著者

Kiyoshi OIZUMI Hiroshi NISHINO Hiroyuki KOIKE Toshio SADA Masaaki MIYAMOTO Tomio KIMURA

出版者

(社)日本薬理学会

雑誌

The Japanese Journal of Pharmacology (ISSN:00215198)

巻号頁・発行日

vol.51, no.1, pp.57-64, 1989 (Released:2006-08-25)

参考文献数

14

被引用文献数

36 45

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CS-905 is a novel dihydropyridine calcium blocker. A single oral administration of CS-905 or nicardipine at doses of 0.3-3.0 mg/kg produced a dosedependent reduction of blood pressure in conscious SHR. CS-905, when administered orally in conscious SHR, was more than 3 times as potent as nicardipine. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in heart rate. An intravenous administration of CS-905 also produced a hypotension with a slow onset and long duration in SHR, but CS-905 was 3 times less potent than nicardipine by intravenous administration. This difference may be attributed to the first pass effect, which was associated with nicardipine but not with CS-905. The blood pressure lowering effects of CS-905 was most potent in DOCA-salt hypertensive rats, followed by SHR, RHR and normotensive rats, in this order. CS-905 is expected to be an antihypertensive agent that is effective on a once a day regimen in clinical settings.

著者

田中 一広 前原 博樹 當銘 保則 上原 史成 金谷 文則

出版者

西日本整形・災害外科学会

雑誌

整形外科と災害外科 (ISSN:00371033)

巻号頁・発行日

vol.65, no.2, pp.328-330, 2016-03-25 (Released:2016-05-16)

参考文献数

5

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初回術後多発肺転移と複数回局所再発を来し治療に難渋した右肘頭骨巨細胞腫にdenosumabが著効した1例を報告する.【症例】18歳,女性.右肘頭骨腫瘍にて当科紹介され,単純X線像,切開生検にて骨巨細胞腫の診断に至った.骨腫瘍掻爬,アルコール処理,自家腸骨移植施行後4ヵ月で肺転移を認め化学療法施行,zoledronateを投与した.術後9ヵ月で局所再発し再手術施行するも,計3度再発を来した.転移性肺腫瘍は徐々に増加,増大し初回手術後4年2ヵ月より肺炎,血胸を来すようになりdenosumabを投与開始した所,転移性病変は縮小し症状改善した.10ヵ月投与後に一旦休薬したが,再度転移性病変が増大したため投与を再開した.以降転移性病変は縮小傾向であり,現在術後6年2ヵ月経過している.

出版者

一般社団法人 国立医療学会

雑誌

医療 (ISSN:00211699)

巻号頁・発行日

vol.16, no.Supplement, pp.149-184, 1962-09-20 (Released:2011-10-19)

著者

結核療法研究協議会

出版者

一般社団法人 日本結核病学会

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.46, no.8, pp.325-333, 1971 (Released:2011-05-24)

参考文献数

6

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Tuberculosis Research Committee (Ryoken) investigated comparatively the therapeutic effects of three regimens, i. e., standard triple treatment with SM⋅INH⋅PAS (EB0 group), standard triple treatment plus EB twice weekly (EB2 group) and standard triple treatment plus EB daily (EB7 group), in order to intensify the initial treatment for pulmonary tuberculosis.The cases with positive tubercle bacilli and cavities were subjected to this study and were allocated at random for three regimens.The total number of the c a ses was 272 at the beginning of the treatment, but 48 cases were excluded from the analysis because of the primary drug resistance, etc. Finally, 74cases of EB0 group, 74 cases of EB2 group and 76 cases of EB7 group were analyzed.SM was injected 1 g a day twice weekly, INH was given O.4 g daily in two divided doses, PAS was administered 10 g daily in three divided doses, and EB was given 750 mg daily or twice weekly at the same day when SM was injected.The background factors of the cases in ea c h group were almost similar, but the cases with abundant bacilli on smear and (_??_) by culture were observed somewhat less frequently in EB2 group than in the other two groups.As to the rates of the radiological improvement and the sputum conversion rate, there was no significant difference among three groups. However, the moderate improvement of the fibrocaseous lesions and cavities were recognized sooner in EB2 and EB7 groups than in EB0 group.The number of cases, in which the regimens were changed because of side effects or ineffectiveness, were 8 cases in EB0, group, 9 cases in EB2 group and 5 cases in EB7 group. The number of cases with positive sputum by smear or culture after 12 month's treatments were 3 in EB0 group, none in EB2 group and 1 in EB7 group. Therefore, the rate of these unsuccesful cases in EB0, group, EB2 group and EB7 group was 16.7%, 13.6% and 8.3%, respectively.In order to prove the difference in the effectiveness among three regimens, the follow up-studies for longer period might be required.

