著者

Khushwant S. BHULLAR Nan SHANG Jianping WU

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.Supplement, pp.S113-S115, 2022-11-30 (Released:2022-11-25)

参考文献数

17

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Bone health is an important medical concern in rapidly aging demographics worldwide. Excessive bone resorption, due to enhanced activity of osteoclasts, is a major underlying cause of bone disorders such as osteoporosis. Inflammation and oxidative stress are key factors contributing to increased osteoclastic activity. Like increased activity of osteoclasts, depletion of osteoblasts also contributes to weakened structural integrity of bone. Considering the epidemiology of bone disorders and aging demographics there is a substantial need for novel bone health therapeutics. IRW (Ile-Arg-Trp), an egg-derived tripeptide, exhibits a spectrum of pharmacological activity. In our recent work, we have shown that IRW inhibits osteoclastogenesis and promotes osteogenesis in the mouse macrophage RAW 264.7 and MC3T3-E1 cells. IRW treatment (25 and 50 μM) significantly inhibited osteoclastogenesis-associated factors [TRAF6 (TNF Receptor Associated Factor 6), Fos Proto-Oncogene (c-Fos), Nuclear Factor of Activated T Cells 1 (NFATc1), and cathepsin K] and upregulated osteogenesis-associated factors [RUNX2 (Runt-related transcription factor 2) and RANKL (Receptor activator of nuclear factor kappa-B ligand)] in the two cell lines. Currently, we are conducting studies to analyze the impact of IRW on Angiotensin II (Ang II)-induced stress in vitro and in vivo. In summary, our recent work presents the ability of IRW to prevent LPS-induced inflammatory bone resorption and activation of osteogenesis activity via multiple signaling pathways.

著者

元嶋 菜美香 杉山 佳生

出版者

日本生涯スポーツ学会

雑誌

生涯スポーツ学研究 (ISSN:13488619)

巻号頁・発行日

vol.19, no.1, pp.27-36, 2022 (Released:2022-12-07)

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Sports volunteers are essential for maintaining and promoting the sports environment. However, with the diversification of activities and changes in individual values, there are a lot of problems. Because of the chronic shortfall of sports volunteers, it is important to identify factors of participation and continuity in recent years.   The purpose of this study is to organize the research methods and factors through a systematic review of studies on the factors of participation and continuity of sports volunteers, and to overview the gap between definitions and actual activities. We selected 32 articles published in Japan that research on factors related to participation and continuation of sports volunteers.   As a result, 18 studies did not specify the definitions of sports volunteers in their studies. Secondly, the common research methods were questionnaires using original scales, and no studies using theoretical models that included continuation behavior. We summarized the factors associated with participation and continuation, most common motive for participation was altruistic. In addition, it was suggested that positive experiences such as "enjoyment" and "satisfaction" in the activity may contribute to the sports volunteer’s continuation.   Finally, it was suggested that the type of sports support activities covered by the survey deviated from the definition of sports volunteerism, and that the survey participants may have a different perception from the definition.

著者

田引 俊和 渡邊 浩美

出版者

日本生涯スポーツ学会

雑誌

生涯スポーツ学研究 (ISSN:13488619)

巻号頁・発行日

vol.19, no.1, pp.37-45, 2022 (Released:2022-12-07)

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This study focuses on the national games of Special Olympics Nippon, a sports organization for people with intellectual disabilities, to examine the effects and significance of the games as a lifelong sports event in the formation of a basic sports environment for people with intellectual disabilities in Japan.   In the 1990s, sports for people with intellectual disabilities had yet to achieve widespread recognition on the part of society as a whole, including on the part of family members and other stakeholders, and opportunities and methods were also not yet adequate. In this context, Special Olympics Nippon has staged summer and winter editions of its national games every 4 years, respectively, since its establishment in 1994. In addition to attracting an increasing number of individual athletes with disabilities, these national games have been expanding the number of matches and events held on each occasion. Moreover, in conjunction with the staging of the games, the organizers have popularized the understanding of sports for people with intellectual disabilities and increased membership and bases of activity across the country. These efforts have set the foundation for lifelong sports for people with intellectual disabilities and facilitated both their development and expansion.   In the background of this development has been the foundational idea of the Special Olympics, which emphasize “participation” rather than “record-keeping” and “winning and losing.” Though these games are staged at the national level, athletes are broadly able to take part, regardless of their competitive skill or degree of disability, and it is this characteristic that has arguably led to their subsequent expansion.   On the other hand, some potential needs remain. It will be necessary to create environments in which people with intellectual disabilities can take part in sports over the course of their lives, beyond the frame of school-based education.

