著者

Kakui Keiichi Katoh Toru Hiruta Shimpei F. Kobayashi Norio Kajihara Hiroshi

雑誌

Zoological Science (ISSN:02890003)

巻号頁・発行日

vol.28, no.10, pp.749-757, 2011

被引用文献数

34

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Phylogenetic relationships within Tanaidacea were analyzed based on sequence data for the 18S rRNA gene. Our results strongly supported a monophyletic group composed of Neotanaidae, Tanaoidea, and Paratanaoidea, with the first two taxa forming a clade. These results contradict three previously suggested hypotheses of relationships. Based on the molecular results, and considering morphological similarities/differences between Neotanaidomorpha and Tanaidomorpha, we demoted Suborder Neotanaidomorpha to Superfamily Neotanaoidea within Tanaidomorpha; with this change, the classification of extant tanaidaceans becomes a two-suborder, four-superfamily system. This revision required revision of the diagnoses for Tanaidomorpha and its three superfamilies. The results for Apseudomorpha were ambiguous: this taxon was monophyletic in the maximum likelihood and Bayesian analyses, but paraphyletic in the maximum parsimony and minimum evolution analyses.

著者

内炭 広志 羽豆 智之 小合 祐輔 近藤 麻理奈 開本 浩矢 Uchizumi Hiroshi Hazu Tomoyuki Ogo Yusuke Kondo Marina Hirakimoto Hiroya ウチズミ ヒロシ ハズ トモユキ オゴウ ユウスケ コンドウ マリナ ヒラキモト ヒロヤ

出版者

大阪大学経済学会・大阪大学大学院経済学研究科

雑誌

大阪大学経済学 (ISSN:24240397)

巻号頁・発行日

vol.68, no.1, pp.116-131, 2018-06

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論文

著者

FUKUDA Toshio KOBAYASHI Hiroshi

出版者

一般社団法人日本機械学会

雑誌

Bulletin of JSME (ISSN:00213764)

巻号頁・発行日

vol.29, no.256, pp.3545-3552, 1986

被引用文献数

3

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This paper presents a new concept of a flexible and versatile shape reconfigurable control mechanism of a robot, called a versatile robotnoid (Vroid), which can be applied for plant maintenance work and other outdoor operational works, where the working environments are restricted due to mobile space and terrain. The Vroid I based on the multiple link-wheel mechanism has abilities of passing through rough terrains, passing over obstacles and going up and down stairways. Compare with the conventional wheel, crawler and legged locomotion types of the mobile mechanisms, the proposed Vroid I is considered superior with respect to flexibility and adaptability to working environments. Utilizing the redundance of joints in degrees of freedom, a method of the joint static control sequence is proposed to minimize the torques required to joint rotation under some constraints, which can easily be solved by the linear programming approach.

著者

Hiroshi Mabuchi Toru Kita Masunori Matsuzaki Yuji Matsuzawa Noriaki Nakaya Shinichi Oikawa Yasushi Saito Jun Sasaki Kazuaki Shimamoto Hiroshige Itakura the J-LIT Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.66, no.12, pp.1096-1100, 2002 (Released:2002-11-25)

参考文献数

26

被引用文献数

84 103

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Hyperlipidemia is primarily implicated in the progression of coronary heart disease (CHD) and its treatment is essential for patients with a history of CHD. Statins such as simvastatin, the lipid-lowering agents, are well-known for their ability to normalize patient's serum lipid levels. The Japan Lipid Intervention Trial study of simvastatin is the first nationwide investigation of the relationship between serum lipid levels and the development of CHD in Japanese patients with hypercholesterolemia. Of 5,127 patients, exclusively with a history of documented CHD at enrollment, 4,673 were treated with open-labeled simvastatin at an initial dose of 5-10 mg/day and were monitored for 6 years. The risk of coronary events tended to be higher in patients with a serum total cholesterol (TC) ≥240 mg/dl compared with total cholesterol <240 mg/dl. The concentration of low-density lipoprotein cholesterol (LDL-C) positively correlated and that of high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of CHD. Each 10 mg/dl decrease in LDL-C and each 10 mg/dl increase in HDL-C concentration reduced the risk of CHD by 8.0% (95% confidence interval 3.8-12.0) and 28.3% (95% CI 13.9-40.3), respectively. A reasonable therapeutic strategy to reduce CHD progression in patients with prior CHD under low-dose statin treatment might be regulating the serum LDL-C concentration to at least <120 mg/dl and HDL-C >40 mg/dl, respectively. (Circ J 2002; 66: 1096 - 1100)

