著者

Eri Katsuyama Ken-ei Sada Noriko Tatebe Haruki Watanabe Takayuki Katsuyama Mariko Narazaki Koichi Sugiyama Katsue S. Watanabe Hiroshi Wakabayashi Tomoko Kawabata Jun Wada Hirofumi Makino

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.8, pp.991-994, 2016 (Released:2016-04-15)

参考文献数

16

被引用文献数

8

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Idiopathic intracranial hypertension (IIH) is a syndrome of increased intracranial pressure and presents as an intractable headache, vomiting, and ophthalmologic manifestations. We herein report the case of a young girl who presented with bilateral abducens nerve palsy due to IIH as the onset of systemic lupus erythematosus (SLE). The patient was successfully treated with corticosteroid therapy. Our case lacked the typical symptoms of IIH, such as headache or nausea; therefore, it is necessary to carefully determine the cause of bilateral abducens nerve palsies. The development of IIH in SLE patients is a rare occurrence, but this manifestation should not be overlooked.

著者

Orikasa Yuki Masese Titus Koyama Yukinori Mori Takuya Hattori Masashi Yamamoto Kentaro Okado Tetsuya Huang Zhen-Dong Minato Taketoshi Tassel Cédric Kim Jungeun Kobayashi Yoji Abe Takeshi Kageyama Hiroshi Uchimoto Yoshiharu

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-07-11

被引用文献数

288

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高エネルギー密度・高安全性・低コスト二次電池の開発に成功 -リチウムからマグネシウム金属へ-. 京都大学プレスリリース. 2014-07-11.

著者

Dah-Renn FU Daiki KATO Yoshifumi ENDO Tsuyoshi KADOSAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0693, (Released:2016-04-15)

被引用文献数

10

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Nasal lymphoma is the most common nasal tumor in cats and is generally a solitary and radiosensitive tumor. We retrospectively evaluated the response to radiation and survival time in relation to apoptosis and Ki-67 indices in feline nasal lymphomas treated with radiation therapy. The apoptotic and Ki-67 indices were evaluated with TUNEL and immunohistochemical staining in 30 biopsy tissues that were taken before any treatment. These two indices were compared, and differences between different treatment response groups were analyzed. The correlation between the median survival times (MST) and the indices was estimated using the Kaplan Meier method, and statistical differences between survival curves were analyzed using a log-rank method. With regard to apoptotic index, a statistical difference was observed between the samples taken from cats with complete response and stable disease (1.22% vs. 0.45%; P=0.045). The Ki-67 index in cats with both complete response and partial response was significantly higher than in cats with stable disease (44.4% and 39.6% vs. 16.3%; P<0.001 and P=0.008, respectively). The cats with a high level of apoptosis (>0.9%) nasal lymphoma were not significantly prolonged MSTs (P=0.202), however, high Ki-67-positive (>40%) cats experienced a statistically significant relationship with longer survival time (P=0.015). Our results indicate that spontaneous apoptotic and Ki-67 indices are strong predictors for response to radiation therapy in feline nasal lymphomas.

著者

Seungbum Son Kunho Han Wi-Young So

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.3, pp.718-721, 2016 (Released:2016-03-31)

参考文献数

16

被引用文献数

2

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[Purpose] Our aim was to evaluate the relationships between waist and mid-thigh circumference, used as proxy measures of trunk and lower limb strengths, respectively, and selected parameters of driver and putting performance in Korean college golfers. [Subjects and Methods] The participants were 103 college golfers (81 male, 20 to 27 years old). Measurements of body composition, waist and mid-thigh circumference, and grip strength, as well as assessment of golf performance, including driver distance, driver swing speed, putting accuracy, and putting consistency, were performed at the golf performance laboratory at Konkuk University in Chungju-si, Republic of Korea. Average round score was obtained from 10 rounds of golf completed during the study period. The relationships between strength measures and golf performance were evaluated by partial correlation analysis, with adjustment for age, golf experience, and body mass index. [Results] Waist circumference did not correlate with any of the performance variables in both males and females. Mid-thigh circumference correlated with putting consistency (r = 0.364) in males and with putting consistency (r = 0.490) and accuracy (r = 0.547) in females. No other significant correlations between waist and mid-thigh circumference and golf performance were identified. [Conclusion] Lower limb strength may be an important component of putting performance. Further studies are needed to fully characterize the contributions of trunk strength to performance.

