著者
Beppu Toru Ishiko Takatoshi Chikamoto Akira Komori Hiroyuki Masuda Toshiro Hayashi Hiromitsu Okabe Hirohisa Otao Ryu Sugiyama Shinichi Nasu Jiro Horino Kei Takamori Hiroshi Baba Hideo ベップ トオル イシコ タカトシ チカモト アキラ コモリ ヒロユキ マスダ トシロウ ハヤシ ヒロミツ オカベ ヒロヒサ オオタオ リュウ スギヤマ シンイチ ナス ジロウ ホリノ ケイ タカモリ ヒロシ ババ ヒデオ 別府 透 石河 隆敏 近本 亮 小森 宏之 増田 稔郎 林 洋光 岡部 弘尚 太田尾 龍 杉山 眞一 那須 二郎 堀野 敬 高森 啓史 馬場 秀夫
出版者
H.G.E. Update Medical Publishing Ltd.
雑誌
Hepato-Gastroenterology (ISSN:01726390)
巻号頁・発行日
vol.59, no.114, pp.542-545, 2012-03

Background/Aims: To clarify the clinical benefits of the maneuver in right-side hepatectomy. Methodology: Eighty-one patients with liver tumor (54 hepatocellular carcinoma, 17 metastatic liver tumor and 10 other tumors) treated with a right-side hepatectomy were prospectively analyzed. The patients were divided into the following three groups: a conventional approach (group A, n=21); liver dissection under the hanging maneuver after liver mobilization (group B, n=19) and liver dissection under the hanging maneuver prior to liver mobilization (group C, n=41). Results: The liver hanging maneuver was safely performed in all the patients in groups B and C. Tumor size had a significantly positive correlation with the amount of intraoperative blood loss (R=0.52, p<0.05) in group A only. The patients in groups B and C had a significantly lower intraoperative use of blood loss (both p<0.01), operation time (p<0.05 and p<0.01) and the frequency of blood product (both p<0.05), in comparison to group A, respectively. The postoperative morbidity and the mortality rates were similar in the three groups. Conclusions: Liver hanging maneuver is a safe procedure, which can decrease intraoperative blood loss and administration of blood product in right-side hepatectomy.
著者
Kodai Murasawa Masato Takamura Masayoshi Kumagai Yoshimasa Ikeda Hiroshi Suzuki Yoshie Otake Takayuki Hama Shinsuke Suzuki
出版者
The Japan Institute of Metals and Materials
雑誌
MATERIALS TRANSACTIONS (ISSN:13459678)
巻号頁・発行日
pp.M2017380, (Released:2018-06-01)
参考文献数
22
被引用文献数
6

Neutron diffraction profile analysis using the whole profile fitting method is useful for obtaining microscopic information on metallic materials. To determine an appropriate fitting approach for obtaining reasonable and non-arbitrary results, we applied diffraction line profile analyses using the Convolutional Multiple Whole Profile (CMWP) method to diffraction patterns obtained using the Engineering Materials Diffractometer (TAKUMI, BL19) at the Materials and Life Science Facility (MLF) of the Japan Proton Accelerator Research Complex (J-PARC). The tensile specimens of 780 MPa grade bainitic steel were uniaxially stretched until the plastic strain reached a value of 0.05. We performed CMWP analyses on the obtained diffraction patterns during tensile test with various initial parameters of dislocation density and crystallite size. These parameters were optimized in the fitting procedures to minimize the weighted sums of squared residuals (WSSRs). Following this approach, we found that unsuitable initial parameter values resulted in unreasonable convergence. Therefore, initial fitting parameters should be chosen to ensure that the initial profiles are as broad as possible. Reasonable results were obtained following this suggestive approach even when the strain anisotropy parameter is set to arbitrary values.
著者
Sohei Yoshimura Masatoshi Koga Shoichiro Sato Kenichi Todo Hiroshi Yamagami Masaya Kumamoto Ryo Itabashi Tadashi Terasaki Kazumi Kimura Yoshiki Yagita Yoshiaki Shiokawa Kenji Kamiyama Satoshi Okuda Yasushi Okada Shunya Takizawa Yasuhiro Hasegawa Tomoaki Kameda Satoshi Shibuya Yoshinari Nagakane Yasuhiro Ito Hideki Matsuoka Kazuhiro Takamatsu Kazutoshi Nishiyama Kyohei Fujita Teppei Kamimura Daisuke Ando Toshihiro Ide Takeshi Yoshimoto Masayuki Shiozawa Soichiro Matsubara Yoshitaka Yamaguchi Naoto Kinoshita Takayuki Matsuki Junji Takasugi Keisuke Tokunaga Kyoko Higashida Kazunari Homma Kazuomi Kario Shoji Arihiro Kazunori Toyoda for the SAMURAI Study Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-18-0067, (Released:2018-06-01)
参考文献数
27
被引用文献数
34

Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry in Japan.Methods and Results:NVAF patients within 7 days after onset of ischemic stroke/TIA were enrolled in 18 stroke centers. Outcome measures included ischemic and bleeding events and death in the 2-year follow-up period. We enrolled 1,116 patients taking either warfarin (650 patients) or DOACs (466 patients) at acute hospital discharge. DOAC users were younger and had lower National Institutes of Health Stroke Scale, CHADS2and discharge modified Rankin Scale scores than warfarin users (P<0.0001 each). Incidences of stroke/systemic embolism (adjusted hazard ratio, 1.07; 95% CI, 0.66–1.72), all ischemic events (1.13; 0.72–1.75), and ischemic stroke/TIA (1.58; 0.95–2.62) were similar between groups. Risks of intracranial hemorrhage (0.32; 0.09–0.97) and death (0.41; 0.26–0.63) were significantly lower for DOAC users. Infection was the leading cause of death, accounting for 40% of deaths among warfarin users.Conclusions:Stroke/TIA patients receiving DOACs for secondary prevention were younger and had lower stroke severity and risk indices than those receiving warfarin. Estimated cumulative incidences of stroke and systemic embolism within 2 years were similar between warfarin and DOACs users, but those of death and intracranial hemorrhage were significantly lower among DOAC users.
著者
MASAO MIYAUCHI ROKURO ENDO MASAFUMI HISAOKA HIROSHI YASUDA ISAO KAWAMOTO
出版者
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
雑誌
The Journal of Antibiotics (ISSN:00218820)
巻号頁・発行日
vol.50, no.5, pp.429-439, 1997-05-25 (Released:2006-11-25)
参考文献数
23
被引用文献数
16 25

We have studied an ester prodrug of a carbapenem to develop a potent orally active β-lactam antibiotic. A variety of 1β-methylcarbapenem derivatives have been synthesized. We have found that some derivatives having an amide group in the C-2 side chain show potent and well balanced antibacterial activities as well as high stability against dehydropeptidase-I. Oral absorption of derivatives has been optimized by modifying the C-3 ester promoiety. Pivaloyloxymethyl (1R, 5S, 6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(R)-5-oxopyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylate, CS-834, has been selected as the most promising compound for further evaluation.
著者
和泉 浩 IZUMI Hiroshi
出版者
秋田大学教育文化学部
雑誌
秋田大学教育文化学部研究紀要. 人文科学・社会科学自然科学 (ISSN:1348527X)
巻号頁・発行日
vol.71, pp.25-36, 2016-03-01

There has been a flurry of studies on senses, sound, hearing and listening, alongside of studies on body, inhumanities and social sciences since the early 1990s. These studies reconsider the modern visualist paradigm,hegemony of vision and modernity through excavating other senses ― hearing, touch, taste, smell ― in varioussocial, historical and cultural contexts, therefore they share aims, concepts and theoretical frameworks with postmodernism,post-structuralism, gender studies, queer studies, post-colonialism, spatial-turn. This paper outlines thesociological perspective on relationships between senses and society, sees viewpoints of recent studies on senses,especially sound studies in a sociological light, and sheds light on the problems relating to ‘alternative’ ways ofthinking and ‘reflexivity’ ― positioning and accounting for own positions and questions ― which is insisted as animportant point of sensuous scholarship and sound studies. Including this abstract, studies on senses are obsessedwith visualist concepts and metaphors, and ‘alternative’ ways of thinking and ‘reflexivity’ should confront thisthorny problem which might not be solved by constructivism, contextualism and thought of ‘in-betweenness’which apparently deny dualisms. This paper also points out that sound studies must take seriously Judith Butler’sassertion: ‘It would make no sense to define gender as the cultural interpretation of sex, if sex itself is a genderedcategory’, in order to reconsider dualisms; nature and society, sound and auditory culture, body (matter) andsociety, and sound studies should reflect its naturalistic name.
著者
Hiroshi Yatsuya Yuanying Li Yoshihisa Hirakawa Atsuhiko Ota Masaaki Matsunaga Hilawe Esayas Haregot Chifa Chiang Yan Zhang Koji Tamakoshi Hideaki Toyoshima Atsuko Aoyama
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20170048, (Released:2018-03-17)
参考文献数
36
被引用文献数
12