著者

都築 誉史 松井 博史 木村 泰之 ツヅキ タカシ マツイ ヒロシ キムラ ヤスユキ Takashi Tsuzuki Hiroshi Matsui Yasuyuki Kimura

雑誌

応用社会学研究 = The journal of applied sociology

巻号頁・発行日

vol.48, pp.37-52, 2006-03-25

著者

Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Tomomi Ohishi Naoko Okino Toshihito Kitamura Weinong Guo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-1424, (Released:2018-07-26)

参考文献数

17

被引用文献数

15

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Background:The objective of the present analyses was to describe the baseline characteristics and treatment of the Japanese patients with HFrEF in THE PARALLEL-HF study.Methods and Results:Key demographic, clinical and laboratory findings, along with treatment, were reported and compared with patients enrolled in the PARADIGM-HF trial and other contemporary randomized clinical trials and registries of Japanese patients with HFrEF. In addition, the MAGGIC and EMPHASIS-HF risk scores were calculated. A total of 225 Japanese patients were randomized in PARALLEL-HF with a mean age of 67.9 years and the majority of the patients being male (85.8%) and in NYHA Class II (93.8%). Key baseline characteristics in PARALLEL-HF were generally comparable with PARADIGM-HF, and other contemporary clinical trials and registries of Japanese HFrEF patients. Patients enrolled in PARALLEL-HF were well treated with conventional evidence-based therapy at baseline (angiotensin-converting enzyme inhibitor inhibitor/angiotensin receptor blocker, 62.7%/37.3%; β-blockers, 94.7%; mineralocorticoid receptor antagonist, 59.1%). Despite the evidence-based treatment and most patients being in NYHA Class II, these patients had a low LVEF (mean 28.1%) and were at high risk of cardiovascular mortality and morbidity as assessed by the MAGGIC and EMPHASIS-HF risk scores.Conclusions:Overall, the patients in PARALLEL-HF were largely representative of contemporary ambulatory patients with HFrEF who are well treated with evidence-based therapies. PARALLEL-HF will determine whether sacubitril/valsartan provides similar improvements in clinical outcomes in Japanese HFrEF patients as observed in the PARADIGM-HF study.

著者

Yoshimitsu CHIKAMOTO Masahide KIMOTO Masayoshi ISHII Masahiro WATANABE Toru NOZAWA Takashi MOCHIZUKI Hiroaki TATEBE Takashi T. SAKAMOTO Yoshiki KOMURO Hideo SHIOGAMA Masato MORI Sayaka YASUNAKA Yukiko IMADA Hiroshi KOYAMA Masato NOZU Fei-fei JIN

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.90A, pp.1-21, 2012 (Released:2012-06-07)

参考文献数

52

被引用文献数

14 24

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Sea surface temperature (SST) predictability in the Pacific on decadal timescales is examined in hindcast experiments using the coupled atmosphere-ocean model MIROC with low, medium, and high resolutions. In these hindcast experiments, initial conditions are obtained from an anomaly assimilation procedure using the observed oceanic temperature and salinity while prescribing natural and anthropogenic forcing based on the IPCC concentration scenarios. Our hindcast experiments show the predictability of SST in the western subtropical Pacific, the Indian Ocean, and the tropics to the North Atlantic. Previous studies have examined the SST predictability in the Indian Ocean and the Atlantic, but SST predictability in the western subtropical Pacific has not been evaluated. In the western Pacific, the observed SST anomalies in the subtropics of both hemispheres increased rapidly from the early 1990s to the early 2000s. While this SST warming in the western subtropical Pacific is partly explained by global warming signals, the predictions of our model initialized in 1995 or 1996 tend to simulate the pattern of the SST increase and the associated precipitation changes. This large climate change around the late 1990s may be related to phenomena such as the recent increase in the typhoon frequency in Taiwan and the weakened East Asian monsoon reported by recent studies.