著者

大場 啓介 長嶺 拓夫 森 博輝 佐藤 勇一

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

pp.14-00593, (Released:2015-02-24)

参考文献数

8

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This paper describes the investigations of the characteristic about the sound generation of a nose flute experimentally. The nose flute is attached to the upper part of a container. If air is passed to a nose flute, sound will occur. The volume of a container is changed and the generated sound is measured. The natural frequencies of an experimental device are calculated and we confirm that it is in agreement with frequency of sound generated in experiment. We show that nose flute is a unique musical instrument with the point that a nose flute has only an edge part and uses people's mouth for a resonance body part. The frequencies of resonance sound can be calculated from the capacity in a mouth, the thickness and the area of an opening of a nose flute. When people play a nose flute, it is thought that only the first mode of vibration is used.

著者

佐々木 俊弥 山崎 和彦

出版者

Japanese Society for the Science of Design

雑誌

日本デザイン学会研究発表大会概要集

巻号頁・発行日

pp.257, 2012 (Released:2012-06-11)

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情報時代においては、コンピュータや通信に代表される情報技術の発展とグローバルな情報社会化が急速に進んでいる。その中で情報デザインは、20 世紀半ばに人々のために情報技術をヒューマナイズし、新しい知的生活環境を生み出す使命を持って生まれた。こうした歴史認識に立ち、未来を展望することで考えられるユーザインターフェースデザインの一つがアンビエントインターフェースである。モノが人の行動や状況をセンシングし、能動的に人にはたらきかけるというように、コミュニケーション作用やリアルタイム性が強調されるアンビエントインターフェースを新たなユーザ体験のデザインに生かせないかと考え、研究では1 人暮らしの学生の食生活に焦点を当てることにした。1 人暮らしの学生にとって食とは、直接健康に影響する日々の課題の1 つと言える。アンビエントインターフェースによって毎日の食のシーンが楽しくなる体験をデザインすることを目的とする。調査によってアンビエントインターフェースの定義を明確にすると共に、人間中心設計(HCD)の手法を用いてユーザエクスペリエンスデザインの観点から、プロトタイプを制作する。

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.44, no.8, pp.584-584, 2001 (Released:2001-11-01)

被引用文献数

2

出版者

一般社団法人 溶接学会

雑誌

溶接学会誌 (ISSN:00214787)

巻号頁・発行日

vol.60, no.3, pp.170-181, 1991-04-05 (Released:2011-08-05)

著者

Shiko Gen Ryuichi Usui Takaya Sasaki Kanako Nobe Aya Takahashi Keisuke Okudaira Naofumi Ikeda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.10, pp.1327-1329, 2016 (Released:2016-05-15)

参考文献数

8

被引用文献数

2

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A 79-year-old man on hemodialysis was hospitalized for further investigation. Early gastric cancer was diagnosed by gastrointestinal endoscopy and endoscopic submucosal dissection (ESD) was performed. Fever and abdominal pain thereafter developed, and a severe inflammatory response was observed on a blood test. Contrast computed tomography (CT) showed ulcer-like projections and soft tissue surrounding the aorta, from the celiac to left renal artery. An infected aneurysm was diagnosed. Although infected aneurysms developing after laparoscopic cholecystectomy or biopsy of contiguous esophageal duplication cyst have been reported, those developing after ESD have not. When fever and abdominal pain develop after ESD, an infected aneurysm should be considered and contrast CT performed.

