著者
森川 稔
出版者
公益社団法人 日本都市計画学会
雑誌
都市計画論文集 (ISSN:09160647)
巻号頁・発行日
vol.19, pp.493-498, 1984-10-25 (Released:2020-09-01)
参考文献数
3

A half of residents living in the public housing around Osaka Inner Area came from the provinces. But many of younger householders were born in Osaka City and have been there. Therefore the following is important. Younger families live by their parents in the city. And it balances the age-grade.
著者
遊川 和彦 深田 武志
出版者
日経BP社 ; 1985-
雑誌
日経マネー (ISSN:09119361)
巻号頁・発行日
no.417, pp.100-103, 2017-03

──子供が巣立った中年夫婦の危機をコミカルに描いた初監督作品「恋妻家宮本」を楽しく見ました。阿部寛さんの妻役の天海祐希さんがとても魅力的に撮れていると感じたのですが、何か特別な演出をされたのですか。 天海さんは普通にしていると、はつらつとし…
著者
Kazuya Shirato Naganori Nao Shutoku Matsuyama Tsutomu Kageyama
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.73, no.3, pp.181-186, 2020-05-29 (Released:2020-05-22)
参考文献数
21
被引用文献数
13 26

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is usually diagnosed through highly sensitive and specific genetic tests such as real-time reverse transcription polymerase chain reaction (RT-PCR). Currently, two real-time RT-PCR assays targeting the upE and ORF1a regions of the MERS-CoV genome are widely used, and these are the standard assays recommended by the World Health Organization (WHO). The MERS outbreaks to date suggest that rapid diagnosis and subsequent isolation of infected patients, particularly superspreaders, are critical for containment. However, conventional real-time RT-PCR assays require large laboratory instruments, and amplification takes approximately 2 h. These disadvantages limit rapid diagnosis. Here, an ultra-rapid real-time RT-PCR test was established comprising a multiplex assay for upE and ORF1a running on a mobile PCR1100 device. As few as five copies of the MERS-CoV RNA can be detected within 20 min using the standard WHO assays in the mobile PCR device, with the sensitivity and specificity being similar to those of a conventional real-time PCR instrument such as the LightCyler, thereby enabling timely intervention to control MERS-CoV infection.

1 0 0 0 虜人日記

著者
小松真一著
出版者
筑摩書房
巻号頁・発行日
1975

1 0 0 0 週刊明星

出版者
集英社
巻号頁・発行日
vol.31(49)(1547);1988・12・22, 1988-12

1 0 0 0 現代詩手帖

著者
思潮社 [編]
出版者
思潮社
巻号頁・発行日
vol.29, no.12, 1986-12

1 0 0 0 週刊現代

出版者
講談社
巻号頁・発行日
vol.29(10)(1435);1987・3・7, 1987-03
出版者
日経ホーム出版社
雑誌
日経マネー (ISSN:09119361)
巻号頁・発行日
no.299, pp.36-39, 2007-11

「リスクのある資産を持っている方は、今すぐに売り払ってください」。草野グローバルフロンティア代表取締役の草野豊己さんは、8月初旬に出演したテレビ番組の最後で、そうコメントしたという。折しも、外国人投資家が日本株を売り越し始めたころだ。草野さんの予想通り、8月中旬に日経平均株価は急落。世界の金融市場も一時的に停滞した。
著者
Toshiro Niwa Mari Morimoto Takako Hirai Tomomi Hata Misato Hayashi Yurie Imagawa
出版者
The Japanese Society of Toxicology
雑誌
The Journal of Toxicological Sciences (ISSN:03881350)
巻号頁・発行日
vol.41, no.1, pp.143-146, 2016-02-01 (Released:2016-01-13)
参考文献数
21
被引用文献数
7 16

The effects of three kinds of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activity of human hepatic cytochrome P450 (P450 or CYP) were investigated. Metabolic activities of P450s expressed in recombinant Escherichia coli at substrate concentrations around the Michaelis constant were compared in the presence or absence of the antibiotics. Amoxicillin, ampicillin, and piperacillin at 0.5 or 1 mM concentrations neither inhibited nor stimulated CYP2C9-mediated tolbutamide methylhydroxylation, CYP2D6-mediated dopamine formation from p-tyramine, or CYP3A4- or CYP3A5-mediated testosterone 6β-hydroxylation. However, amoxicillin and piperacillin inhibited CYP2C8-mediated aminopyrine N-demethylation at 50% inhibitory concentration of 0.83 and 1.14 mM, respectively. These results suggest that piperacillin might inhibit CYP2C8 clinically, although the interactions between these three penicillin-based antibiotics and other drugs that are metabolized by P450s investigated would not be clinically significant.