著者

Miyata Emi Kouno Hirohiko Kamiyama Daisuke Kamazuka Tomoyuki Mihara Mototsugu Fukuda Mitsunori Matsuta Kensaku Tsunemi Hiroshi Minamisono Tadanori Tomida Hiroshi Miyaguchi Kazuhisa

出版者

Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physics

雑誌

Japanese journal of applied physics. Pt. 1, Regular papers & short notes (ISSN:00214922)

巻号頁・発行日

vol.42, no.7, pp.4564-4570, 2003-07-15

参考文献数

18

被引用文献数

5

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We have investigated the radiation damage effects on a charge-coupled device (CCD) to be used for the Japanese X-ray mission, the monitor of all-sky X-ray image (MAXI), onboard the international space station (ISS). A temperature dependence of the dark current as a function of incremental dose is studied. We found that the protons having energy of ${>}292$ keV seriously increased the dark current of the devices. In order to improve the radiation tolerance of the devices, we have developed various device architectures to minimize the radiation damage in orbit. Among them, nitride oxide enables us to reduce the dark current significantly and therefore we adopted nitride oxide for the flight devices. We also compared the dark current of a device in operation and that out of operation during the proton irradiation. The dark current of the device in operation became twofold that out of operation, and we thus determined that devices would be turned off during the passage of the radiation belt. The temperature dependence of the dark current enables us to determine the electron trap level that generates the dark current. We fitted dark current as a function of temperature by the thoretical models and found that the dark current increase after proton irradiations is caused by, at least, two kinds of electron trap levels. The shallow trap level ($E_{\text{c}}-E_{\text{t}} < 0.2$ eV where $E_{\text{c}}$ and $E_{\text{t}}$ are the energy at the bottom of the conduction band and the energy level of electron trap) might be associated with oxygen which is dominant at the operating temprature of ${>}210$ K. On the other hand, another trap level is located roughly at the center of the silicon bandgap which might be associated with divacancies or P–V traps. We finally investigated the spatial distribution of the low-energy protons in the orbit of the ISS. Their density has a peak around $l \sim 20{{\degree}}$ and $b \sim -55{{\degree}}$ independent of the altitude. The peak value is roughly two orders of magnitude higher than that at the South Atlantic Anomaly.

著者

小池 克行 霞 英樹 佐々木 祐哉 石川 和広 松沢 要一 岩﨑 浩 Katsuyuki Koike Hideki Kasumi Yuya Sasaki Kazuhiro Ishikawa Youichi Matsuzawa Hiroshi Iwasaki

出版者

上越教育大学

雑誌

上越教育大学教職大学院研究紀要 = Bulletin of Teaching Profession Graduate School Joetsu University of Education (ISSN:2187882X)

巻号頁・発行日

vol.3, pp.103-110, 2016-02-29

著者

Moalla Rached Baldet Pierre Gibon Yves Chiaki Matsukura Toru Ariizumi Hiroshi Ezura Naoya Fukuda

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-150, (Released:2018-02-16)

被引用文献数

14

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Calcium is widely accepted as the main factor responsible for blossom-end rot (BER) appearance in tomato (Solanum lycopersicum L.) fruit. However, reactive oxygen species (ROS), which can damage plant tissues have also been proposed to initiate BER appearance in tomatoes and other fruit-bearing vegetables. Ascorbate, the major antioxidant in tomato fruit, is generally lower during green fruit development, which corresponds to the stage of BER appearance. Accordingly, one hypothesis is that tomato cultivars with a lower susceptibility to BER under salt stress have higher ascorbate contents and thus better control of ROS levels. In this study, to clarify the relationship between BER incidence and oxidative stress, two BER resistant cultivars, ‘Managua RZ’ and ‘House Momotaro’ and one BER-susceptible cultivar ‘Reiyoh’, were cultivated under salinity or standard nutrient solution (control) conditions. Calcium, potassium, magnesium, total hydro-soluble antioxidants, and ascorbate concentrations were measured in the distal pericarp 1 to 2 days prior to symptom appearance and during symptom appearance in healthy and affected fruits. When salt stress was applied, only BER-resistant cultivars showed a significant increase in ascorbate contents prior to BER appearance as compared with their levels under the control condition. In contrast, pre-BER Ca2+ concentrations did not associate with the BER susceptibility of each cultivar. Interestingly, ‘Reiyoh’ showed much higher K+/Ca2+ and (K++Mg2+)/Ca2+ ratios than the two other cultivars in healthy fruits due to a strong tendency towards lowered Ca2+ concentrations. A similar tendency was also observed in apple “bitter pit”. The ability to increase the fruit antioxidant capacity and maintain mineral balance under salt stress conditions may explain the resistance to BER development in highly resistant cultivars, probably by the avoidance of oxidative-induced cell necrosis and stabilization of the cell membranes, respectively.