著者

Takashima Shin-ichiro Usui Soichiro Kurokawa Keisuke Kitano Teppei Kato Takeshi Murai Hisayoshi Furusho Hiroshi Oda Hiroyuki Maruyama Michiro Nagata Yoshiki Usuda Kazuo Kubota Koji Takeshita Yumie Sakai Yoshio Honda Masao Kaneko Shuichi Takamura Masayuki

出版者

BMJ Publishing Group

雑誌

Open Heart (ISSN:20533624)

巻号頁・発行日

vol.3, no.1, 2016-06-01

被引用文献数

4

---

Objective: Comprehensive profiling of gene expression in peripheral blood leucocytes (PBLs) in patients with acute coronary syndrome (ACS) as a prognosticator is needed. We explored the specific profile of gene expression in PBLs in ACS for long-term risk stratification. Methods: 30 patients with ACS who underwent primary percutaneous coronary intervention (PCI) and 15 age-matched adults who participated in medical check-ups were enrolled from three centres. Peripheral blood samples were collected to extract RNA for microarray analyses. Results: During the 5-year follow-up, 36% of this cohort developed the expected non-fatal coronary events (NFEs) of target lesion revascularisation (TLR) and PCI for a de novo lesion. Class comparison analysis (p<0.005) demonstrated that 83 genes among 7785 prefiltered genes (41 upregulated vs 42 downregulated genes) were extracted to classify the patients according to the occurrence of NFE. Pathway analysis based on gene ontology revealed that the NFEs were associated with altered gene expression regarding the T-cell receptor signalling pathway in ACS. Univariate t test showed that the expression level of death-associated protein kinase1 (DAPK1), known to regulate inflammation, was the most significantly negatively regulated gene in the event group (0.61-fold, p<0.0005). Kaplan-Meier curve analysis and multivariate analysis adjusted for baseline characteristics or clinical biomarkers demonstrated that lower DAPK1 expression in PBL emerged as an independent risk factor for the NFEs (HR: 8.73; CI 1.05 to 72.8, p=0.045). Conclusions: Altered gene expression in T-cell receptor signalling in PBL in ACS could be a prognosticator for secondary coronary events. © Published by the BMJ Publishing Group Limited.

著者

Ohara Masayuki Kohori Sadayuki Shinmura Hiroshi Tsuboi Junji

出版者

一般社団法人 日本機械学会

雑誌

The Proceedings of International Symposium on Seed-up and Service Technology for Railway and Maglev Systems : STECH

巻号頁・発行日

vol.2009, pp._354324-1_-_354324-5_, 2009

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On JR Central's conventional lines, approximately 190km of track are replaced annually as one aspect of the company's line maintenance. The replacement work uses rails having a length of 25 meters, which are called standard-length rails, and those having a length of 200m or 150m, which are known as long welded rails. The standard-length rails are transported by rail from the Nagoya Port Materials Center and the long welded rails from the Hamamatsu Rail Center. Previously, this rail transport was carried out using three electric locomotives (EF64, EF58), one diesel locomotive (DD51), and 41 flat cars (open railroad freight cars). However, over 30 years have passed since these vehicles had been manufactured and alternatives were needed because these vehicles have become obsolete, so a railway diesel car type rail transport car was newly developed. [photograph] Standard-length rail transport car & [photograph] long welded rail transport car Figure 1: Series Kiya 97 rail transport carIn developing a rail transport car, use requirements are considerably different from those for passenger vehicles, so the design was implemented so as to take into account factors such as loading conditions, impact of rails laid across cars, and the circumstances during rail unloading. This report will focus particularly on the newly developed bogie and the parts related to the new constant low speed function.

著者

YABU Hiroshi

出版者

北海道大学水産学部 = FACULTY OF FISHERIES, HOKKAIDO UNIVERSITY

雑誌

北海道大學水産學部研究彙報 (ISSN:00183458)

巻号頁・発行日

vol.27, no.2, pp.51-62, 1976-08

著者

谷口 保太郎 本田 弘 柳川 兵一 山室 宗文 柴田 貞一 堀 勇吉 生田 鹿之丞 [タニグチ ヤスタロウ] [ホンダ ヒロシ] [ヤナガワ ヘイイチ] ヤマムロ ソウブン [シバタ テイイチ] [ホリ ユウキチ] [イクタ シカノジョウ] [Honda Hiroshi] Yamamuro Sobun

