著者

Hiroshi OKAJIMA Toru ASAI Shigeyasu KAWAJI

出版者

The Society of Instrument and Control Engineers

雑誌

Transactions of the Society of Instrument and Control Engineers (ISSN:04534654)

巻号頁・発行日

vol.44, no.10, pp.793-801, 2008-10-31 (Released:2013-02-25)

参考文献数

19

被引用文献数

1 1

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This paper is concerned with optimal reference tracking control problem for discrete time 1-DOF/2-DOF systems. It is well known that l2 norm of an error, which is defined by difference between an output and a reference, does not turn zero for all possible controllers when plant is given as a non-minimum phase system. Purpose of this research is to derive closed-form expression of the optimal value of l2 norm of the error and its controller. The references for tracking are e.g. step, sine, impulse train, triangle wave and linear combination of these signals. Therefore, we can handle various signals as a reference. Moreover, our results can also characterize impact of the relative degree of plant. Those effectiveness are shown by numerical examples.

著者

Hiroshi Ishii Qiang Ma Masatoshi Yoshikawa

出版者

Information Processing Society of Japan

雑誌

Journal of Information Processing (ISSN:18826652)

巻号頁・発行日

vol.20, no.1, pp.207-215, 2012 (Released:2012-01-15)

参考文献数

20

被引用文献数

1 7

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We propose a novel method for the incremental construction of causal networks to clarify the relationships among news events. We propose the Topic-Event Causal (TEC) model as a causal network model and an incremental constructing method based on it. In the TEC model, a causal relation is expressed using a directed graph and a vertex representing an event. A vertex contains structured keywords consisting of topic keywords and an SVO tuple. An SVO tuple, which consists of a tuple of subject, verb and object keywords represent the details of the event. To obtain a chain of causal relations, vertices representing a similar event need to be detected. We reduce the time taken to detect them by restricting the calculation to topics using topic keywords. We detect them on a concept level. We propose an identification method that identifies the sense of the keywords and introduce three semantic distance methods to compare keywords. Our method detects vertices representing similar events more precisely than conventional methods. We carried out experiments to validate the proposed methods.

著者

So TANABE Satohiro ITAGAKI Shuyi SUN Kyohei MATSUI Takamasa KINOSHITA Shigeki NISHII Yojiro YAMAMOTO Yasuhiro SADANAGA Hiroshi SHIIGI

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.37, no.11, pp.1597-1601, 2021-11-10 (Released:2021-11-10)

参考文献数

27

被引用文献数

2

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Enterohemorrhagic Escherichia coli are a dangerous bacterium known to be harmful to the human body, with some infections even resulting in death. Given this danger, food factories are required to perform a quick bacterial test to confirm the absence of this pathogen prior to shipping. We have developed a novel molecular imprinting polymer (MIP) particle that has encapsulated gold nanoparticles (AuNPs) and which can function as both a receptor and an optical signal transmitter in biological systems. This MIP particle is artificially synthesized and can be engineered to specifically recognize and capture antigens on the bacterial cell membrane. In addition, MIP particles containing AuNPs generate strong scattered light signals, and binding of the MIP particles improves the optical intensity of the target bacterial cells. This enables clear visualization under a dark-field microscope and quantification of the target bacteria using the scattering light intensity. Here we describe the successful quantification of Escherichia coli O157 cells in real meat samples using this technology in conjunction with a simple labelling step.

著者

小野 朋典 Midorikawa Yoshiyuki Yamamoto Satoshi Ujiie Hiroshi 小野 朋典 緑川 義行 山本 聰 氏家 宏

出版者

琉球大学理学部

雑誌

琉球大学理学部紀要 (ISSN:02869640)

