著者

Shun Utsunomiya Yusuke Kishi Masafumi Tsuboi Daichi Kawaguchi Yukiko Gotoh Manabu Abe Kenji Sakimura Kazuma Maeda Hiroshi Takemoto

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

pp.2021.01017, (Released:2021-03-08)

参考文献数

48

被引用文献数

3

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Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. Together, these results suggest that elevated expression of Ezh1 contributes to maturation of cortical neurons.

著者

岩﨑 浩 Hiroshi Iwasaki

出版者

上越教育大学数学教室

雑誌

上越数学教育研究

巻号頁・発行日

no.13, pp.23-32, 1998-03

著者

HASHIMOTO,Hiroshi

出版者

日本動物学会

雑誌

日本動物学彙報

巻号頁・発行日

vol.54, no.3, 1981-09-20

著者

Hiroshi Namikawa

出版者

National Museum of Nature and Sciece

雑誌

国立科学博物館研究報告A類(動物学) (ISSN:18819052)

巻号頁・発行日

vol.48, no.1, pp.1-4, 2022-02-22 (Released:2022-02-22)

参考文献数

9

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In addition to polyps of the anthoathecate hydroid Koellikerina bouilloni previously reported exclusively on old, eroded shells of live gastropods (Nassarius festivus) in Ibaraki Prefecture, Japan, the polyps of three additional epizoic anthoathecate hydroid species (Dicoryne conybearei, Stylactaria misakiensis and Leuckartiara sp.) were found on similar condition N. festivus shells in different localities in Japan. Because polyps of these hydroid species were not found on fresh shells, it is suggested that N. festivus could avoid colonization by the hydroids whilst occupying fresh shells, but not older eroded ones, the latter therefore providing a suitable substrate for the hydroid polyps.

著者

島田 一雄 若林 良二 鈴木 弘 武藤 憲司 田中 健二 浅井 紀久夫 結城 皖曠 近藤 喜美夫 シマダ カズオ ワカバヤシ リョウジ スズキ ヒロシ ムトウ ケンジ タナカ ケンジ アサイ キクオ ユウキ キヨヒロ コンドウ キミオ Kazuo Shimada Ryoji Wakabayashi Hiroshi Suzuki Kenji Muto Kenji Tanaka Kikuo Asai Kiyohiro Yuki Kimio Kondo

雑誌

メディア教育研究

巻号頁・発行日

vol.2, pp.29-42, 1999

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現在、国内の高等教育機関が利用している2つのディジタル衛星通信システム、SCSとUnSATを接続して、1997年に都立航空高専で開催された2つのイベントを全国の大学・高専に配信する実験を行った結果について述べる。最初にSCSとUnSATの概要を述べ、続いて、「高等技術教育フォーラム'97」の内容を紹介する。次に、このフォーラム配信実験システムと実験方法を示し、予備実験とフォーラム当日の本実験について述べる。さらに、予備実験に対する航空高専学生と本実験に対する受信各局の参加者へのアンケート調査で得られた主観評価結果を示す。続いて、「第5回衛星設計コンテスト」の内容とその配信実験の概要を述べ、受信各局の参加者へのアンケート調査で得られた主観評価結果を示し、両実験の主観評価結果の比較を行う。最後に考察を行い、衛星通信の教育利用に対する問題点の分析と解決の指針、知見を述べ、異なる2衛星通信システム接続による教育・研究交流ネットワーク構築への手がかりが得られたことを示す。Experiments on a new distribution system formed by joining two digital satellite communication systems, SCS and UnSAT, were successfully carried out. The "Advanced Technological Education Forum '97"and the "Fifth Satellite Design Contest" were distributed experimentally from Tokyo Metropolitan College of Aeronautical Engineering to universities and national colleges in 1997. The present study showed that the satellite communication network constructed by joining SCS and UnSAT can be applied practically for the educational and research activites. After a brief introduction of SCS and UnSAT, we describe our method of constructing the system and present the results of a questionnaire investigation.

