著者

吉田 憲司 赤塚 純一 石塚 只夫 伊藤 健 岩堀 豊 上野 篤史 郭 東潤 小島 孝之 進藤 重美 高戸谷 健 田口 秀之 多田 章 徳川 直子 富田 博史 中 右介 仲田 靖 永吉 力 野口 正芳 平野 義鎭 二村 尚夫 堀之内 茂 本田 雅久 牧野 好和 水野 拓哉 水野 洋 村上 哲 村上 義隆 山本 一臣 渡辺 安 大貫 武 鈴木 広一 二宮 哲次郎 静粛超音速研究機開発チーム Yoshida Kenji Akatsuka Junichi Ishizuka Tadao Ito Takeshi Iwahori Yutaka Ueno Atsushi Kwak Dong-Youn Kojima Takayuki Shindo Shigemi Takatoya Takeshi Taguchi Hideyuki Tada Akira Tokugawa Naoko Tomita Hiroshi Naka Yusuke Nakata Yasushi Nagayoshi Tsutomu Noguchi Masayoshi Hirano Yoshiyasu Futamura Hisao Horinouchi Shigeru Honda Masahiro Makino Yoshikazu Mizuno Takuya Mizuno Hiroshi Murakami Akira Murakami Yoshitaka Yamamoto Kazuomi Watanabe Yasushi Onuki Takeshi Suzuki Hirokazu Ninomiya Tetsujiro S3TD Design Team

出版者

宇宙航空研究開発機構

雑誌

宇宙航空研究開発機構研究開発資料 = JAXA Research and Development Memorandum (ISSN:13491121)

巻号頁・発行日

vol.JAXA-RM-10-007, 2010-07-10

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宇宙航空研究開発機構では,将来のブレイクスルーとしての超音速旅客機実現を目指し2005年10月に飛行実験に成功した小型超音速実験機(NEXST-1)に引き続き,新たな飛行実験プロジェクトとして,2006年度より「静粛超音速研究機」(S3TD:Silent SuperSonic Technology Demonstrator)の予備設計に着手し,2008年~2009年度に基本設計を実施した.S3TDは,完全自律離着陸及び超音速飛行可能な無人機で,ソニックブーム低減技術を飛行実証することを目的としたものである.本報告書では,超音速飛行実験計画及び飛行実験システム(研究機システム及び実験場システム)の設計検討について,JAXAが独自に検討した成果及びJAXAとプライムメーカの契約に基づき実施された成果をまとめる.

著者

Ryuta Shigefuku Kyoko Yoshikawa Mone Tsukimoto Hirono Owa Yasuyuki Tamai Masahiko Tameda Suguru Ogura Ryosuke Sugimoto Hideaki Tanaka Akiko Eguchi Kazushi Sugimoto Hiroshi Hasegawa Motoh Iwasa Hayato Nakagawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9701-22, (Released:2022-06-21)

参考文献数

14

被引用文献数

5

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A 70-year-old man was diagnosed with hepatocellular carcinoma (HCC) with portal vein invasion and lung metastases, for which atezolizumab plus bevacizumab (ATZ/BEV) was initiated. After two months, computed tomography revealed tumor growth accompanied by ascites, right ventricular invasion, exacerbation of the lung metastases, and main portal vein invasion. However, continuation of ATZ/BEV caused remarkable size reductions in all lesions, finally resulting in the disappearance of the vascular invasion and lung metastases after nine cycles of treatment. The tumor growth was considered to reflect pseudoprogression, which is difficult to distinguish from hyperprogression. We herein report a remarkable HCC case of pseudoprogression on ATZ/BEV.