著者

Chuwa Tei Teruhiko Imamura Koichiro Kinugawa Teruo Inoue Tohru Masuyama Hiroshi Inoue Hirofumi Noike Toshihiro Muramatsu Yasuchika Takeishi Keijiro Saku Kazumasa Harada Hiroyuki Daida Youichi Kobayashi Nobuhisa Hagiwara Masatoshi Nagayama Shinichi Momomura Kazuya Yonezawa Hiroshi Ito Satoshi Gojo Makoto Akaishi Masaaki Miyata Mitsuru Ohishi WAON-CHF Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.4, pp.827-834, 2016-03-25 (Released:2016-03-25)

参考文献数

32

被引用文献数

42

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Background:Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain.Methods and Results:In 19 institutes, we prospectively enrolled hospitalized patients with advanced HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission and BNP >300 pg/ml regardless of more than 1 week of medical therapy. Enrolled patients were randomized into Waon therapy or control groups. Waon therapy was performed once daily for 10 days with a far infrared-ray dry sauna maintained at 60℃ for 15 min, followed by bed rest for 30 min covered with a blanket. The primary endpoint was the ratio of BNP before and after treatment. In total, 76 Waon therapy and 73 control patients (mean age 66 years, men 61%, mean plasma BNP 777 pg/ml) were studied. The groups differed only in body mass index and the frequency of diabetes. The plasma BNP, NYHA classification, 6-min walk distance (6MWD), and cardiothoracic ratio significantly improved only in the Waon therapy group. Improvements in NYHA classification, 6MWD, and cardiothoracic ratio were significant in the Waon therapy group, although the change in plasma BNP did not reach statistical significance. No serious adverse events were observed in either group.Conclusions:Waon therapy, a holistic soothing warmth therapy, showed clinical advantages in safety and efficacy among patients with advanced HF. (Circ J 2016; 80: 827–834)

著者

Jean-Bernard Henrotin Cyndie Picot Myriam Bouslama Dorothée Collot-Fertey Anca Radauceanu Marie-thérèse Labro Béatrice Larroque Alain-Claude Roudot Nessryne Sater Mostafa Ould Elhkim Dominique Lafon

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.57, no.6, pp.485-496, 2015 (Released:2015-12-25)

参考文献数

49

被引用文献数

11

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Objectives: The aim of this study was to perform a systematic review and to use a meta-analytical approach to assess quantitatively the risk of adverse pregnancy outcomes in hairdressers and cosmetologists. Methods: A systematic literature search up to 1 February 2012 was carried out using major bibliographic databases, grey literature, contacts with research teams working on the subject, review papers and reference lists of selected articles. Observational studies reporting measures of effects in relation with body care (hairdressers, cosmetologists, etc.) and reproductive disorders were included. Study quality was assessed by three reviewers. The estimated risk ratios (RR) from all studies reporting on identical outcomes were combined using an average of logarithm transformation of estimated RR weighted by their inverted variance. Statistical heterogeneity across studies was assessed using Cochran's Q test. To explore the sources of heterogeneity, several sensitivity analyses and subgroup analyses were conducted based on study quality, country, study period, alcohol consumption, smoking habit, jobs and control populations. Results: Nineteen studies were selected and reviewed in-depth. The combined risk ratios (RRcs) of five reproductive outcomes were calculated and found to be significantly increased for four outcomes: time to pregnancy, which had an RRc of 1.11 (95% CI: 1.03–1.19); premature birth, which had an RRc of 1.05 (95% CI: 0.99–1.11); small for gestational age, which had an RRc of 1.24 (95 CI%: 1.10–1.41); low birth weight, which had an RRc of 1.21 (95% CI: 1.06–1.39); and embryonic and fetal losses, which had an RRc of 1.19 (95% CI: 1.03–1.38). Conclusions: This work confirms a weak increase in risk of some reproductive disorders in female hairdressers/cosmetologists. However, the evidence level is rather weak, and a causal association between job and reproductive outcomes cannot be asserted.(J Occup Health 2015; 57: 485–496)