著者

Yuko Tada Ippei Kanazawa Masakazu Notsu Ken-ichiro Tanaka Nobuaki Kiyohara Motofumi Sasaki Toshitsugu Sugimoto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.10, pp.1275-1278, 2016 (Released:2016-05-15)

参考文献数

16

被引用文献数

1 4

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Objective We herein conducted a retrospective study to evaluate the long-term efficacy and safety of sitagliptin treatment in elderly patients with type 2 diabetes mellitus. Methods We analyzed the changes in glycemic control in 112 Japanese type 2 diabetes patients over 65 years of age treated with 50 mg/day sitagliptin. Hemoglobin A1c (HbA1c) levels, liver and kidney functions, and usage of hypoglycemic agents were recorded for 24 months. Results HbA1c levels were significantly decreased, and the significance of HbA1c reduction was maintained during the observation period [from 7.7±1.1% to 7.2±0.7% (p Conclusion Sitagliptin treatment continually decreases the HbA1c level for 24 months and is useful to reduce the dose of sulfonylurea in elderly patients with type 2 diabetes.

著者

Keita Kirito Minoru Sakamoto Nobuyuki Enomoto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.10, pp.1341-1344, 2016 (Released:2016-05-15)

参考文献数

19

被引用文献数

21

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Ruxolitinib is a useful treatment option for myelofibrosis since it effectively resolves splenomegaly and constitutional symptoms. After the widespread use of ruxolitinib outside of clinical trials, a series of case reports indicated a potential risk of ruxolitinib-associated opportunistic infections, including the reactivation of the hepatitis B virus (HBV). We herein report the case of a polycythemia vera patient who showed an elevation of HBV-DNA viral DNA with an elevation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) after the initiation of ruxolitinib. Anti-viral therapy with entecavir was immediately started and the HBV viral load thereafter decreased with an improvement of the liver function. Physicians should thus be aware of the potential risk of ruxolitinib-associated HBV reactivation.

著者

Mineto Ota Hideyuki Iwai Kaori Imai Mari Kamiya Yoko Yoshihashi-Nakazato Nobuyuki Miyasaka Hitoshi Kohsaka

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.10, pp.1367-1370, 2016 (Released:2016-05-15)

参考文献数

16

被引用文献数

7

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We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.

著者

Keishiro SHIMURA Hitoshi ITO Hiroshige HIBASAMI

出版者

(社)日本薬理学会

雑誌

The Japanese Journal of Pharmacology (ISSN:00215198)

巻号頁・発行日

vol.33, no.2, pp.403-408, 1983 (Released:2006-11-07)

参考文献数

25

被引用文献数

26 24

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On crossed immunoelectrophoresis, human serum C3 (the third component of complement) converted by antitumor polysaccharides (ATSO [antitumor polysaccharide oral], AB-P [Agaricaus blazei/polysaccharide], GU-P [Grifora umbellata polysaccharide], PS-K [polysaccharide Kureha] and zymosan) moved faster than native C3, appearing as the 3rd peak. The ratio of height of the 3rd peak to the α2-macroglobulin (α2-M) peak was linearly proportional to the dose of ATSO. At the dose of 500 μg/ml antitumor polysaccharides, the ratios were higher than 0.76, and the ratios for the serum treated with polysaccharide of no antitumor activity (dextran and gum arabic) were less than about 0.52. This ratio readily determined in vivo can be used as a measure for the antitumor activity of polysaccharides.