著者

Hiroshi INOUE Lan LAN Zhengjian KE Yan YANG Feng ZHENG Dan MAO Seiji GODA

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.41, no.1, pp.159-166, 2022-01-25 (Released:2022-02-01)

参考文献数

65

被引用文献数

1

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The aim of this study was to investigate the effects of surface reaction-type pre-reacted glass-ionomer (S-PRG) filler eluate on Matrix metalloproteinase (MMP)-1 and MMP-3 secretion by human gingival fibroblasts (HGF). The S-PRG filler eluate contains 6 ions (F, Na, Al, B, Sr and Si) released from the S-PRG filler. The S-PRG filler eluate stimulation induced a slight secretion of MMP-1 and MMP-3 by HGF. It also enhanced the phosphorylation of p38 and ERK. The increase in MMP-1 and MMP-3 secretion by the inflammatory cytokine TNF-α was suppressed by the S-PRG filler eluate. TNF-α-induced increases in the phosphorylation of ERK were slightly enhanced by S-PRG filler eluate. These findings may prompt the development of new therapeutic agents for oral inflammation with materials composed of S-PRG filler eluate.

著者

木宮 直仁 平川 博 Naohito Kimiya Hiroshi Hirakawa

出版者

東京海洋大学

雑誌

東京海洋大学研究報告 (ISSN:18800912)

巻号頁・発行日

no.9, pp.21-37, 2013-02

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本稿では、これまで編著した「あ~し」の続編として、「す~」で始まる用語について、対訳語が複数あるものを取り上げ、類義語との異同に関する注釈を付け、用例は実例を調査して、できるだけ多く提示することを試みた。法律用語の中には、請求金額のように、ビジネス用語や日常語と法律用語とが異なるものがあり、このような場合は訳語の使い分けができるように工夫することを心掛けた。また、あらぬ誤訳が生じることが懸念される場合は、特殊な法律専門用語よりも、対訳語として一般的に用いられる表現を優先的に取り上げるように配慮した。 著者らは商事法和英辞典の作成途上にあり、本稿には不十分なところも多々あると考えている。お気づきの点があれはご教示願いたい。東京海洋大学海洋工学部流通情報工学科社労士・行政書士 産業法務相談室

著者

Takanori Ikeda Takeshi Yamashita Masaharu Akao Hirotsugu Atarashi Yukihiro Koretsune Ken Okumura Wataru Shimizu Hiroyuki Tsutsui Kazunori Toyoda Atsushi Hirayama Masahiro Yasaka Takenori Yamaguchi Satoshi Teramukai Tetsuya Kimura Jumpei Kaburagi Atsushi Takita Hiroshi Inoue

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.86, no.2, pp.202-210, 2022-01-25 (Released:2022-01-25)

参考文献数

41

被引用文献数

3

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Background:Data on outcomes for patients with atrial fibrillation (AF) and active cancer are scarce. The effect of active cancer on thrombosis and bleeding risks in elderly (≥75 years) patients with non-valvular AF (NVAF) enrolled in the All Nippon AF In the Elderly (ANAFIE) Registry were prospectively analyzed.Methods and Results:In this subanalysis of the ANAFIE Registry, a prospective, multicenter, observational study conducted in Japan, we compared the incidence rates of clinical outcomes between active cancer and non-cancer groups. Relationships between primary outcomes and anticoagulation status were evaluated. Of the 32,725 patients enrolled in the Registry, 3,569 had active cancer at baseline; 92.0% of active cancer patients received anticoagulants (23.7%, warfarin; 68.2%, direct oral anticoagulants [DOACs]). Two-year probabilities of stroke/systemic embolic events (SEE) were similar in the cancer (3.33%) and non-cancer (3.16%) groups. Patients with cancer had greater incidences of major bleeding (2.86% vs. 2.04%), all-cause death (10.95% vs. 6.77%), and net clinical outcomes (14.63% vs. 10.00%) than those without cancer. In patients without cancer, DOACs were associated with a decreased risk of stroke/SEE, major bleeding, all-cause death, and net clinical outcome compared with warfarin. No between-treatment differences were observed in patients with active cancer.Conclusions:Active cancer had no effect on stroke/SEE incidence in elderly NVAF patients, but those with cancer had higher incidences of major bleeding events and all-cause death than those without cancer.

