著者

Colloque franco-japonais [sur la théorie des équations differentielles dans le champ complexe] 4. 1985. Strasbourg

出版者

l'Institut de recherche mathématique avancée

巻号頁・発行日

1988

著者

Ichiro WAKABAYASHI Kunihiro SAKAMOTO Hidehisa MASUI Sachiko YOSHIMOTO Akihisa KANAMARU Eizo KAKISHITA Hiroshi HARA Masashi SHIMO-OKA Kiyoyasu NAGAI

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.33, no.4, pp.198-203, 1994 (Released:2006-03-27)

参考文献数

22

被引用文献数

10 17

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A case control study was performed with 142 leukemia patients and 284 controls matched for age and sex. Occupation, birth order, past medical history, and drinking and smoking habits were compared in these two groups. Persons born first or fourth were found to have a higher incidence of leukemia. History of a fracture was one of the risk factors for acute leukemia, and a history of gastroduodenal ulcer was a risk factor for chronic leukemia. This may suggest that extensive exposure to X-rays in diagnosis and treatment is a risk factor for leukemia. There was a significant dose-response relationship between the amount of smoking and the incidence of acute nonlymphocytic leukemia, but not between the amount of alcohol consumption and the incidence of leukemia. Thus, smoking was one of the risk factors for acute leukemia.(Internal Medicine 33:198-203, 1994)

著者

Kang Sung Lee Eunhye Ko Sang-Yeol Lee

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.3, pp.293-295, 2013-03-25 (Released:2013-05-10)

参考文献数

18

被引用文献数

5

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[Purpose] This study investigated how the toe spreader affects muscle activities during gait in order to enhance the clinical decision-making process regarding the different characteristics of toe spreader materials. [Subjects] Twenty healthy participants were recruited. [Methods] Repeated measures of tibialis anterior (TA) and peroneus longus (PL) EMG activities (%RVC) were evaluated with and without toe separators made of two different materials (i.e., soft and hard). [Results] Compared to walking without a toe spreader, TA activity was significantly increased by the soft toe spreader and was decreased by the hard one. PL activity was significantly decreased by the soft toe spreader. [Conclusion] The altered TA and PL activities observed in this study may be the result of the toe spreader providing medio-lateral foot support during walking.

著者

野村 泰幸 Nomura Yasu-yuki

出版者

大阪大学世界言語研究センター

雑誌

大阪大学世界言語研究センター論集 (ISSN:18835139)

巻号頁・発行日

vol.6, pp.175-183, 2011-09-28

著者

Tatsunori MASATANI Masahito ASADA Madoka ICHIKAWA-SEKI Miho USUI Mohamad A. TERKAWI Kei HAYASHI Shin-ichiro KAWAZU Xuenan XUAN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0274, (Released:2013-09-11)

被引用文献数

4 8

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Peroxiredoxins (Prxs) are a family of antioxidant enzymes. Here, we cloned a 2-Cys Prx, BgTPx-1, from the canine Babesia parasite B. gibsoni. Sequence identity between BgTPx-1 and 2-Cys Prx of B. bovis was 81% at the amino acid level. Enzyme activity assay by using recombinant BgTPx-1 (rBgTPx-1) indicated that BgTPx-1 has antioxidant activity. Antiserum from a mouse immunized with rBgTPx-1 reacted with parasite lysates and detect a protein with a monomeric size of 22 kDa and also a 44 kDa protein, which might be an inefficiently reduced dimer. BgTPx-1 was expressed in the cytoplasm of B. gibsoni merozoites. These results suggest that the BgTPx-1 may play a role to control redox balance in the cytoplasm of B. gibsoni.

著者

Narita Shin-Ichiro Masui Chigusa Suzuki Takehiro Dohmae Naoshi Akiyama Yoshinori

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

2013-09-03

被引用文献数

61

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膜タンパク質の組立と分解に関わる新規プロテアーゼを発見. 京都大学プレスリリース. 2013-09-03.

著者

Duan Lian Hong Young-Joo Yasuno Yoshiaki

出版者

Optical Society of America

雑誌

Optics Express (ISSN:10944087)

巻号頁・発行日

vol.21, no.13, pp.15787-15808, 2013-06

被引用文献数

25

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An automated choroidal vessel segmentation and quantification method for high-penetration optical coherence tomography (OCT) was developed for advanced visualization and evaluation of the choroidal vasculature. This method uses scattering OCT volumes for the segmentation of choroidal vessels by using a multi-scale adaptive threshold. The segmented choroidal vessels are then processed by multi-scale morphological analysis to quantify the vessel diameters. The three-dimensional structure and the diameter distribution of the choroidal vasculature were then obtained. The usefulness of the method was then evaluated by analyzing the OCT volumes of normal subjects.