著者

川原谷 浩 安孫子 勤 松葉谷 治 KAWARAYA Hiroshi ABIKO Tsutomu MATSUBAYA Osamu

出版者

秋田大学大学院理工学研究科

雑誌

秋田大学大学院理工学研究科研究報告 = Scientific and technical reports of Graduate School of Engineering Science, Akita University (ISSN:24324108)

巻号頁・発行日

no.37, pp.31-36, 2016

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At Noboribetsu, Hokkido, hydrogen and oxygen isotopic ratios (δD and δ18O) of precipitation collected in about one month interval were measured from 1979 to 1983. Although the easurement is rather old, it is useful to explain the isotopic characteristics of precipitation in the southern coast area of Hokkaido. δD, δ18O and d value (d=δD-8δ18O) of annual mean precipitation at Noboribetsu are -60‰, -8.9‰ and 11, respectively. The relationships of δD and δ18O show obvious difference between winter season and spring to fall season, and the d value is 21 in the winter season and higherthan the value of 9 in the spring to fall season, as like as the characteristics observed at Akita, Ryori and Rokkasho in thenorthern Honshu. The relationship in the spring to fall season is similar to those at Akita, Ryori and Rokkasho, and thisimplies that the Noboribetsu precipitation in the spring to fall season may be brought by the process similar to those in theabove three localities. On the contrary, the relationship in the winter season is different from those of above three localitiesimplying some difference in precipitation process. However, the d value of annual mean precipitation at Noboribetsu isthe same as Ryori located at the Pacific Ocean coast of northern Honshu, because the precipitation amount in the winterseason is fairly smaller than that in the spring to fall season at Noboribetsu as like as Ryori. The isotopic ratios of smallrevers in the Noboribetsu area are similar to those of several small rivers at the southern coast of Hokkaido, and thisimplies that the isotopic ratios of precipitation at the southern coast of Hokkaido have characteristics similar to those atNoboribetsu.Records monitoring the airflow's temperature and absolute humidity revealed a periodic nature of the variations. Suchseasonal changes had an approximate cycle length of six months and can be modeled by a harmonic vibration equation. The dewcondensation observed at the rock surface can be explained by the calculation results based on the measured values. Theconstraints of equation (6) are practically negligible at a Hyakumeishi level, which was apparent from the induction of theproposed theoretical formula. The seasonal thermal variations of the environment and the dew generation mechanism can beattributed to heat balance in the entire mining area. Finally, the primary results of this study are considered to be fundamentaldata to the case of variously utilized underground spaces.

著者

菅野 博史 Hiroshi KANNO

出版者

創価大学人文学会

雑誌

創価大学人文論集 (ISSN:09153365)

巻号頁・発行日

no.23, pp.27-51, 2011-03-01 (Released:2017-06-09)

著者

吉川 虎雄 戸谷 洋 Torao YOSHIKAWA Hiroshi TOYA

雑誌

南極資料 (ISSN:00857289)

巻号頁・発行日

vol.1, pp.1-13, 1957-12

著者

Hiroshi ASHIGAI Yuta KOMANO Guanying WANG Yasuji KAWACHI Kazuko SUNAGA Reiko YAMAMOTO Ryoji TAKATA Mika MIYAKE Takaaki YANAI

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.37, no.1, pp.19-24, 2018 (Released:2018-01-27)