Background: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men.Methods: We followed 3,540 male participants of Aichi Workers’ Cohort Study, who were aged 35–64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study’s model.Results: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects.Conclusion: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.
著者
和泉 浩 IZUMI Hiroshi
出版者
秋田大学教育文化学部
雑誌
秋田大学教育文化学部研究紀要 人文科学・社会科学 = Memoirs of Faculty of Education and Human Studies, Akita University. The humanities & the social sciences (ISSN:24334979)
巻号頁・発行日
vol.73, pp.11-21, 2018-02-23

The purpose of this paper is to consider Tim Ingold’s four objections to the concept of The purpose of this paper is to consider Tim Ingold’s four objections to the concept of soundscape, in order to reconsider the concept of soundscape in relation to the concepts of light, sound, landscape, related to sound studies, study of visual culture and auditory culture. Ingold thinks ‘the concept of sound scape would be better abandoned’ based on the four reasons. This paper points out six problems with Ingold’s objections. (1) Ingold defines sound as ‘I can hear’ depending on Maurice Merleau-Ponty’s phenomenology and he also situates sound as ‘medium’, but he does not explain the relationship between Merleau-Ponty’s ‘il y a’ and James Gibson’s ‘medium’. ‘il y a’ and ‘medium’ are different. (2) Phenomenological existential conditions are fundamental in a sense, but cultural, social and historical contexts or conditions of sound, light and ontology should be considered. (3) Sound and light have different aspects. (4) His strong nostalgia for nature and past causes narrowing experiences of sound and soundscape. (5) Although he criticizes the confusion of ‘scape’ with ‘scope’, he confuses them in his argument. (6) One can explain nothing in the pure fluxes of medium, distinctions must be made to say something.oundscape, in order to reconsider the concept of soundscape in relation to the concepts of light, sound, landscape, related to sound studies, study of visual culture and auditory culture. Ingold thinks ‘the concept of sound scape would be better abandoned’ based on the four reasons. This paper points out six problems with Ingold’s objections. (1) Ingold defines sound as ‘I can hear’ depending on Maurice Merleau-Ponty’s phenomenology and he also situates sound as ‘medium’, but he does not explain the relationship between Merleau-Ponty’s ‘il y a’ and James Gibson’s ‘medium’. ‘il y a’ and ‘medium’ are different. (2) Phenomenological existential conditions are fundamental in a sense, but cultural, social and historical contexts or conditions of sound, light and ontology should be considered. (3) Sound and light have different aspects. (4) His strong nostalgia for nature and past causes narrowing experiences of sound and soundscape. (5) Although he criticizes the confusion of ‘scape’ with ‘scope’, he confuses them in his argument. (6) One can explain nothing in the pure fluxes of medium, distinctions must be made to say something.
著者
Toshiya Kojima Katsuhito Fujiu Nobuaki Fukuma Hiroshi Matsunaga Tsukasa Oshima Jun Matsuda Takumi Matsubara Yu Shimizu Gaku Oguri Eriko Hasumi Hiroyuki Morita Issei Komuro
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-17-1114, (Released:2018-04-13)
参考文献数
20
被引用文献数
7

Background:Periprocedural anticoagulation is important in catheter ablation (CA) of atrial fibrillation (AF) and there is increasing evidence that uninterrupted vitamin K antagonist (VKA) therapy is superior to interrupted anticoagulation strategies. Since the emergence of direct oral anticoagulants (DOACs), numerous studies have shown promising results for their use in uninterrupted strategies. However, further studies are needed to further define the efficacy and safety of performing AF ablation with uninterrupted factor XA inhibitors or direct thrombin inhibitors.Methods and Results:We have performed CA of AF without discontinuation of either VKA or DOAC therapy since April 2014. A total of 376 patients with AF underwent CA including pulmonary vein isolation. All of the patients were divided into 2 groups (uninterrupted VKA or uninterrupted DOACs). Anticoagulation with DOACs was associated with fewer complications than uninterrupted VKA therapy (P=0.04). There were significant differences between groups in the rates of congestive heart failure, left ventricular ejection fraction, body weight, and estimated glomerular filtration rate and of the CHADS2, CHA2DS2-VASc and HAS-BLED scores. Therefore, we also analyzed the results using the propensity score-matching method. We found no significant difference in periprocedural complications between uninterrupted VKA or DOACs therapy (P=0.65).Conclusions:CA of AF without discontinuation of DOACs is not inferior to CA without discontinuation of a VKA, with regard to ischemic or hemorrhagic complications.
著者
Ryoko TOMITA Kenichiro TODOROKI Hiroshi MARUOKA Hideyuki YOSHIDA Toshihiro FUJIOKA Manabu NAKASHIMA Masatoshi YAMAGUCHI Hitoshi NOHTA
出版者
The Japan Society for Analytical Chemistry
雑誌
Analytical Sciences (ISSN:09106340)
巻号頁・発行日
vol.32, no.8, pp.893-900, 2016-08-10 (Released:2016-08-10)
参考文献数
22
被引用文献数
1 12