著者

吉岡 曠 Hiroshi Yoshioka

出版者

學習院大學文學部

雑誌

研究年報 = The annual collection of essays and studies, Faculty of Letters (ISSN:04331117)

巻号頁・発行日

no.6, pp.153-176, 1960-03-30

著者

Kazufumi Nakamura Toru Miyoshi Satoshi Akagi Norihisa Toh Yukihiro Saito Yoichi Takaya Masatoki Yoshida Koji Nakagawa Satoshi Kawada Hironobu Toda Takashi Miki Rie Nakayama Fumi Yokohama Keishi Ichikawa Masashi Yoshida Makiko Taniyama Nobuhiro Nishii Teiji Akagi Hiroshi Morita Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0349, (Released:2022-06-29)

参考文献数

3

被引用文献数

1

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The 86thAnnual Scientific Meeting of the Japanese Circulation Society was held in a web-based format on March 11–13, 2022. In accordance with the internationalization policy of the JCS, the meeting was held with the Asian Pacific Society of Cardiology Congress 2022. The main theme was “Cardiology Spreading its Wings”. The number of patients with heart failure and other cardiovascular diseases is increasing dramatically, and the fields dealt with by cardiovascular medicine are also greatly expanding. This conference was both intellectually satisfying and exciting for all participants, who numbered over 14,900. The meeting was completed with great success, and the enormous amount of cooperation and support from all involved was greatly appreciated.

著者

Takahiro Yonezawa Masahide Nishibori Yoshio Yamamoto Takeshi Sasaki Kohei Kudo Hiroshi Ogawa Hideki Endo Fumihito Akishinonomiya

出版者

Japan Poultry Science Association

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

pp.0220027, (Released:2022-06-25)

被引用文献数

2

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Japanese native chickens (JNCs) comprise approximately 50 breeds, making Japan a diversity hotspot for native chicken breeds. JNCs were established through the repeated introduction of chickens from foreign countries. Jidori, which is the generic name of JNC breeds whose ancestral morphology resembles that of their wild progenitor (red junglefowls), is generally thought to have propagated from north East Asia (Korea and north China) to ancient Japan. However, mitochondrial haplogroup D, which is abundant in Island Southeast Asia (ISEA) as well as the Pacific but relatively rare in other regions, can be observed in some Jidori breeds (e.g., Tosa-Jidori, Tokuji-Jidori) with high frequency, leading to speculation that chickens from ISEA or the Pacific also contributed genetically to JNCs. To test this hypothesis, we sequenced the mitochondrial genomes of Jidori breeds and conducted phylogeographic analysis. Our results indicate that the JNC Haplogroup D belongs to Sub-haplogroup D2, which is currently only observed in Xinjiang, northwest China, and not to Sub-haplogroup D1, which is widely distributed in the ISEA-Pacific region. The other mitochondrial haplogroups of Jidori examined in this study also showed affinity to those of chickens native to north East Asia. Therefore, our findings support the north East Asian origin hypothesis for Jidori.

著者

Takaoki Saneyasu Miku Ueda Kanami Nagata Jiawei Chai Kazuhisa Honda Hiroshi Kamisoyama

出版者

Japan Poultry Science Association

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

pp.0220040, (Released:2022-06-25)

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Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism. In the present study, we investigated the possible involvement of central TGF-β/Smad signaling in feeding regulation in chickens. Central administration of TGF-β1 resulted in phosphorylation of Smad2 in the hypothalamus of chicks and suppressed feed intake without changing the gene expression of hypothalamic appetite-regulating neuropeptides (neuropeptide Y, agouti-related protein, proopiomelanocortin, and corticotropin-releasing factor). However, neither fasting nor refeeding induced the phosphorylation of hypothalamic Smad2. These findings suggest that the activation of hypothalamic TGF-β/Smad signaling suppresses feed intake in chicks but it might not occur in response to feeding status.

著者

Indrapriyadarsini Sendilkkumaar Shahrzad Mahboubi Hiroshi Ninomiya Hideki Asai

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)

巻号頁・発行日

vol.11, no.4, pp.409-421, 2020 (Released:2020-10-01)

参考文献数

30

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Recurrent Neural Networks (RNNs) are powerful sequence models that are particularly difficult to train. This paper proposes an adaptive stochastic Nesterov's accelerated quasi-Newton (aSNAQ) method for training RNNs. Several algorithms have been proposed earlier for training RNNs. However, due to high computational complexity, very few methods use second-order curvature information despite its ability to improve convergence. The proposed method is an accelerated second-order method that attempts to incorporate curvature information while maintaining a low per iteration cost. Furthermore, direction normalization has been introduced to solve the vanishing and/or exploding gradient problem that is prominent in training RNNs. The performance of the proposed method is evaluated in Tensorflow on benchmark sequence modeling problems. The results show that the proposed aSNAQ method is effective in training RNNs with a low per-iteration cost and improved performance compared to the second-order adaQN and first-order Adagrad and Adam methods.