著者

Hadji-Minaglou Francis 前田 久仁子

出版者

フレグランスジャーナル社

雑誌

Aromatopia (ISSN:09184295)

巻号頁・発行日

vol.11, no.5, pp.23-29, 2002

著者

Girolamo Cardano édités traduits et annotés par Jean-Yves Boriaud

出版者

L.S. Olschki

巻号頁・発行日

2008

著者

Chen George Tai-Jen

出版者

社団法人日本気象学会

雑誌

気象集誌 (ISSN:00261165)

巻号頁・発行日

vol.72, no.6, pp.959-983, 1994-12-25

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1981-86年の5-6月における客観解析データ、可視および赤外雲画像、雲頂温度を用いて、アジアモンスーン域での、大規模な大気循環を研究した。流線関数、速度ポテンシャル、風の発散成分、対流インデックスと水蒸気場を解析した。これらの要素の半月平均の分布を示し、華南および台湾における梅雨入り前(5月1-15日)から梅雨明け後(6月16-30日)にいたる、大規模循環場の変化の特徴を明らかにした。さらに対流活動が活発・不活発な季節と前線を選び出し、大規模循環場の年々変動と季節の中での変動を検討した。得られた結果は以下のようにまとめられる。(1)華南および台湾における梅雨は、5月16-31日に南シナ海での夏の南西モンスーンの開始と同時に始まる。(2)深い対流域、ITCZ、および亜熱帯高気圧の北上は、華南および台湾での梅雨明け後(6月16-30日)に、梅雨前線帯が楊子江および日本付近で、準定常的な位置をとるのと同時に起こる。同時に北東インドからビルマにかけての地域で、下層の低気圧が上層の高気圧を伴う、準バロトピックなモンスーン循環システムが形成される。(3)活発な梅雨季は、北方の(傾圧的な)システムの南下と、梅雨地域での水蒸気収束が特徴的である。不活発な梅雨季ではその逆の状況となる。(4)活発と不活発な梅雨前線とでは、主に下層の循環が異なっている。活発な梅雨前線はベンガル湾および熱帯西太平洋起源の南西モンスーンを伴う一方、不活発な梅雨前線は、太平洋高気圧からの南東風または東風を伴っている。高い水蒸気量、強い水蒸気流束とその収束が、活発な前線に伴ってみられる。(5)活発な前線がより頻繁に出現する時は、活発な梅雨季となり、不活発な前線が多い時は、不活発な梅雨季となる。

著者

吉崎 正憲 瀬古 弘 加藤 輝之 小司 禎教 永戸 久喜 別所 康太郎 郷田 治稔 X-BAIU-99観測グループ

出版者

社団法人日本気象学会

雑誌

天気 (ISSN:05460921)

巻号頁・発行日

vol.47, no.3, pp.217-224, 2000-03-31

参考文献数

7

被引用文献数

10

著者

Miyako Yuasa-Kawase Daisaku Masuda Taiji Yamashita Ryota Kawase Hajime Nakaoka Miwako Inagaki Kazuhiro Nakatani Kazumi Tsubakio-Yamamoto Tohru Ohama Akifumi Matsuyama Makoto Nishida Masato Ishigami Toshiharu Kawamoto Issei Komuro Shizuya Yamashita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.20, no.5, pp.514-515, 2013 (Released:2013-05-29)

参考文献数

48

著者

Yanai Goichi Hayashi Takashi Zhi Qi Yang Kai-Chiang Shirouzu Yasumasa Shimabukuro Takashi Hiura Akihito Inoue Kazutomo Sumi Shoichiro

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.5, 2013-05-28

被引用文献数

31

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膵島細胞と間葉系幹細胞の融合細胞を用いた糖尿病治療実験に成功 -新しい重症糖尿病治療法の開発に期待-. 京都大学プレスリリース. 2013-05-29.

著者

Shinohara Masanobu Io Katsuhiro Shindo Keisuke Matsui Masashi Sakamoto Takashi Tada Kohei Kobayashi Masayuki Kadowaki Norimitsu Takaori-Kondo Akifumi

出版者

Nature Publishing Group

雑誌

Scientific Reports (ISSN:20452322)

巻号頁・発行日

vol.2, 2012-11-13

被引用文献数

86

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新規発癌遺伝子アポベック3による新たな発癌機構. 京都大学プレスリリース. 2012-11-14.