著者

Yosuke Watanabe Richard A. Cohen Reiko Matsui

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0317, (Released:2016-05-06)

参考文献数

64

被引用文献数

23

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Antioxidants are expected to improve cardiovascular disease (CVD) by eliminating oxidative stress, but clinical trials have not shown promising results in chronic CVD. Animal studies have revealed that reactive oxygen species (ROS) exacerbate acute CVDs in which high levels of ROS are observed. However, ROS are also necessary for angiogenesis after ischemia, because ROS not only damage cells but also stimulate the cell signaling required for angiogenesis. ROS affect signaling by protein modifications, especially of cysteine amino acid thiols. Although there are several cysteine modifications, S-glutathionylation (GSH adducts; -SSG), a reversible cysteine modification by glutathione (GSH), plays an important role in angiogenic signal transduction by ROS. Glutaredoxin-1 (Glrx) is an enzyme that specifically removes GSH adducts in vivo. Overexpression of Glrx inhibits, whereas deletion of Glrx improves revascularization after mouse hindlimb ischemia. These studies indicate that increased levels of GSH adducts in ischemic muscle are beneficial in promoting angiogenesis. The underlying mechanism can be explained by multiple targets of S-gluathionylation, which mediate the angiogenic effects in ischemia. Increments in the master angiogenic transcriptional factor, HIF-1α, reduction of the anti-angiogenic factor sFlt1, activation of the endoplasmic reticulum Ca2+pump, SERCA, and inhibition of phosphatases may occur as a consequence of enhanced S-glutathionylation in ischemic tissue. In summary, inducing S-glutathionylation by inhibiting Glrx may be a therapeutic strategy to improve ischemic angiogenesis in CVD.

著者

堤 明純

出版者

一般社団法人 日本総合健診医学会

雑誌

総合健診 (ISSN:13470086)

巻号頁・発行日

vol.43, no.2, pp.313-319, 2016 (Released:2016-05-01)

参考文献数

41

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職場におけるメンタルヘルス不調のスクリーニングについては、スクリーニング効率がさほど高くないこと、スクリーニングの有効性を示すエビデンスが乏しいことに留意する必要がある。調査対象のセグメンテーションや層別尤度比の活用は、こういった課題解決のキーとなりうる。職場におけるスクリーニングの対象となる障害としては、頻度が多く、適切なケアによる対策の効果が、障害を有するケースと職場ともに認められているうつ病性障害の優先順位が高いが、最近は自閉症スペクトラム障害や適応障害なども注目されている。自閉症スペクトラム障害は、以前考えられていたよりも頻度が多く、職場不適応や難治性うつ病のハイリスク要因として認識されるようになっている。適応障害も長期の疾病休業の原因として職場でよく遭遇する、職業性要素の強いメンタルヘルス不調の一つである。適切な職場環境の調整により、不必要な休業や障害が取り除かれる可能性があり、スクリーニングを実施する価値がある。職場においては、層別尤度比などの検査特性を検討している研究は少なく、対象となる障害とともに、いかに実施すると効率的なスクリーニングができるかを含めた方法論に関する検証の蓄積が望まれる。

著者

Wen-Dien CHANG Tzu-Shiang Lin Joe-Air JIANG Chang-Wang LIU Chia-Pang CHEN Da-Wei LAI Hsu-Cheng LU Chung-Wei YEN Ping-Lang YEN

出版者

Asian Agricultural and Biological Engineering Association

雑誌

Engineering in Agriculture, Environment and Food (ISSN:18818366)

巻号頁・発行日

vol.5, no.3, pp.83-89, 2012-07-06 (Released:2012-07-06)

