著者

Sang-Min SHIN Suhee KIM Jin-Gi HONG Yong-Jun KIM

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0049, (Released:2014-04-09)

被引用文献数

1 12

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The aim of study was to evaluate the effects of insulin-like growth factor I (IGF-I) on canine sperm function during cooled and freeze-thaw storage. Extenders supplemented with different IGF-I concentrations (0, 100 and 200 ng/ml) were added to canine spermatozoa and the sperm samples were stored at 4°C for 48 hr or freeze-thawed. Sperm motility, morphology, plasma-membrane integrity (PMI) and mitochondrial membrane potential (MMP) were evaluated. IGF-I had no effect on PMI or morphology during cooling and freeze-thawing. However, IGF-I alleviated the reduction in progressive motility and MMP caused by cooled storage and led to an improvement in MMP after freeze-thawing. In conclusion, IGF-I can be helpful to maintain progressive motility of canine spermatozoa during hypothermic storage via increased MMP.

著者

グ-バレフ V.S.

出版者

日本原子力産業会議

雑誌

原子力資料 (ISSN:03870928)

巻号頁・発行日

no.221, pp.p11-21, 1989-06

著者

Yuuichi Nakano Mitsuo Iwadate Hideaki Umeyama Y-h. Taguchi

出版者

一般社団法人 情報処理学会

雑誌

IPSJ Transactions on Bioinformatics (ISSN:18826679)

巻号頁・発行日

vol.7, pp.2-15, 2014 (Released:2014-01-17)

参考文献数

15

被引用文献数

1

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Type III secretion system (T3SS) effector protein is a part of bacterial secretion systems. T3SS exists in the pathogenic and symbiotic bacteria. How the T3SS effector proteins in these two classes differ from each other should be interesting. In this paper, we successfully discriminated T3SS effector proteins between plant pathogenic, animal pathogenic and plant symbiotic bacteria based on feature vectors inferred computationally by Yahara et al. only from amino acid sequences. This suggests that these three classes of bacteria employ distinct T3SS effector proteins. We also hypothesized that the feature vector proposed by Yahara et al. represents protein structure, possibly protein folds defined in Structural Classification of Proteins (SCOP) database.

著者

Hirotaka YANAGAWA Hitoshi HATAI Takahiro TAODA Hassadin BOONSRIROJ Kazunori KIMITSUKI Chun-Ho PARK Toshifumi OYAMADA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0097, (Released:2014-03-26)

被引用文献数

1 9

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An 11-year-old mixed breed dog was presented with signs of anorexia. Radiographic and ultrasound examination revealed a large mass in the heart, between the right atrium and the right ventricle. Upon gross inspection, a multilobulated tumor arising from the right atrial wall and occupying the right atrium was identified. Microscopical analysis demonstrated that this tumor consisted of neoplastic cells with granular cytoplasm, which were separated into nests by fine fibrovascular stroma, and was negative for Grimelius’s method. Immunohistochemical examinations revealed that the neoplastic cells expressed chromogranin A, synaptophysin and neuron specific enolase. Electron microscopy revealed that the cytoplasm of the neoplastic cells held secretory granules. Based on these pathological findings, the tumor was diagnosed as a paraganglioma. This report is a rare case of primary paraganglioma deriving from the right atrium and provides a detailed characterization of its morphological features.

著者

Yusuke HORI Takatoshi OZAKI Yoshimitsu YAMADA Teruaki TOZAKI Heui-Soo KIM Ayaka TAKIMOTO Maiko ENDO Noboru MANABE Miho INOUE-MURAYAMA Kazuo FUJITA

出版者

日本ウマ科学会

雑誌

Journal of Equine Science (ISSN:13403516)

巻号頁・発行日

vol.24, no.3, pp.31-36, 2013 (Released:2013-09-30)