巻号頁・発行日

no.47, pp.p115-151, 1989-03

被引用文献数

1

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本報告は1984年から1987年にかけて実施された琉球大学海洋学科の乗船実習RN-84,-86,及び-87航海で得られた,沖縄本島南方沖,慶良問ギャップ,石垣・西表島周辺海域からの底質サンプルの記載を主目的とする。採取されたサンプルはピストン・コアが8点,グラブ・サンプルが6点, ドレッジ・サンプルが25点に及んだ。記載に先立って行なった予察的研究の結果,次のような点が示唆された。1) 慶良問ギャップ(海裂)では,in situ の島尻層群最上部の泥岩を抜くピストン・コアや,同層群の鮮新銃から最下部更新統部分にわたる泥岩礁を含むドレッジ・サンプルのほかに,浮遊性有孔虫殻を多く含む lime-grainstone (更新統石灰岩?)が採取された.今後の調査で音波探査や深海カメラ等による海底観察と並行した底質サンプリングが行なわれるならば,本海裂の形成運動解明に貢献するであろう。2) 石垣・西表島南方の海溝斜面が先島海段に達する区域の水深2675mの地点より,石灰質砂層と半深海性シルト層の繰り返しから成る turbidite のピストン・コアを採取した。島弧の傾動運動との関連性を,今後追及すべきであろう。そのほかにも,径約5cmに達する大型底性有孔虫・Cycloclybeus carpenteriの生態に関する情報や,西表海底火山が想定されていた位置からの lime-grainstone の採取など,注目すべき材料が得られた。

著者

Hiroshi Tateishi Mika Tateishi Mohamed O Radwan Takuya Masunaga Kosuke Kawatashiro Yasunori Oba Misato Oyama Natsuki Inoue-Kitahashi Mikako Fujita Yoshinari Okamoto Masami Otsuka

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.69, no.11, pp.1123-1130, 2021-11-01 (Released:2021-11-01)

参考文献数

41

被引用文献数

12

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A disintegrin and metalloproteinase 17 (ADAM17) is a zinc-dependent enzyme that catalyzes the cleavage of the extracellular domains of various transmembrane proteins. ADAM17 is regarded as a promising drug target for the suppression of various diseases, including cancer metastasis. We synthesized a new ADAM17 inhibitor, SN-4, composed of a zinc-binding dithiol moiety and an appendage that specifically binds to a pocket of ADAM17. We show that SN-4 inhibits the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro. This activity was reduced by the addition of zinc, indicating the importance of the zinc chelating dithiol moiety. Inhibition of TNF-α cleavage by SN-4 in cells was also observed, and with an IC50 of 3.22 µM, SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat. Furthermore, SN-4 was shown to inhibit cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion. Molecular docking showed good fitting of the specificity pocket-binding group and one SH of SN-4 and hinted at possible means of structural optimization. This study provides clues for the development of potent and selective ADAM17 inhibitors.

著者

Satoshi MIZOGUCHI Yuki SAITO Shinnosuke TAKAMICHI Hiroshi SARUWATARI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E104-D, no.11, pp.1971-1980, 2021-11-01

被引用文献数

1

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We propose deep neural network (DNN)-based speech enhancement that reduces musical noise and achieves better auditory impressions. The musical noise is an artifact generated by nonlinear signal processing and negatively affects the auditory impressions. We aim to develop musical-noise-free speech enhancement methods that suppress the musical noise generation and produce perceptually-comfortable enhanced speech. DNN-based speech enhancement using a soft mask achieves high noise reduction but generates musical noise in non-speech regions. Therefore, first, we define kurtosis matching for DNN-based low-musical-noise speech enhancement. Kurtosis is the fourth-order moment and is known to correlate with the amount of musical noise. The kurtosis matching is a penalty term of the DNN training and works to reduce the amount of musical noise. We further extend this scheme to standardized-moment matching. The extended scheme involves using moments whose orders are higher than kurtosis and generalizes the conventional musical-noise-free method based on kurtosis matching. We formulate standardized-moment matching and explore how effectively the higher-order moments reduce the amount of musical noise. Experimental evaluation results 1) demonstrate that kurtosis matching can reduce musical noise without negatively affecting noise suppression and 2) newly reveal that the sixth-moment matching also achieves low-musical-noise speech enhancement as well as kurtosis matching.