著者

松﨑 淳 長ヶ原 誠

出版者

日本生涯スポーツ学会

雑誌

生涯スポーツ学研究 (ISSN:13488619)

巻号頁・発行日

vol.19, no.1, pp.13-25, 2022 (Released:2022-12-07)

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Previous research has illustrated the need for event organizers to take proactive measures to deal with anticipated accidents of risk concerning the organization of sports events. However, the risk management method adopted by the event organizer at the planning stage of the events, when they are required to decide on whether to hold the events under uncertain circumstances brought about by external risk incidents, remains unclear. The purpose of this study was to examine the judgement process in hosting international lifelong-sport events under uncertainty. We collected archival materials and studied the World Masters Games 2021, its organizing committee, and its stakeholders. We identified 13 elements of uncertainty that were significant of stakeholders’ hosting events in uncertainty. These include: reachability of event value, possibility of duplication of event schedule, opaqueness in financing, difficulty in securing staff, difficulty in securing equipment, difficulty in securing event venue, feasibility of pre-event, difficulties in securing participants and ensuring safety, difficulty in securing volunteer-staff, difficulties in developing a cooperation system, transport/accommodation coordination risks, opaqueness of comprehension/agreement of host, and feasibility of holding the ceremony. In order to cope with the uncertainty, the Organizing Committee (1) interviewed relevant organizations, (2) referred to the Tokyo 2020 Olympics and Paralympics Games, (3) conducted a survey on stakeholders of the Games, and (4) collected statistical evidence related to infectious diseases. Based on these measures, the decision to postpone the event to 2022 was made after controlling the uncertainty related to the decision on whether to host the Games or not. Insight into the key uncertainty dimensions of event planning phase in international lifelong-sports events that judgement criteria of postpone is given, and several practical recommendations are suggested for event organizer and event stakeholder.

著者

野田 賢 長谷部 伸治 西谷 紘一

出版者

公益社団法人 化学工学会

雑誌

化学工学会 研究発表講演要旨集 化学工学会第70年会

巻号頁・発行日

pp.587, 2005 (Released:2005-08-30)

著者

堀 秀行 田邊 樹郎 福留 みのり 川崎 勉 出田 秀尚

出版者

医学書院

巻号頁・発行日

pp.1369-1373, 2006-08-15

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目的:中心窩下の脈絡膜新生血管に対して行った光線力学療法と,これにトリアムシノロンアセトニド40mgのテノン囊下注射を併用した3か月後の効果の比較。対象と方法:過去8か月間に,中心窩下の脈絡膜新生血管に対して光線力学療法を行った68例68眼を対象とした。51眼には光線力学療法のみを行い,17眼にはトリアムシノロン注射を併用した。結果:両群の間でlogMAR視力と中心窩網膜厚の変化量に有意差はなかった。病変部最大直径の減少量は,光線力学療法単独群よりもトリアムシノロン併用群のほうが有意に大きかった(p<0.01)。結論:中心窩下の脈絡膜新生血管に対する光線力学療法の3か月後の評価では,これ単独よりも,トリアムシノロンのテノン囊下注射を併用したほうが病変の大きさを減少させる効果が大きい。

著者

栗林 信行

出版者

パワーエレクトロニクス学会

雑誌

パワー・エレクトロニクス研究会講演論文集 (ISSN:03877043)

巻号頁・発行日

vol.7, pp.47-48, 1982-03-31 (Released:2010-07-01)