参考文献数

25

被引用文献数

10

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Atopic dermatitis (AD) is a chronic inflammatory skin disease that causes dry skin and functional disruption of the skin barrier. AD is often accompanied by allergic inflammation. AD patient suffer from heavy itching, and their quality of life is severely affected. Some pharmaceuticals for AD have some side effects such as skin atrophy. So it is necessary to develop mild solutions such as food ingredients without side effects. There are various causes of AD. It is especially induced by immunological imbalances such as IFN-γ reduction. IFN-γ has an important role in regulating IgE, which can cause an allergy reaction. NC/Nga mice develop AD and IgE hyperproduction. In a previous study, we revealed that administration of polysaccharide from black currant (R. nigrum) has an effect on immunomodulation. It induces IFN-γ production from myeloid dendritic cells. We named this polysaccharide cassis polysaccharide (CAPS). In this report, we studied the effect of administering CAPS on atopic dermatitis in NC/Nga mice. Thirty NC/Nga mice that developed symptoms of atopic dermatitis were used. We divided them into three groups (control, CAPS administration 12 mg/kg/day, CAPS administration 60 mg/kg/day). For 4 weeks, we evaluated clinical score, serum IgE levels, gene expression of spleen, and skin pathology. We revealed that CAPS administration improves atopic dermatitis symptoms. We also found that CAPS administration suppresses IgE hyperproduction and induces IFN-γ gene transcription in the spleen. Finally, we confirmed that CAPS administration suppresses mast cell migration to epidermal skin. These results indicated that CAPS has an effect on AD.

著者

Khoirun NISA Sue Yee LIM Tatsuyuki OSUGA Nozomu YOKOYAMA Masahiro TAMURA Noriyuki NAGATA Kazuyoshi SASAOKA Angkhana DERMLIM Rommaneeya LEELA-ARPORN Tomoya MORITA Noboru SASAKI Keitaro MORISHITA Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0525, (Released:2018-02-02)

被引用文献数

6

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Quantitative contrast-enhanced ultrasonography (CEUS) enables non-invasive and objective evaluation of intestinal perfusion by quantifying the intensity of enhancement on the intestine after microbubble contrast administration. During CEUS scanning, sedation is sometimes necessary to maintain animal cooperation. Nevertheless, the effect of sedative administration on the canine intestinal CEUS is unknown. This study aimed to investigate the effect of sedation with a combination of butorphanol and midazolam on the duodenal CEUS-derived perfusion parameters of healthy dogs. For this purpose, duodenum was imaged following contrast administration (Sonazoid®, 0.01 ml/kg) in six healthy beagles before and after intravenous injection of a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg). Furthermore, hemodynamic parameters including blood pressure and heart rate were recorded during the procedure. Five CEUS derived perfusion parameters including time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), wash-in and wash-out rates (WiR and WoR, respectively) before and after sedation were statistically compared. The result showed that no significant change was detected in any of perfusion parameters. Systolic and mean arterial pressures significantly reduced after sedative administration, but diastolic arterial pressure and heart rate did not significantly change. Moreover, no significant partial correlation was observed between perfusion parameters and hemodynamic parameters. Thus, we concluded that the combination did not cause significant influence in duodenal CEUS perfusion parameters and could be a good option for sedation prior to duodenal CEUS in debilitated dogs.

著者

Tomoyo OKAZAKI Hiroyasu KOIZUMI Hiroshi NOGAWA Akihisa KODAIRA Tomotaro NIHEI Hideo MATSUMURA

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2017-183, (Released:2018-01-26)

参考文献数

33

被引用文献数

1

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This study aimed to investigate how different compositions of experimental silane-based primers in a methyl methacrylate solution containing 3-(trimethoxysilyl)propyl methacrylate (3-TMSPMA) or 3-(4-methacryloyloxyphenyl)propyl trimethoxysilane (3-MPPTS) might act as silicon dioxide bonding agents. With or without post-silanization heat treatment, primer-treated quartz discs were bonded using the MMA-TBB resin and their bond strengths were evaluated. The disks were primed with one of the following materials: 1 mol% 3-TMSPMA, 2 mol% 3-TMSPMA, 1 mol% 3-MPPTS, and 2 mol% 3-MPPTS. Shear bond strength was determined both before and after thermocycling. Statistical analyses were performed with non-parametric procedure (Kruskal-Wallis, Mann-Whitney U, and Steel-Dwass tests). Both primers were effective with heat treatment to enhance bonding between quartz and the MMA-TBB, and the bonding durability of the 1 and 2 mol% 3-MPPTS (16.8 and 24.9 MPa) with heat groups was significantly higher than in the 1 and 2 mol% 3-TMSPMA (5.4 and 9.8 MPa) with heat groups.