著者

Yuichi Sawayama Takashi Yamamoto Yukinori Tomita Kohei Asada Noriaki Yagi Megumi Fukuyama Akashi Miyamoto Hiroshi Sakai Tomoya Ozawa Tetsuichiro Isono Daiki Hira Tomohiro Terada Minoru Horie Yoshihisa Nakagawa

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.9, pp.1575-1581, 2020-08-25 (Released:2020-08-25)

参考文献数

18

被引用文献数

5 13

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Background:The association between cytochrome P450 (CYP) 2C19 genotypes and adverse events in patients treated with clopidogrel or prasugrel after percutaneous coronary intervention (PCI) in the Japanese population is unclear.Methods and Results:This study consisted of 1,580 patients whoseCYP2C19genotypes were assessed at Shiga University of Medical Science Hospital, and 193 clopidogrel-treated and 217 prasugrel-treated patients who were followed more than 1 year after receiving PCI were analyzed. Among 1,580 patients, the prevalence of normal, intermediate, and poor metabolizers was 32%, 49%, and 17%, respectively. Overall incidence of the primary outcome, defined as a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, ischemic stroke, or major bleeding was not significantly different between the clopidogrel and prasugrel groups (adjusted hazard ratio [HR] 1.98, 95% confidence interval [CI] 0.85–4.61, P=0.12). Among patients with theCYP2C19loss-of-function (LOF) allele, however, the incidence of the primary outcome was significantly higher in the clopidogrel group (adjusted HR 3.19, 95% CI 1.10–9.24, P=0.03), whereas no difference was observed among patients without theCYP2C19LOF allele (adjusted HR 0.67, 95% CI 0.14–3.26, P=0.62).Conclusions:Among patients with theCYP2C19LOF allele, the use of clopidogrel was significantly associated with increased adverse events. Thus, further investigation is needed to establish the practical use ofCYP2C19genotyping.

著者

山本 幸⽣ 三浦 昭 平田 成 石川 博 YAMAMOTO Yukio MIUIRA Akira HIRATA Naru ISHIKAWA Hiroshi

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

2020年度 宇宙科学情報解析シンポジウム = Space Science Informatics Symposium FY2020

巻号頁・発行日

2021-02

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2020年度宇宙科学情報解析シンポジウム(2021年2月19日. オンライン開催)

著者

Fumiya Mizuno Satoko Koganemaru Hiroshi Irisawa Akira Saito Takashi Mizushima

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.6, pp.20210041, 2021 (Released:2021-10-23)

参考文献数

34

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Objective: Knee valgus during jump landing is a cause of knee injuries during sports activities. Body recognition is important for maintaining the knees and other body parts in their proper positions. The aim of this study was to investigate whether knee valgus during jump landing in healthy young women is related to the inaccuracy of recognition of bilateral knee positions in the squatting position.Methods: In 39 healthy young women, the degree of knee valgus was evaluated during the drop vertical jump test using the ratio of the knee separation distance to the ankle separation distance. The accuracy of recognition of bilateral knee positions in the squatting position was evaluated by having the blindfolded subjects indicate with their index fingers the subjective positions of their bilateral patellae by placing their fingers on a horizontal bar positioned in front of them 3 cm below the navel. The difference ratio of the recognized distance to the actual distance between the bilateral patellae was measured as an inaccuracy index.Results: The degree of knee valgus during the drop vertical jump test was positively correlated with the degree of inaccuracy of the recognized knee position with the knees in the neutral position (r=0.358, P=0.025).Conclusions: In healthy young women, knee valgus during jump landing was significantly correlated with the inaccuracy in knee position recognition in the squatting posture. This finding suggests that the assessment of knee position recognition in the squatting position could be useful as a screening tool for preventing knee injuries on jump landing during sports activities.

著者

ROBIN N.M. FEENEY JOHN P. ZERMENO DONALD J. REID SYOZI NAKASHIMA HIROSHI SANO ARMASASTRA BAHAR JEAN-JACQUES HUBLIN TANYA M. SMITH

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.118, no.3, pp.191-198, 2010 (Released:2010-12-21)