著者

Ryoji Hirota Ikuya Shirai Koji Karasawa Yumiko Fujioka

雑誌

22nd IUNS-International Congress of Nutrition

巻号頁・発行日

2022-11-10

著者

栗原 益男

出版者

東洋文庫

雑誌

東洋学報 = The Toyo Gakuho

巻号頁・発行日

vol.38, no.4, pp.430-457, 1956-03

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The present article is a sequel to the writer’s “a Study of the Nature of the Fictitious Relationship of Father and Son in the T’ang and Five Dynasty Periods” (Shigaku-Zasshi, Vol. 62, No. 6). Two types of Chia-tzŭ 假子, i. e. the adopted son, are recognized; namely, by a group and by an individual. But any information of names and ages of individuals can be obtained only in the latter case. They appeared in most cases in the T’ang and Five Dynasty Periods and the fathers adopting them were mainly Fan-shuai 藩帥, i. e. local leaders. This paper is intended to consider the nature of the power of these local leaders, by investigating names and ages of sons adopted by individuals.The fathers gave names including second name indicating age-rank (pei-tzŭ 輩字) to their adopted sons just as to their real sons, and thus controlled the sons under their patriarchal rule. They did not allow their subordinates to adopt sons as they did. The difference in age between fathers and sons was unnaturally small. In general the adopted son was considerably older than the real son and the leaders proclaimed their adoption of Chia-tzŭ before their real sons were born.From these facts it is observed that Fan-shui a playing a leading role during the T’ang and Five Dynasty Periods extended the parentage to non-cognates and they confirmed their rule on the patriarchal caused by the relation

著者

杉山 一男

出版者

近畿大学工学部

雑誌

近畿大学工学部紀要. 人文・社会科学篇 = Annual report, Kindai University Faculty of Engineering (ISSN:24345938)

巻号頁・発行日

no.49, pp.1-50, 2019-12-21

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Herbal medicine refers to any medicinal therapy that employs medicinal leaves, roots, or barks without extracting their active ingredients. Although native herbal medicines are believed to have been used in ancient Japan, the most advanced information on the use of herbal medicine in China reached Japan in the 5th century through the Korean peninsula. Furthermore, although herbal medicines are sometimes used alone, they are usually mixed together and utilized as a prescribed treatment, i.e., a traditional Chinese herbal remedy. Approximately one-third of the Man’yoshu poems, i.e., about 1500, mention plants and almost all of them are used as food, clothing, dyes, and herbal medicines. In this paper, we attempt to provide some insights into both the outlook on the nature and lifestyles of the people in the Manyou era, based on their views and considerations of plants, as well as an overview of the state of ancient medicine. Specifically, the Man’yoshu poems in which plants were mentioned as useful herbal medicines were selected. In addition, the inherent active ingredients, pharmaceutical effect, and the traditional Chinese prescriptions for each plant were studied. [要約]天然に存在する薬効をもつ草根木皮などから有効成分を抽出することなく用いる薬の総称を生薬という。古来、我が国においても独自の生薬があったと考えられるが、生薬を含む医薬に関する中国の最新の知識は、5 世紀頃、朝鮮半島を経て伝来した。生薬は単独で用いることもあるが、多くはいくつかの生薬を配合した処方薬―漢方薬として使われる。一方、万葉集に採録された4516首の歌の約1/3にあたる1500首余りに植物が詠み込まれており、その植物の多くは、生薬のほか食糧・衣料・染料などとして用いられた。本報では、万葉人が植物にもつイメージや捉え方から、彼らの自然観や生活様式を味わうとともに、古代の医薬の在り方を概観した。即ち、万葉集の中から生薬として有用な植物を織り込んだ歌を取り上げ、個々の草根木皮に含まれる医薬成分と薬効、そして漢方処方について検討した。

著者

高橋 秀俊

出版者

公益社団法人 応用物理学会

雑誌

応用物理 (ISSN:03698009)

巻号頁・発行日

vol.41, no.5, pp.488-493, 1972-05-10 (Released:2009-02-09)

参考文献数

1

著者

Samantha Lee Huey Jesse T. Krisher Shobha A. Udipi Padmini Ghugre Varsha M. Thakker Harsha V. Chopra Ramesh D. Potdar Jere D. Haas Julia L. Finkelstein Saurabh Mehta

雑誌

22nd IUNS-International Congress of Nutrition

巻号頁・発行日

2022-11-10

著者

関西大学図書館

出版者

関西大学図書館

巻号頁・発行日

2009-07

出版者

偕行社

巻号頁・発行日

vol.(321)臨時増刊, 1977-11

著者

玉木存著

出版者

三一書房

巻号頁・発行日

1998

著者

Sing-Chung Li Shih-Ping Lin Chiao-Ming Chen Kang-Ling Wang Kun-Lin Wu

雑誌

22nd IUNS-International Congress of Nutrition

巻号頁・発行日

2022-11-10

著者

山本 勝市

出版者

東京商科大学

巻号頁・発行日

1940

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博士論文

著者

山田 創一

出版者

専修大学法学会

雑誌

専修法学論集 (ISSN:03865800)

巻号頁・発行日

vol.138, pp.263-281, 2020-03-15