著者

Hiroshi Kurazumi Ryo Suzuki Bungo Shirasawa Yosuke Miyazaki Hiroki Tateishi Tetsuro Oda Takayuki Okamura Akihito Mikamo Masafumi Yano Kimikazu Hamano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0949, (Released:2022-02-09)

参考文献数

23

被引用文献数

2

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Background:Transcatheter aortic valve implantation (TAVI) is increasingly being performed in very elderly patients, although its efficacy and validity remain unclear. This study evaluated real-world TAVI outcomes in Japanese nonagenarians with severe aortic stenosis.Methods and Results:This single-center study retrospectively assessed the early and long-term clinical outcomes of TAVI in nonagenarians (n=35) and in patients aged <90 years (group Y; n=171). There were no in-hospital deaths in either group. The device success rate and early safety were comparable between the 2 groups. The 5-year rates of freedom from cardiac events and deaths were equivalent in both groups. The cumulative survival rate at 5 years was non-significantly lower in nonagenarians (32.6% in nonagenarians vs. 57.5% in patients aged <90 years, P=0.49). There were no differences in the 5-year survival between nonagenarians after TAVI and the sex- and age-matched populations (P=0.18). The Cox regression model revealed that lower hemoglobin levels were associated with all-cause mortality (P=0.02), and age ≥90 years was not associated with all-cause mortality.Conclusions:The early and long-term clinical outcomes of TAVI for selected Japanese nonagenarians were comparable to those in patients aged <90 years. Nonagenarians who underwent TAVI achieved an acceptable prognosis compared to the sex- and age-matched population; thus, TAVI appears to be effective for treating aortic stenosis in Japanese nonagenarians.

著者

Tatsuhiro Ishida Hiroshi Kiwada

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.6, pp.889-891, 2013-06-01 (Released:2013-06-01)

参考文献数

36

被引用文献数

45 62

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In contrast to the general assumption that polyethyleneglycol (PEG)-conjugated substances lack immunogenicity and antigenic, it has been reported that they can elicit antibodies against PEG (mainly anti-PEG immunoglobulin M (IgM)). In patients, the presence of anti-PEG antibodies may limit therapeutic efficacy of PEGylated substances as a consequence of inducing rapid clearance of and neutralizing biological activity of the substances. Here, we introduce specific examples of PEGylated substances including several PEGylated proteins and PEGylated particles (PEGylated nanocarriers) which induce anti-PEG antibody responses. Finally, we emphasize that the immunogenicity of PEGylated substances should be tested in the development stage and that the titer of anti-PEG antibodies in patients should be pre-screened and monitored prior to and throughout a course of treatment with a PEGylated substance.

著者

Kazuya Morimatsu Hiroshi Takahashi

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会第二種研究会資料 (ISSN:24365556)

巻号頁・発行日

vol.2021, no.BI-019, pp.01, 2021-10-30 (Released:2021-11-09)

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無形資産のみで売上を構成するものとした場合、企業は人材の獲得ならびに能力開発により能力を蓄え、各市場への配分の仕方において、その成果の違いが表れるだろう。その際、意思決定者は、ビジョンを元に行動の指針となる制度を設計する必要があるが、制度は通例に基づいて設計されることが多く、また、この制度設計の手法やその効果について定量的な観点からみた研究は少ないため、研究が望まれている。そこで、本研究は、産業と企業行動をエージェントベースモデルを通じてモデル化し、人材の流動性を鑑みた制度設計を通じて、優秀な業績を上げるために重要な意思決定の解明を目指す。