著者

Mitsuharu Hosono Hiroshi Yasumoto Shintaro Kuwauchi Yoshino Mitsunaga Uetsuki Tomohiko Naoki Minato Kohei Kawazoe

出版者

The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery

雑誌

Annals of Thoracic and Cardiovascular Surgery (ISSN:13411098)

巻号頁・発行日

vol.28, no.3, pp.180-185, 2022 (Released:2022-06-20)

参考文献数

12

被引用文献数

1

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Purpose: The effect of our comprehensive strategy to reduce pain after minimally invasive mitral valve repair through a right mini-thoracotomy was assessed retrospectively.Methods: Our comprehensive strategy constituted the following: planned rib cutting to avoid rib injury, sufficient intercostal muscle division to mobilize the cut rib, limiting the number of intercostal ports, avoiding nerve entrapment, continuous extra-pleural intercostal nerve block, and regular use of oral non-steroidal anti-inflammatory drugs. We compared patients treated with this comprehensive strategy (Group S, n = 13) and patients before this strategy was implemented (Group C, n = 13). We used a numerical rating scale (NRS) as a pain scale during the first 3 days postoperatively.Results: The average NRS was significantly lower in Group S (0.82 ± 0.49) than in Group C (2.40 ± 1.46) (P <0.01). The maximum NRS was also significantly lower in Group S (3.23 ± 1.17) than in Group C (5.69 ± 2.43) (P <0.01). The number of patients using additional single-dose analgesic were significantly less in Group S (23.1%) than in Group C (84.6%) (P <0.01).Conclusion: Our comprehensive pain control strategy effectively reduced postoperative pain in minimally invasive mitral valve repair.

著者

Yuki NAGAMATSU Hiroshi NAGAMATSU Hiroshi IKEDA Hiroshi SHIMIZU

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2020-454, (Released:2021-06-30)

参考文献数

47

被引用文献数

4

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Electrolyzed waters, containing mainly hypochlorous acid, are used in dental practice because of their high microbicidal effect. For wider use, three neutral electrolyzed water-based gels, namely, HOCl-containing aqueous gels were prepared with a thickening/gelling agent in this study. We evaluated their microbicidal effects against four strains and storage stabilities indicated by available chlorine concentration. Immediately after preparation, all gels (70 ppm) could completely remove microbes by a 3-min treatment. The gel prepared with xanthan gum remarkably reduced its available chlorine concentration even under shaded and refrigerated storage conditions, failing to maintain its microbicidal effect following 1-day storage, whereas other gels, prepared with carboxyvinyl polymer or agar, maintained effective concentration (>20 ppm), with high microbicidal effects following 9-day and 21-day storage, respectively. Neutral electrolyzed water-based gels might be useful to remove oral microbes. Based on our results, agar is the most suitable thickening/gelling agent from the viewpoint of storage stability.

著者

Takao Fujisawa Terufumi Shimoda Keisuke Masuyama Kimihiro Okubo Kohei Honda Mitsuhiro Okano Toshio Katsunuma Atsuo Urisu Yasuto Kondo Hiroshi Odajima Kazuyuki Kurihara Makoto Nagata Masami Taniguchi Shoichiro Taniuchi Satoru Doi Tomoshige Matsumoto Shoji Hashimoto Akihiko Tanaka Kensuke Natsui Nahoko Abe Hideki Ozaki

出版者

Japanese Society of Allergology

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.67, no.3, pp.347-356, 2018 (Released:2018-07-28)

参考文献数

49

被引用文献数

7

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Background: To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial.Methods: Japanese patients aged 5-65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria. The treatment period was 52 weeks, and patients who were willing to continue the treatment received TO-204 beyond 52 weeks. This clinical trial is registered at the Japan Pharmaceutical Information Center (Japic CTI-121900).Results: Between July 2012 and May 2015, 44 patients (28 with AR and 16 with allergic BA) were enrolled into the study. All patients were included in the analysis. The duration of treatment ranged from 23 to 142 weeks and the median maintenance dose was 200 Japanese allergy units (JAU). Adverse events occurred in 22 patients (50%). The most common adverse event was local reactions related to the injection sites. Four patients experienced anaphylactic reactions when they were treated with the dose of 500 JAU. Two patients experienced anaphylactic shock with the doses of 1000 JAU at onset. These 6 patients could continue the study with dose reduction.Conclusions: Safety profile of TO-204 was acceptable in Japanese patients with HDM-induced AR or allergic BA. Higher doses should be administered carefully, because the risk of anaphylaxis increased at doses of 500 or 1000 JAU.