出版者

龍南會

雑誌

龍南會雜誌

巻号頁・発行日

vol.95, pp.44-44, 1902-11-20

著者

HUAI-YING ZHENG KAZUO KOJIMA HIROSHI IKEGAYA TOMOKAZU TAKASAKA TADAICHI KITAMURA YOSHIAKI YOGO

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.113, no.3, pp.291-293, 2005 (Released:2005-12-21)

参考文献数

6

被引用文献数

2 2

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We used the JC virus genotyping method to investigate the origins of Greenland Inuits. Using polymerase chain reaction, we detected six JC virus isolates in urine samples collected from Inuits in northwestern and southeastern Greenland. Phylogenetic analysis of the complete and partial DNA sequences of these isolates demonstrated that all isolates belonged to the EU-a1/Arc cluster previously identified in native northeastern Siberians (e.g. Chukchis and Koryaks) and Canadian Inuits. This finding suggests a close contact or affinity between Greenland Inuits and other circumarctic populations.

著者

Haruhi Yamada Yukiko Katsumori Miki Kawano Shumpei Mori Ryo Takeshige Jun Mukai Hiroshi Imada Hiroyuki Shimoura Hachidai Takahashi Tadasu Horai Yutaka Okita Ken-ichi Hirata

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.12, pp.1763-1767, 2018-06-15 (Released:2018-06-15)

参考文献数

12

被引用文献数

5

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A 73-year-old man, with congestive heart failure due to combined valvar disease, underwent curative surgery. Although the surgery was successful, his clinical course was eventful because of pulmonary complications, and he began to deteriorate mentally. Quetiapine was prescribed, which appeared to effectively settle his mental status. Following the administration of quetiapine, however, he developed acute kidney injury (AKI) that required continuous hemodiafiltration. Subsequent to discontinuation of quetiapine, his renal function gradually improved. Atypical antipsychotic drugs, including quetiapine, are frequently used to treat delirium in elderly patients in the intensive-care setting. This case highlights a potential risk of quetiapine-related AKI.

著者

JUN-ICHI YAMASHITA SETSUO TAKEDA HIROSHI MATSUMOTO NORIO UNEMI MITSUGI YASUMOTO

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.6, pp.2373-2381, 1987-06-25 (Released:2009-10-19)

参考文献数

12

被引用文献数

3 3

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Various O-alkoxyalkyl derivatives of 2'-deoxy-5-trifluoromethyluridine (F3Thd) were synthesized, and the antitumor activities of the compounds against sarcoma 180 were examined by oral administration to mice. Among the formal-type derivatives, 3', 5'-di-O-ethoxymethyl (3), 3', 5'-di-O-benzyloxymethyl (12), 5'-O-benzyloxymethyl (13) and 3'-O-benzyloxymethyl (14) compounds showed high activities, which were six-fold higher than that of F3Thd itself. Since acetal-type derivatives were unstable under acidic conditions, antitumor testing of the compounds was also carried out with co-administration of sodium bicarbonate. 5'-O- (1-Ethoxypropyl) -F3Thd (25) and 5'-O- (1-benzyloxypropyl) -F3Thd (37) showed the highest activities among the acetal-type derivatives, but the ED50 values of the compounds were not lower than those of effective formal-type compounds.These O-alkoxyalkyl derivatives of F3Thd are resistant to degradation by thymidine phosphorylase and are activated by microsomal drug-metabolizing enzymes after absorption.

著者

Miyako Tanaka Fukashi Serizawa Yohei Nagaoka Takuya Jimbo Kazuki Kawashima Takeshi Asakura Hiroshi Otomo Kenichi Yokota

出版者

The Editorial Committee of Annals of Vascular Diseases

雑誌

Annals of Vascular Diseases (ISSN:1881641X)

巻号頁・発行日

vol.11, no.1, pp.148-152, 2018-03-25 (Released:2018-03-25)

参考文献数

7

被引用文献数

6

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We report our experience of two cases of refractory cellulitis caused by peripheral micro-arteriovenous fistulas (AVFs) in the lower extremity. The micro-AVFs were so small that they could not be located accurately; further, the patients’ symptoms differed markedly from those previously reported for AVF. AVF is known to cause ischemic symptoms. In contrast, micro-AVF causes congestive symptoms and remains undetected in the majority of patients. Identification of this pathology is crucial to enable effective treatment by the ligation of the incompetent perforator vein that increases venous hypertension, leading to congestive symptoms.

