著者
大塚 誠也 黒崎 奏澪 小川 充洋
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55, no.5, pp.472, 2017

<p>近年、Oculus Riftや PlayStation VRなどの3Dヘッドセットを用いた比較的安価なバーチャルリアリティ (VR) 環境が実現され、普及しつつある。VR 鑑賞中やVR環境下での労働時の生体計測のために、本研究では 3D ヘッドセットに組み込める生体計測を提案する。ヘッドセットを着用するだけで生体計測が可能となれば、VR環境下では必ず生体情報を取得可能となる。今回、最初の試みとして、VRヘッドセットに内蔵可能な光電脈波プローブを用いた脈波計測を行ったので報告する。光電脈波計測のために、小型の反射型プローブを開発し、被験者の前額部から脈波の導出を試みた。被験者は、光電脈波計測と同時にVRヘッドセットを着用した。計測に用いる光源には緑色LEDと近赤外LEDを試行した。結果、いずれの波長においても光電脈波を観察することができたが、近赤外を用いた光電脈波では、被験者の自発的な瞬目時に大きなアーチファクトを観察し、脈波を観察することができなかった。一方、緑色光電脈波においては、瞬目時においても安定した計測を達成することができた。また、緑色光電脈波において、VRモニタの明滅や被験者の呼吸などの影響を受けずに、脈波ピークを観測することが可能であった。以上の結果から、VRヘッドセットを着用しただけで計測を意識することなく光電脈波を計測可能なシステムの可能性が示されたものと考えられた。本研究の一部はJSPS科研費 15H02798の助成を受けたものです。</p>
著者
八木 雅和 谷口 達典 山田 憲嗣
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55, no.3, pp.164, 2017

<p>医療・ヘルスケア機器イノベーションを実現する人材を育成するために、東北大学、東京大学、大阪大学が連携し、スタンフォード大学と提携して、2015年にジャパン・バイオデザインが設立された。そして、既に著しい成果を挙げているスタンフォード バイオデザイン プログラムをもとに4大学で開発し、実践集中型人材育成プログラム ジャパン・バイオデザイン フェローシッププログラムを2015年から共同で日本において実施している。本プログラムは、10ヶ月間で医療現場の問題・ニーズを探索・評価・定義し、解決策を創出して、最終的な事業化を目指すものである。昨年7月に第1期生が修了し、現在、第2期生がプロジェクトを推進中である。本講演では、まず、ジャパン・バイオデザインとは何なのか?これまでどのような活動を行ってきたのか、について報告する。そして、今後どのように展開するのかについて情報共有し議論する。また、このような中で、大阪大学での具体的な活動・成果、そして、将来展望について情報共有・議論する。</p>
著者
山越 康弘 小川 充洋 山越 健弘 田村 俊世 山越 憲一
出版者
社団法人日本生体医工学会
雑誌
生体医工学 : 日本エム・イー学会誌 (ISSN:1347443X)
巻号頁・発行日
vol.46, no.1, pp.49-57, 2008-02-10
参考文献数
27
被引用文献数
3