参考文献数

18

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Intradialytic hypotension (IDH) is a very common complication during hemodialysis. IDH may lead to nausea, vomiting, or anxiety. In some severe cases, it may cause shock or death. Each hemodialysis treatment generally lasts for four to six hours and must be repeated two or three times a week. Currently, the hemodialysis procedure may lead to dangerously low blood pressure when blood pressure is not frequently assessed by medical staff. Therefore, the purpose of this work is to use the technologies of wireless sensor networks (WSN), global systems for mobile communications (GSM), and a MySQL database to develop a PC-based gateway and an automatic monitoring system to collect physiological data during hemodialysis and continuously monitor the IDH status of patients. The clinical definition of IDH during hemodialysis is a decrease in the systolic pressure of at least 20 mmHg and a decrease in the mean arterial pressure (MAP) of at least 10 mmHg. Our system uses a threshold-based algorithm to monitor and record the systolic and mean arterial blood pressure readings. The GSM module is utilized to send medical staff a warning message, and the message is displayed on the monitor if the readings reach a critical point. The experimental results show that this monitoring system is highly reliable.

著者

増山 浩人

出版者

日本哲学会

雑誌

哲学 (ISSN:03873358)

巻号頁・発行日

vol.2013, no.64, pp.191-205_L13, 2013 (Released:2014-07-10)

参考文献数

7

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Das „Design“-Argument ist ein Argument, das aus der Zweckmäßigkeit der Dinge in der Welt auf den Urheber der Welt schließt. Bekanntlich hat Hume in den Dialogen über natürliche Religion dieses Argument aufgrund seiner Theorie der Kausalitüt kritisiert. Es ist aber in der Literatur nicht besonders berücksichtigt worden, dass Kant in den Prolegomena gegen Humes Kritik einen Einwand erhoben hat.In diesem Aufsatz wird die Frage behandelt, wie sich Kant mit Humes Kritik des „Design“-Arguments auseinandersetzt. Zuerst wird Kants Interpretation von Humes Dialogen rekonstruiert. Kant versteht Humes Kritik des „Design“-Arguments als einen grundsätzlichen Einwand gegen den Theismus; Hume behauptet nach Kant, dass Anthropomorphismus und Theismus einerseits untrennbar voneinander und andererseits vollkommen unvereinbar miteinander seien. Als Antwort auf diese Überlegung stellt Kant den Begriff der Kausalität in Frage, der Humes Kritik am Theismus zugrunde liegt. Dies muss zweitens aufgeklärt werden. Kants Theorie der Kausalität ist in zweierlei Hinsicht von gro&szliger Bedeutung: Zum einen macht sie deutlich, dass die Begriffe von Ursache und Wirkung für alle Erscheinungen objektiv gelten; zum anderen ermöglicht dies, Gott und Welt in ein Verhältnis zu setzen, ohne ihm menschliche Eigenschaften unmittelbar beizulegen. Diese Theorie macht eine unerlässliche Voraussetzung für Kants Verteidigung des Theismus aus. Schließlich geht es drittens um die Eigenart und Bedeutung der Als-Ob-Methode. Im Gegensatz zu den Überlegungen des „Design“- Arguments nimmt die Als-Ob-Methode den Begriff der Analogie im Sinne der Proportionalität in Anspruch. Mit Hilfe dieser Methode kann man erkennen, dass das Verhältnis Gottes zur Welt dem der Menschen zu ihren Produkten, nämlich der Kausalität der Freiheit ähnlich ist. Daraus folgt zwar eine Art von Anthropomorphismus; damit werden aber Gott diejenigen Prädikate nicht unmittelbar zugeschrieben, die dem Menschen eigen sind. So zeigt Kant gegen Hume die Kompatibilität von Theismus und Anthropomorphismus.

