著者

Khoirun NISA Sue Yee LIM Masayoshi SHINOHARA Noriyuki NAGATA Kazuyoshi SASAOKA Angkhana DERMLIM Rommaneeya LEELA-ARPORN Tomoya MORITA Nozomu YOKOYAMA Tatsuyuki OSUGA Noboru SASAKI Keitaro MORISHITA Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0174, (Released:2017-08-05)

被引用文献数

5

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Contrast-enhanced ultrasonography (CEUS) with microbubbles as a contrast agent allows the visualization and quantification of tissue perfusion. The assessment of canine intestinal perfusion by quantitative CEUS may provide valuable information for diagnosing and monitoring chronic intestinal disorders. This study aimed to assess the repeatability (intraday variability) and reproducibility (interday variability) of quantitative duodenal CEUS in healthy dogs. Six healthy beagles underwent CEUS three times within one day (4-hour intervals) and on two different days (1-week interval). All dogs were sedated with a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg) prior to CEUS. The contrast agent (Sonazoid®) was administered using the intravenous bolus method (0.01 ml/kg) for imaging of the duodenum. Time-intensity curves (TIC) were created by drawing multiple regions of interest (ROIs) in the duodenal mucosa, and perfusion parameters, including the time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates (WiR and WoR, respectively), were generated. Intraday and interday coefficients of variation (CVs) for TTP, PI, AUC, WiR, and WoR were <25% (range, 2.27–23.41%), which indicated that CEUS was feasible for assessing duodenal perfusion in healthy sedated dogs. Further study of CEUS in dogs with chronic intestinal disorders is necessary to evaluate its clinical applicability.

著者

Nishiwaki Hiroshi

出版者

島根大学法文学部

雑誌

Memoirs of the Faculty of Law and Literature (ISSN:03886859)

巻号頁・発行日

vol.18, no.2, pp.(139)-(178), 1992-12-25

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本稿は、「北尾次郎 『森の妖精』−翻刻(2の1)−」(『島根大学法文学部紀要 文学科編 第17号−II,1992,7)の続編をなすものである。 翻刻に際しては、前稿の基本原則を踏襲したが、「表記が統一されていないため、読みずらい」との指摘を考慮し、今後は現代ドイツ語の標準的表記に統一することにした。したがって,前稿「凡例」の3.で挙げられているような表記にも変更を加えたが、註により原文の表記がわかるよう配慮した。(ただし、ss → Bの変更は、あまりに数が多いため、註を省略した。) 註には通し番号をつけず、本文には * をつけ、註ではぺ一ジ数を明示することで、その箇所が特定できるようにした。

著者

Nishiwaki Hiroshi

出版者

島根大学法文学部

雑誌

Memoirs of the Faculty of Law and Literature (ISSN:03886859)

巻号頁・発行日

vol.19, no.2, pp.109-130, 1993-07-25

著者

Nishiwaki Hiroshi

出版者

島根大学法文学部

雑誌

Memoirs of the Faculty of Law and Literature (ISSN:03886859)

巻号頁・発行日

vol.20, no.2, pp.119-142, 1993-12-25

著者

藤本 博 フジモト ヒロシ Hiroshi Fujimoto

出版者

立教大学アメリカ研究所

雑誌

立教アメリカン・スタディーズ = Rikkyo American studies (ISSN:13464825)

巻号頁・発行日

no.38, pp.25-40, 2016-03

著者

本田 宏 HONDA Hiroshi

出版者

北海学園大学開発研究所

雑誌

開発論集 (ISSN:0288089X)

巻号頁・発行日

no.98, pp.11-34, 2016-09

著者

Yoko Aoki Yohei Matoba Shizuka Tanaka Kazue Yahagi Sueshi Ito Hiroshi Yoshida Tsutomu Itagaki Katsumi Mizuta

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.69, no.4, pp.350-351, 2016 (Released:2016-07-22)

参考文献数

7

被引用文献数

5

著者

Kyoichiro Yazaki Masato Otsuka Shohei Kataoka Mitsuru Kahata Asako Kumagai Koji Inoue Hiroshi Koganei Kenji Enta Yasuhiro Ishii

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-1261, (Released:2017-03-22)

