著者

Daisuke Sueta Koichi Kaikita Nobukazu Okamoto Soichiro Yamabe Masanobu Ishii Yuichiro Arima Miwa Ito Yu Oimatsu Tatsuro Mitsuse Satomi Iwashita Eiichi Nakamura Seiji Hokimoto Hiroshi Mizuta Hisao Ogawa Kenichi Tsujita for the ESCORT-TKA Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0612, (Released:2017-09-16)

参考文献数

50

被引用文献数

4

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Background:The pharmacological advantage of combining physiotherapy with anticoagulants for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) is not fully known. Herein we investigated the potential benefit of this combination therapy in patients undergoing TKA.Methods and Results:The 38 patients were randomly assigned to a physiotherapy group (n=19) or a physiotherapy plus 30 mg/day edoxaban group (n=19). The occurrence of VTE was evaluated, as were serial changes in parameters measured by the Total Thrombus-formation Analysis System, a novel system for quantitatively analyzing thrombus formation using microchips with thrombogenic surfaces (collagen plus tissue factor, atheroma [AR]-chip). Combination therapy significantly reduced the incidence of VTE after TKA compared with monotherapy (P=0.038). The area under the curve (AUC) of thrombus formation for the AR-chip (AR10-AUC30) was significantly lower in the combination group (P=0.001) on Day 7 after TKA than before TKA, but no significant change was observed with monotherapy (P=0.809). In 13 VTE-positive patients, AR10-AUC30was significantly lower in the combination group (n=3) than in the monotherapy group (n=10) on Day 7 (P=0.045).Conclusions:The combination of physiotherapy and edoxaban significantly reduced the incidence of VTE after TKA compared with physiotherapy alone. However, it is possible that VTE occurrence after TKA is not only associated with thrombogenicity, but also rheological factors.

著者

Hiroshi NISHIOKA Hirofumi KODERA

出版者

Society of Environmental Conservation Engineering

雑誌

Journal of Environmental Conservation Engineering (ISSN:03889459)

巻号頁・発行日

vol.34, no.4, pp.301-305, 2005-04-20 (Released:2010-03-18)

参考文献数

8

被引用文献数

1

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シダ植物の重金属含有量を調べるために, 兵庫県内7地域に自生するシダ133試料を採取した.蛍光X線分析法および原子吸光分析法を用いて測定した結果, 以下の事実を得た.1) ウラジロ科のコシダやウラジロはいずれもマンガンについて比較的高いX線強度が得られた.2) S1地域において採取したシシガシラには数千ppmの鉛が含有されていた.3) シシガシラにおける鉛含有量は根茎, 根および葉身の順に高かった.

著者

石田 裕 HIROSHI ISHIDA Contribution from the Entomological Laboratory Saikyo University

雑誌

西京大学学術報告. 農学 = The scientific reports of the Saikyo University. Agriculture (ISSN:03709329)

巻号頁・発行日

vol.5, pp.117-118, 1953-09-01

著者

Toki Hiroshi

出版者

Published for the Yukawa Institute for Theoretical Physics and the Physical Society of Japan

雑誌

Progress of theoretical physics. Supplement (ISSN:03759687)

巻号頁・発行日

no.168, pp.602-609, 2007

参考文献数

9

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We study the role of pion for the structure of finite nuclei. We take the chiral sigma model, where the pions are the Nambu-Goldstone bosons of chiral symmetry breaking. We then take the finite pion mean field in the relativistic mean field approximation. We study first the nuclei in the range of A=36 to A=64 with equal number of neutrons and protons. We find that the magic number gap at N = Z = 28 appears due to the finite pion mean field effect. The pion provides a large spin-orbit splitting effect due to a mechanism totally different from the ordinary spin-orbit term of the relativistic origin. On the other hand, we are not able to shift the magic number appearing at A=36 instead of A=40, which is now a motivation to work out the parity and charge projection. The standard projection technique provides an integro-differential equation for the Dirac equation. As an example, we work out ^4He in the relativistic chiral mean field model. We find good properties for the ground state energy and the size and the pion energy contribution. The form factor also comes out to be quite satisfactory. We then switch to the non-relativistic method to describe the large tensor correlations in terms of the tensor optimized shell model (TOSM). We describe ^4He and ^9Li in TOSM where the tensor force is treated fully by taking enough configuration space. We show important consequenses of the tensor correlations caused by the tensor interaction due to the Pauli blocking effect on the phase shifts of neutron scattering from ^4He and the halo structure of ^<11>Li.