参考文献数

48

被引用文献数

25 35

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Dental enamel thickness continues to feature prominently in anthropological studies of ape and human evolution, as well as studies of preventative oral care and treatment. Traditional studies of enamel thickness require physical sectioning of teeth for linear and scaled measurements. Recent applications of microtomographic imaging allow scientists to employ larger and more diverse samples, including global samples of recent humans as well as fossil hominin teeth. Unfortunately, little is known about the degree of enamel thickness variation among human populations, particularly across the dentition. This study employed microtomography to virtually image, section, and quantify the average enamel thickness of a sample of clinically extracted Indonesian canine and premolar teeth. This virtual sample was compared to physically sectioned African and European teeth. The results demonstrate that average enamel thickness is similar among human dentitions; no significant differences were detected within tooth positions, which is surprising given developmental differences between European and African canines and premolars. When populations were combined, differences were found in average enamel thickness between maxillary and mandibular premolars, and between canines and premolars within both dental arcades. This finding is potentially due to differences in premolar morphology and a trend of increasing enamel thickness distally throughout the dentition. The finding of limited population variation within tooth positions and significant variation between tooth positions is consistent with previous two-dimensional and three-dimensional studies of human molar enamel thickness. Average enamel thickness in canines and premolars does not differ between the sexes in our sample, although male teeth tend to have larger enamel and dentine cross-sectional areas, enamel–dentine junction lengths, and bi-cervical diameters. Males have significantly greater dentine area and enamel–dentine junction length than females for maxillary canines and premolars. The results of this study suggest that enamel thickness values in mixed-populations of humans are appropriate for comparisons with fossil hominins.

著者

Takanari Kitazono Kazunori Toyoda Kazuo Kitagawa Takehiko Nagao Hiroshi Yamagami Shinichiro Uchiyama Norio Tanahashi Masayasu Matsumoto Kazuo Minematsu Izumi Nagata Masakatsu Nishikawa Shinsuke Nanto Yasuo Ikeda Toshiaki Shirai Kenji Abe Akira Ogawa PRASTRO-I Study Group

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.56093, (Released:2020-06-04)

参考文献数

19

被引用文献数

10

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Aims: The efficacy of antiplatelet therapy may vary among different disease subtypes. Prasugrel is generally a more potent, consistent, and fast-acting platelet inhibitor than clopidogrel. This sub-analysis of the phase III comparison of PRAsugrel and clopidogrel in Japanese patients with ischemic STROke (PRASTRO-I) trial aimed to assess the differences in efficacy of these treatments for each stroke subtype. Methods: In the PRASTRO-I trial, a total of 3,753 patients with ischemic stroke were recruited from 224 centers throughout Japan and randomized (1:1) to prasugrel (3.75 mg/day) or clopidogrel (75 mg/day) for 96 weeks. For the sub-analysis, strokes were classified as large-artery atherosclerosis, small-artery occlusion (lacunar), stroke of other etiology, and stroke of undetermined etiology. The cumulative incidence of primary events (ischemic stroke, myocardial infarction, and death from other vascular cause) and hazard ratios (HRs) were calculated for each subgroup. Results: For patients with large-artery atherosclerosis, the primary event incidence was 3.8% in the prasugrel group and 4.8% in the clopidogrel group (HR 0.79; 95% confidence interval [CI] 0.45–1.40). For patients with small-artery occlusion, the incidence was 3.3% in the prasugrel group and 3.9% in the clopidogrel group (HR 0.83; 95% CI 0.46–1.53). For patients with stroke of undetermined etiology, the incidence was 4.6% in the prasugrel group and 3.0% in the clopidogrel group (HR 1.56; 95% CI 0.90–2.72). The incidence of bleeding was similar across subtypes. Conclusions: Although statistical significance was not reached, the efficacy of prasugrel was potentially different between stroke subtypes, warranting further studies.

著者

末盛 博文 Suemori Hirofumi Hirai Yuko Hamasaki Kanya Kodama Yoshiaki Mitani Hiroshi Landes Reid D. Nakamura Nori

出版者

Public Library of Science

雑誌

PLOS ONE (ISSN:19326203)

