著者

Takahiro Yonezawa Masahide Nishibori Yoshio Yamamoto Takeshi Sasaki Kohei Kudo Hiroshi Ogawa Hideki Endo Fumihito Akishinonomiya

出版者

Japan Poultry Science Association

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

vol.59, no.4, pp.316-322, 2022 (Released:2022-10-25)

参考文献数

34

被引用文献数

2

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Japanese native chickens (JNCs) comprise approximately 50 breeds, making Japan a diversity hotspot for native chicken breeds. JNCs were established through the repeated introduction of chickens from foreign countries. Jidori, which is the generic name of JNC breeds whose ancestral morphology resembles that of their wild progenitor (red junglefowls), is generally thought to have propagated from north East Asia (Korea and north China) to ancient Japan. However, mitochondrial haplogroup D, which is abundant in Island Southeast Asia (ISEA) as well as the Pacific but relatively rare in other regions, can be observed in some Jidori breeds (e.g., Tosa-Jidori, Tokuji-Jidori) with high frequency, leading to speculation that chickens from ISEA or the Pacific also contributed genetically to JNCs. To test this hypothesis, we sequenced the mitochondrial genomes of Jidori breeds and conducted phylogeographic analysis. Our results indicate that the JNC Haplogroup D belongs to Sub-haplogroup D2, which is currently only observed in Xinjiang, northwest China, and not to Sub-haplogroup D1, which is widely distributed in the ISEA-Pacific region. The other mitochondrial haplogroups of Jidori examined in this study also showed affinity to those of chickens native to north East Asia. Therefore, our findings support the north East Asian origin hypothesis for Jidori.

著者

笹川 裕史 Hiroshi Sasagawa

雑誌

関学西洋史論集 (ISSN:03860043)

巻号頁・発行日

no.42, pp.33-48, 2019-03-31

著者

SHIMA,Hiroshi

出版者

東京昆蟲學會

雑誌

昆蟲

巻号頁・発行日

vol.53, no.1, 1985-03-25

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The Oriental genus Uromedina is revised. Uromedina rufipes sp. nov. is described and illustrated from Japan. Three known species, atrata, caudata and eumorphophaga, are redescribed and illustrated. Females of atrata and caudata are described for the first time. A key to the 4 species of the genus is provided.

著者

Syota SEINO Takeru KIMOTO Hidemi YOSHIDA Kunikazu TANJI Tomoh MATSUMIYA Ryo HAYAKARI Kazuhiko SEYA Shogo KAWAGUCHI Kazushi TSURUGA Hiroshi TANAKA Tadaatsu IMAIZUMI

出版者

Biomedical Research Press

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.39, no.3, pp.105-115, 2018-06-01 (Released:2018-06-12)

参考文献数

41

被引用文献数

10 15

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Accumulation and oligomerization of amyloid-beta (Aβ) peptides have been known to be a potent cause of neurodegenerative diseases such as Alzheimer’s disease (AD). To expand the possibilities of preventing AD, we investigated the effects of resveratrol dimers, gnetin C and ε-viniferin, on Aβ 1–42 (Aβ42) production and the reduced cell viability observed after Aβ42 treatment (monomers, 10 μM) in cultured SH-SY5Y human neuroblastoma cells. Among them, addition of gnetin C (20 μM) into the media reduced Aβ42 production most efficiently. Gnetin C suppressed the expression of β-site amyloid precursor protein-cleaving enzyme-1 (BACE1, β-secretase). Furthermore, gnetin C ameliorated the Aβ42-reduced cell viability most significantly. Concomitantly, gnetin C reduced intracellular Aβ oligomers (ca. 15 and 130 kDa) and elevated both levels of intracellular and extracellular Aβ monomers. Under the treatment with or without Aβ42, gnetin C upregulated the expression of matrix metalloproteinase-14 (MMP-14) which is assumed to be an Aβ-decomposing enzyme. Gnetin C may thereby prevent Aβ toxicity by suppressing BACE1 and enhancing MMP-14, together with reducing both internalization and oligomerization of exogenous Aβ monomers. The use of gnetin C may lead to the prevention of Aβ-mediated diseases, particularly AD.