著者

Eun-Mi LEE Ah-Young KIM Eun-Joo LEE Jin-Kyu PARK Tae-Hwan KIM Se-Il PARK Kyu-Shik JEONG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0715, (Released:2016-03-13)

被引用文献数

1

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A 13-year-old castrated male Yorkshire terrier dog had a soft splenic mass, which measured 11 cm in the greatest diameter. Microscopically, the parenchyma of the spleen was completely replaced by myxoid substances. Numerous spindle and stellate cells were loosely arranged in the myxoid stroma, and variable vessels of variable sizes were observed in a loose matrix with poorly defined margins. Immunohistochemical analysis showed that tumor cells were positive for desmin and alpha-SMA, but negative for S-100. Interestingly, intravascular tumor embolus with positive α-SMA expression was observed. This case is meaningful, because angiomyxoma, a rare tumor of dogs, occurs in the spleen. Even in human cases, splenic angiomyxoma was not reported.

著者

Sato-Iwanaga Junko Yu Zhiping Dutton Robert Tsuchiya Hideaki

出版者

Institute of Physics

雑誌

Jpn. J. Appl. Phys. (ISSN:00214922)

巻号頁・発行日

vol.55, no.4, 2016-02-29

被引用文献数

1

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The nonlinear characteristics arising from the third-order intermodulation distortion (IMD3) of MOSFETs are investigated by harmonic-balance device simulation. First, to identify the spatial location in a MOSFET, where IMD3 is mostly generated, a conventional n-MOSFET structure is simulated, and it is found that IMD3 generation is located at the top surface over the channel–drain p–n junction where a high lateral electric-field exists. Second, to alleviate the impact of IMD3, we proposed and simulated three types of n-MOSFET structures with a low lateral electric-field around the channel–drain junction. We demonstrated that a low-distortion MOSFET can be realized by optimizing the doping concentration profile at the channel–drain junction. In particular, the introduction of a thin layer of a low-doped n-type surface-channel and a low-doped n-type drain at the top of p-type well and n-type drain regions resulted in a marked IMD3 reduction of as much as 8 dBm in IMD3 power characteristics, in comparison with a conventional structure.

著者

Chiara Bernelli Kunihiro Shimamura Kenichi Komukai Davide Capodanno Francesco Saia Roberto Garbo Francesco Burzotta Vasile Sirbu Micol Coccato Gianluca Campo Luigi Vignali Hirosada Yamamoto Giampaolo Niccoli Elena Ladich Giuseppe Biondi-Zoccai Giulio Guagliumi

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-1140, (Released:2016-02-08)