参考文献数

17

被引用文献数

41

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Background:Quantitative flow ratio (QFR) is a newly developed image-based index for estimating fractional flow reserve (FFR).Methods and Results:We analyzed 151 coronary arteries with intermediate stenosis in 142 patients undergoing wire-based FFR measurement using dedicated software. Predefined contrast flow QFR, which was derived from 3-dimensional quantitative coronary angiography (3-D QCA) withThrombolysis in Myocardial Infarction (TIMI) frame counts, was compared with FFR as a reference. QFR had good correlation (r=0.80, P<0.0001) and agreement (mean difference: 0.01±0.05) with FFR. After applying the FFR cut-off ≤0.8, the overall accuracy rate of QFR ≤0.8 was 88.0%. On receiver operating characteristics analysis, the area under the curve was 0.93 for QFR. In contrast, 3-D QCA-derived anatomical indices had insufficient correlation with FFR and diagnostic performance compared with QFR.Conclusions:QFR had good correlation and agreement with FFR and high diagnostic performance in the evaluation of intermediate coronary stenosis, suggesting that QFR may be an alternative tool for estimating myocardial ischemia.

著者

Aiko Mitsuzawa Hiroyuki Miyamoto Hiroshi Ueda

出版者

日本プランクトン学会、日本ベントス学会

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.12, no.2, pp.115-122, 2017-05-30 (Released:2017-06-06)

参考文献数

29

被引用文献数

14

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Copepod nauplii are the primary food item for early-stage marine fish larvae, but their feeding selectivity on the nauplii of different copepod species has not been well studied. This study revealed feeding selectivity in the dominant preflexion larvae of three fishes Sebastiscus marmoratus, Sebastes sp. and Ammodytes japonicus in the Seto Inland Sea, Japan, in spring and winter. Copepod nauplii and eggs numerically constituted 80–91% of the prey items in their guts. Chesson’s preference index for the nauplii of various copepod species was positive for Calanus sinicus and Paracalanus parvus sensu lato, negative for Acartia omorii, and negative or neutral for Oithona similis. This result is probably attributable to the size and swimming behavior of the prey species. The preference index in A. japonicus larvae was not significantly different between the nauplii of different species, suggesting that the larvae are less selective than the other two fishes. The preference index for Calanus eggs was very high, especially in Sebastiscus marmoratus and Sebastes sp., and most of the eggs in the guts were shrunken, probably due to digestion. In terms of volume, C. sinicus nauplii and eggs in gut contents represented 36–72% of total copepod nauplii and >80% of total copepod eggs, respectively, because of high selectivity by fish larvae and their large individual volumes compared with the dominant copepods. This indicates that C. sinicus is the most important prey species for early fish larvae despite their low abundance in the environment.

著者

GOKAN Nobuo NAGASHIMA Takayuki VISSCHER Saralee N. ANDO Hiroshi

出版者

日本昆虫学会

雑誌

昆蟲 (ISSN:09155805)

巻号頁・発行日

vol.47, no.3, pp.258-271, 1979-09-25

被引用文献数

3

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The fine structure of the compound eye of Galloisiana nipponensis, a species of Grylloblattidae of the Order Grylloblattodea was observed. The eye is composed of about forty ommatidia arranged in an elliptic area. The surface of the eye is covered with many arabesque structures which are presumably a waxy substance. The cornea is biconvex and has many pore canals. The number of retinula cells in an ommatidium is irregular, but is usually twelve. These cells are arranged in two groups, i. e., distal and proximal, and each retinula cell bears a rhabdomere forming the fused rhabdom. Rhabdomic microvilli are irregular in arrangement and become vacuolar appearance in the proximal part of rhabdomeres. In this species the pigment cells are not differentiated into the primary and secondary pigment cells.