著者

Yushi Takenouchi Shuhei Wada Takuro Masumura Toshihiro Tsuchiyama Hiroshi Okano Shusaku Takagi

出版者

The Iron and Steel Institute of Japan

雑誌

ISIJ International (ISSN:09151559)

巻号頁・発行日

vol.62, no.10, pp.2000-2007, 2022-10-15 (Released:2022-10-19)

参考文献数

23

被引用文献数

2

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Stress relaxation tests were conducted in the elastic region of an ultralow carbon martensitic steel (Fe–18%Ni alloy) to quantitatively analyze the effect of mobile dislocations on the low elastic limit of the steel. The elastic limit of the as-quenched material was measured at 255 MPa, although its tensile strength was as high as 720 MPa. The stress relaxation tests, which were performed at 255 MPa, revealed a remarkable stress reduction due to the movement of the mobile dislocations present in the as-quenched material. The total dislocation density barely changed during the test, while the distribution parameter (M-value) decreased significantly, indicating that the mobile dislocations exhibited stable arrangements. The 5% cold rolling before the relaxation tests suppressed the relaxation and simultaneously increased the elastic limit to a maximum, 435 MPa. By estimating the mobile dislocation density by relating the stress reduction in the stress relaxation tests to the distance of the dislocation movement evaluated via transmission electron microscopy (TEM) observations, it was estimated that the mobile dislocation density of the 5%-cold-rolled material was lowered to ~1/10 of that of the as-quenched material.

著者

石破 洋 Hiroshi ISHIBA

雑誌

島根女子短期大学紀要 (ISSN:02889226)

巻号頁・発行日

vol.36, pp.A13-A24, 1998-03-30

著者

末次 弘 スエツグ ヒロシ hiroshi suetsugu

出版者

東洋大学井上円了記念学術センター

雑誌

井上円了センター年報 = Annual report of the Inoue Enryo Center (ISSN:13427628)

巻号頁・発行日

no.11, pp.173-187, 2002-07-20

著者

Tamotsu Tanaka Kazuya Koyama Naoko Takahashi Katsuya Morito Hanif Ali Momoyo Azuma Kozo Kagawa Hiroshi Kawano Rumana Yesmin Has Mutsumi Aihara Yasuhiko Nishioka

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.69, no.3.4, pp.196-203, 2022 (Released:2022-10-17)

参考文献数

26

被引用文献数

2

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Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonias. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are signaling lipids that evoke growth factor-like responses to many cells. Recent studies revealed the involvement of LPA and S1P in the pathology of IPF. In this study, we determined LPA, S1P and ceramide 1-phosphate (C1P) in peripheral blood plasma of IPF patients, and examined correlation to the vital capacity of lung (VC), an indicator of development of fibrosis. Blood plasma samples were taken from eleven patients with IPF and seven healthy volunteers. The lipids of the sample were extracted and subjected to liquid chromatography-tandem mass spectrometry for analysis. Results showed that there is a significant negative correlation between VC and plasma LPA levels, indicating that IPF patients with advanced fibrosis had higher concentration of LPA in their plasma. Average of S1P levels were significantly higher in IPF patients than those in healthy subjects. Although it is not statistically significant, a similar correlation trend that observed in LPA levels also found between VC and S1P levels. These results indicated that plasma LPA and S1P may be associated with deterioration of pulmonary function of IPF patients. J. Med. Invest. 69 : 196-203, August, 2022

著者

Hiroshi Kanbayashi Carola Hommerich Naoki Sudo

出版者

Japanese Association For Mathematical Sociology

雑誌

理論と方法 (ISSN:09131442)

巻号頁・発行日

vol.36, no.2, pp.259-277, 2021 (Released:2022-03-31)

著者

Masamichi KUWAJIMA Hiroaki FUJIHARA Hiroyoshi SEI Asako UMEHARA Masako SEI Tomi T. TSUDA Akiko SUKENO Tatsuya OKAMOTO Akiko INUBUSHI Yoichi UETA Toshio DOI Hiroshi KIDO

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.54, no.6, pp.911-925, 2007 (Released:2008-02-20)

参考文献数

46

被引用文献数

13 14

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The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined. Using mice with systemic carnitine deficiency (JVS mice), we examined this mechanism, focusing on the weaning period (days 14-28 postpartum). For normal mice, the survival rate was 100%, and no hypoglycemia was observed at all. Gastric lactose began to decrease on day 17, and cellulose increased sharply in amount thereafter. For JVS mice, the survival rate was 77% on day 14 and 28% on day 28. From day 21 on, hypoglycemia was noted. Gastric lactose had disappeared almost completely by day 17, and cellulose was almost undetectable from days 14 to 28. Expression of orexin mRNA in the hypothalamus did not differ between JVS and normal mice on day 14, but was suppressed in JVS mice on days 21 and 28. When JVS mice were fed a carnitine-rich diet, suppression of expression of orexin mRNA in hypothalamus was eliminated, and on day 28 lactose and cellulose were detected in the stomach without hypoglycemia. In conclusion, the suppression of the expression of orexin in the hypothalamus during the weaning period may be involved in the marked anorexia in JVS mice, which eventually leads to death from hypoglycemia.