著者

Ryo Iketani Yohei Kawasaki Hiroshi Yamada

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.11, pp.1976-1982, 2017-11-01 (Released:2017-11-01)

参考文献数

43

被引用文献数

12

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We performed a systematic review and Bayesian network meta-analysis to determine atypical antipsychotics that are effective and safe for the treatment of psychosis in Parkinson’s disease (PD). We conducted a comprehensive literature search using PubMed/MEDLINE, Cochrane Library, and Japana Centra Revuo Medicina (Ichu-shi Web). We used randomized controlled trials evaluating the utility of atypical antipsychotics for the treatment of psychosis in PD using the Brief Psychiatric Rating Scale (BPRS) and the Unified PD rating Scale parts III (UPDRS-III) as the endpoints. Posterior distributions of mean differences between each treatment and placebo were estimated using Bayesian network meta-analysis. The distributions describing each treatment effect were expressed as means (95% credible intervals). Ten trials involving any two treatment arms using clozapine (64 subjects in four trials), olanzapine (99 subjects in three trials), quetiapine (79 subjects in five trials), risperidone (five subjects in one trial), or placebo (156 subjects in seven trials) were finally included in the present study. Pooled estimates of each posterior distribution based on the BPRS were as follows: clozapine, −2.0 (−6.7 to 2.7); olanzapine, 0.5 (−2.3 to 3.4); quetiapine, 0.3 (−3.9 to 4.5); and risperidone, −4.7 (−57.4 to 53.3). Based on the UPDRS-III, the pooled estimates were clozapine, 0.7 (−3.8 to 4.3); olanzapine, 2.8 (0.8 to 5.1); quetiapine, 3.3 (−0.7 to 5.8); and risperidone, 4.5 (−57.7 to 63.4). Although clozapine had an effective and relatively safe profile, all atypical antipsychotics included in the present study may be unsafe, as they may worsen motor function when compared to placebo.

著者

Chisato Noguchi Kazuyo Kamitori Akram Hossain Hiroshi Hoshikawa Ayako Katagi Youyi Dong Li Sui Masaaki Tokuda Fuminori Yamaguchi

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.238, no.2, pp.131-141, 2016 (Released:2016-01-30)

参考文献数

32

被引用文献数

32

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Glucose is a major energy source for mammalian cells and is transported into cells via cell-specific expression of various glucose transporters (GLUTs). Especially, cancer cells require massive amounts of glucose as an energy source for their dysregulated growth and thus over-express GLUTs. d-allose, a C-3 epimer of d-glucose, is one of rare sugars that exist in small quantities in nature. We have shown that d-allose induces the tumor suppressor gene coding for thioredoxin interacting protein (TXNIP) and inhibits cancer cell growth by G1 cell cycle arrest. It has also been reported that GLUTs including GLUT1 are over-expressed in many cancer cell lines, which may contribute to larger glucose utilization. Since d-allose suppresses the growth of cancer cells through the upregulation of TXNIP expression, our present study focused on whether d-allose down-regulates GLUT1 expression via TXNIP expression and thus suppresses cancer cell growth. Western blot and real-time PCR analyses revealed that d-allose significantly induced TXNIP expression and inhibited GLUT1 expression in a dose-dependent manner in three human cancer cell lines: hepatocellular carcinoma (HuH-7), Caucasian breast adenocarcinoma (MDA-MB-231), and neuroblastoma (SH-SY5Y). In these cell lines, d-allose treatment inhibited cell growth. Importantly, d-allose treatment decreased glucose uptake, as measured by the uptake of 2-deoxy d-glucose. Moreover, the reporter assays showed that d-allose decreased the expression of luciferase through the hypoxia response element present in the tested promoter region. These results suggest that d-allose may cause the inhibition of cancer growth by reducing both GLUT1 expression and glucose uptake.