著者

Tetsuo Minamino Shuichiro Higo Ryo Araki Shungo Hikoso Daisaku Nakatani Hiroshi Suzuki Takahisa Yamada Masaaki Okutsu Kouji Yamamoto Yasushi Fujio Yoshio Ishida Takuya Ozawa Kiminori Kato Ken Toba Yoshifusa Aizawa Issei Komuro EPO-AMI-II Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0889, (Released:2018-02-02)

参考文献数

21

被引用文献数

15

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Background:Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan. In total, 198 STEMI patients with low left ventricular ejection fraction (LVEF <50%) were randomly assigned to receive intravenous administration of EPO (6,000 or 12,000 IU) or placebo within 6 h of successful percutaneous coronary intervention. At 6 months, there was no significant dose-response relationship in LVEF improvement among the 3 groups tested (EPO 12,000 IU: 5.4±9.3%, EPO 6,000 IU: 7.3±7.7%, Placebo: 8.1±8.3%, P=0.862). Low-dose EPO also did not improve cardiac function, as evaluated by 99 mTc-MIBI SPECT or NT-proBNP at 6 months and did not increase adverse events.Conclusions:Administration of low-dose EPO did not improve LVEF at 6 months in STEMI patients (UMIN000005721).

著者

寺岡 寛 Hiroshi Teraoka 中京大学経営学部

雑誌

中京経営研究 = Chukyo keiei kenkyu (ISSN:09199209)

巻号頁・発行日

vol.13, no.1, pp.259-268, 2003-09-01

著者

Masao OGASAWARA Toshitaka TAMANO Hiroshi MIMURA Samon YANAGIMOTO Yukihisa KURIYAMA

出版者

The Iron and Steel Institute of Japan

雑誌

Tetsu-to-Hagane (ISSN:00211575)

巻号頁・発行日

vol.64, no.7, pp.947-957, 1978-06-01 (Released:2010-02-22)

参考文献数

16

被引用文献数

1 1

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A laboratory test for unstable ductile fracture of mild steels was developed. Shear crack was initiated from very deep notch. Some devices such as “pipe tabs” were employed to reduce the stiffness of the system enough to make shear crack continue to grow in an unstable manner.Four kinds of pipe materials were tested using the present test method and three kinds of them with low ductility showed unstable ductile fracture. Fracture toughness for the onset of unstable ductile fracture in these steels was evaluated and was correlated successfully to Cvshelf, upper shelf of absorbed energy in Charpy test.Slow crack growth test was also performed by means of high stiffness tensile system, “R-cruve” to ductile crack growth being obtained experimentally. A model to ductile crack growth was proposed by the use of the modification of Dugdale model, by which R-curves were finely described. Critical G-values for the onset of the unstable ductile crack propagation were shown to be well compared to the values estimated from the R-curves.Thus, both the ductile slow growth and its rapid propagation are shown to be well characterised by the values of notch ductility.

著者

Akira Kido Shozo Yoshida Emiko Shimoda Yukako Ishida Masatoshi Hasegawa Hiroshi Kobayashi Kanya Honoki Hirosei Horikawa Yasuhito Tanaka

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.1, pp.20160009, 2016 (Released:2016-12-21)

参考文献数

15

被引用文献数

1

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Objective: Radiotherapy is an essential component of curative or palliative therapy for patients with uterine cervical cancer. Although advances in radiotherapy have led to longer survival, survivors may consequently be at risk of pelvic insufficiency fracture (PIF). We retrospectively reviewed medical records and clinical outcomes to assess the impact of PIF on walking disability. Methods: Between January 2002 and December 2009, 145 uterine cancer patients treated with radiotherapy in our hospital were reviewed. Among these, 15 patients (10.3%) were diagnosed with PIF. The types of fractures were identified according to the AO/OTA classification system. Medical records were examined to establish the time to first diagnosis of PIF, the type of fracture, and clinical outcomes. Disability was assessed using Barthel index mobility scores. Results: The median time to PIF detection was 16 months. Of the 15 patients with PIF, 14 had type B fractures (7 cases of B2 and 7 cases of B3) and 1 had a type C fracture. Among 11 patients with pelvic pain, 6 achieved pain control but 5 patients with bilateral lesions in the posterior arch or lateral compression of the sacrum developed pain that finally resulted in walking disability and a lower performance status. Conclusions: PIF causes severe motor disturbance in patients with unstable fracture types. Routine imaging checkups were useful during the 5 years after completion of radiotherapy; in nine patients the fracture progressed for longer than 1 year. In cancer rehabilitation for PIF patients, continuous assessment is essential for predicting walking disability.