巻号頁・発行日

vol.10, no.8, 2015-08-21

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It is becoming clear that apparently normal somatic cells accumulate mutations. Such accumulations or propagations of mutant cells are thought to be related to certain diseases such as cancer. To better understand the nature of somatic mutations, we developed a mouse model that enables in vivo detection of rare genetically altered cells via GFP positive cells. The mouse model carries a partial duplication of 3' portion of X-chromosomal HPRT gene and a GFP gene at the end of the last exon. In addition, although HPRT gene expression was thought ubiquitous, the expression level was found insufficient in vivo to make the revertant cells detectable by GFP positivity. To overcome the problem, we replaced the natural HPRT-gene promoter with a CAG promoter. In such animals, termed HPRT-dup-GFP mouse, losing one duplicated segment by crossover between the two sister chromatids or within a single molecule of DNA reactivates gene function, producing hybrid HPRT-GFP proteins which, in turn, cause the revertant cells to be detected as GFP-positive cells in various tissues. Frequencies of green mutant cells were measured using fixed and frozen sections (liver and pancreas), fixed whole mount (small intestine), or by means of flow cytometry (unfixed splenocytes). The results showed that the frequencies varied extensively among individuals as well as among tissues. X-ray exposure (3 Gy) increased the frequency moderately (~2 times) in the liver and small intestine. Further, in two animals out of 278 examined, some solid tissues showed too many GFP-positive cells to score (termed extreme jackpot mutation). Present results illustrated a complex nature of somatic mutations occurring in vivo. While the HPRT-dup-GFP mouse may have a potential for detecting tissue-specific environmental mutagens, large inter-individual variations of mutant cell frequency cause the results unstable and hence have to be reduced. This future challenge will likely involve lowering the background mutation frequency, thus reducing inter-individual variation.

著者

Rumi Kozakai Shigeki Tsuzuku Kyonosuke Yabe Fujiko Ando Naoakira Niino Hiroshi Shimokata

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.10, no.1sup, pp.77-81, 2000 (Released:2007-11-30)

参考文献数

21

被引用文献数

22 25

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To prevent a decline in gait with age, it is necessary to investigate age-related changes in gait performance and detect related factors. The purpose of this study was to assess the association between gait ability and leg extension power among middle-aged and elderly people. Height, weight, maximum gait velocity (MGV) and leg extension power (LEP) were measured in 752 males and females who participated in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). Age-related changes in MGV and LEP and the association between MGV and LEP were assessed. There were significant decline trends in height, weight, MGV and LEP with advancing age (p<0.001). MGV showed a significantly positive correlation with LEP (in males: r=0.48 p<0.001, in females: r=0.47; p<0.001). Subjects aged 60yrs and over showed a significantly higher correlation than those under 60yrs in males, but not in females, after adjustment for height and weight. Although the relationships between MGV and LEP were different by age and gender, LEP may be one of the important factors in maintaining gait ability. J Epidemiol, 2000 ; 10 : S77-S81.

著者

Naoakira Niino Shigeki Tsuzuku Fujiko Ando Hiroshi Shimokata

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.10, no.1sup, pp.90-94, 2000 (Released:2007-11-30)

参考文献数

17

被引用文献数

87 115

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Frequencies and circumstances of falls were assessed among 1030 middle-aged and elderly people who participated in the NILS-LSA (National Institute for Longevity Sciences, Longitudinal Study of Aging) from November, 1997 to March, 1999 and responded to the questionnaires. The variables analyzed in the present study were demography and history of falls in the past one year. Circumstances of falls, e.g. time, location, activities associated with falls, cause of falls and degree of injury due to falls were asked when the subjects experienced a fall. Fear of falling was also investigated in all subjects. The prevalence of falls was 12.9% in the middle-aged group (40-59yr.) and 16.5% in the elderly group (60-79yr.). The distribution of time, location, activity associated with falls, cause and injury due to falls corresponded with previous fall studies among community-dwelling elderly people. The incidence of falls was extremely high during the daytime and outdoors. Falls occurred most frequently while walking. The majority of falls were due to extrinsic factors. About 40% of all falls caused no injury. As to the fear of falling, about 30% of the middle-aged subjects and about 60% of the elderly subjects reported that they were fearful. Our results suggested that fall accidents are not rare, even in middle-aged people. J Epidemiol, 2000 ; 10 : S90-S94.