著者

青木 祐子 小林 尚志 隈崎 達夫 高木 博 高木 亮 林 宏光 若林 洋行 中條 秀信 市川 太郎 Takagi Hiroshi Aoki Yuko Kumazaki Tatsuo Kobayasni Hisashi Ichikawa Taro Nakajyo Hidenobu Wakabayashi Yoshiyuki Hayashi Hiromitsu Takagi Ryo クマザキ タツオ タカギ ヒロシ アオキ ユウコ コバヤシ ヒサシ イチカワ タロウ ナカジョウ ヒデノブ ワカバヤシ ヨシユキ ハヤシ ヒロミツ タカギ リョウ

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.58, no.5, pp.238-240, 1998-04-25

著者

TAGUCHI SEIICHI ARAKAWA KUMIKO YOKOYAMA KEIICHI TAKEHANA SHINO TAKAGI HIROSHI MOMOSE HARUO

出版者

The Society for Biotechnology, Japan

雑誌

Journal of Bioscience and Bioengineering (ISSN:13891723)

巻号頁・発行日

vol.94, no.5, pp.478-481, 2002

被引用文献数

1

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Processing and activation of the precursor of an extracellular <i>Streptomyces</i> transglutaminase were achieved by using three <i>Streptomyces</i> proteases (SAM-P20, SAM-P26 and SAM-P45), all of which are widely distributed in <i>Streptomyces</i>. The use of these proteases would allow us to develop a production process for the active form of this enzyme in recombinant bacteria.<br>

著者

Hiroshi HAMADA

出版者

Japanese Association For Mathematical Sociology

雑誌

理論と方法 (ISSN:09131442)

巻号頁・発行日

vol.31, no.2, pp.242-260, 2016 (Released:2017-01-16)

参考文献数

58

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The purpose of this study is to formalize a generative model for income and capital inequality by focusing on the accumulation process of human and network capital. Using this model, we attempt to provide theoretical explanations to three empirical questions. First, why is the relationship between economic growth and income inequality expressed as an inverted U-curve? Second, why does societal relative deprivation increase when economic growth rises (the so-called China puzzle)? Third, why is income inequality stable despite the reduction of human capital inequality? The model assumes that people in a society experience repeatedly random chances of gaining capital interest with a success probability p. People gain additional capital as an interest when they succeed and incur a cost when they fail randomly. We show that the capital distribution approaches a lognormal distribution, and as an output of Cobb-Douglas production function, income distribution is also subject to a lognormal distribution. Analyzing the Gini coefficient and the average income as a function of parameters of the model, we derive the following implications. 1) The inverted U-curve is realized by the expansion of success chance. 2) The China puzzle occurs because the increase of average income and Gini coefficient are simultaneously followed by the expansion of success probability p under the range p∈(0,0.5). 3) The income inequality is stable, though human capital inequality decreases because of human and network capital elasticity and network capital diminishes the impact of human capital equalization on income inequality.

著者

Hiroshi SASAKI Tomoyoshi HOSOKAWA Yoshiharu NAWATA Kunio ANDO

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.38, no.8, pp.1463-1466, 1974 (Released:2008-11-27)

参考文献数

11

被引用文献数

6

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Ascochlorin and its analogs were isolated from the filter cake of the fermented broth of a fungus, Ascochyta viciae Libert; the compounds obtained were ascochlorin, LL-Z1272δ, LL-Z1272 ε, ascofuranone, ascofuranol and a new analog, C23H31ClO5. Some of these prenyl phenols show hypolipidemic activity in both normolipidemic and hyperlipidemic rats. Details of the structure determination for ascochlorin are presented. The structure of the new analog was elucidated as 4'-hydroxy-5'-hydroascochlorin.

著者

TOSHIAKI HAYASHI TAKAO NOTO YOSHIHARU NAWATA HIROSHI OKAZAKI MIKIO SAWADA KUNIO ANDO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.35, no.7, pp.771-777, 1982 (Released:2006-04-12)

参考文献数

17

被引用文献数

16 25

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A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad spectrum antimicrobial and antitumor activity.