著者

Takuji TACHIBANA Yusuke HIROTA Keijiro SUZUKI Takehiro TSURITANI Hiroshi HASEGAWA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Communications (ISSN:09168516)

巻号頁・発行日

pp.2022EBN0001, (Released:2022-10-03)

被引用文献数

4

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To accelerate research on Beyond 5G (B5G) technologies in Japan, we propose an algorithm that designs mesh-type metropolitan area network (MAN) models based on a priori Japanese regional railway information, because ground-truth communication network information is unavailable. Instead, we use the information of regional railways, which is expected to express the necessary geometric structure of our metropolitan cities while remaining strongly correlated with their population densities and demographic variations. We provide an additional compression algorithm for use in reducing a small-scale network model from the original MAN model designed using the proposed algorithm. Two Tokyo MAN models are created, and we provide day and night variants for each while highlighting the number of passengers alighting/boarding at each station and the respective population densities. The validity of the proposed algorithm is verified through comparisons with the Japan Photonic Network model and another model designed using the communication network information, which is not ground-truth. Comparison results show that our proposed algorithm is effective for designing MAN models and that our result provides a valid Tokyo MAN model.

著者

Makoto MIZUSHIMA Yukitomo ISHI Hiroshi IKEDA Ikuma ECHIZENYA Takuya OTSUKA Tomoko MITSUHASHI Shigeru YAMAGUCHI Miki FUJIMURA

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.237-242, 2022-12-31 (Released:2022-07-27)

参考文献数

25

被引用文献数

5

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Methotrexate-associated lymphoproliferative disorder (MTX-LPD) occurs in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). MTX-LPD is typically associated with Epstein-Barr virus (EBV) infection and regresses with MTX discontinuation. On the other hand, EBV-negative MTX-LPDs are less common and are more likely to show partial or no regression after MTX discontinuation. There were no standard chemotherapeutic options for refractory MTX-LPD. We present a case of EBV-negative MTX-LPD in the central nervous system (CNS) that was successfully treated with rituximab, methotrexate, procarbazine, and vincristine (R-MPV), followed by reduced-dose whole-brain radiotherapy (rdWBRT), following the same treatment protocol as primary CNS lymphoma. A 59-year-old woman with RA treated with MTX presented with gradually developing staggered gait, memory deficit, and disorientation. Multiple lesions with heterogeneous contrast enhancement were discovered using brain magnetic resonance imaging. The patient was suspected of having MTX-LPD, but discontinuing MTX did not result in regression of the brain lesions. She underwent a biopsy from the left parietal lesion. The tissue was pathologically diagnosed as diffuse large B-cell lymphoma. Furthermore, pathological examination through EBV-encoded ribonucleic acid in situ hybridization demonstrated a lack of EBV infection. She was ultimately diagnosed with EBV-negative CNS MTX-LPD. We applied chemotherapy with R-MPV and rdWBRT. The patient achieved a complete response. In the case of CNS MTX-LPD without EBV infection, chemotherapy with R-MPV followed by rdWBRT may be considered.

著者

Kenji Momo Takeo Yasu Seiichiro Kuroda Sonoe Higashino Eiko Mitsugi Hiromasa Ishimaru Kazumi Goto Atsuko Eguchi Kuniyoshi Sato Masahiro Matsumoto Takashi Shiga Hideki Kobayashi Reisuke Seki Mikako Nakano Yoshiki Yashiro Takuya Nagata Hiroshi Yamazaki Shou Ishida Naoki Watanabe Mihoko Tagomori Noboru Sotoishi Daisuke Sato Kengo Kuroda Dai Harada Hitoshi Nagasawa Takashi Kawakubo Yuta Miyazawa Kyoko Aoyagi Sachiko Kanauchi Kiyoshi Okuyama Satoshi Kohsaka Kohtaro Ono Yoshiyasu Terayama Hiroshi Matsuzawa Mikio Shirota

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.10, pp.1489-1494, 2022-10-01 (Released:2022-10-01)

参考文献数

19

被引用文献数

1

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The aim of this study was to determine the proportion of near-miss dispensing errors in hospital pharmacies in Japan. A prospective multi-center observational study was conducted between December 2018 and March 2019. The primary objective was to determine the proportion of near-miss dispensing errors in hospital pharmacy departments. The secondary objective was to determine the predictive factors for near-miss dispensing errors using multiple logistic regression analysis. The study was approved by the ethical committee at The Institute of Medical Sciences, University of Tokyo, Japan. A multi-center prospective observational study was conducted in 20 hospitals comprising 8862 beds. Across the 20 hospitals, we assessed data from 553 pharmacists and 53039 prescriptions. A near-miss dispensing error proportion of 0.87% (n = 461) was observed in the study. We found predictive factors for dispensing errors in day-time shifts: a higher number of drugs in a prescription, higher number of quantified drugs, such as liquid or powder formula, in a prescription, and higher number of topical agents in a prescription; but we did not observe for career experience level for clinical pharmacists. For night-time and weekend shifts, we observed a negative correlation of near-miss dispensing errors with clinical pharmacist experience level. We found an overall incidence of near-miss dispensing errors of 0.87%. Predictive factors for errors in night-time and weekend shifts was inexperienced pharmacists. We recommended that pharmacy managers should consider education or improved work flow to avoid near-miss dispensing errors by younger pharmacists, especially those working night or weekend shifts.