We performed a comprehensive quantification of 20 amino acids in RPMI 1640 medium-cultured human colorectal adenocarcinoma cells to evaluate the efficacy of 5-fluorouracil treatment under hypoxic and hypoglycemic conditions, which mimic the tumor microenvironment. In this study, we developed a simple and comprehensive analytical method by using LC-MS/MS connected to the Intrada amino acid column, which eluted amino acids within 9 min. The present method covered a linearity range of 3.6 – 1818 μM, except for Gly (227 – 1818 μM), Ala, Asp, His (7.1 – 1818 μM each), and Trp (3.6 – 909 μM). The limits of detection were in the range of 0.02 – 38.0 pmol per injection in a standard solution. Amino acid concentration data were analyzed using principal-component analysis to represent samples on two-dimensional graphs. Linear discriminant analysis was used to classify samples on the score plots. Using this approach, the effect of 5-fluorouracil treatment could be successfully discriminated at high discrimination rates. Moreover, several amino acids were extracted from corresponding loading plots as candidate markers for distinguishing the effects of the 5-fluorouracil treatment or tumor microenvironmental conditions. These results suggest that our proposed method might be a useful tool for evaluating the efficacy of anticancer drugs in the tumor microenvironment.
著者
水上 浩 Hiroshi Mizukami 目白大学外国語学部アジア語学科
雑誌
目白大学総合科学研究 = Mejiro journal of social and natural sciences (ISSN:1349709X)
巻号頁・発行日
vol.(2), pp.151-164, 2006

This paper attempts to introduce briefly the activities of a certain school of pencak silat, a kind of martial arts practiced all over Indonesia. Adding to this aim, the author attempts to examine whether or not the argument of "craft language" discussed by students of Japanese traditional performing arts could be able to be applied for this martial art from Indonesia. In the practice of pencak silat, coaches use some kinds of unique expressions using language mainly during the practice of breathing techniques. These expressions, however, are different from "craft language" in the strict sense. This is because coaches use these expressions for the purpose of students' meeting their own "correctness".
著者
Toru Hifumi Hayato Yoshioka Kazunori Imai Toshihiro Tawara Takashi Kanemura Eiju Hasegawa Hiroshi Kato Yuichi Koido
出版者
The Japanese Society of Intensive Care Medicine
雑誌
日本集中治療医学会雑誌 (ISSN:13407988)
巻号頁・発行日
vol.18, no.4, pp.607-610, 2011-10-01 (Released:2012-03-20)
参考文献数
18
被引用文献数
1 1

The cases of intake of organophosphate pesticides reported in Japan are mainly due to oral ingestion associated with attempted suicides. We report a case of organophosphate pesticide poisoning in which percutaneous absorption was suspected to be the cause. A 61-year-old woman was brought to our hospital because of consciousness disturbance. She was found lethargic, lying in the bathroom, by her husband. She had a significant medical history of hypertension. On admission, her Glasgow coma scale (GCS) score was 14/15. Her vital signs were as follows: body temperature, 35.3°C; blood pressure, 185/102 mmHg; heart rate, 106 /min; and respiratory rate, 23 /min. Her oxygen saturation was 100%. Her pupils were 2 mm in diameter, equal in size, round, and reactive. The rest of the examination was unremarkable. Chest X-ray, head CT, and head MRI were performed, but failed to identify the cause of the consciousness disturbance. Three hours after arrival, her oxygen saturation level had fallen and diaphoresis, miosis, and lacrimation had developed, while she was intubated under sedation. Prior to tracheal intubation, we asked her whether she had taken any organophosphate agent, which she denied. No organophosphate smell was detected from the endotracheal tube. Nine hours after arrival, her cholinesterase level was reported to be 11 IU/l, and we could finally confirm the diagnosis. Pralidoxime and atropine therapy was accordingly started. Seventeen hours after arrival, her family brought bottles of pesticide (smithion®) to the hospital. It transpired that she had handled this organophosphate pesticide without wearing gloves, and that earlier she had received abrasions to her hands. Therefore, it was assumed that the organophosphate was easily absorbed through her skin. Critical care physicians should bear in mind that whenever they see patients with consciousness disturbance, percutaneously absorbed organophosphate poisoning could be one of the causes.
著者
Hiroshi Takasaki Charles Philip Gabel
出版者
The Society of Physical Therapy Science
雑誌
Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日
vol.29, no.8, pp.1409-1415, 2017 (Released:2017-08-09)
参考文献数
31
被引用文献数
11