著者

齋藤 洋 サイトウ ヒロシ Hiroshi SAITO

出版者

東洋大学法学会

雑誌

東洋法学 = Toyohogaku (ISSN:05640245)

巻号頁・発行日

vol.54, no.3, pp.320-288, 2011-03-29

著者

Hiromi Shinano Sakiko Miyazaki Kayo Miura Hiroshi Ohtsu Naohiro Yonemoto Kiyoshi Matsuoka Hakuou Konishi Hiroyuki Daida Mitsue Saito Kazuhiro Sase

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.4, pp.235-242, 2020-04-10 (Released:2020-04-10)

参考文献数

48

被引用文献数

1 2

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Background:The prognosis of cancer survivors has dramatically improved, but effective strategies for cancer treatment-related cardiovascular disorders (CTRCD) remain to be elucidated in the emerging field of cardio-oncology. In this study, we investigated risk factors for CTRCD in breast cancer patients treated with trastuzumab.Methods and Results:We performed a retrospective analysis of 141 consecutive women who received adjuvant trastuzumab, and underwent baseline (BL) and follow-up (FU) echocardiography at Juntendo University between April 2010 and December 2016. The major concomitant treatment was anthracyclines in 94% and radiotherapy in 53%. During the median treatment period of 11 months, there were 22 (15.6%) cardiology consultations, 3 (2.1%) treatment interruptions with irreversible CTRCD, and no deaths. Left ventricular ejection fraction (LVEF) was decreased from a median 67.5% (BL) to 63.4% (FU; P<0.0001), with reduced LVEF noted in 26.2% at FU<90%BL, in 13.5% at FU<BL–10%, and in 5.7% at LVEFFU<53%. A significantly greater percentage of patients with CTRCD (FU<BL–10% and LVEFFU<53%) had cardiovascular risk factors (CVRF; 42.9% vs. 8.2%, P=0.02). On multivariable analysis, CVRF were also significantly associated with CTRCD (OR, 11.96; 95% CI: 1.30–110.34).Conclusions:Adjuvant trastuzumab for early-stage breast cancer was associated with reduced LVEF; and CVRF were an independent predictor for CTRCD. The concomitant effect of anthracyclines should not be underestimated, even at lower doses.

著者

Toshifumi Nagata Fabien Lombardo Hiroshi Ezura

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.3, pp.387-390, 2021-09-25 (Released:2021-09-25)

参考文献数

14

被引用文献数

2

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The HAWAIIAN SKIRT (HWS) gene was originally described in Arabidopsis for the characteristic fusion of sepals in the mutant. A tomato line mutated in the putative ortholog gene was isolated in a previous study. The tomato hws-1 mutant showed facultative parthenocarpy and produced fruits with elevated Brix, revealing the gene as a hopeful resource for crop improvement. To confirm the orthology relationship between the Arabidopsis and tomato HWS genes, the hws-1 mutant was complemented with either the tomato wild-type genomic fragment or the Arabidopsis sequence of the gene. In both complementation experiments, defective phenotypes of hws-1 are rescued, albeit to different extents. Recovery of these phenotypes, which include parthenocarpic fruit production, increased Brix, loss of leaflet serration, alteration of bud and petal shape, firmly establishes SlHWS as an ortholog of the originally described HWS in Arabidopsis. This work indicates that the function of HWS is likely to be conserved in a wide range of plant species.