金沢大学大学院自然科学研究科An optical method recently proposed for non-invasive in vivo blood glucose concentration (BGL) measurement, named "Pulse Glucometry", was combined and compared with four multivariate analyses for constructing calibration models: Principal Component Regression (PCR), Partial Least Squares Regression (PLS), Artificial Neural Network (ANN), Support Vector Machines Regression (SVMsR). A very fast spectrophotometer for "Pulse Glucometry" provides the total transmitted radiation spectrum (I_λ) and the cardiac-related pulsatile component (ΔI_λ) superimposed on I_λ in human fingertips over a wavelength range from 900 to 1700 nm with resolution of 8 nm in 100 Hz sampling. From a family of I_λs measured, which include information relating to blood constituent such as BGL values, differential optical densities (ΔOD_λs, where ΔOD_λ=Log(1+ΔI_λ/I_λ)) were obtained and normalized by the ΔOD_λ values at 1100 nm. Finally, the 2nd derivatives of the normalized ΔOD_λs(Δ^2OD_λs) along wavelengths were calculated as regressors. Subsequently, calibration models from paired data sets of regressors(the values of Δ^2OD_λs) and regressand (the corresponding known BGL values) were constructed with PCR, PLS, ANN and SVMsR. The results show that each calibration model provides a relatively good regression with a modified 5-fold cross validation for total 95 paired data, in which the BGLs ranged from 100.7-246.3 mg/dl. The results were evaluated by the Clarke error grid analysis and all data points obtained from all calibration models fell within the clinically acceptable regions (region A or B). Among them, ANN and SVMsR calibration provided the best plot distributions (in ANN; Region A: 77 plots (81.1%), B: 18 plots (18.9%). in SVMsR; Region A: 78 (82.1%), B: 17 (17.9%)). Total calculation time of SVMsR is about 100 times shorter than ANN. These results suggest that a calibration model using SVMsR is highly promising for "Pulse Glucometry.
著者
神山 英昇 北間 正崇 清水 久恵 山下 政司 横山 徹 小島 洋一郎 清水 孝一
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55Annual, no.Proc, pp.593-594, 2017-05-03 (Released:2017-09-13)
参考文献数
1

We have proposed a noninvasive technique to observe an arteriovenous fistula using an optical transillumination image of a blood vessel. To improve the accuracy of inner-diameter measurement of the vessel, we examined the effectiveness of the imagesubtraction technique using multi-wavelength light sources. In the experiment, we fabricated a model-phantom to simulate a human forearm. It contained the tube filled with replaceable absorber liquid which simulated the blood in different wavelengths of illuminating light. The transillumination images of the blood column were recorded with the liquid of different absorption coefficients. The imagesubtraction technique was applied and the images were analyzed. With the subtraction, the sharpness of the column image was improved by 55%, and the error in the diameter measurement was reduced from 28% to 4%. This result verified the effectiveness of the image-subtraction to promote the clinical application of the proposed technique for the controlled care of the arteriovenous fistula.
著者
宇野 富徳 王 力群 三分一 史和 外池 光雄 金田 輝男
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.48, no.1, pp.59-65, 2010-02-10 (Released:2010-11-17)
参考文献数
17

We investigated the olfactory “Kansei” information processing for two kinds of smells by measuring the brain activities associated with olfactory responses in humans. In this study, the brain activities related to discrimination and recognition of odors were examined using functional magnetic resonance imaging (fMRI). In experiment 1, odor stimuli (lemon-like and banana-like) were presented using a block design in a blinded manner, and the kind of fruits was identified by its odor. The frontal and temporal lobe, inferior parietal lobule, cingulate gyrus, amygdaloid body and parahippocampal gyrus were primarily activated by each odor based on conjunction analysis. In experiment 2, as a result of performing an oddball experiment using the odors of experiment 1, the active areas were mainly found in the temporal lobe, superior and inferior parietal lobule, insula, thalamus, supramarginal gyrus, uncus and parahippocampal gyrus. Moreover, these regions overlapped with the emotional circuit. These experimental results suggest that common brain activities accompany the discrimination and cognition associated with odor stimuli, which may underlie the olfactory responses relevant to the higher brain function and emotions associated with olfactory function.
著者
福島 大志 西川 敦 宮崎 文夫 関野 正樹 安室 喜弘 松崎 大河 細見 晃一 齋藤 洋一
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.49, no.1, pp.122-131, 2011-02-10 (Released:2011-12-13)
参考文献数
16