参考文献数

23

被引用文献数

1 5

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Background:The role of culprit plaque and related atherothrombotic components on incomplete stent apposition (ISA) occurrence after primary percutaneous coronary intervention (p-PCI) is unknown.Methods and Results:ST-segment elevation myocardial infarction (STEMI) patients undergoing p-PCI with an everolimus-eluting stent were prospectively investigated with optical coherence tomography (OCT) of the infarct-related artery before, after stenting and at 9 months. OCT data, aspirated thrombus and serum inflammatory biomarkers were analyzed. 114 patients with 114 lesions were evaluated. Acute ISA occurred in 82 lesions (71.9%), preferentially in larger vessels with a median area of 0.2 mm2. The presence of thrombus before stent implantation (odds ratio (OR) 5.5, 95% confidence interval (CI) [1.1–26.9], P=0.04) and the lipid content in the target segment (OR 1.3, 95% CI [1.0–1.5], P=0.04) independently predicted acute ISA. At 9-month follow-up, ISA persisted in 46 lesions (56.1%). The volume of acute ISA significantly predicted persistent ISA (OR 1.3, 95% CI [1.1–1.5], P=0.01). Late-acquired ISA occurred in 39 lesions (34.2%) with a median area of 0.3 mm2. Red/mixed thrombus before stent implantation (OR 3.7, 95% CI [1.0–13.3], P=0.05) and length of the underlying ruptured plaque (OR 1.7, 95% CI [1.1–2.8] P=0.02) were independently associated with late-acquired ISA.Conclusions:In STEMI patients, culprit plaque and atherothrombotic components of the infarct-related artery significantly contribute to the onset of acute and late ISA. ISA persistence at follow-up depends on the initial volume of acute ISA.

著者

im Auftrage des Max-Plank-Instituts für Geschichte bearbeitet von Wilhelm Kohl

出版者

Walter de Gruyter

巻号頁・発行日

1999

著者

Hee Soon Shin Min-Jung Bae Sun Young Jung Hye-Jeong See Yun Tai Kim Jeong-Ryong Do Su Yeon Back Sang-Won Choi Dong-Hwa Shon

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.38, no.11, pp.1707-1713, 2015-11-01 (Released:2015-11-01)

参考文献数

26

被引用文献数

9

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Trachelospermi caulis is used widely as an herbal medicine in oriental countries to attenuate fever and pain. We wished to reveal the novel function of this herb and its active component on barrier function in intestinal epithelial cells. Monolayers of intestinal epithelial cells (Caco-2) were used to evaluate the transepithelial electrical resistance (TEER) and quantity of permeated ovalbumin (OVA) as indices of barrier function. T. caulis increased TEER values on cell monolayers and decreased OVA permeation across cell monolayers. To ascertain the active component of T. caulis, the extract was isolated to five fractions, and the effect of each of these fractions on intestinal barrier function examined. Chloroform and ethyl acetate fractions showed increased TEER values and decreased OVA flux. Chloroform and ethyl acetate fractions contained mainly trachelogenin and its glycoside, tracheloside. Trachelogenin increased TEER values and decreased OVA flux by enhancing the tight-junction protein occludin (but not tracheloside) in Caco-2 monolayers. These findings demonstrated that trachelogenin, an active component of T. caulis, might help to attenuate food allergy or inflammatory bowel disease through inhibition of allergen permeation or enhancement of the intestinal barrier.

著者

キムラ-スティーブン チグサ

出版者

国際日本文化研究センター

雑誌

日文研フォーラム

巻号頁・発行日

vol.第145回, pp.1-50, 2005-03

著者

Ui-Cheol Jeong Cheol-Yong Kim Young-Han Park Gak Hwang-Bo Chan-Woo Nam

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.1, pp.46-50, 2016 (Released:2016-01-30)

参考文献数

20

被引用文献数

12

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[Purpose] This study aimed to examine the effects of self-mobilization techniques for the sciatic nerves on the quality of life in patients with chronic low back pain in the lower limbs accompanied by radiating pain. [Subjects and Methods] The subjects were divided into two groups: a group receiving of lumbar segmental stabilization exercise training including sciatic nerve mobilization techniques, which included 8 males and 7 females, and a group receiving lumbar segmental stabilization exercise training, which included 8 males and 7 females. [Results] There were statistically significant differences in comparison of measurement results between the groups before and after the intervention. [Conclusion] Application of mobilization techniques for the sciatic nerves may promote healing of the soft tissues by stimulating the functions of the nervous system to improve nervous system adaptability and decrease sensitivity, helping to alleviate the symptoms.

