著者

豊里友行著

出版者

榕樹書林 (発売)

巻号頁・発行日

2015

著者

峯岸 正典

出版者

日本宗教学会

雑誌

宗教研究. 別冊 (ISSN:21883858)

巻号頁・発行日

vol.87, pp.482-483, 2014-03-30

著者

西井 美穂

出版者

日本宗教学会

雑誌

宗教研究. 別冊 (ISSN:21883858)

巻号頁・発行日

vol.87, pp.323-324, 2014-03-30

著者

花岡 永子

出版者

日本宗教学会

雑誌

宗教研究 (ISSN:03873293)

巻号頁・発行日

vol.77, no.2, pp.439-463, 2003-09-30

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「"生活の宗教″としてのキリスト教」を二十一世紀の現在において論究するには、キリスト教の内部だけに留まることは不可能である。何故ならば、遅くとも二十世紀後半には物理学においてのみならず各宗教においても、多元性や相補性を視野に入れざるを得ず、更には諸宗教の根源に遡って、諸宗教の始原での「根源的いのち」の経験の視座から各宗教を考察することが必要だからである。今世紀の諸宗教に通底していると考えられる「根源的いのち」乃至は「霊性」の同一経験は、各民族、各国家の文化に基礎づけられた表現やその方法の相違によって大きく相違してきたと理解され得る。そこで本小論では、仏教との比較の中でテーマが考察される。従って、一切の二元性や両極性が超脱された世俗化、更には聖俗1如の境涯が、仏教での「日常底」との比較の中で論究される。

著者

浅井 成海 吾勝 常行

出版者

龍谷大学

雑誌

佛教文化研究所紀要 (ISSN:02895544)

巻号頁・発行日

vol.42, pp.43-58, 2003-11-30

著者

Yong-Qiang Shan Yan-Ping Zhu Jing Pang Yan-Xiang Wang Dan-Qing Song Wei-Jia Kong Jian-Dong Jiang

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.10, pp.1562-1569, 2013-10-01 (Released:2013-10-01)

参考文献数

41

被引用文献数

11 40

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This study was designed to improve the absorption and hypoglycemic efficacy of berberine (BBR), which is a substrate of P-glycoprotein (P-gp), by combination with a P-gp inhibitor tetrandrine (Tet). Flow cytometry and LC-MS/MS were used to determine the cellular efflux or retention of chemicals. Pharmacokinetic study was performed in ICR mice following oral administration of the study compounds. The hypoglycemic efficacies of the compounds were evaluated in diabetic KK-Ay mice. In the in vitro experiments, Tet significantly inhibited the efflux and increased the uptake of P-gp substrates rhodamine-123 as well as BBR in MCF7/DOX cells and Caco-2 intestinal cells. Meanwhile, Tet greatly reduced the expression of P-gp in Caco-2 cells. The inhibition of BBR efflux by Tet was translated into improved pharmacokinetics in vivo. When co-administered, Tet dose-dependently increased the average maximum concentration (Cmax) and area under concentration–time curve (AUC0–24) of BBR in mice. Tet itself had no impact on glucose metabolism. However, it greatly potentiated the hypoglycemic efficacy of BBR in diabetic KK-Ay mice. In addition, we found that Tet had moderate inhibitory effect on the catalytic activity of CYP3A4, which played a role in the bio-transformation of BBR, and this may also take part in the improvement of the pharmacokinetics of BBR. In summary, combination with P-gp inhibitors such as Tet can improve the pharmacokinetics and hypoglycemic efficacy of BBR greatly; this implicates a feasible strategy for exploring the therapeutic effects of BBR and other pharmaceuticals which are substrates of P-gp.

著者

Erina Ikeda Tetsuya Goto Kaori Gunjigake Kayoko Kuroishi Masae Ueda Shinji Kataoka Takashi Toyono Mitsushiro Nakatomi Yuji Seta Chiaki Kitamura Tatsuji Nishihara Tatsuo Kawamoto

出版者

日本組織細胞化学会

雑誌

ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)

巻号頁・発行日

pp.15022, (Released:2016-02-10)

被引用文献数

5

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Several theories have been proposed regarding pain transmission mechanisms in tooth. However, the exact signaling mechanism from odontoblasts to pulp nerves remains to be clarified. Recently, ATP-associated pain transmission has been reported, but it is unclear whether ATP is involved in tooth pain transmission. In the present study, we focused on the vesicular nucleotide transporter (VNUT), a transporter of ATP into vesicles, and examined whether VNUT was involved in ATP release from odontoblasts. We examined the expression of VNUT in rat pulp by RT-PCR and immunostaining. ATP release from cultured odontoblast-like cells with heat stimulation was evaluated using ATP luciferase methods. VNUT was expressed in pulp tissue, and the distribution of VNUT-immunopositive vesicles was confirmed in odontoblasts. In odontoblasts, some VNUT-immunopositive vesicles were colocalized with membrane fusion proteins. Additionally P2X3, an ATP receptor, immunopositive axons were distributed between odontoblasts. The ATP release by thermal stimulation from odontoblast-like cells was inhibited by the addition of siRNA for VNUT. These findings suggest that cytosolic ATP is transported by VNUT and that the ATP in the vesicles is then released from odontoblasts to ATP receptors on axons. ATP vesicle transport in odontoblasts seems to be a key mechanism for signal transduction from odontoblasts to axons in the pulp.