著者

Sandi SUFIANDI Hiromichi OBARA Huai-Che HSU Shin ENOSAWA Naoto MATSUNO Hiroshi MIZUNUMA

出版者

一般社団法人 日本機械学会

雑誌

Journal of Biomechanical Science and Engineering (ISSN:18809863)

巻号頁・発行日

pp.17-00325, (Released:2017-10-12)

参考文献数

33

被引用文献数

5

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A sufficient number of functional live hepatocytes delivered to a recipient is necessary for cell therapy. Preventing cell viability loss during the cell injection process is important to improve the clinical outcomes of hepatocyte transplantation. The critical location of cell viability loss is important to identify the causal relationship between the viability loss and cell injection process. In this study, the critical location of cell viability loss was determined experimentally in a rectangular microchannel by microscopic high-speed camera observations. Live hepatocyte distributions were investigated upstream and downstream, and measured on three planes, top, center, and bottom, under horizontally or vertically supplied conditions of the syringe orientation. Sedimented and uniform dispersion conditions of the live hepatocyte distribution at upstream of the microchannel were classified according to observations at horizontal and vertical syringe orientations, respectively. Higher hepatocyte viability loss was found under the sedimented condition. The results suggested that the critical location of hepatocyte viability loss was on the bottom plane of the microchannel. Furthermore, physical causes of the hepatocyte viability loss were found by micro-scale observations of the cell velocity and diameter during the cell injection process. This information may contribute to development of a guideline for the cell injection process to improve hepatocyte transplantation.

著者

Megumi Koizumi Hiroshi Ito Yoshihiro Kaneko Yutaka Motohashi

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.18, no.5, pp.191-196, 2008 (Released:2008-10-01)

参考文献数

22

被引用文献数

14 57

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Background: Many studies have focused on disease causality, but few of them deal with health-promoting factors. Thus, we examined the effect of having a sense of purpose in life (ikigai) on mortality from cardiovascular disease (CVD). Methods: In 1988, we conducted a prospective cohort study of 2,959 Japanese subjects, ranging in age from 40 to 74 years, and followed them till the end of 2003. The level of their sense of purpose in life was evaluated by a self-administered questionnaire. After excluding those with a history of heart disease, stroke, or malignant tumor, 1,618 subjects (832 men and 786 women) who had completed the questionnaire were used in the analyses with Cox's proportional hazards model. Results: During the average 13.3 years of follow up, 249 deaths (172 men and 77 women) occurred as a result of all causes: 32 from heart disease, 31 from stroke, 63 from CVD, and 104 from malignant tumors. The adjusted hazard ratios for death in men with a strong sense of purpose in life, as compared with those with a low sense of purpose, were 0.28 (95% confidence interval: 0.10-0.84) for stroke, 0.56 (0.28-1.10) for CVD, and 0.62 (0.45-0.86) as a result of all causes. In women, no significant relationship was found between having a sense of purpose in life and mortality; this was possibly because the smaller number of deaths reduced the statistical significance. Conclusion: We found that in men, having a sense of purpose in life affected the risk of death as a result of all causes, stroke, and CVD.

著者

NUGROHO Bayu D.A. PRIMA Ardiansyah O.D. KANNO Hiromitsu SAMESHIMA Ryoji FUJII Hiroshi LOPEZ Larry CM.