著者

Tetsuo Shimada Naoya Hijikata Ken-ichi Tokita Kiyoshi Uchida Masayuki Kurechi Hitoshi Suginome Yumi Yamada Hiroyoshi Higuchi

出版者

日本鳥学会

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.15, no.1, pp.37-45, 2016 (Released:2016-02-05)

参考文献数

30

被引用文献数

5

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Japan hosts more than 40% population of Brent Goose Branta bernicla wintering in East Asia. We used satellite-tracking technology to monitor the seasonal movements and habitat usage of Brent Goose wintering in northern Japan. We marked five geese on the Oya sandy beach, Miyagi Prefecture, northeast Honshu, on 21 January 2014. The geese utilized areas along the seacoast, especially concentrating at a small bay, close to the capture site. Most of the geese offshore were found at fishery rafts. No geese were found more than 2 km offshore or more than 6 km from the capture site along the seacoast. In early April, the geese left the southern Sanriku coast and moved up to eastern Hokkaido, crossing the sea directly or via the coastal areas of Iwate and Aomori Prefectures. The geese predominantly remained in the vicinity of the Veslovskiy Peninsula, Kunashiri (Kunashir) Island, while some were distributed along the northern coast of the Nemuro Peninsula. We identified eastern Hokkaido and Kunashiri Island as important stopover sites for Brent Goose wintering in Japan.

著者

Hsien-Te Peng Chen-Yi Song

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.12, pp.3873-3878, 2015 (Released:2015-12-28)

参考文献数

35

被引用文献数

1 2

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[Purpose] The purpose of this study was to investigate the effect of leg press and leg press with hip adduction exercise training on patellar alignment and pain in patients with patellofemoral pain (PFP). [Subjects and Methods] Seventeen patients participated in this study. Eight weeks of leg press or leg press with hip adduction training, including progressive lower-limb weight-training and stretching, was given. Patellar alignment (tilt and displacement) and pain measurements were conducted before and after leg press or leg press with hip adduction training. Patellar tilt angle and the bisect offset index were measured on axial computed tomography scans of the fully extended knee position with the quadriceps relaxed and contracted. Pain was assessed by using a 10-cm visual analog scale. [Results] No differences were found in patellar tilt and displacement with the quadriceps either relaxed or contracted after leg press and leg press with hip adduction. However, significant pain reduction was evident in both leg press and leg press with hip adduction. [Conclusion] The results indicated that patellar realignment does not appear to mediate pain alleviation. Furthermore, hip adduction in addition to leg press training had no additive beneficial effect on patellar realignment or pain reduction.

著者

Al-Adawi Samir 鄭 志誠 辻内 琢也 葉山 玲子 吉内 一浩 熊野 宏昭 久保木 富房

出版者

一般社団法人日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.45, no.12, pp.933-941, 2005-12-01

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国際的にみて, 精神的外傷を引き起こすような死別に対し, 十分に対処がとられている社会は少ない.これにもかかわらず, 死別に対する反応を社会的特性という観点でとらえる人類学的研究はごくわずかであり, 死への悲嘆反応は, 心身医学的問題としてとらえられている傾向がある.本稿では, オマーンの伝統的な社会に存続する不慮の死における死者の生き返り(zombification), そして呪術や魔法に関する信仰(信念)を紹介する.これらの反応は社会的に容認されており, 死者の死の否定を基礎としている.さらに考察では, これらを説明モデルという概念を用いて分析し, 世界各地で観察される類似する悲嘆反応を欧米のタナトロジー(死亡学)研究におけるそれと比較し, 新たな視点で論じる.