著者

Tomohiro TAKATANI Hiroshi AKAEDA Teruo KAKU Masahide MIYAMOTO Hirohiko MUKAI Tamao NOGUCHI

出版者

Japanese Society for Food Hygiene and Safety

雑誌

Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) (ISSN:00156426)

巻号頁・発行日

vol.39, no.4, pp.292-295_1, 1998-08-05 (Released:2009-12-11)

参考文献数

11

被引用文献数

5 5

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最近, 九州地域ではこれまで例がほとんどない Gymnodinium catenatum により二枚貝が毒化している. 1998年1月下旬, 熊本県天草の宮野河内湾で天然マガキが麻痺性貝毒 (PSP) により毒化した. 同湾から, 1996年の大分県蒲江に引き続き, G. catenatum が密度308細胞/mLで確認された. カキの毒性値は3.0~263MU/gを示し, HPLC分析の結果, その毒成分はカキ, プランクトンともにC1 (PX1), C2 (PX2) を主成分としていた. この結果, カキは食物連鎖を通して G. catenatum により毒化したと結論した.

著者

Yusei HISATOMI Daichi NAKAYAMA Hiroshi MATSUYAMA

出版者

THE JAPAN SOCIETY OF HYDROLOGY AND WATER RESOURCES

雑誌

JOURNAL OF JAPAN SOCIETY OF HYDROLOGY AND WATER RESOURCES (ISSN:09151389)

巻号頁・発行日

vol.28, no.3, pp.109-123, 2015-05-05 (Released:2015-08-12)

参考文献数

38

被引用文献数

4

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本研究の目的は,武蔵野台地における長期的な地下水流動を,数値モデルを利用して再現すること,及び長期的な地下水流動の変化と土地利用との関係を定量的に明らかにすることである.モデルはUSGS(アメリカ地質調査所)が開発したMODFLOW(有限差分法を用いた3次元地下水流動解析モデル)を利用した.シミュレーションは土地利用データのある1976年~2012年を対象とし,MODFLOWを用いて1日ごとの地下水位を算出した.また,4種類のGCMデータを用いて2013年~2050年における地下水流動の予測シミュレーションも行った. 計算された地下水位のデータを用いて,1977年~2012年の地下水位の低下量と観測井戸における涵養域の減少量を算出したところ,両者の間に正の相関関係があることが分かった.この要因として,1977年~2012年に,水田や農地,森林などの透水面の面積が減少し,建物用地などの不透水面の面積が増加していることが示された.2013年~2050年の地下水流動の将来予測では,土地利用が変化しないと考えると,将来的に適度な強度の降水量が増加することで地下水位が上昇することが示唆された.

著者

KUNIAKI TATSUTA HIROSHI MUKAI MASAAKI TAKAHASHI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.53, no.4, pp.430-435, 2000-04-25 (Released:2008-09-19)

参考文献数

14

被引用文献数

13 29

著者

Hiroyasu NOMA Hiroshi KAWACHI Yoshiaki FUMA Kazuyoshi TAKEYASU Masahiro TOOI

出版者

Japanese Society of Oral and Maxillofacial Surgeons

雑誌

Japanese Journal of Oral and Maxillofacial Surgery (ISSN:00215163)

巻号頁・発行日

vol.18, no.4, pp.450-455, 1972-08-15 (Released:2011-07-25)

参考文献数

13

被引用文献数

1

著者

Makio Saeki Hiroshi Egusa

出版者

The Japanese Pharmacological Society

雑誌

Folia Pharmacologica Japonica (ISSN:00155691)

巻号頁・発行日

vol.144, no.6, pp.277-280, 2014 (Released:2014-12-10)