著者

Hiroshi MARUYAMA Yasumasa IWASAKI Makoto TSUGITA Naoko OGAMI Koichi ASABA Toshihiro TAKAO Hiromichi NAKABAYASHI Keiji SHIMIZU Kozo HASHIMOTO

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.55, no.2, pp.425-428, 2008 (Released:2008-05-10)

参考文献数

11

被引用文献数

12 13

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An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration.

著者

Atsuhiko Sakamoto Mitsuyoshi Hirokawa Masahiro Ito Hiroshi Naganuma Osamu Suzuki Yuko Hashimoto Shinichi Suzuki Hiroki Shimura

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.68, no.6, pp.621-630, 2021 (Released:2021-06-28)

参考文献数

22

被引用文献数

6

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Histological classification and cytology reporting format described in General Rules for the Description of Thyroid Cancer, the 8th edition (2019) (the Japanese General Rules) were briefly introduced. Moreover, the differences between “the Japanese General Rules”, and WHO Histological Classification, the 4th edition (2017) and The Bethesda System for Reporting Thyroid Cytopathology, the 2nd edition (2018) were also explained. The Japanese General Rules did not accept the borderline lesions of thyroid tumor which were newly shown in WHO Histological Classification. We believe it is not necessary to introduce these borderline lesions in daily practice in Japan. Borderline lesions were proposed for avoiding over-surgery for thyroid cancer patients. In the United States, when the patient is diagnosed as malignant on cytology, total thyroidectomy is generally recommended. However, there is no over-surgery in Japan, because surgeons have several choices of treatment for thyroid cancer patients. This article is the first that the Japanese General Rules was shown by foreign language. Therefore, this will be advantageous to us when we present our opinion concerning histology and cytology of thyroid tumor to the world.

著者

Miyuki Konya Shiho Arima Daiki Lee Masaki Ohtawa Kenta Shimoyama Takashi Fukuda Ryuji Uchida Hiroshi Tomoda Noriyuki Yamaotsu Nobutada Tanaka Tohru Nagamitsu

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.70, no.4, pp.261-268, 2022-04-01 (Released:2022-04-01)

参考文献数

19

被引用文献数

3

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Habiterpenol is a G2 checkpoint inhibitor isolated from the culture broth of Phytohabitans sp. 3787_5. Here, we report the synthesis of new habiterpenol analogs through the total synthesis process of habiterpenol and evaluating the analogs for G2 checkpoint inhibitory activity. We investigated two different synthetic approaches for total synthesis, with intramolecular conjugate addition and Ti(III)-mediated radical cyclization as key reactions. Although the former was unsuccessful, the latter reaction facilitated stereoselective total synthesis and determination of the absolute configuration of habiterpenol. The extension of these chemistries to a structure–activity relationship (SAR) study gave new habiterpenol analogs, which could not be derived from natural habiterpenol and only be synthesized by applying the total synthesis. Therefore, this study provides important insights into SAR studies of habiterpenol.

著者

Nobuhiro FUJITA Akihiro NISHIE Yoshiki ASAYAMA Kousei ISHIGAMI Yasuhiro USHIJIMA Yukihisa TAKAYAMA Daisuke OKAMOTO Koichiro MORITA Ken SHIRABE Kazuhiro KOTO Yuichiro KUBO Yoshinao ODA Hiroshi HONDA

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

vol.15, no.1, pp.111-120, 2016-01-01 (Released:2016-01-12)