Repetitive Transcranial Magnetic Stimulation (rTMS) is effective for intractable diseases of the nervous system. As the effects of rTMS last only several hours, rTMS therapies need to be continued daily. Under present circumstances, it is difficult to use rTMS in patients' home, because only experienced physicians in limited hospitals can use the expensive and complicated rTMS system. Therefore, we developed a magnetic navigation system for home use of rTMS. The proposed system uses inexpensive and small magnetic sensors; hence it is suitable for home use. By using the proposed method, even people who have no medical knowledge and technique can easily navigate the coil to the optimal position preliminarily specified by expert physicians. Our system needs to collect some dataset which consists of magnetic field and the corresponding position of the coil at the patients' initial visit. Since it is bothersome to collect a large number of dataset, we reduced the dataset by approximation using multi-regression analysis.
著者
中尾 誠 赤土 和也 山崎 健一 寺田 堂彦 藤里 俊哉 吉浦 昌彦 筒井 博司
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.47, no.6, pp.560-565, 2009-12-10 (Released:2010-07-21)
参考文献数
8

If we regard skeletal muscle as an actuator, we see it has excellent flexibility and efficiency, properties that artificial actuators such as electric motors or mechanical engines do not have. We have been researching the creation of miniaturized bio-actuators that use cultured skeletal muscle. We reported that stimulation was very important to culture myoblast and to develop skeletal muscle. We obtained skeletal muscle by cultivating C2C12 cells using unidirectional mechanical stimulation. We developed a Bio-Actuator System as a mode for a skeletal muscle system in which this cultured skeletal muscle was used as actuator unit. This Bio-Actuator System was made to imitate the musculoskeletal system and consisted of one joint, two arms, one flexor muscle and one extensor muscle. One arm was fixed on the base, and the other arm was able to rotate freely about the joint axis. Because skeletal muscle can only contract, we used cultured skeletal muscle as flexor muscle and sliced silicon elastic sheet as extensor muscle. Experiments were conducted with this Bio-Actuator System in a culture medium. By applying pulsed voltage to the culture medium, the bio-actuator unit was contracted and relaxed. By repeating these contractions and expansions, we observed that the tip of the arm vibrated periodically.
著者
和宇慶 真 小濱 剛 吉田 久
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55Annual, no.3PM-Abstract, pp.219-219, 2017 (Released:2017-09-13)

脳活動を非侵襲的に計測する手法としてfNIRSが広く利用されている。これは脳神経活動により発生する酸素消費を、近赤外光を用いて血中ヘモグロビン濃度の変化として観測するものである。しかしながら、fNIRS観測信号には生理学的要因によるものや、身体の動きに伴う全身性の血流量変化が含まれる。本研究ではこれらの問題に対し、Yamadaらの分離モデルを用いて観測信号を機能成分と全身成分に分離した。また、先行研究では機能成分の係数をグローバルな値として-0.6に固定していたが、計測部位によって有意な差があったため、全ての係数を数値計算により動的に決定した。このモデルを用いて観測信号を分離した結果、被験者の動きによる大きな血流量変化が全身成分として分離され、機能成分のベースラインが安定した。また、機能成分の係数を固定した場合に比べ、全ての観測信号において相互情報量が小さくなった。この結果は、計測領域やタスクによって最適な係数が異なる可能性があるため、検討の余地があると考えられる。
著者
山口 昌樹 花輪 尚子 吉田 博
出版者
社団法人日本生体医工学会
雑誌
生体医工学 : 日本エム・イー学会誌 (ISSN:1347443X)
巻号頁・発行日
vol.45, no.2, pp.161-168, 2007-06-10
参考文献数
26
被引用文献数
28

In order to realize a novel handheld monitor for the sympathetic nervous system, we fabricated an analytical system for salivary amylase activity (sAMY) using a dry-chemistry system called a"Cocoro Meter." The device to quantify sAMY using an activity rate method was completely automated. This method was made possible by the fabrication of a disposable test-strip equipped with built-in salivacollecting and reagent papers, and an automatic saliva transfer mechanism. Within a range of sAMY between 0-200 kU/l, the calibration curve for the monitor showed a coefficient of R^2=0.988 and CV (coefficient of variation) of 10.2%. The reproducibility between devices was within 10%. Moreover, it was demonstrated that : (i) the quantitativity of the sample collected by the test-strip was sufficient, (ii) the sublingual area was suitable as the sampling site of the saliva, and (iii) 30 s was sufficient for saliva sampling. Considering all of these effects including the saliva sampling site, a 12.1% CV was obtained for this monitor. A total of 1 min was sufficient to analyze the sAMY. Thus, this study demonstrated that the monitor might be used as a good index for psychological research.
著者
加藤 雄斗 鈴木 健嗣
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55Annual, no.Proc, pp.508-509, 2017-05-03 (Released:2017-09-13)
参考文献数
4

