assigned to long-term (December 27, 2006 - April 8, 2007, 1.5 months before pollen exposure) or short-term (February 15, 2007: after cedar pollen dispersal - April 8, 2007) drinking of a 'benifuuki' tea drink containing 34mg O-methylated catechin per day. Each subject recorded their daily symptom scores in a diary. The primary efficacy variable was the mean weekly nasal symptom medication score during the study period. Results: The nasal symptom medication score in the long-term intake group was significantly lower than that of the short-term intake group at the peak of pollen dispersal. The symptom scores for throat pain, nose-blowing, tears, and hindrance to activities of daily living were significantly better in the long-term group than the short-term group. In particular, the differences in the symptom scores for throat pain and nose-blowing between the 2 groups were marked. Conclusions: We conclude that drinking 'benifuuki' tea for 1.5 months prior to the cedar pollen season is effective in reducing symptom scores for Japanese cedar pollinosis.

著者

Mikawa Takumi Maruyama Takeshi Okamoto Koji Nakagama Hitoshi Lleonart Matilde E Tsusaka Takeshi Hori Kousuke Murakami Itsuo Izumi Taisuke Takaori-Kondo Akifumi Yokode Masayuki Peters Gordon Beach David Kondoh Hiroshi

出版者

The Rockefeller University Press

雑誌

The Journal of cell biology (ISSN:00219525)

巻号頁・発行日

vol.204, no.5, pp.729-745, 2014-03-03

被引用文献数

31

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細胞老化から癌化への変換のカギとなる解糖系制御機構解明に成功 -代謝を標的とした新しい抗がん剤開発に期待-. 京都大学プレスリリース. 2014-02-24.

著者

Shingo MAEDA Koichi OHNO Kazuyuki UCHIDA Hirotaka IGARASHI Yuko GOTO-KOSHINO Yasuhito FUJINO Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0060, (Released:2014-05-15)

被引用文献数

7 19

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Serine proteases elicit cellular responses via protease-activated receptor-2 (PAR-2) which is known to regulate inflammation and the immune response. Although the gastrointestinal tract is exposed to large amounts of proteolytic enzymes, the role of PAR-2 in canine inflammatory bowel disease (IBD) remains unclear. The objective of this study was to investigate the effects of PAR-2 activation on inflammatory cytokine/chemokine gene expression in canine intestine and the expression of intestinal PAR-2 and fecal serine protease activity in dogs with IBD. Duodenal biopsies from healthy dogs were cultured and treated ex vivo with trypsin or PAR-2 agonist peptide, and inflammatory cytokine/chemokine gene expression in the tissues was then quantified by real-time PCR. PAR-2 mRNA and protein expression levels in the duodenal mucosa were examined by real-time PCR and immunohistochemistry, respectively. Fecal serine protease activity was determined by azocasein assay. In ex vivo-cultured duodenum, trypsin and PAR-2 agonist peptide induced significant up-regulation of mRNA expression levels of interleukin-1 β (IL-1β), IL-8, mucosae-associated epithelial chemokine (MEC) and fractalkine, and this up-regulation was inhibited by a serine protease inhibitor. Duodenal PAR-2 mRNA and protein expression levels were higher in dogs with IBD than in healthy control dogs. Fecal serine protease activity was significantly elevated in dogs with IBD, and the level of activity correlated positively with the clinical severity score. These results suggest that PAR-2 may contribute to the pathogenesis of canine IBD by inducing expression of inflammatory mediators in response to luminal serine proteases.

著者

E. Wulff-Barreiro

出版者

CODATA

雑誌

Data Science Journal (ISSN:16831470)

巻号頁・発行日

vol.10, pp.13-23, 2011-11-27 (Released:2011-11-27)

参考文献数

17

被引用文献数

1

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As observational data has attained new legal status, allowing their integration into open Internet systems, and experimental data continues to be assembled in common and free platforms, state of the art, easy to access data repositories have been designed in Spain. These repositories have removed many obstacles to re-utilization of GIS and other data. European legislation has also made advances in opening biodiversity data, including a European space in the Latin-American grid infrastructure. Open access biomedical repositories attract commercial attention while astronomical, meteorological, and oncological institutions promote data quality and access. This paper describes recent approaches to open access data for science in Spain.