参考文献数

28

被引用文献数

7 9

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Purpose: We attempted to clarify the relationship between the signal intensity (SI) in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging and the efficacy of hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinomas (HCCs).Methods: We enrolled 14 patients with HCCs who underwent gadoxetic acid-enhanced MR imaging prior to HAIC using cisplatin and 5-fluorouracil. In the hepatobiliary phase, we calculated the SI of the HCCs and the background liver. In cases with multiple HCCs, we calculated the SI of the largest lesion. Patients were classified into high (n = 7) and low intensity (n = 7) groups based on the median value of the SI ratio (SI of the tumor/SI of the background liver). We analyzed progression-free survival using the Kaplan-Meier method and the log-rank test. In the 5 patients with a history of HCC surgery, we compared the expression of immunohistochemical organic anion-transporting polypeptide (OATP) 8 between the high and low intensity groups by chi-square test.Results: The SI ratios were 0.568 ± 0.093 (mean ± standard deviation) in the high intensity group and 0.251 ± 0.086 in the low intensity group. Compared to the group with low signal intensity, the group with high signal intensity demonstrated significantly lower serum levels of alpha fetoprotein (AFP) (P = 0.0350), significantly higher progression-free survival (P = 0.0108), better differentiation of tumor grade at histologic examination (P = 0.0253), and significantly higher OATP8 expression (P = 0.0253).Conclusion: Patients with HCCs of high SI ratio in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging can respond better to HAIC.

著者

Hiroshi Kobe Akihiro Ito Yosuke Nakanishi Akira Kuriyama Hiromasa Tachibana Tadashi Ishida

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9534-22, (Released:2022-05-31)

参考文献数

16

被引用文献数

3

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Objective The coronavirus disease 2019 (COVID-19) pandemic continues to spread across the world, and the utility of many drugs for treatment has been suggested. However, few studies have examined the efficacy and safety of treatment with baricitinib, remdesivir, and dexamethasone. Methods A retrospective, cohort study of patients who were admitted to Kurashiki Central Hospital in Japan between April 6 and June 29, 2021, was conducted. Differences in patients' background characteristics, clinical outcomes, and safety were investigated in the groups with and without baricitinib treatment. The primary outcome was the bacterial infection rate, and the secondary outcome was the 28-day mortality rate. An inverse probability of treatment weighting (IPTW) analysis, including 12 covariates, was used as a propensity score analysis to reduce biases. Results In total, there were 96 patients, including 43 in the baricitinib-containing therapy (BCT) group and 53 in the non-baricitinib-containing therapy (non-BCT) group. In the BCT group, the ordinal scale on admission was 2.3% with 4, 51.1% with 5, 23.3% with 6, and 23.3% with 7. In the non-BCT group, the ordinal scale was 1.9% with 3, 18.9% with 4, 58.5% with 5, 13.2% with 6, and 7.5% with 7. After adjusting by the IPTW analysis, the BCT group did not have an increased bacterial infection rate (odds ratio [OR], 1.1; 95% confidence interval [CI], 0.36-3.38; p=0.87) or 28-day mortality rate (OR, 0.31; 95% CI, 0.07-1.3; p=0.11) compared with the non-BCT group. Conclusion BCT can be administered without increasing the infection risk compared with non-BCT.

著者

Chizuru Futatsuya Hiroshi Minato Yurie Okayama Kazuyoshi Katayanagi Hiroshi Kurumaya Mizuki Yuasa Koichi Nishi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.59, no.12, pp.1541-1547, 2020-06-15 (Released:2020-06-15)

参考文献数

22

被引用文献数

3

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Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a generally slow-progressing rare disorder of unknown etiology. The direct cause of death in cases of IPPFE is rarely investigated. We experienced an autopsy case of a Japanese man with IPPFE and found aspiration pneumonia to be the major trigger of death. The individual had left vocal cord paralysis at admission, which may have contributed to aspiration pneumonia, and which probably was affected by the fibrous adhesion of the left apex of the chest wall resulting from IPPFE. The prevention of aspiration pneumonia is important for maintaining the respiratory function, especially in IPPFE patients with repeated pneumothorax.