Myoelectric upper limb prosthesis has some problems such as its stability of contact condition or determination of the optimum position of electrodes. This study reports the Development of a socket integrated with array electrode for myoelectric upper limb prosthesis. This array electrode, which was made of conductive cloth, can cope with various shapes of stumps of amputees. The advanced socket integrated with the developed array electrodes has capabilities to determine the appropriate positions of electrodes without much considering the location. The prototype is valid for detecting EMG signals for the control of myoelectric upper limb prosthesis.
著者
蘇日 塔拉図 外山 寛 小杉 剛 木竜 徹 林 豊彦 飯島 淳彦 前田 義信 山崎 健
出版者
一般社団法人 日本生体医工学会
雑誌
生体医工学 : 日本エム・イー学会誌 = Transactions of the Japanese Society for Medical and Biological Engineering : BME (ISSN:1347443X)
巻号頁・発行日
vol.48, no.1, pp.98-105, 2010-02-10
参考文献数
17
被引用文献数
2

Visually induced motion sickness is one of the detrimental effects of video images on human psychosomatic state. Several studies for alleviating this effect have been cumulated in recent years. One of the studies reported that people with high heart rate tended to be immune to the motion sickness. This fact motivated us to assume that the increase of subjects' heart rate through physical exercise before video watching could prevent them from the motion sickness. Then we investigated the effects of video exposure with such pre-exercise on the motion sickness. First we recorded psychosomatic state of 23 volunteers using the simulator sickness questionnaire (SSQ) before and after watching extremely unpleasant video images of a mountain-bike ride capable of visually inducing motion sickness. Then we classified them into nausea and non-nausea groups, based on SSQ evaluation. Subjects' heart rate in nausea group increased gradually during video exposure, while that in non-nausea group was nearly constant. By imposing a 5-minute pre-exercise on 12 subjects in nausea group before video exposure, 10 subjects became immune to the motion sickness, demonstrating that the pre-exercise would be efficient for alleviating the motion sickness. In addition subjects' heart rate in nausea group remained at a higher level during video exposure than at rest, whereas it returned to the rest level immediately after the pre-excise without video exposure.
著者
丸山 敏弘 塩澤 成弘 牧川 方昭
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.44, no.1, pp.177-183, 2006 (Released:2008-02-27)
参考文献数
11
被引用文献数
1

Recently, much research has been done to evaluate mental stress based on heartbeat fluctuation and lower restraint, and a non-invasive ECG measurement method is been expected to be able to record the heartbeat during daily life. In this study, a new ECG measuring method that uses capacity coupled electrodes without any reference electrode is proposed. In this paper, five different settings of signal electrodes and ground connections were compared: One capacity coupled signal electrode with no ground electrode, two capacity coupled signal electrodes with no ground electrode, two capacity coupled signal electrodes with a common ground electrode on the skin, one capacity coupled signal electrode with one capacity coupled ground electrode, and two capacity coupled signal electrodes with the amplifier grounded. We also examined our new ECG measurement method under different electrical environments: in a noise-filled laboratory, outdoors with no commercial electrical power nearby, and inside a car with the engine and air conditioner operating. As a result, our new measurement method proved to be effective for obtaining ECG signals during daily life.
著者
川口 浩和 小林 哲生
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.49, no.4, pp.551-557, 2011-08-10 (Released:2012-01-18)
参考文献数
10