著者

米丸 健太 鈴木 壯

出版者

日本スポーツ心理学会

雑誌

スポーツ心理学研究 (ISSN:03887014)

巻号頁・発行日

2016

被引用文献数

1

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The psychological growth process in becoming an independent athlete, and how others influence this process through psychological counseling was investigated. Counseling was conducted for an athlete that had difficulties in enhancing her performance and complained, "I'm not sure what I am." The counseling continued for three years through 101 interviews. During counseling, she discussed issues related to her performance and how she reconsidered herself. As a result, she became able to take initiatives during competitions and with other people, and grew up to become an independent athlete. Moreover, her performance was enhanced. Analyzing the process of counseling indicated the following. (1) An athlete progresses and becomes independent in the process of attempting to solve performance issues. (2) An athlete that is dependent on the instructions of significant others become a separate individual during the counseling process and grow up to be an independent athlete: namely, the athlete experiences an internal death is reborn as an independent person by overcoming difficulties through trial and error. (3) Listening and understanding an athlete's mind-body experiences can support efforts, lead to new discoveries and to new insights. Ultimately, the athlete accomplishes changes in performance, as well as in personal relationships. These findings suggest that dialogues during counseling are significant for the psychological development and performance enhancements of athletes. These perspectives would help us to understand the process of psychological development in athletes and would be useful for providing future psychological support for athletes.

著者

集英社 [編]

出版者

集英社

巻号頁・発行日

vol.4(25), no.151, 1961-06

著者

日本医史学会 [編]

出版者

日本医史学会

巻号頁・発行日

no.1203, 1934-01

著者

藤田徳太郎 著

出版者

楽浪書院

巻号頁・発行日

1941

著者

鈴木道運 願出

巻号頁・発行日

1930

著者

大井 次三郎

出版者

日本植物分類学会

雑誌

植物分類・地理 (ISSN:00016799)

巻号頁・発行日

vol.4, no.4, pp.230-233, 1935-12-01

出版者

出雲寺万次郎

巻号頁・発行日

vol.[1], 1854

著者

小宮 一郎

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.59, no.1, pp.27-29, 2016

著者

小宮 一郎

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.59, no.1, pp.18-19, 2016

著者

山内 賢幸 坊農 真弓 相原 健郎 西本 一志

雑誌

研究報告ヒューマンコンピュータインタラクション(HCI)

巻号頁・発行日

vol.2010-HCI-137, no.10, pp.1-8, 2010-03-12

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学会の懇親会や結婚式の披露宴などの立食形式パーティーで会話の輪から孤立している人がいる. この会話の輪に入ることが出来ていない状態の人を「孤立者」と呼ぶ.本研究では立食形式パーティーの映像を使いハンドアノテーションを行う.そしてそこから得られたアノテーションデータを用いて孤立者の検出を行う.今回提案する検出手法は会話集団を見つけ,それ以外の人を孤立者とする方法である.人が映像を見て直感的に孤立者と判断したデータと提案手法で得られた結果との比較を行い,どれだけ孤立者が検出できたのかを明らかにする.またその結果から今後の課題についても検討を行う.

著者

小田省吾 等著

出版者

朝鮮史学会

巻号頁・発行日

vol.中世史, 1927

著者

一方井 祐子 伊澤 栄一

出版者

慶應義塾大学大学院社会学研究科

雑誌

慶應義塾大学大学院社会学研究科紀要 : 社会学・心理学・教育学 : 人間と社会の探究 (ISSN:0912456X)

巻号頁・発行日

no.73, pp.49-55, 2012

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論文Affiliative social interactions play a crucial role in the formation and maintenance of social bonding in the form of a cooperative relationship among group members in a wide range of social animals. Behavioural functions of affiliative interactions have been extensively investigated in mammals including primates and carnivores, but little is known about such behavioural functions in birds. Because many bird species form and maintain male‒female pair bonding as a cooperative social unit, they are good animal models to study the evolution of cooperative behaviour. In this study, we investigated the involvement of affiliative interactions in the formation and maintenance of pair bonds in a life-long monogamous bird, budgerigar (Melopsittacus undulatus). To verify the involvement of these interactions, we compared the frequency of affiliative interactions between pair bonded and non-pair bonded male‒female dyads over 3 months after introducing a novel flock. To characterize the potential frequency change in affiliative interactions, a similar comparison was conducted for aggressive interactions. We observed that affiliative interactions drastically increased together with pair bond formation 2 weeks after introducing the flock and decreased thereafter. However, a certain high frequency level of affiliative interactions was maintained even after pair bond formation. In contrast, aggressive interactions were observed to transiently increase along with pair bond formation but gradually disappeared thereafter. No such change was found in non-pair bonded male‒female dyads in both affiliative and aggressive interactions. These results suggest that affiliative interactions are involved in pair bond formation and maintenance.

著者

帝国学士院 編

出版者

帝国学士院

巻号頁・発行日

vol.大正3年, 1917