著者

Koichi Sagawa Tsugutoshi Suzuki Kohta Takei Masaru Miura Hideaki Ueda Hitoshi Horigome Hiroshi Ono Naoki Ohashi Seiichi Sato Hideo Fukunaga Hisaaki Aoki Aya Miyazaki Heima Sakaguchi Eiichiro Morishima Kaori Oki Naokata Sumitomo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0967, (Released:2022-08-18)

参考文献数

30

被引用文献数

1

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Background: The prospective Control of HEART rate in inFant and child tachyarrhythmia with reduced cardiac function Using Landiolol (HEARTFUL) study investigated the effectiveness and safety of landiolol, a short-acting β1 selective blocker, in children.Methods and Results: Twenty-five inpatients aged ≥3 months to <15 years who developed supraventricular tachyarrhythmias (atrial fibrillation, atrial flutter, supraventricular tachycardia, and inappropriate sinus tachycardia) were treated with landiolol. The primary endpoint, the percent of patients with a reduction in heart rate ≥20% from the initial rate of tachycardia, or termination of tachycardia at 2 h after starting landiolol, was achieved in 12/25 patients (48.0%; 95% CI 28.4–67.6), which exceeded the predetermined threshold (38.0%). At 2 h after starting landiolol administration, heart rate had decreased by ≥20% in 45.8% (11/24) and recovery to sinus rhythm was achieved in 40.0% (6/15) of the patients. Adverse reactions (ARs) occurred in 24.0% (6/25) of patients, and the study was discontinued in 4.0% (1/25) of the patients; however, none of these ARs were considered serious. The most common AR was hypotension (20.0% [5/25] of patients).Conclusions: The HEARTFUL study has demonstrated the efficacy of landiolol, by reducing heart rate or terminating tachycardia, in pediatric patients with supraventricular tachyarrhythmias. Although serious ARs and concerns were not identified in this study, physicians should be always cautious of circulatory collapse due to hypotension.

著者

Kazuyoshi SASAOKA Hiroshi OHTA Tomohito ISHIZUKA Tatsuyuki OSUGA Keitaro MORISHITA Noboru SASAKI Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.10, pp.1385-1390, 2022 (Released:2022-10-01)

参考文献数

26

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A 12-year-old neutered male Chihuahua was diagnosed with acute brain infarction in the right middle cerebral artery (MCA) territory. Transcranial Doppler ultrasonography (TCD) was performed to assess the local cerebral blood flow at the time of diagnosis and after 4 and 31 hr. Initially, the right MCA retained blood flow but with a lower cerebral blood flow velocity (CBFV; 14.9 cm/sec) than the left MCA (27.9 cm/sec). The TCD vascular resistance variables were higher in the right than in the left MCA. An increase in the CBFV and a decrease in TCD vascular resistance variables were observed, consistent with improvements in neurological symptoms. TCD can be a non-invasive, and easy-to-use modality for bedside monitoring of cerebral edema and infarction.

著者

Hiroshi KIBA

出版者

Japanische Gesellschaft für Germanistik

雑誌

Neue Beiträge zur Germanistik (ISSN:24330906)

巻号頁・発行日

vol.111, pp.207-209, 2003 (Released:2018-03-31)

著者

Hiroshi MATSUO

出版者

Japanische Gesellschaft für Germanistik

雑誌

Neue Beiträge zur Germanistik (ISSN:24330906)

巻号頁・発行日

vol.111, pp.211-261, 2003 (Released:2018-03-31)

著者

Raymond N. Burton-Smith Jun Tsunoda Chihong Song Hiroshi Ueno Takeshi Murata Ryota Iino Kazuyoshi Murata

雑誌

第60回日本生物物理学会年会

巻号頁・発行日

2022-09-02

著者

Akiko Kuribayashi-Yuge Yoko Kato Isao Ueda Hiroshi Nittono Masako Taniike Ikuko Mohri

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.50, pp.31-62, 2021 (Released:2022-01-13)

参考文献数

42

著者

Hiroshi Ogawara

出版者

The Society of English Studies

雑誌

現代英米文化 (ISSN:24330728)

巻号頁・発行日

vol.16, pp.15-22, 1985-12-30 (Released:2017-09-07)