参考文献数

17

被引用文献数

1

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骨粗鬆症治療薬は骨吸収抑制薬と骨形成促進薬に分類される.従来の骨粗鬆症治療薬は骨吸収抑制薬が主流であったが,破骨細胞と骨芽細胞の活性が共役する機構が存在するために長期的には骨形成が低下して効果が減弱したり副作用が生じたりする問題点があった.骨形成促進薬anabolic agent としてはヒト副甲状腺ホルモン(parathyroid hormone:PTH)製剤であるテリパラチドが現在唯一の治療薬である.我々は破骨細胞におけるnuclear factor of activated T cells (NFAT)シグナルをターゲットとした骨吸収抑制薬の創薬を当初の目的として,RAW264.7 細胞を用いたセルベースアッセイ系を構築し,様々な化合物ライブラリーを用いた創薬スクリーニングを行ってきた.スクリーニング中に多くのNFAT 活性化小分子化合物を発見し,これらの破骨細胞を活性化させる化合物が,anabolic therapy に使用できる可能性があるのではないかと考えた.Anabolic agent として唯一臨床応用されているPTH 製剤が血中のカルシウム濃度を上昇させるしくみの一つに,骨吸収の促進がある.したがって,PTH の骨吸収促進という教科書的事実に固執していたら,テリパラチドが骨形成促進薬として開発されることもなかったであろう.PTH の持続的投与は骨吸収の促進をもたらすが,間歇的投与intermittent PTH(iPTH)treatment によるPTH の骨形成促進作用に注目したことが,テリパラチドという骨形成促進薬の開発につながった.我々はこのテリパラチドの例をヒントに,あえて破骨細胞の活性化薬をスクリーニングすることから,新しい骨形成促進薬を開発できないかと考えている.

著者

Hiroshi Hoshino Shouichi Fujita Yoko Goto Takeomi Isono Tsuyoshi Ishinazaka Yasunori Sakurai Hisato Iwata Akio Kazusaka Mayumi Ishizuka Shinsuke Tanabe

出版者

The Japanese Society of Environmental Toxicology

雑誌

環境毒性学会誌 (ISSN:13440667)

巻号頁・発行日

vol.6, no.1, pp.1-10, 2003 (Released:2010-07-01)

参考文献数

23

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o clarify the levels of organochlorine compounds (OCs) and the metabolism of OCs in the body of Steller sea lion Eumetopias jubatus migrating along the coast of Hokkaido, OCs in the sea lion's blubbers for each age, sex and reproductive status were determined by gas chromatography linked to ion trap mass spectrometer. In sea lions, the compounds accumulated in the highest concentrations are DDT and its metabolites (DDTs) suggesting these animals are still exposed to DDTs from the surrounding land. The levels of DDTs and polychlorinated biphenyls (PCBs) in sea lions may cause small effects such as the induction of drug metabolizing enzymes. The concentrations of DDTs, PCBs, hexachlorocyclohexanes and chlordanes in the old female sea lions were lower than those in the males and young females. This is most likely due to the loss of these compounds during nursing. In addition, the concentrations of each compound differed in the degree of difference between the young and the old females. This result may reflect ecological and physiological difference between the young and the old females. The proportions of tetrachlorinated biphenyl concentrations with vicinal hydrogen atoms in para- and meta- positions to total tetrachlorinated biphenyl concentrations were found to be higher in older animals implying low “phenobarbital inducible type” enzyme activity.

著者

Yoshie Ojima Kinya Sawada Hiroshi Fujii Tsuyoshi Shirai Ayako Saito Saeko Kagaya Satoshi Aoki Yoichi Takeuchi Tomonori Ishii Tasuku Nagasawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9848-17, (Released:2017-12-27)

参考文献数

47

被引用文献数

7

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A previously healthy 58-year-old man was admitted for muscle pain and weakness (manual muscle testing [MMT] of 4/4 for upper and lower limbs). We detected elevated levels of inflammatory makers and PR3-anti-neutrophil cytoplasmic antibody (ANCA). Subsequently, the muscle weakness rapidly progressed to an MMT of 2 for all limbs. Magnetic resonance imaging indicated muscle edema, and the CK level increased to 29,998 U/L. mPSL and cyclophosphamide pulse therapy improved the patient symptoms. MMT recovered to 4 for all limbs. A muscle biopsy showed degenerated muscle fibers surrounded by neutrophil-predominant infiltration. In addition, lamina elastic breakdown and fibrinoid necrosis of arterioles were observed. A final diagnosis of microscopic polyangiitis (MPA) limited to the muscles was made.