Eye-blink activities are major artifacts for electroencephalogram (EEG) measurements. Various methods have been reported for removing eye-blink artifacts from EEGs. Almost all previous methods focus on how much eye-blink artifacts are removed. However, they concurrently remove a part of EEGs together with eye-blink artifacts. Instead, we focus on how much true EEGs remains, and proposed a localized removal method for eye-blink artifacts. The proposed method is based on the combinations of independent component analysis (ICA). empirical mode decomposition (EMD) and Kalman filter. In addition, we proposed a novel simulation model to test performances of the proposed and previous methods. This simulation model indicates that the proposed method shows the best performance and reduces information loss of EEGs than previous methods.
著者
徳重 あつ子 阿曽 洋子 伊部 亜希 岡 みゆき 片山 恵
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.47, no.1, pp.15-27, 2009-02-10 (Released:2009-08-13)
参考文献数
43

This study examined the effect of sitting positions on cerebral activation for people in bed and analyzed postural significance. The subjects were 30 healthy adults. We recorded their EEGs in α and β band and performed a subjective test in supine and sitting positions with the head of the bed elevated at 30° and 80°. First, measurements were made in the supine position for 5 minutes, and the head of the bed was then elevated. Measurement continued in the sitting position for 15 minutes at 3 stages: Stages 1, 2, and 3. Using the supine position as a baseline, we compared the supine and sitting positions. We also compared the two angles, 30° and 80°. The EEG showed a significant increase at the 80° for all measured regions and intervals, and a partially significant increase was noted at 30°. Comparing the effect of different angles confirmed the significance of 80° at Stages 1 and 2. Moreover retention time of cerebral activation at 80° is longer than that at 30°. The subjective test also confirmed a higher degree of awakening in the sitting position and in a bed at 80°. Consequently, the effect of the sitting position verified cerebral activation.
著者
鶴岡 典子 河野 隆宏 松永 忠雄 永富 良一 芳賀 洋一
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.54, no.5, pp.207-217, 2016-10-10 (Released:2017-01-14)
参考文献数
20
被引用文献数
1

Quantitative measurement of sweating rate is a useful indicator of the state of autonomic nerves and related factors such as stress response or body temperature regulation. Specifically, it is known that mental stress increases mental sweating, and deep body temperature and dehydration increase thermal sweating. Therefore, continuous sweat measurement with a small sweating rate meter is expected to be useful for the management of mental stress as well as the prevention of heat stroke. In this study, two small sweating rate meters, one having high resolution and the other having a large dynamic range, were developed and used to measure mental sweating and thermal sweating. These devices determine the sweating rate by the conventional method, which measures the humidity difference between ambient air and air moistened by sweat. Measurement resolution and dynamic range can be adjusted by controlling the air flow rate. The device for measuring mental sweating rate consists of a main body, which has an air pump and two humidity sensors, and a capsule connected to the main body by tubes in which air flows. The device for measuring thermal sweating rate has a pump and two humidity sensors, an aperture instead of a capsule, and a flow channel on a flexible substrate. The mental sweating rates during arithmetic and speech tasks were measured on the plantar aspect of the big toe using the mental sweating rate meter. The present study on part of the sole showed two sweating types ; a reaction type and a low-reaction type. During the mental stress tasks, sweating rate increased by 0.43 mg/min/cm2 compared to that at rest in reaction type subjects, but by less than 0.1 mg/min/cm2 in low-reaction type subjects, showing very low responses to stimulations. The thermal sweating rate during immersion of the lower legs in warm water was measured using the thermal sweating meter worn on the forearm. Sweating rate increased by approximately 0.4 mg/min/cm2 on average due to thermal stress, and was also successfully measured. These results show that the small sweating rate meters developed in this study can be used for measuring mental and thermal sweating rates.
著者
水野 松本 由子 田中 康仁 林 拓世 岡本 永佳 西村 治彦 稲田 紘
出版者
一般社団法人 日本生体医工学会
雑誌
生体医工学 : 日本エム・イー学会誌 = Transactions of the Japanese Society for Medical and Biological Engineering : BME (ISSN:1347443X)
巻号頁・発行日
vol.48, no.1, pp.11-24, 2010-02-10
参考文献数
32
被引用文献数
2