出版者

JAPAN CLIMATOLOGY SEMINAR

雑誌

JAPANESE PROGRESS IN CLIMATOLOGY (ISSN:00753467)

巻号頁・発行日

vol.2013, pp.1-10, 2013-12

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Although there has been a high interest to investigate the relationship between climate and crop yields in Indonesia, little evidence is available for crops in highland of the country. This study evaluates the relationships between global climate indices (Southern Oscillation Index, SOI; sea surface temperature, SST) and rain-fed crop yields in Gunungkidul district, highland of South-Central Java. Principal Component Analysis (PCA) approach was used to summarize the averaged SSTs during planting season for the El Nino monitoring regions: IOBW (Indian Ocean Basin-Wide), Nino.West and Niiio.3. Crops yield of each sub-district of the area was detrended using a 5-year moving average to enhance reliability of the data. For some sub-districts, the first principal component of SSTs was negatively correlated to crop yield residuals of corn and soybean while SOI was positively correlated to that of corn and dryland paddy.インドネシアにおいては気候と農作物収量との関係に高い関心が寄せられているが,高地農業に関しては進展が少ない状況である。本研究では,南方振動指数(SOI)および海水面温度(SST)のグローバル指数とジャワ島南央部に位置するグヌンキドウール地区における天水農作物収量との関係を分析した。3つの地域(IOBW, Niňo.WestおよびNiňo.3)のSSTに対して主成分分折(PCA)を適用し,その代表となる主成分を抽出した。各地域の作物収量データの信頼性を向上させるために,元の収量データとその5年移動平均値から残差を計算し,正規化した。いくつかの地域では,SSTの第1主成分とトウモロコシ・ダイズの残差との間に負の相関を示し,またSOIはトウモロコシ・陸稲の残差との間に正の相関を示すことが明らかとなった。

著者

Shigeo Godo Yu Kawazoe Hiroshi Ozaki Motoo Fujita Daisuke Kudo Ryosuke Nomura Hiroaki Shimokawa Shigeki Kushimoto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.19, pp.2603-2609, 2017-10-01 (Released:2017-10-01)

参考文献数

23

被引用文献数

5

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Thyroid storm is a life-threatening disorder that remains a therapeutic challenge. Although β-blockers are the mainstay for treatment, their use can be challenging in cases complicated by rapid atrial fibrillation and decompensated heart failure. We present a case of thyroid storm-associated atrial fibrillation and decompensated heart failure complicated by gastrointestinal dysfunction secondary to diffuse peritonitis that was successfully managed by a switching therapy, in which the continuous intravenous administration of landiolol was changed to bisoprolol via transdermal patch, in the acute phase treatment. This switching therapy may offer a promising therapeutic option for this potentially lethal disorder.

著者

Hisaji SHIMIZU Atsuhisa TAKEKOSHI Osamu TANIGUCHI Hiroshi KIMURA Ushio KAWABE

出版者

The Japan Society of Mechanical Engineers

雑誌

Bulletin of JSME (ISSN:00213764)

巻号頁・発行日

vol.15, no.88, pp.1299-1305, 1972 (Released:2008-02-15)

参考文献数

2

被引用文献数

1 2

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A superconductive magnet is generally thought unsuitable for a magnetic bearing because this magnet must be placed in liquid helium. The authors propose a new rotor-supporting system suing the strong magnetic field of a superconductive magnet. The experimental prototype was manufactured and its performances were evaluated experimentally and theoretically. The prototype consists of a cryostat, superconductive magnets, a rotor, mechanical auxiliary bearing, and so on. This newly devised cryostat can transmit an attractive force to a rotor which is placed in a normal temperature atmosphere. The bearing can suspend a rotor with hundreds of kilograms in the thrust direction using a mechanical auxiliary bearing in the radial direction. Besides, complete levitation is made possible when the currents of magnets are controlled automatically.