参考文献数

15

被引用文献数

2 12

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Genetic polymorphisms in genes related to neurotransmitters or hormones affect personality or behavioral traits in many animal species including humans. In domestic animals, the allele frequency of such genes has been reported to be different among breeds and it may account for breed differences in behavior. In this study, we investigated breed differences in horses in the dopamine receptor D4 gene (DRD4), which has been reported to affect horse personality. We collected samples from seven horse breeds including those native to Japan and Korea, and compared the sequence of the DRD4 exon3 region among these breeds. We found that there were two types of polymorphisms (VNTR and SNPs) in the exon3 region, and some of them seemed to be breed-specific. In addition, we found that the allele frequency of G292A, reported to be associated with horse personality, differed greatly between native Japanese horses and Thoroughbred horses. The frequency of the A allele which is associated with low curiosity and high vigilance, was much lower in native Japanese horses (Hokkaido, 0.03; Taishu, 0.08) than in Thoroughbreds (0.62). This difference may account for breed differences in personality or behavioral traits. Further studies of the function of these polymorphisms and their effect on behavior are indicated.

著者

ハフマン マイケル エー (2009) HUFFMAN M A LECA Jean-Baptiste

出版者

京都大学

雑誌

特別研究員奨励費

巻号頁・発行日

2007

---

本研究は計3年度(19~21年度)に渡る計画で、今回の実績概要は最終年度の21年度の8ヶ月に渡って行った研究である。本研究の目的に添って、ニホンザルの文化的行動の一つとして知られている石遊び行動を体系的に霊長類研究所の集団飼育ニホンザル群の個体追跡による詳細による分析や加齢による変化、数量的に行動の学習過程の評価,学習によって伝承される(文化的行動)という仮説を初めて行動実験によって検証出来るデータを採集した。複数の地域におけるSH行動の比較および横断的、実験的アプローチを組み合わせた結果、以下のことが明らかになった:1)ニホンザルのSH行動の総レパートリーは45種のパターンによって構成されていた2)それぞれの群れが持つSH行動レパートリーには変異があり、ある群れで顕著に観察されるSH行動が他の群れでは全く観察されないこともあった3)こうしたSH行動のレパートリーは地理的に近い群れ同士が明確なクラスタを形成しており、文化圏のようなものが観察された4)遺伝的要因と、いくつかの明白な環境要因がこうしたSH行動のレパートリーに影響を与えるという仮説は否定された5)群れサイズと性・年齢構成およびグループの凝集性はSHを行う群れ個体の割合に影響を与えることがあることが示唆された6)社会的要因は文化的行動としてのSHの獲得とその維持において重要な役割を果たす。SHの学習モデルとして幼児が母親の行動を観察することによって起こる直接的な効果と、他個体がSHを行ったことにより1箇所にまとめて石が残され、それが刺激となってSHが始まるという間接的な効果が観察された7)いくつかのグループではSHがすでにtransformation phaseに達していると思われた。ここではSHの行動パターンがより複雑に多様になっており、さらにSHが起こる文脈の拡大が認められた。

著者

Wen-Cheng Liu Chih-Weim Hsiang Hsian-He Hsu Wei-Chou Chang

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.5, pp.523-523, 2014 (Released:2014-03-01)

参考文献数

2

著者

Morris-Suzuki Tessa 小菅 信子

出版者

岩波書店

雑誌

世界 (ISSN:05824532)

巻号頁・発行日

no.670, pp.113-120, 2000-01

著者

Bing-jie Zheng Yue-ping Yin Zhi Xiang Yan Han Mei-qin Shi Ning Jiang Rui-xing Yu Xiang-sheng Chen

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.67, no.1, pp.17-21, 2014 (Released:2014-01-22)