著者

AOKI Takuma SUNAHARA Hiroshi SUGIMOTO Keisuke ITO Tetsuro KANAI Eiichi NEO Sakurako FUJII Yoko WAKAO Yoshito

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.9, pp.1187-1190, 2015

被引用文献数

2

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Dynamic left ventricular outflow tract obstruction (DLVOTO) is a common condition in cats and humans. In this case report, a dog is described with DLVOTO secondary to severe intra-abdominal hemorrhage caused by a hemangiosarcoma. The dog was a 9-year-old, 35.7-kg, spayed female German Shepard dog that presented with a history of tachypnea and collapse. A Levine II/VI systolic murmur was present at the heart base. Abdominal ultrasonography revealed a splenic mass and a large amount of ascites. Echocardiography showed a reduced left ventricular diameter and an increased aortic velocity caused by systolic anterior motion (SAM) of the mitral valve apparatus. The heart murmur and the SAM were resolved after treatment including a splenectomy and a blood transfusion.

著者

Yuki SAITO Shinnosuke TAKAMICHI Hiroshi SARUWATARI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E100-D, no.8, pp.1925-1928, 2017-08-01

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This paper proposes Deep Neural Network (DNN)-based Voice Conversion (VC) using input-to-output highway networks. VC is a speech synthesis technique that converts input features into output speech parameters, and DNN-based acoustic models for VC are used to estimate the output speech parameters from the input speech parameters. Given that the input and output are often in the same domain (e.g., cepstrum) in VC, this paper proposes a VC using highway networks connected from the input to output. The acoustic models predict the weighted spectral differentials between the input and output spectral parameters. The architecture not only alleviates over-smoothing effects that degrade speech quality, but also effectively represents the characteristics of spectral parameters. The experimental results demonstrate that the proposed architecture outperforms Feed-Forward neural networks in terms of the speech quality and speaker individuality of the converted speech.

著者

仲地 博 Nakachi Hiroshi

出版者

琉球大学法文学部

雑誌

琉大法学 (ISSN:04857763)

巻号頁・発行日

no.65, pp.83-114, 2001-03

著者

Yuji NONAKA Takayuki IZUMO Toshihiro MAEKAWA Hiroshi SHIBATA

出版者

BMFH出版会

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.36, no.3, pp.121-128, 2017 (Released:2017-07-13)

参考文献数

48

被引用文献数

1

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We investigated if the orally administered Lactobacillus pentosus strain S-PT84 (S-PT84) might show anti-stress activity and ameliorate stress-induced immune suppression in mice. Stress of mice induced an increase in serum corticosterone and a decrease in splenic natural killer activity and in the number of splenocytes versus control mice. However, these changes were not observed in stressed mice that had been administered S-PT84. Furthermore, interleukin (IL)-12 and IL-10 production, which was downregulated in lipopolysaccharide-activated macrophages from stressed mice, was maintained at control levels in the macrophages of stressed mice that had been fed S-PT84. Interferon-γ production, which was downregulated in concanavalin A-activated splenocytes from stressed mice, tended to be maintained at control levels in stressed mice that had been fed S-PT84, although IL-4 production by these cells was not influenced by S-PT84 administration. Additionally, reduced glutathione (GSH) levels were decreased in serum and peritoneal macrophages from stressed mice versus controls, but these GSH levels were significantly higher in stressed animals that had been administered S-PT84 compared with those that had not. These results suggest that S-PT84 exerts anti-stress activity through immune modulation and/or antioxidative activity.

著者

高橋 圭太 井上 浩 TAKAHASHI Keita INOUE Hiroshi

出版者

秋田大学工学資源学部

雑誌

秋田大学工学資源学部研究報告 (ISSN:13457241)

巻号頁・発行日

no.30, pp.1-7, 2009-10-01

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Recent advances of office automation and information technology cause the increase of the complaint of ocular fatigue, musculoskeletal fatigue and mental fatigue for VDT (visual display terminal) workers. It becomes obvious as problem on industrial safety and health. A quantitative analysis on the stress and fatigue by scientific data is very useful. In this paper, the results of quantitative analysis focused on total working hours with quantitative indexes of HRV (heart rate variability) used on evaluation in autonomic function are discussed. VDT workers group with longer total working hours has different HRV and CVrri (Coefficient of variation of R-R interval) than one of control group. The extent of stress and fatigue may differ with total working hours.