著者

松田 央 Hiroshi MATSUDA

雑誌

神戸女学院大学論集 = KOBE COLLEGE STUDIES

巻号頁・発行日

vol.51, no.2, pp.115-137, 2004-12-20

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Friedrich Nietzsche (1844-1900), a German philosopher designates European Nihilism (der europaische Nihilismus) which is a radical character in the western occurrence, a spiritual movement in the long-range western history, according to Heideggerian interpretation. Nietzsche thinks that Christianity is the origin of European Nihilism and it created European moral values. The Christian morality was the highest value to the European traditional culture. However according to Nietzsche's view, the aim of the Christian morality, namely kingdom of God is not yet achieved and the European morality is never improved. Accordingly there appeared atheism that denies God's existence. Nietzsche talks of 'God's death' in "The Joyful Knowledge (Die frohliche Wissenschaft)", the number 125. Nietzsche denied the Christian God and developed Perspectivism, named the eternal recurrence to endure European Nihilism. He tried to conquer himself and experience the eternal joy which was the affirmation of his life. Moreover he created a new god, named the superman (Ubermensch) which is the subject of the conquest of the self, and proclaimed 'the God's death' to revive truly human beings. However we must notice that Nietzsche's thought of the superman has its source in Christian God-man thought.

著者

SOLIS SANCHEZ Ana Ofelia del Carmen TAKADA Hiroshi

出版者

横浜法学会

雑誌

横浜法学 (ISSN:21881766)

巻号頁・発行日

vol.30, no.1, pp.239-277, 2021-09-25

著者

Noriyuki Nakatsu Yoshinobu Igarashi Taiki Aoshi Isao Hamaguchi Masumichi Saito Takuo Mizukami Haruka Momose Ken J. Ishii Hiroshi Yamada

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.42, no.4, pp.491-497, 2017-08-01 (Released:2017-07-13)

参考文献数

28

被引用文献数

7 15

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Diethyl ether (ether) had been widely used in Japan for anesthesia, despite its explosive properties and toxicity to both humans and animals. We also had used ether as an anesthetic for euthanizing rats for research in the Toxicogenomics Project (TGP). Because the use of ether for these purposes will likely cease, it is required to select an alternative anesthetic which is validated for consistency with existing TGP data acquired under ether anesthesia. We therefore compared two alternative anesthetic candidates, isoflurane and pentobarbital, with ether in terms of hematological findings, serum biochemical parameters, and gene expressions. As a result, few differences among the three agents were observed. In hematological and serum biochemistry analysis, no significant changes were found. In gene expression analysis, four known genes were extracted as differentially expressed genes in the liver of rats anesthetized with ether, isoflurane, or pentobarbital. However, no significant relationships were detected using gene ontology, pathway, or gene enrichment analyses by DAVID and TargetMine. Surprisingly, although it was expected that the lung would be affected by administration via inhalation, only one differentially expressed gene was extracted in the lung. Taken together, our data indicate that there are no significant differences among ether, isoflurane, and pentobarbital with respect to effects on hematological parameters, serum biochemistry parameters, and gene expression. Based on its smallest affect to existing data and its safety profile for humans and animals, we suggest isoflurane as a suitable alternative anesthetic for use in rat euthanasia in toxicogenomics analysis.

著者

Nobue Saito Toshimi Sairenchi Fujiko Irie Hiroyasu Iso Kyoko Iimura Hiroshi Watanabe Takashi Muto Hitoshi Ota

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.229, no.3, pp.203-211, 2013 (Released:2013-02-27)