著者

Tetsuro Konishi Kaori Hayashi Hiroshi Sugiyama

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.56, no.16, pp.2119-2123, 2017-08-15 (Released:2017-08-15)

参考文献数

12

被引用文献数

3

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Objective We attempted to clarify the factors related to the aggravation of depression in patients with subacute myelo-optico-neuropathy (SMON) caused by clioquinol intoxication more than 35 years previously. Methods We investigated changes in the depressive mental states that occurred with aging in 19 Japanese SMON patients (mean age, 78.3 years; range, 66-89 years) according to their scores on the Japanese version of the Zung Self-rating Depression Scale (SDS), which were obtained 3-10 years previously and their current scores. The depressive state was further evaluated using simultaneous semi-structured interviews. Results The depressive mental states of 6 patients, whose current total SDS scores had increased by ≥10% in comparison to the previous score, were considered to have been aggravated with aging. The mean current total SDS score of these six patients was significantly higher than the mean score of the 13 patients whose conditions were not aggravated. Among the 20 SDS questionnaires, the patients whose conditions were aggravated showed significantly higher scores in diurnal variation, sleep disturbance and weight loss. The semi-structured interviews revealed that physical disabilities due to the sequelae of SMON, a lack of acceptance of SMON, and a decline in social activities were important factors in the aggravation of their depressive mental states with aging. Conclusion The maintenance of social activities with public support was important for coping among Japanese SMON patients with a depressive mental state, especially those who could not walk independently or who could not go outside freely without assistance.

著者

Hidenori Nakamori Miki Tomita Hiroshi Azuma Takehiro Masuzawa Toru Tokuoka

出版者

日本植物分類学会

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.68, no.2, pp.83-92, 2017 (Released:2017-09-12)

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Miscanthus (Poaceae) comprises about 20 species, of which seven species and two forms occur in Japan. There is controversy whether M. condensatus is a separate species or a variety or subspecies of M. sinensis. To determine its taxonomic status, we conducted a molecular phylogenetic analysis using DNA sequences of the atpB-rbcL, psbC-trnS(UGA), rpl20-rps12, trnL(UAA)-trnF(GAA), trnS(GGA)- trnT(UGU), and nuclear ITS regions, and the Adh1 gene from 31 samples of the seven Japanese species of Miscanthus. The neighbor-joining (NJ) tree based on the cpDNA sequences shows that M. condensatus and M. sinensis share two haplotypes, and that the nuclear ITS and Adh1 sequences of the two species are identical, making it difficult to distinguish M. condensatus from M. sinensis based on DNA sequences. The evidence indicates that hybridization between the two species has proceeded rapidly, or that M. condensatus is derived from a diverging lineage of M. sinensis. The status of M. condensatus remains controversial, but our findings support provisionally treating M. condensatus as the infraspecific taxon, M. sinensis var. condensatus.

著者

都出 比呂志 ツデ ヒロシ Tsude Hiroshi

出版者

大阪大学大学院文学研究科

雑誌

待兼山論叢. 史学篇 (ISSN:03874818)

巻号頁・発行日

vol.27, pp.1-26, 1993

著者

小山 奈都子 高橋 有里 石田 陽子 菊池 和子 渡辺 皓 Natsuko OYAMA Yuri TAKAHASHI Yoko ISHIDA kazuko KIKUCHI Hiroshi WATANABE 岩手県立大学看護学部 岩手県立大学看護学部 岩手県立大学看護学部 岩手県立大学看護学部 山形大学医学部看護学科

雑誌

岩手県立大学看護学部紀要 = Journal of the Faculty of Nursing, Iwate Prefectural University (ISSN:13449745)

巻号頁・発行日

vol.7, pp.97-100, 2005-03-01

著者

中村 博司 Hiroshi Nakamura

雑誌

時計台 (ISSN:09183639)

巻号頁・発行日

no.76, pp.18-23, 2006-04-01

著者

植木 寛 山崎 康晴 肥後 克彦 本屋敦 敏雄 川畑 尚代 森田 哲生 ウエキ ヒロシ ヤマサキ ヤスハル ヒゴ カツヒコ モトヤシキ トシオ カワバタ ヒサヨ モリタ テツオ Hiroshi UEKI Yasuharu YAMASAKI Katsuhiko HIGO Toshio MOTOYASHIKI Hisayo KAWABATA Tetsuo MORITA