参考文献数

30

被引用文献数

1 6

---

The objective of this study was to determine the prevalence of urethral Mycoplasma genitalium infections among male patients attending a sexually transmitted disease (STD) clinic in China and identify risk factors associated with this disease. A total of 423 patients were recruited in Hezhou City, Guangxi Province, China, and each was requested to complete a questionnaire regarding sociological and sexual behaviors. First-void urine samples were collected for M. genitalium analysis by polymerase chain reaction. Of the 406 urine samples collected, 114 were M. genitalium-positive, giving a prevalence rate of 28.1%. Univariate logistic regression analysis showed that M. genitalium infection was associated with younger age, having received at least senior high school education, and single marital status. In both univariate and multivariate logistic regression analyses, M. genitalium infection was found to be associated with lack of symptoms for STD in the past year (adjusted odds ratio [AOR] = 2.839; 95% CI = 1.495–5.392; P = 0.001), no use of condoms with steady partners in the past year (AOR = 2.830; 95% CI = 1.468–5.455; P = 0.002), and having sexual encounters with female sexual workers within the past 3 months (AOR = 2.955; 95% CI = 1.637–5.336; P < 0.0003). The observed high rate of M. genitalium infection among male STD patients in Hezhou City indicates an M. genitalium epidemic in the study population; thus, the national surveillance program and clinical health providers in China should more closely monitor this disease.

著者

Tsutsui N. Aoki S. Fukugita M. Hashimoto S. Ishikawa K-I. Ishizuka N. Iwasaki Y. Kanaya K. Kaneko T. Kuramashi Y. Okawa M. Onogi T. Taniguchi Y. Ukawa A. Yoshié T.

出版者

American Physical Society

雑誌

Physical review D (ISSN:15507998)

巻号頁・発行日

vol.70, no.11, pp.111501, 2004-12

被引用文献数

24 15

---

We present a quenched lattice QCD calculation of the alpha and beta parameters of the proton decay matrix element. The simulation is carried out using the Wilson quark action at three values of the lattice spacing in the range a[approximate]0.1-0.064 fm to study the scaling violation effect. We find only mild scaling violation when the lattice scale is determined by the nucleon mass. We obtain in the continuum limit,

著者

Aoki S. Fukugita M. Hashimoto S. Ishikawa K-I. Ishizuka N. Iwasaki Y. Kanaya K. Kaneda T. Kaya S. Kuramashi Y. Okawa M. Onogi T. Tominaga S. Tsutsui N. Ukawa A. Yamada N. Yoshié T.

出版者

American Physical Society

雑誌

Physical review D (ISSN:05562821)

巻号頁・発行日

vol.62, no.1, pp.014506, 2000-06

被引用文献数

74 95

---

We present a model-independent calculation of hadron matrix elements for all dimension-6 operators associated with baryon number violating processes using lattice QCD. The calculation is performed with the Wilson quark action in the quenched approximation at β=6/g2=6.0 on a 282×48×80 lattice. Our results cover all the matrix elements required to estimate the partial lifetimes of (proton,neutron)→(π,K,η)+(ν̅ ,e+,μ+) decay modes. We point out the necessity of disentangling two form factors that contribute to the matrix element; previous calculations did not make the separation, which led to an underestimate of the physical matrix elements. With a correct separation, we find that the matrix elements have values 3–5 times larger than the smallest estimates employed in phenomenological analyses of the nucleon decays, which could give strong constraints on several GUT models. We also find that the values of the matrix elements are comparable with the tree-level predictions of the chiral Lagrangian.

著者

Xin Liu Hua Wang Guang Li Hui-Zhe Huang Yi-Quan Wang

出版者

日本遺伝学会

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

vol.88, no.4, pp.261-269, 2013 (Released:2014-01-25)

参考文献数

25

被引用文献数

2 10

---

Vertebrate Pax1 gene is a member of Pax gene family and encodes a transcription factor associated with crucial roles in the development of pharyngeal pouch, scletrotome and limb bud. In zebrafish, the genome contains two Pax1 paralogs, DrPax1a and DrPax1b, which share high sequence similarity with other Pax1 genes. To elucidate the function of zebrafish DrPax1b gene, we first examined the gene expression pattern and found that it was mainly expressed in the endodermal pharyngeal pouch, caudal somites, notochord, and fin bud. Then, we performed knockdown experiments using antisense morpholino oligonucleotides, which lead to the defects in the vertebral column, tail, pharyngeal skeleton, and pectoral fin. Additionally, we also found that the mouse MmPax1 mRNA, but not the amphioxus AmphiPax1/9 mRNA, could rescue the MO-induced defects. Furthermore, sequence alignment revealed that the N-terminal region of vertebrate Pax1 and amphioxus Pax1/9 were highly conserved, whereas their C-terminal regions were relatively divergent. However, the chimeric Am(N)Dr(C)Pax1, Mm(N)Dr(C)Pax1 and Dr(N)Mm(C)Pax1 mRNA could partially rescue the defects, while the Dr(N)Am(C)Pax1 mRNA could not. In conclusion, our data demonstrate a conserved function of DrPax1b in the development of the vertebral column, pectoral fin and pharyngeal skeleton formation in zebrafish and also provide critical insight into the functional evolution of Pax1 gene by changing its C-terminal sequence.