著者

Shuichi TAKAGI Naoharu IWAI Ryoko YAMAUCHI Sunao KOJIMA Shinji YASUNO Takeshi BABA Masahiro TERASHIMA Yoshiaki TSUTSUMI Shoji SUZUKI Isao MORII Sotaro HANAI Koh ONO Shunroku BABA Hitonobu TOMOIKE Atsushi KAWAMURA Shunichi MIYAZAKI Hiroshi NONOGI Yoichi GOTO

出版者

日本高血圧学会

雑誌

Hypertension Research (ISSN:09169636)

巻号頁・発行日

vol.25, no.5, pp.677-681, 2002 (Released:2003-04-26)

参考文献数

28

被引用文献数

49 113

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In epidemiological studies, moderate alcohol consumption has been consistently associated with a reduced risk of myocardial infarction (MI). About half of Japanese show an extremely high sensitivity to alcohol (ethanol), which is due to a missense mutation from glutamic acid (Glu) to lysine (Lys) at codon 487 in an isoenzyme of aldehyde dehydrogenase (ALDH2) with a low Km. We obtained a preliminary result that subjects homozygous for the Lys 487 allele had higher risk for myocardial infarction. The purpose of the present study was to assess this hypothesis by employing a larger cohort of subjects with MI. The experimental group consisted of 342 male subjects with demonstrated MI who were selected randomly from our outpatient clinic. As controls, we employed 1, 820 male subjects with no cardiovascular complications who were selected from the Suita Study. All subjects provided their written informed consent to participate in the genetic analyses. Subjects with MI were older and had higher body mass index, higher prevalence of diabetes mellitus, higher prevalence of smoking habit, higher prevalence of the Lys/Lys genotype (homozygous for Lys 487 allele), and lower high density lipoprotein (HDL) cholesterol level (HDL-C). The ALDH2 genotype affected the level of alcohol consumption, and HDL-C. Multiple logistic analyses indicated that the odds ratio of the Lys/Lys genotype to the Lys/Glu+Glu/Glu genotype was 1.56 (p =0.0359). Inclusion of HDL-C as one of the independent variables downplayed the importance of the ALDH2 genotype. This may indicate that the ALDH2 genotype affects MI via its effects on HDL-C. In conclusion, the ALDH2 Lys/Lys genotype is a risk factor for myocardial infarction in Japanese men due to its influence on HDL cholesterol level. (Hypertens Res 2002; 25: 677-681)

著者

LIU Xiaobo EICHENBERGER Michael FUJIOKA Yuuichiro DONG Jinhua UEDA Hiroshi

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.28, no.9, pp.861-867, 2012

被引用文献数

10

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The development of a rapid and specific assay for 17β-estradiol (E2) will accelerate its <i>in vitro</i> diagnostics and/or environmental pollution control. Here, we employed an open-sandwich (OS) selection scheme to improve the sensitivity for E2 in an OS immunoassay, which is based on antigen-dependent stabilization of the antibody (Ab) variable region, Fv, where the two domains (V_H and V_L) dissociated in the absence of an antigen. The V_H domain of a cloned anti-E2 antibody displayed on M13 phage was randomly mutated, and after three OS biopanning rounds, a mutant that showed higher sensitivity in OS-ELISA for E2 was identified. Interestingly, compared with the wild-type V_H, the cross-reactivity of the mutant was significantly decreased for the analogous steroid testosterone, both in OS and competitive ELISAs. This is the first report concerning selection for an anti-hapten Ab without using any hapten-carrier conjugates, and the method will be especially suitable for selecting Ab fragments that show better performance in hapten OS immunoassays.

著者

恒元 博 ツネモト ヒロシ Tsunemoto Hiroshi

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.42, no.9, pp.823-847, 1982-09-25

著者

Mamoru Hayano Takeru Makiyama Tsukasa Kamakura Hiroshi Watanabe Kenichi Sasaki Shunsuke Funakoshi Yimin Wuriyanghai Suguru Nishiuchi Takeshi Harita Yuta Yamamoto Hirohiko Kohjitani Sayako Hirose Fumika Yokoi Jiarong Chen Osamu Baba Takahiro Horie Kazuhisa Chonabayashi Seiko Ohno Futoshi Toyoda Yoshinori Yoshida Koh Ono Minoru Horie Takeshi Kimura

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0064, (Released:2017-06-20)

