著者
坂本義和著
出版者
岩波書店
巻号頁・発行日
2004
著者
竹中 伸夫
出版者
熊本大学教育学部附属教育実践総合センター
雑誌
熊本大学教育実践研究
巻号頁・発行日
vol.32, pp.21-29, 2015-02-27

The aim of this study is to inquire the possibility of History Education taking up the person in the past in junior high school in the based on the analysis of textbooks in England and on the development of lessons. Consequently, I explained a method defined the learning by reevaluating the person in the past, and made the four prefectures of this method differed from a method by sympathizing clear by the analysis of textbooks in England. And I developed the lessons accepted the four prefectures, "Tsunayosi Tokugawa - Is he the fifth Tokugawa Shogun loved enthusiastically only the dog, or the politician promoting the principles of civilian government? ".
著者
澤田 天瑞
出版者
日本庭園学会
雑誌
日本庭園学会誌 (ISSN:09194592)
巻号頁・発行日
vol.2007, no.17, pp.39-53, 2007-08-31 (Released:2011-05-20)
参考文献数
22

Saint Sennyo, the head priest of Higashi Honganji temoje asked Ishikawa Jozan to design a garden early in the Edo period. This is called Shoseien Garden of Higashi Honganji temple.I consider it to be a “Kaiyushiki Garden”. It reproduced “the Kawarain Garden” of the Minister of the Left, Prince Minamoto Toru (822 - 895). The main theme of this garden is “Kawarain”. and the design is based on “the salt pan of Mutsu district”, and the configuration is “the Noh song Toru”
著者
熊谷 雄治 藤田 朋恵 横田 愼一 澤田 実花 井澤 志名野 鈴木 勇一 立岡 和弘 庄田 隆 矢後 和夫
出版者
The Japanese Society of Clinical Pharmacology and Therapeutics
雑誌
臨床薬理 (ISSN:03881601)
巻号頁・発行日
vol.33, no.5, pp.205-213, 2002-09-30 (Released:2010-06-28)
参考文献数
8

Objectives: Tibolone (KB-889) is a novel compound that possesses tissue-specific hormonal effects. We investigated the pharmacokinetics of tibolone in postmenopausal women in four pharmacokinetic studies, namely a dose linearity study, a multiple dose study, a study in fasted condition, and a study in elderly. In this report, the results obtained from the above four studies are summarized.Methods: In the dose linearity study, a single dose of 0.5 mg, 1 mg and 2 mg of tibolone was administered to 6 postmenopausal women using a 3-period crossover method with at least a 7-day wash-out period between treatments. In the multiple dose study, 2 mg of tibolone was administered once daily for 4 days to 6 postmenopausal women. In the study in fasted condition, a single dose of 2 mg of tibolone was administered to 6 postmenopausal women after overnight fasts. In the study in elderly, a single dose of 2 mg of tibolone was administered to 6 elderly women aged 65 or older. Plasma and urine concentrations of tibolone and its metabolites were measured.Results and Conclusion: Plasma concentrations of the 3α-OH and 3β-OH metabolites of tibolone were measured, since the levels of tibolone and its Δ4-isomer were under or near the detection limits. After single dose administration of 0.5, 1 and 2 mg of tibolone, the means of Cmax and AUC0-12h of plasma 3α-OH metabolite were 2.3, 3.5 and 6.5 ng/mL and 10.2, 18.5 and 36.7 ng·Eh/mL, respectively, and those of 3β-OH metabolites were 0.9, 1.7 and 3.1 ng/mL and 4.6, 8.8 and 17.7 ng·Eh/mL, respectively. The means of Tmax and T1/2 (6-12h) of plasma 3α-OH and 3β-OH metabolites were between 3.7 and 5.7 h, and between 3.2 and 4.4 h, respectively. The pharmacokinetic properties of tibolone were considered to be linear within the dose range of 0.5 mg to 2 mg. In the multiple dose study, no accumulation was found. When comparing the pharmacokinetic parameters obtained from the study in fasted condition with those of day 1 of the multiple dose study, the absorption of tibolone was rapid under fasted condition, but AUC was not influenced by food intake. [The means of Tmax of 3α-OH and 3β-OH metabolites were 1.17 and 1.33 h in fasted condition, and 3.83 and 4.00 h on day 1 of multiple dose.] Finally no difference in pharmacokinetics was found between postmenopausal women and elderly women in the comparison of the pharmacokinetic parameters obtained from the study in the elderly and those of day 1 of the multiple dose study.
著者
原 征彦 渡辺 真由美
出版者
社団法人 日本食品科学工学会
雑誌
日本食品工業学会誌 (ISSN:00290394)
巻号頁・発行日
vol.36, no.12, pp.951-955, 1989
被引用文献数
37

茶のタンニン(ポリフェノール)成分として緑茶からカテキン類を4種,紅茶からテアフラビン類を4種分離精製した.これらがボツリヌス菌の芽胞および栄養細胞に対して示す抗菌力を最小発育阻止濃度(MIC)により求めた.芽胞はパウチ法,栄養細胞は画線法でそれぞれを嫌気培養し,ポリフェノール濃度の違いによる菌の生育の有無を調べた.その結果,ガレートカテキン類およびテアフラビン類は100~300ppmの濃度で,ボツリヌス菌の芽胞の発芽および栄養細胞の増殖を阻止した. <BR>同じポリフェノール類が,他の耐熱性有芽胞細菌の芽胞および栄養細胞に対しても抗菌力を示すか否かにつき同じくMIC試験を行なったところ,菌により低濃度で発育が阻止される場合と高濃度でも発育が阻害されない場合とがあり,一定の傾向はみられなかった. <BR>なお本報の一部は日本食品工業学会第35回大会シンポジウム10)において発表した.
著者
金子 隆一
出版者
日本映像学会
雑誌
映像学 (ISSN:02860279)
巻号頁・発行日
vol.33, pp.28-31, 1986-01-31 (Released:2017-06-30)
参考文献数
7

Nobuo Ina (1898-1978) wrote “Return To Photography”(1932) that was his first article on photography.He introduced New German Photography Theories – “Neue Sachlichkeit”, “Reportage-Photo”, “Bauhaus” and others into Japan. They gave photography new concepts; “Real - Photography”, “Photography as Documents and Report of life”, “Photography as Light Plastic”.Ina added another concept; “Photographer as Social Being”. This article also discussed a historical vision on modern photography. His point of view was always focused on the active relation of photography to society.After World War II Nobuo Ina wrote several articles on the history of photography. “Establishment of Modern Photography and its Evolution” was published serially from 1964 to 1968 in which he opposed Beaumont Newhall’s and Helmut Gernsheim’s historical visions on modern photography. He believed that the true origin of modern photography was in Germany.Ina positioned Japanese photography in the History of World Photography from this point of view.
著者
原口 一博 鈴木 哲夫
出版者
講談社
雑誌
週刊現代
巻号頁・発行日
vol.53, no.12, pp.46-48, 2011-03-19