雑誌

福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University

巻号頁・発行日

vol.14, pp.114-115, 1996

著者

Hiroshi Furuta Adam Pander Keisuke Takano Hiroki Miyaji Akimitsu Hatta Makoto Nakajima

出版者

応用物理学会

雑誌

2017年第78回応用物理学会秋季学術講演会

巻号頁・発行日

2017-07-21

著者

田中 弘 Tanaka Hiroshi

出版者

神奈川大学経済学会

雑誌

商経論叢 = Review of economics and commerce (ISSN:02868342)

巻号頁・発行日

vol.50, no.2, pp.1-29, 2015-03

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論説

著者

野々下 豪 塩山 善之 國武 直信 Nakamura Katsumasa Nomoto Satoshi Ohga Saiji Toriya Youichi Ono Minoru Honda Hiroshi

出版者

福岡医学会

雑誌

福岡医学雑誌 (ISSN:0016254X)

巻号頁・発行日

vol.100, no.1, pp.26-31, 2009-01-25

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This study aimed to evaluate the efficacy and toxicity of concurrent chemoradiotherapy and adjuvant chemotherapy for T2N0 glottic squamous cell carcinoma. Between May 1993 and March 2004, 32 patients with T2N0 glottic squamous cell carcinoma received concurrent chemoradiotherapy as the primary treatment modality for larynx preservation. Radiotherapy was delivered five days a week using a once-daily fractionation of 2.0 Gy (median total dose: 70 Gy). The chemotherapy regimen comprised carboplatin in 4 patients, carboplatin and tegafur and uracil in 7, carboplatin and futraful in 2, and futraful in 19 patients. Twenty-four patients received adjuvant chemotherapy with tegafur and uracil. Initial local tumor control was achieved in 30 patients (94%). The 5-year overall survival and 5-year local control rates were 97% and 70%, respectively. Univariate analysis revealed adjuvant chemotherapy as a significant prognostic factor for the local control rate (P = 0.038). The 5-year local control rate in patients treated or not treated with adjuvant chemotherapy was 82% and 42%, respectively. No significant differences in the local control rate were noted in overall treatment time, total radiation dose, age, and disease extension to the subglottis. With regard to adverse reactions, grade 3 neutropenia and grade 3 hepatotoxicity were observed in 1 and 2 patients, respectively. We observed no severe late complications (RTOG/EORTC criteria Grade 3-4) related to this combination therapy. Concurrent chemoradiotherapy and adjuvant chemotherapy was effective but with mild toxicity, and adjuvant chemotherapy significantly improved local control. We suggest the use of this combination therapy for achieving a local control of T2N0 glottic squamous cell carcinoma.目的:T2N0声門癌に対する化学放射線療法,補助化学療法の効果,有害事象の遡及的検討.対象・方法:1993年5月から2004年3月に喉頭温存を目的に初回治療として化学放射線療法を施行されたT2N0声門癌の32例.放射線治療は1日1回,1回2Gy,週5回施行され,総線量の中央値は70Gy.化学療法はカルボプラチン単独が4例,カルボプラチンとUFT の併用が7例,カルボプラチンとフトラフールの併用が2例,フトラフール単独が19 例.化学放射線療法終了後24 例にUFTによる補助化学療法を施行.結果:一次治療効果でCRであったのは30例(94%).5年粗生存率,5年局所制御率はそれぞれ97%,70%.局所制御に関する単変量解析では,補助化学療法の施行により有意な改善を認めた(P=0.038).5年局所制御率は補助化学療法の有無でそれぞれ,82%,42%.総治療期間,総線量,年齢,病変の声門下への進展の有無では有意差は認めなかった.有害事象に関してはgrade3 の好中球減少を1例,grade3の肝機能障害を2例に認めた.重篤な晩期有害事象は認めなかった.結論:T2N0 声門癌に対する補助化学療法は局所制御に関して統計学的に有意な改善が認められ,また有害事象は軽度であり,有用性が示唆された.