著者

R. V. Krafft-Ebing著 大日本文明協會編

出版者

大日本文明協會

巻号頁・発行日

1913

著者

editor-in-chief Ruth Chadwick

出版者

Academic Press

巻号頁・発行日

2012

著者

Ken-ichi Wakabayashi Yoshimasa Kurata Tomoo Harada Yasushi Tamaki Naohiro Nishiyama Toshio Kasamatsu

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.37, no.4, pp.691-698, 2012-08-01 (Released:2012-08-01)

参考文献数

23

被引用文献数

10 22

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Glycidol fatty acid esters (GEs) have been identified as contaminants in refined edible oils. Although the possible release of glycidol (G) from GEs is a concern, little is known about the conversion of GEs to G in the human body. This study addressed the toxicokinetics of glycidol linoleate (GL) and G in male Crl:CD(SD) rats and cynomolgus monkeys. Equimolar amounts of GL (341 mg/kg) or G (75 mg/kg) were administered by gavage to each animal. G was found in both species after the G and GL administration, while plasma GL concentrations were below the lower limit of quantification (5 ng/ml) in both species. In rats, the administration of GL or G produced similar concentration-time profiles for G. In monkeys, the Cmax and AUC values after GL administration were significantly lower than those after G administration. The oral bioavailability of G in monkeys (34.3%) was remarkably lower than that in rats (68.8%) at 75 mg/kg G administration. In addition, plasma G concentrations after oral administration at three lower doses of GL or G were measured in both species. In monkeys, G was detected only at the highest dose of G. In contrast, the rats exhibited similar plasma G concentration-time profiles after GL or G administration with significantly higher G levels than those in monkeys. In conclusion, these results indicate that there are remarkable species differences in the toxicokinetics of GEs and G between rodents and primates, findings that should be considered when assessing the human risk of GEs.

著者

Shi-Xia ZHANG Nan ZHANG Jian-Tao ZHang Hong-Bin WANG Long PAN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0538, (Released:2013-04-25)

被引用文献数

1 10

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Colopexy was accomplished in eight healthy mixed-breed dogs by use of a 3-portal laparoscopic technique, without major intraoperative and postoperative complications. A permanent adhesion between the colon and the abdominal wall was observed. Concentrations of acute-phase protein C-reactive protein (CRP) were measured in serum as a marker of systemic inflammation postoperatively, and no relevant increase in CRP concentrations.

著者

Sunhee Shin Seongho Yeon Dongsun Park Jiyoung Oh Hyomin Kang Sunghyun Kim Seong Soo Joo Woo-Taek Lim Jeong-Yong Lee Kyung-Chul Choi Ki Yon Kim Seung Up Kim Jong-Choon Kim Yun-Bae Kim

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.33, no.2, pp.273-278, 2010-02-01 (Released:2010-02-01)

参考文献数

56

被引用文献数

22 25 10

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The effects of a silk amino acid (SAA) preparation on the physical stamina and male reproductive function of mice were investigated. Eight-week-old male ICR mice (29—31 g) were orally administered SAA (50, 160 or 500 mg/kg) for 44 d during 30-min daily swimming exercise. The mice were subjected to a weight-loaded (5% of body weight) forced swimming on the 14th, 28th and 42nd day to determine maximum swimming time, and after a 2-d recovery period (treated with SAA without swimming exercise), parameters related to fatigue and reproductive function were analyzed from blood, muscles and reproductive organs. Repeated swimming exercise increased the maximum swimming time to some extent, in spite of a marked reduction in body weight gain, and SAA further enhanced the stamina in a dose-dependent manner. Forced swimming exercises increased blood parameters of tissue injury, but depleted blood glucose and tissue glycogen, which were substantially prevented by SAA treatment. In addition, SAA significantly reduced the muscular thiobarbituric acid-reactive substances and blood corticosterone content increased by forced swimming. Swimming exercise decreased the blood testosterone level, which was recovered by SAA, leading to enhanced sperm counts. These combined results indicate that SAA not only enhances physical stamina by minimizing damage to tissues, including muscles, as well as preventing energy depletion caused by swimming stress, but also improves male reproductive function by increasing testosterone and sperm counts.

著者

Monden Akito Nakae Daikai Kamiya Toshihito Sato Shin-ichi Matsumoto Ken-ichi

出版者

Nara Institute of Science and Technology

巻号頁・発行日

2001-09

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Existing researches suggest that the code clone (duplicated code) is one of the factors that degrades the design and structure of software and lowers the software quality such as readability and maintainability. However, the influence of code clones on software quality has not been quantitatively clarified yet. In this paper we tried to quantitatively clarify the relation between code clones and the software reliability and maintainability of twenty years old software. As a result, we found that modules having a code clone (clone-included modules) are more reliable than modules having no code clone (non-clone modules) in average. Nevertheless, the modules having very large code clones (more than 200 lines) are less reliable than non-clone modules. We also found that clone-included modules are less maintainable than non-clone modules; and, modules having larger code clone are less maintainable than modules having smaller code clone.