[Purpose] To translate and culturally adapt the Örebro Musculoskeletal Screening Questionnaire (ÖMSQ-12) into Japanese (ÖMSQ-12-J), and to preliminarily investigate practicality from the clinicians’ perspectives, and determine inter-session reliability. [Subjects and Methods] This study included four phases: cross-cultural adaptation (Phases 1–2); survey among 14 clinicians (two medical doctors and 12 physiotherapists) about the practicality of using the questionnaire in six perspectives (speed of evaluation/treatment; capacity to detect patients with yellow flags; attitude towards management with bio-psycho-social perspectives; quality of evaluation/treatment; considerations of communications with patients at history-taking, physical assessments and interventions; and general clinical usefulness) based on their experiences with patients (Phase 3); and investigation of inter-session reliability among 50 patients with musculoskeletal disorders (Phase 4). [Results] The ÖMSQ-12-J was developed in Phases 1–2 using the recommended international guidelines for cultural adaptation and translation. In Phase 3, most responses were in the 3-positive options (35.7–78.6%). In Phase 4, the Intraclass Correlation Coefficient for each item ranged from 0.71–0.99 and 0.92 for the total score. [Conclusion] This study developed the ÖMSQ-12-J, which has preliminary evidence of good practicality and moderate-strong inter-session reliability. Further investigation is required to determine the predictive and prognostic capacity within a problematic musculoskeletal Japanese population.
著者
Rina NABETA Hironari OSADA Misato OGAWA Ayana HASEGAWA Miori KISHIMOTO Hirotada MURAYAMA Toshinori YOSHIDA Makoto SHIBUTANI Hiroshi ITOH Keitaro OHMORI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.79, no.9, pp.1489-1493, 2017 (Released:2017-09-12)
参考文献数
10
被引用文献数
2

A 9-year-old, spayed female Chihuahua was presented with a 1-week history of lethargy and anorexia. Abdominal ultrasonography and computed tomography found bilateral adrenal masses without metastasis. Serum cortisol levels that were sampled before and after an adrenocorticotropic hormone stimulation test were within reference ranges. Lethargy and anorexia completely resolved after short-term fluid therapy; the clinical signs did not occur for approximately 8 months until her sudden death. A postmortem examination revealed bilateral adrenocortical carcinomas and liver metastasis. Primary adrenocortical carcinomas developed in the dog met the definition of bilateral incidental adrenal gland masses (IAGMs). This is the first case report to demonstrate based on histological identification that adrenocortical carcinomas cause bilateral IAGMs in dogs.
著者
TAKEDA Hiroshi YAMAMOTO Yutaka
出版者
Atomic Energy Society of Japan
雑誌
Journal of Nuclear Science and Technology (ISSN:00223131)
巻号頁・発行日
vol.13, no.7, pp.372-381, 1976

For analyzing the mixing of particles in a spouted bed, a model is proposed, which assumes that : (a) the spouted bed consists of a spout part characterized by perfect mixing and an annulus part occupied by piston flow, (b) the ingress of particles from annulus into spout takes place within a zone below a depth h below the top of the annulus, and (c) the rate of ingress of particles into the spout is constant throughout the bed. <BR>The time-dependence of the concentration <I>C</I>*(<I>t</I>) of marked particles within the spout can be calculated with this model assuming suitable values for unmeasurable parameters. <BR>The value of <I>C</I>*(<I>t</I>) was measured from mixing experiments undertaken using alumina particles, to which a small batch of marked alumina particles was dropped transiently onto the bed in stable operation. <BR>Comparing the experimental data with the calculated results, it was found that : (a) the mixing of particles in the bed can be satisfactorily described with this model, pro-vided that a suitable correction is added to the quantity of particles present in the spout to account for the existence of mixing in the annulus, whereas the model assumed piston flow ; (b) the upper edge of the ingress zone of particles from the spout into the annulus is located in the conical part of the bed. Increasing the flow rate of spouting air short-ened the cycle time of particles, while the mixing rate within one cycle was not affected to any significant extent by changes in flow rate.
著者
Hiroshi Fujita
出版者
Wiley
巻号頁・発行日
1975