著者

Richard Duncan-Jones

出版者

Cambridge University Press

巻号頁・発行日

1982

著者

Richard Duncan-Jones

出版者

Cambridge University Press

巻号頁・発行日

1994

著者

Amaya García-Fernández Francisco Marín Vanessa Roldán José M Gómez-Sansano Diana Hernández-Romero Mariano Valdés Juan G Martinez-Martinez Francisco Sogorb-Garri Gregory YH Lip

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-0992, (Released:2016-01-14)

参考文献数

35

被引用文献数

1 5

---

Background:Patients with nonvalvular atrial fibrillation (AF) who undergo electrical cardioversion (ECV) tend to be younger and have less comorbidity. Long-term anticoagulation after ECV should be based on thromboembolic risk. We sought to study the long-term incidence of thromboembolic events (TE), factors related to TE and compare the predictive value of the CHADS2and CHA2DS2-VASc scores in this particular population.Methods and Results:From January 2008 to June 2012, 571 ECV were performed in 406 consecutive patients with nonvalvular AF. Risk factors for TE and factors related to anticoagulation therapy after ECV were registered. During a follow-up of approximately 2 years, the annual incidence of TE was 1.9%. Factors associated with TE were: poor quality anticoagulation control (hazard ratio [HR]: 2.91; 95% confidence interval [CI]: 1.10–7.80; P=0.03), cessation of anticoagulation after ECV (HR: 8.80; 95% CI: 3.11–25.10; P<0.001), age ≥65 years (HR: 13.65; 95% CI: 1.74–107.16; P=0.01), CHADS2score (HR: 1.59; 95% CI: 1.10–2.29; P=0.01) and CHA2DS2-VASc score (HR: 1.67; 95% CI: 1.30–2.22; P<0.001). Both risk scores predicted TE [c-statistic for CHADS2: 0.68 (95% CI: 0.62–0.74; P=0.005), for CHA2DS2-VASc: 0.75 (95% CI: 0.70–0.80; P<0.001)]. Based on c-statistics, the predictive accuracy of CHA2DS2-VASc was superior (difference between areas: 0.064±0.031; P=0.0403).Conclusions:Important determinants of long-term occurrence of TE after ECV were related to anticoagulant therapy (poor quality anticoagulation and cessation of this therapy over follow-up). The CHA2DS2-VASc score successfully predicts TE after ECV, having better predictive accuracy than the CHADS2score.

著者

Mariko Harada-Shiba Osamu Arisaka Akira Ohtake Tomoo Okada Hideki Suganami NK-104-PH 01 study registration group

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.23, no.1, pp.48-55, 2016-01-06 (Released:2016-01-06)

参考文献数

14

被引用文献数

2 15 2

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Aim: The purpose of this study was to evaluate the efficacy and safety of LIVALO® tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH).Methods: A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin (1 mg/day or 2 mg/day) was administered orally for 52 weeks.The primary endpoint was the percent change in the LDL-cholesterol (LDL-C) concentrations from baseline to endpoint (repeated measures ANCOVA at Weeks 8 and 12). Secondary endpoints included the percentage of patients who achieved the target LDL-C concentration and percent changes in the levels of lipoprotein and lipid parameters at the visit performed at 52 weeks.Results: The percent change in LDL-C from baseline (mean 258 mg/dL for all patients) to the endpoint was -27.3% (95%CI; -34.0, -20.5) and -34.3% (95%CI; -41.0, -27.5) in the patients receiving 1 mg and 2 mg of pitavastatin, respectively. Stable reductions in the total cholesterol (TC), non-HDL cholesterol (non-HDL-C), apolipoprotein B (Apo-B) and LDL-C levels and non-HDL-C/HDL-C and Apo-B/Apo-A1 ratios were observed up to 52 weeks in both groups. One patient in each dose group (14%) reached the treatment target level of 130 mg/dL.Adverse events were observed in seven (100%) patients receiving 1 mg and five (71%) patients receiving 2 mg of pitavastatin, although none were considered related to the study treatment. One patient in the 1 mg group reported a musculoskeletal AE; however, it was attributed to recent excessive exercise.Conclusions: Pitavastatin significantly reduced the LDL-C levels and was well tolerated when administered at usual adult doses in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin is a promising therapeutic agent for pediatric dyslipidemia with few safety concerns.