参考文献数

38

被引用文献数

23

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Background:TheSCN5Agene encodes the α subunit of the cardiac voltage-gated sodium channel, NaV1.5. The missense mutation, D1275N, has been associated with a range of unusual phenotypes associated with reduced NaV1.5 function, including cardiac conduction disease and dilated cardiomyopathy. Curiously, the reported biophysical properties ofSCN5A-D1275N channels vary with experimental system.Methods and Results:First, using a human embryonic kidney (HEK) 293 cell-based heterologous expression system, theSCN5A-D1275N channels showed similar maximum sodium conductance but a significantly depolarizing shift of activation gate (+10 mV) compared to wild type. Second, we generated human-induced pluripotent stem cells (hiPSCs) from a 24-year-old female who carried heterozygousSCN5A-D1275N and analyzed the differentiated cardiomyocytes (CMs). AlthoughSCN5Atranscript levels were equivalent between D1275N and control hiPSC-CMs, both the total amount of NaV1.5 and the membrane fractions were reduced approximately half in the D1275N cells, which were rescued by the proteasome inhibitor MG132 treatment. Electrophysiological assays revealed that maximum sodium conductance was reduced to approximately half of that in control hiPSC-CMs in the D1275N cells, and maximum upstroke velocity of action potential was lower in D1275N, which was consistent with the reduced protein level of NaV1.5.Conclusions:This study successfully demonstrated diminished sodium currents resulting from lower NaV1.5 protein levels, which is dependent on proteasomal degradation, using a hiPSC-based model forSCN5A-D1275N-related sodium channelopathy.

著者

Jun-ichiro Masuda Yukio Ozaki Michikazu Hiramatsu Kaori Sakai Junghee Kim Hiroshi Okubo

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-082, (Released:2017-07-04)

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Effects of photoperiod and temperature on rhizome enlargement (dormancy induction) and accompanied dormancy depth were investigated in this study. Nine-day-old seedlings were transplanted from 26 July at 1 week intervals, and they were grown under a natural photoperiod for 5 weeks in an unheated greenhouse in Fukuoka Prefecture, Japan. Although subterranean stems elongated in the plants grown until 30 August or 6 September, enlarged rhizomes were formed in those grown until 13 September or 20 September. It was revealed from these results that the lotus recognizes a natural photoperiod after 6 September as a short day. When 9 treatments of day length combinations (LD0+SD8–LD8+SD0) were applied to the seedlings, the plants grown under short day after long day treatment of 0 (LD0+SD8), 1 (LD1+SD7), 2 (LD2+SD6), 3 (LD3+SD5), 4 (LD4+SD4), 5 (LD5+SD3), 6 (LD6+SD2), or 7 (LD7+SD1) weeks formed enlarged rhizomes from the fifth, fifth, sixth, seventh, eighth, tenth, twelfth, and fourteenth internodes, respectively. Although photoperiodic treatment in the first week was different between LD0+SD8 and LD1+SD7 treatments, subterranean stems began to enlarge from the same internode (fifth internode) in both treatments. This indicates that photoperiod treatments for the first week do not affect morphology of subterranean stems. Seven treatments of day length combinations (LD2+SD0+LD6–LD2+SD6+LD0) were applied to seedlings after long day treatment for 2 weeks. Enlarged subterranean stems were observed in the plants grown under short day for 6 weeks (LD2+SD6+LD0), but not in those under long day for 6 weeks (LD2+SD0+LD6). On the other hand, subterranean stems elongated again after rhizome enlargement under a subsequent long day following 1 (LD2+SD1+LD5), 2 (LD2+SD2+LD4), 3 (LD2+SD3+LD3), or 4 (LD2+SD4+LD2) weeks of short day. This clarified that morphogenesis in subterranean stems is completely dependent on photoperiod. Further, it is expected that such growth resumption may be attributed to a weak dormant state in the enlarged rhizome. The enlarged rhizomes were exposed to natural low temperatures to examine environmental factors for deepening dormancy. Rhizomes sprouted in all treatments irrespective of exposure to low temperatures when they were transferred to ideal conditions. Rapid growth in leaves and subterranean stems was particularly observed by exposure to low temperature. It was suggested that low temperature is an environmental factor for releasing dormancy, but not for deepening dormancy. It is proposed from these results that subterranean stem growth is completely dependent on photoperiod, and that enlarged rhizomes show weak dormancy.