著者

Hiroshi Azuma Rhett D. Harrison Keiko Nakamura Zhi-Hui Su

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

vol.85, no.3, pp.177-192, 2010 (Released:2010-10-27)

参考文献数

72

被引用文献数

12 14

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The interaction between figs (Ficus, Moraceae) and fig-pollinating wasps (Chalcidoidea, Agaonidae) is one of the most specific mutualisms, and thus is a model system for studying coevolution and cospeciation. In this study we focused on figs and their associated fig-wasps found in the Ryukyu and Bonin (Ogasawara) Islands, Japan, because it has been suggested that breakdown in the specificity may occur in islands or at edge of a species’ distribution. We collected 136 samples of 15 native fig species and 95 samples of 13 associated fig-wasps from all major islands in the Ryukyu Islands, including two fig species and one fig-wasp species endemic to the Bonin Islands. We performed molecular phylogenetic analyses using plastid DNA and nuclear ITS sequences for the figs and nuclear 28S rRNA and mitochondrial COI genes for the fig-wasps to investigate the interspecific phylogenies and intraspecific variation within the mutualism. Our phylogenetic analyses using multiple samples per species show the single clade of each fig (except the Bonin endemic species) and fig-pollinating wasp species. Fig species belonging to the same subgenera formed well-supported clades in both plastid and ITS trees, except for the subgenus Urostigma. Likewise, fig wasps emerging from host fig species belonging to the same subgenera formed mostly well supported clades in both 28S and COI trees. Host specificity between the figs and fig-wasps functions strictly in these islands. There was very little sequence variation within species, and that no major geographic structure was found. The two Bonin endemic species (F. boninsimae and F. nishimurae) or their common ancestor and the associated fig-wasps (Blastophaga sp.) are apparently derived from F. erecta and its associated fig-wasps (B. nipponica), respectively, and probably migrated from the Ryukyu Islands.

著者

Masaru Sakurai Junji Kobayashi Yasuo Takeda Shin-Ya Nagasawa Junichi Yamakawa Junji Moriya Hiroshi Mabuchi Hideaki Nakagawa

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.26, no.8, pp.440-446, 2016-08-05 (Released:2016-08-05)

参考文献数

31

被引用文献数

14 20

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Aims: The present study aimed to investigate relationships among abdominal obesity, metabolic abnormalities, and the prevalence of chronic kidney disease (CKD) in relatively lean Japanese men and women.Participants and methods: The participants included 8133 men and 15 934 women between 40 and 75 years of age recruited from the government health check-up center in Kanazawa City, Japan. The prevalence of abdominal obesity, high blood pressure, dyslipidemia, and high fasting plasma glucose levels were assessed according to the Japanese criteria for metabolic syndrome. The estimated glomerular filtration rate (eGFR) was calculated using the modified Modification of Diet in Renal Disease equation for the Japanese population, and participants with an eGFR <60 mL/min/1.73 m2 and/or proteinuria were diagnosed with CKD.Results: Overall, 23% of males and 14% of females met criteria for CKD. Having more numerous complicated metabolic abnormalities was significantly associated with a higher odds ratio (OR) of CKD for men and women, irrespective of abdominal obesity. However, there was a sex difference in the OR of CKD for obese participants without metabolic abnormalities, such that abdominal obesity without metabolic abnormalities was significantly associated with a higher OR for men (multivariate-adjusted OR 1.63; 95% confidence interval [CI], 1.16–2.28) but not for women (OR 1.01; 95% CI, 0.71–1.44).Conclusions: The present findings demonstrated that obesity without metabolic abnormalities was associated with a higher risk of CKD in men but not women in a relatively lean Japanese population.

著者

青柳 宏 Hiroshi AOYAGI

出版者

宇都宮大学教育学部

雑誌

宇都宮大学教育学部研究紀要.第1部 = The research bulletin of the Faculty of Education, Utsunomiya University. Section 1 (ISSN:24325546)

巻号頁・発行日

no.69, pp.207-236, 2019-03-04

著者

山川 宏 Yamakawa Hiroshi

出版者

宇宙航空研究開発機構

雑誌

宇宙航空研究開発機構特別資料: 低推力・連続加速を用いた宇宙ミッションに関する研究会論文集 = JAXA Special Publication: Collection of Papers Presented at the Meeting on the Study of Space Missions Propelled by Low-Thrust and Sustained Acceleration (ISSN:1349113X)

巻号頁・発行日

vol.JAXA-SP-07-020, pp.33-38, 2008-02-29

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Orbital dynamics of consecutive, low-thrust trajectories is overviewed. Focusing on the thrust direction constraints (e.g., transversal and radial thrust direction constraints), various trajectory design strategies of low-thrust missions are summarized with concrete examples.