参考文献数

25

被引用文献数

13 20

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Liver cancer a global public health concern and well known for poor prognosis. The association between low total cholesterol level and liver cancer has been reported. However, the association between low low-density lipoprotein (LDL) cholesterol levels and liver cancer is still unclear. The aim of this study was to examine the relationship between LDL cholesterol level and liver cancer mortality. A total of 16,217 persons (5,551 men and 10,666 women) aged 40-79 years in 1993 were followed until 2008. LDL cholesterol levels were divided into four categories (< 80 mg/dl, 80-99 mg/dl, 100-119 mg/dl, and ≥ 120 mg/dl). Hazard ratio of LDL cholesterol level for liver cancer mortality was calculated using a multivariable Cox proportional hazards model. Covariates were age, sex, alanine transaminase, body mass index, alcohol intake and smoking status, all of which were correlated with LDL cholesterol levels. There were 51 deaths (32 men and 19 women) from liver cancer. Multivariable hazard ratios of liver cancer deaths for LDL cholesterol levels of < 80 mg/dl was 4.33 (95% confident interval [CI]: 1.94, 9.68), for LDL cholesterol levels of 80-99 mg/dl was 1.03 (95% CI: 0.42, 2.53), and for LDL cholesterol levels of ≥ 120 mg/dl was 0.43 (95% CI: 0.20, 0.92) compared with LDL cholesterol levels of 100-199 mg/dl (p for trend < 0.01). Therefore, low LDL cholesterol levels are associated with elevated risk of liver cancer mortality. Low LDL cholesterol may be a predictive marker for death due to liver cancer.

著者

Gen Adachi Tomoki Oshikawa Hiroshi Akuzawa Koji Kaneoka

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.67, no.3.4, pp.274-279, 2020 (Released:2020-11-05)

参考文献数

32

被引用文献数

2

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The purpose of this study was to clarify the influence of different postures on the activity of the shoulder girdle and lower back muscles while using a smartphone. Sixteen healthy male participants maintained two postures while using a smartphone : a good posture in which the tragus and acromion were closer to the vertical line passing through the greater trochanter, and a poor posture in which the tragus and acromion were farther from the vertical line passing through the greater trochanter. The target muscles were the rhomboid major (Rhom), upper trapezius, middle trapezius, lower trapezius (LT), lumbar erector spinae (LES), and lumbar multifidus (LMF). The activities of the Rhom and LT were significantly lower with poor posture than those with good posture. The activities of LES and LMF were significantly higher with poor posture than those with good posture. The results of this study indicated that poor posture was associated with hypoactivity of the shoulder girdle muscles and hyperactivity of the lower back muscles when compared with good posture. Poor posture for prolonged periods while using a smartphone would lead to malfunction of the shoulder girdle muscles and musculofascial lower back pain. J. Med. Invest. 67 : 274-279, August, 2020

著者

Nobuyuki Katsumata Daisuke Harama Takako Toda Yuto Sunaga Masashi Yoshizawa Yosuke Kono Yohei Hasebe Keiichi Koizumi Minako Hoshiai Tomohiro Saito Sho Hokibara Koji Kobayashi Miwa Goto Tomoaki Sano Makoto Tsuruta Makoto Nakamura Sonoko Mizorogi Masanori Ohta Mie Mochizuki Hiroki Sato Hiroshi Yokomichi Takeshi Inukai

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20210132, (Released:2021-09-04)

参考文献数

42

被引用文献数

9

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Background: Kawasaki disease is suspected to be triggered by previous infection. The prevention measures for coronavirus disease 2019 (COVID-19) have reportedly reduced transmission of certain infectious diseases. Under these circumstances, the prevention measures for COVID-19 may reduce the incidence of Kawasaki disease.Methods: We conducted a retrospective study using registration datasets of patients with Kawasaki disease who were diagnosed in all 11 inpatient pediatric facilities in Yamanashi Prefecture. The eligible cases were 595 cases that were diagnosed before the COVID-19 pandemic (from January 2015 through February 2020) and 38 cases that were diagnosed during the COVID-19 pandemic (from March through November 2020). Incidence of several infectious disease were evaluated using data from the Infectious Disease Weekly Report conducted by the National Institute of Infectious Diseases.Results: Epidemics of various infectious diseases generally remained at low levels during the first 9 months (March through November 2020) of the COVID-19 pandemic. Moreover, the incidence of COVID-19 was 50–80 times lower than the incidence in European countries and the United States. The total number of 38 cases with Kawasaki disease for the 9 months during the COVID-19 pandemic was 46.3% (−3.5 standard deviations [SDs] of the average [82.0; SD, 12.7 cases] for the corresponding 9 months of the previous 5 years. None of the 38 cases was determined to be triggered by COVID-19 based on their medical histories and negative results of severe acute respiratory syndrome coronavirus 2 testing at admission.Conclusion: These observations provide a new epidemiological evidence for the notion that Kawasaki disease is triggered by major infectious diseases in children.