著者

Kaho Miyazaki You Ohkubo Hiroto Yasui Ryoka Tashiro Rintaro Suzuki Hiroshi Teramura Hiroaki Kusano Hiroaki Shimada

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.3, pp.367-371, 2021-09-25 (Released:2021-09-25)

参考文献数

25

被引用文献数

3

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Late embryogenesis abundant protein (LEA) genes are widely conserved in seed plant species and form a multigene family. While some LEAs are known to respond to environmental stresses, the function of many LEAs is unknown. OsLEA5 (Lea14A) interacts with a regulator of the endosperm storage production, FLO2, suggesting that OsLEA5 may be involved in endosperm quality control. RNAi knockdown line of OsLEA5 showed decreased seed weight. Transformant lines overexpressing OsLEA5 exhibited improved quality and seed weight of mature seeds when they were developed under high-temperature conditions, while seed quality strongly declined in wild-type plants exposed to high-temperature stress. These findings indicate that OsLEA5 contributes to suppressing the deterioration of seed quality when developed under high-temperature conditions.

著者

Shinnosuke Mori Shuichi Shimma Hiromi Masuko-Suzuki Masao Watanabe Tetsu Nakanishi Junko Tsukioka Katsumi Goto Hiroshi Fukui Nobuhiro Hirai

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.3, pp.355-366, 2021-09-25 (Released:2021-09-25)

参考文献数

65

被引用文献数

3

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We observed trees of the Japanese apricot, Prunus mume ‘Nanko’ (Rosaceae), bearing two types of flowers: 34% had blue fluorescent pollen under UV irradiation, and 66% had non-fluorescent pollen. The fluorescent pollen grains were abnormally crushed, sterile, and devoid of intine and pollenkitt. The development of microspores within anthers was investigated: in the abnormally developed anthers, tapetal cells were vacuolated at the unicellular microspore stage, and fluorescent pollen was produced. Compounds responsible for the blue fluorescence of pollen were identified as chlorogenic acid and 1-O-feruloyl-β-D-glucose. The anthers with fluorescent pollen contained 6.7-fold higher and 3.8-fold lower amounts of chlorogenic acid and N1,N5,N10-tri-p-coumaroylspermidine, respectively, compared to those with non-fluorescent pollen. The tapetal vacuolization, highly accumulated chlorogenic acid, and deficiency of N1,N5,N10-tri-p-coumaroylspermidine imply that low-temperature stress during the early unicellular microspore stage caused a failure in microsporogenesis. Furthermore, potential effects of the visual difference on the bee behavior were also discussed through the colorimetry. The sterility, likely induced by low-temperature stress, and the preference of honeybees for fluorescence may reduce the pollination efficiency of P. mume.

著者

Ami Takeuchi Mariko Ohnuma Hiroshi Teramura Kenji Asano Takahiro Noda Hiroaki Kusano Koji Tamura Hiroaki Shimada

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.3, pp.345-353, 2021-09-25 (Released:2021-09-25)

参考文献数

31

被引用文献数

16

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The potato tuber starch trait is changed depending on the composition of amylose and amylopectin. The amount of amylopectin is determined by the activity of the starch branching enzymes SBE1, SBE2, and SBE3 in potato. SBE3, a homolog of rice BEI, is a major gene that is abundant in tubers. In this study, we created mutants of the potato SBE3 gene using CRISPR/Cas9 attached to the translation enhancer dMac3. Potato has a tetraploid genome, and a four-allele mutant of the SBE3 gene is desired. Mutations in the SBE3 gene were found in 89 of 126 transformants of potato plants. Among these mutants, 10 lines contained four mutant SBE3 genes, indicating that 8% efficiency of target mutagenesis was achieved. These mutants grew normally, similar to the wild-type plant, and yielded sufficient amounts of tubers. The potato starch in these tubers was similar to that of the rice BEI mutant. Western blot analysis revealed the defective production of SBE3 in the mutant tubers, suggesting that these transformants were loss-of-function mutants of SBE3.