著者

Park Wug-Dong Tanioka Kenkichi

出版者

Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physics

雑誌

Jpn J Appl Phys (ISSN:00214922)

巻号頁・発行日

vol.48, no.4, pp.04C159-04C159-4, 2009-04-25

被引用文献数

4

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The thickness dependence of the avalanche characteristics of a tellurium (Te)-doped amorphous selenium (a-Se) high-gain avalanche rushing amorphous photoconductor (HARP) target is investigated. To improve the quantum efficiency of the a-Se HARP photoconductive target, a Te-doped a-Se photoconductive layer is sandwiched within a-Se HARP target. The avalanche multiplication factor and hole ionization coefficient of the a-Se HARP target are obtained using the result of photocurrent measurement. The multiplication factor in the avalanche mode exponentially increases with increasing electric field by avalanche multiplication phenomena over the threshold field. The quantum efficiency of the 8-μm-thick a-Se HARP target in the avalanche mode is higher than that of the thin HARP target below 2 μm thickness. Also the spectral response, decay lag, and light-transfer characteristics are studied.

著者

伊ケ崎 賢一 伊ケ崎 賢一 IKAZAKI Ken-iti

出版者

奈良学芸大学

雑誌

奈良学芸大学紀要 (ISSN:0369321X)

巻号頁・発行日

vol.1, no.2, pp.113-121, 1952-03

著者

Giduck Park Sung-bum Ju Hyun Jeong Jang

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.23, no.6, pp.937-939, 2011 (Released:2012-01-19)

参考文献数

16

被引用文献数

5 7

---

[Purpose] The purpose of this study was to examine the effect of pelvic adjustment using the Gonstead technique on the stability of elderly men. [Subjects] In this study, 20 elderly men were divided into a pelvic adjustment group (PAG, n = 10) and a control group (CG, n = 10). [Methods] Using a Balance Performance Monitor (SMS Health care, England), the sway area, sway path length, and sway maximum (max) velocity of the center of the body were measured to assess the stability of the subjects. [Results] Changes in the variables of stability were analyzed, and based on the results, the PAG showed significant improvement in all items (the sway area, sway path length and sway max velocity of the center of the body) after the intervention of the pelvic adjustment compared to before while the CG did not show any significant improvement. [Conclusion] Pelvic adjustment using the Gonstead technique can be used to improve the stability of elderly men.

著者

Kyung-Mee PARK Hyun-Suk NAM Heung-Myong WOO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.11, pp.1529-1533, 2013 (Released:2013-12-03)

参考文献数

23

被引用文献数

3 7

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An 8-year-old male mongrel dog that had undergone renal transplantation was presented 25 days later with an acute cough, anorexia and exercise intolerance. During the investigation, neutrophilic leukocytosis was noted, and thoracic radiographs revealed caudal lung lobe infiltration. While being treated with two broad-spectrum antibiotics, clinical signs worsened. Pneumonia due to infection with multidrug-resistant (MDR) Pseudomonas (P.) aeruginosa, sensitive only to imipenem and amikacin, was confirmed by bacteria isolation. After treatment with imipenem-cilastatin without reducing the immunosuppressant dose, clinical signs completely resolved. During the 2-year follow-up period, no recurrence was observed. To the best of authors’ knowledge, this is the first report of pneumonia caused by MDR P. aeruginosa in a renal recipient dog and successful management of this disease.