The aim of this research was to assess the physiological signals which were relevant working efficiency under mental workload. Eleven healthy subjects were examined. In the first step, their mood status and stress level were evaluated with questionnaire methods:&ldquo;Profile of Mood States (POMS)&rdquo; and &ldquo;Stress Self Rating Scale (SSRS)&rdquo;, respectively. In the second step, electroencephalography (EEG) and photoplethysmography under the mental workload tasks in four auditory stimuli (silent circumstance, white noise, classical music, and up-tempo music) were measured. The mental workload tasks consisted of two parts:performing Uchida-Kraepelin test (calculating task:CAL) on PC monitor in two minutes and fixating on a crosshair image (after CAL) in two minutes. A procedure of the mental workload task in each auditory stimulus was repeated three times. EEG data were analyzed using a discrete Fourier transform to obtain power spectral density (PSD) in theta, alpha, and beta bands. Pulse waves from photoplethysmography were analyzed for estimating the pulse wave amplitude (PWA) and length (PWL). PSDs of theta band in silent circumstance and classical music under and after CALs, alpha band in classical music under and after CALs, and beta band in up-tempo music under CAL on most or all areas were significantly larger than those in the other auditory stimuli. The results of photoplethysmography analysis showed that changes of PWA and PWL in silent circumstance and classical music were more stable than those in the other auditory stimuli. It was suggested that the classical music would not only affect brain activity under the mental workload and augment the efficiency of it, but also facilitate recovery of the physiological conditions from the stressful situations. These events from the physiological point of view showed that working environments could be considered to avoid adding stress on the brain function and autonomic nervous system during and even after the tasks.
著者
土井 俊祐 井出 博生 竹内 公一 藤田 伸輔
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.55, no.1, pp.45-49, 2017-02-10 (Released:2017-04-25)
参考文献数
9

Personal Health Records (PHRs), a system that enables people to manage, share, and apply personal healthcare data using information and communication technology, is expected to be an effective method to realize a vigorous society with longevity. However, it is not clear how the user's opt-in agreement and self-management of personal data may be achieved. Thus, we developed a new method to optimize opt-in agreement and access control for users in a PHR developed at Chiba University, the Social Health Assist Chiba (SHACHI). In SHACHI, participating facilities such as hospitals, clinics, pharmacies, and nursing care services display a user's unique two-dimensional bar code on a web browser. The user reads the bar code by him/herself using the “SHACHI App,” which is installed on his/her smart phone beforehand. SHACHI considers this process to signify the user's opt-in agreement. Moreover, users can retract or resume this agreement using the SHACHI App at any time. This system enables the users to self-manage personal data in PHRs. The new system satisfies government requirements and the conditions required for PHR presented in a previous study. This new system can be adopted easily by other PHRs. We plan to identify the required functionalities of standard PHRs and secondary utilization of data stored in PHRs which may be managed through the new system.
著者
新川 拓也 河内 了輔 萩野 知香 西 恵理 高田 慶応 湊 小太郎
出版者
一般社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.49, no.3, pp.501-507, 2011
被引用文献数
1

The aim of this study was to clarify the mechanical action of the infant tongue during sucking. Therefore we developed an artificial nipple that contained multiple small built-in force sensors which was capable of measuring tongue-artificial nipple contact pressure in real-time. A force sensor was a cantilever structure composed of a thin stainless steel beam and all-purpose foil strain gauges attached to the surface of the beam. The signals obtained from the force sensor were amplified, and were transferred to a PC via a USB port. Using this system, measurements were taken in three infants. The output waveform was observed in all subjects, and the rate of sucking was about two times per second. In addition, the pressure waveform indicated peristalsis-like movement of tongue in infants with established oral feeding. This system can quantitatively measure individual differences in tongue movement.