著者

Shohei Nosaki Ken Hoshikawa Hiroshi Ezura Kenji Miura

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.38, no.3, pp.297-304, 2021-09-25 (Released:2021-09-25)

参考文献数

60

被引用文献数

31

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The production of recombinant proteins is important in academic research to identify protein functions. Moreover, recombinant enzymes are used in the food and chemical industries, and high-quality proteins are required for diagnostic, therapeutic, and pharmaceutical applications. Though many recombinant proteins are produced by microbial or mammalian cell-based expression systems, plants have been promoted as alternative, cost-effective, scalable, safe, and sustainable expression systems. The development and improvement of transient expression systems have significantly reduced the period of protein production and increased the yield of recombinant proteins in plants. In this review, we consider the importance of plant-based expression systems for recombinant protein production and as genetic engineering tools.

著者

Haruka KATAOKA Nanami KOITA Natsuko Ito KONDO Hiroshi C. ITO Momoko NAKAJIMA Kunikazu MOMOSE Hiroko IIMA Tomoo YOSHINO Tomoko AMANO Takio KITAZAWA Daiji ENDOH Nobuyoshi NAKAJIMA Hiroki TERAOKA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0516, (Released:2022-01-18)

被引用文献数

4

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The red-crowned crane Grus japonensis in Hokkaido, Japan forms a closed population as a residence that is independent of the mainland population. Based on observations of a limited number of individuals as well as cranes in captivity, red-crowned cranes are omnivores and eat fish, worms, insects and plants in their own territories except in winter, when they are fed with dent corn that is supplied in eastern Hokkaido. DNA metabarcoding based on high throughput sequencing was carried out using universal primer sets for cytochrome oxidase subunit I gene. Feces from 27 chicks collected in June and July in the period from 2016 to 2018 and intestinal contents from 33 adult and subadult cranes that were found dead almost throughout year in 2006–2013 in the field in eastern Hokkaido were used. Although compositions varied considerably in the cranes, both insects and fish were found in adults and subadults to the same extents, while insects were predominant in chicks. Both insects and fish were detected in all seasons for adults and subadults. Horse flies, scarab beetles and weevils accounted for the most of the insects regardless of the life stage. Dace, stickleback, flatfish and sculpin were the major fish species in adults, while chicks ate almost only stickleback. The results provide the first comprehensive data on carnivorous diets in wild red-crowned cranes in eastern Hokkaido as basis for conservation of red-crowned cranes, for which the life style and area continuing to change.

著者

Ko NAKASUMI Naoki YAMAMOTO Taro TAKAMI Harumichi ITOH Kazuhito ITAMOTO Hiro HORIKIRIZONO Toshie ISERI Munekazu NAKAICHI Yuki NEMOTO Hiroshi SUNAHARA Kenji TANI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.1, pp.114-120, 2022 (Released:2022-01-13)

参考文献数

34

被引用文献数

3

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Transcatheter arterial embolization (TAE) and transcatheter arterial chemoembolization (TACE) are standard treatments for advanced hepatocellular carcinoma (HCC) and particularly for unresectable tumors or liver metastases in humans. However, reports on TACE used in veterinary medicine are few. This study aimed to evaluate the feasibility and safety of drug-eluting bead transarterial chemoembolization (DEB-TACE). We performed DEB-TACE in four clinically normal dogs and pharmacokinetically compared the results against hepatic arterial infusion (HAI) of cisplatin in two dogs. Drug-eluting beads (DEB) loaded with cisplatin were injected through a microcatheter for selective embolization of the left hepatic artery. After embolization, computed tomography (CT) images and histological examination findings were obtained during a 4-week observation period. Serum platinum concentrations were measured to evaluate cisplatin after each procedure. Biochemical analysis was performed during a 12-week observation period. Embolization was successful in all dogs, and there were no clinically apparent abnormalities. Embolization was confirmed up to 4 weeks after DEB-TACE in two of the four dogs and up to 1 week in the other two dogs using postoperative CT images. Cisplatin was not detected in peripheral veins in all dogs after DEB-TACE, but it was detected in trace amounts after HAI. DEB-TACE using cisplatin was safe and well tolerated by normal dogs. DEB-TACE may be useful in terms of determining systemic toxicity and drug concentration within tumors.