著者

Ryo Ito Noriko Satoh-Asahara Hajime Yamakage Yousuke Sasaki Shinji Odori Shigeo Kono Hiromichi Wada Takayoshi Suganami Yoshihiro Ogawa Koji Hasegawa Akira Shimatsu

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.19976, (Released:2013-11-22)

参考文献数

56

被引用文献数

4 36

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Aim: Previous epidemiological studies demonstrated that the ratio of n-6 to n-3 polyunsaturated fatty acids is associated with cardiovascular diseases. We herein investigated whether the beneficial effect of highly purified eicosapentaenoic acid(EPA) on arterial stiffness is associated with changes in the ratio of polyunsaturated fatty acids, such as EPA, docosahexaenoic acid(DHA) and dihomo-γ-linolenic acid(DGLA), relative to arachidonic acid(AA), in obese Japanese patients with dyslipidemia. Methods: The EPA/AA, DHA/AA and DGLA/AA ratios were compared between obese patients with(n=94) and without (n=31) dyslipidemia. Among the former group, 88 patients received either highly purified EPA treatment(1.8g daily, n=45) or treatment without EPA(control, n=43). Results: At baseline, the ratios of DHA/AA and DGLA/AA were significantly(P<0.05) higher in obese patients with dyslipidemia than in those without, while the EPA/AA ratio was similar between patients with and without dyslipidemia. EPA significantly reduced the hemoglobin A1c, total cholesterol, triglycerides, CRP, cardio-ankle vascular index(CAVI)(an index of arterial stiffness) and the DGLA/AA ratio relative to the control at three months after the treatment. On the other hand, EPA significantly increased the adiponectin level and EPA/AA ratio(P<0.05). A multivariate regression analysis revealed that only age, an increase in the EPA/AA ratio and a decrease in the CRP level were significant determinants of a reduction of the CAVI by EPA. Conclusion: These findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia.

著者

内村 太郎 古関 潤一 桑野 玲子 東畑 郁生 西江 俊作 WANG Lin QIAO Jian-Ping YANG Zongji HUANG Dong HUANG An-Bing LU Chin-Wei

出版者

埼玉大学

雑誌

基盤研究(B)

巻号頁・発行日

2013-04-01

---

中国、台湾、日本で、強い地震によって損傷を受けた自然斜面が、その後の豪雨をきっかけに崩壊する「地震と降雨の複合的な作用」による斜面災害を対象として調査研究を行った。(1)地震で強震を受けた山岳地域の斜面で、踏査、機器を使った調査と観測、現地実験を行い、斜面の不安定化の実態とメカニズムを把握し、危険な斜面の抽出の方法や災害を軽減する方法を提案した。(2)低コストで簡易な斜面表層の変状の観測装置を用いて、斜面災害の前兆をとらえ、早期警報によって被害を軽減する技術の実用化を推進した。さらに、多点計測や、弾性波を用いた斜面監視など、新しい技術を開発した。

著者

Ju Myeong Jin Hong Young-Joo Makita Shuichi Lim Yiheng Kurokawa Kazuhiro Duan Lian Miura Masahiro Tang Shuo Yasuno Yoshiaki

出版者

Optical Society of America

雑誌

Optics Express (ISSN:10944087)

巻号頁・発行日

vol.21, no.16, pp.19412-19436, 2013-08

被引用文献数

95

---

An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced JMT achieves a sufficiently long depth measurement range for clinical cases of posterior eye disease. Furthermore, a fine spectral shift compensation method based on the cross-correlation of calibration signals was devised for stabilizing the phase of OCT, which enables a high sensitivity Doppler OCT measurement. In addition, a new theory of JMT which integrates the Jones matrix measurement, Doppler measurement, and scattering measurement is presented. This theory enables a sensitivity-enhanced scattering OCT and high-sensitivity Doppler OCT. These new features enable the application of this system to clinical cases. A healthy subject and a geographic atrophy patient were measured in vivo, and simultaneous imaging of choroidal vasculature and birefringence structures are demonstrated.

著者

Menger Pierre-Michel

出版者

岩波書店

雑誌

経済研究 (ISSN:00229733)

巻号頁・発行日

vol.40, no.4, pp.379-382, 1989-10-16