著者

神崎 繁

出版者

日本哲学会

雑誌

哲学 (ISSN:03873358)

巻号頁・発行日

vol.2013, no.64, pp.58-77_L6, 2013 (Released:2014-07-10)

参考文献数

22

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In his Topics Aristotle criticises an alleged definition of being as ‘capable of being acted on or acting on (to dynaton pathein e poiesai)’ (Top. 146a21-32, 148a18-21, cf. 139a4-8). There is an echo of passages where Plato described ‘power of acting on and being acted on (dynamis tou poiein kai paschein)’ as a ‘horos’ of being in the Sophist, though he wavered between this conjunctive formulation (Soph. 248c8) and disjunctive ones (247d8-e2, 248c4-5). A ‘horos’ can be interpreted as a definition or a criterion (G. E. R. Owen insisted on the former meaning, criticising Cornford's preference for the latter). In this respect, Aristotle - who takes it solely disjunctively - would definitely have been on Cornford’s side, judging from his remarks on some of the deficiencies in disjunctive definitions.In the Sophist, the Eleatic stranger asked whether ‘knowing and being known are cases of acting on, or being acted on, or both? Is one of them acting on and the other being acted on? Or is neither a case of either?’ (248d4-7). But in due course Theaetetus responds that if the Friends of the Forms insist on the Forms'unchangeability, they must choose the last option, i. e. in the case of the Forms, neither knowing nor being known is either acting on or being acted on. But this choice implies, in exchange for defending their unchangeability, that the Forms cannot be known. Insofar as Forms are known, they are changed by being acted on, and this is a serious obstacle for the Friends of the Forms. So Aristotle finds the crux of an argument in the equation of being acted on with being changed. And this becomes his target to be resolved.In due course Aristotle must have realized these exchanges left behind one option unscrutinized, i.e. the knower is acted on by the Forms which the knower knows. In the case of sense-perception, though it was in dialectical arguments refuting Protagoras' secret doctrine in the Theaetetus, Plato had already suggested that perceiving is not acting on its objects but rather being acted on by the objects (Theaet. 156a-157b). But later in the Timaeus, Plato still treated sight-perception as an acting on rather than being acted on because he believes that in ‘the visual stream, like makes contact with like and coalesces with it to make up a single homogeneous body aligned with the direction of the eyes’ (Tim. 45b-46c, cf. 67c-68d). When Aristotle explains the so-called doxographical method of collecting preceding views, he mentions the following remarks; ‘We see by admission of something into ourselves, not by an emission; for so it is, too, in the case of the other senses; for in hearing we admit something into ourselves; we do not emit; and we taste in the same way.’ (Top. 105b6-9). This suggests that he criticizes Plato's analysis of vision without mentioning him and even tries to change that view by an analogy with the other senses. We can acknowledge this as a dialectical procedure like ‘change of mind’ (metabibazein) described in E. E. 1216b30 and Top. 101a33.......

著者

AKIRA NAITO MICHIHIRO YAJIMA HIDEHIKO FUKAMACHI KOJI USHIKOSHI YING-JIE SUN YOSHIFUSA SHIMIZU

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.175, no.4, pp.285-288, 1995 (Released:2006-08-31)

参考文献数

13

被引用文献数

4 10

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NAITO, A., YAJIMA, M., FUKAMACHI, H., USHIKOSHI, K., SUN, Y.-J. and SHIMIZU, Y. Electromyographic (EMG) Study of the Elbow Flexors during Supination and Pronation of the Forearm. Tohoku J. Exp. Med., 1995, 175 (4), 285-288 - Activities of the elbow flexors during supination and pronation of the forearm in a normal human volunteer were studied by an electromyography (EMG). The volunteer performed the movement slowly or quickly holding elbow flexion at various angles with or without a load. The biceps brachii showed an increase and a decrease of EMG activities during supination and pronation, respectively. The brachialis and brachioradialis showed a reduction and an increment of EMU activities accompanied by an increase and a decrease of EMG activities in the biceps brachii, respectively. These findings seem to indicate that reciprocal contractions among the elbow flexors permit the biceps brachii to work for supination without an induction of elbow flexion.

著者

板井 昌典

出版者

一般社団法人 日本数学会

雑誌

総合講演・企画特別講演アブストラクト (ISSN:18843972)

巻号頁・発行日

vol.1999, no.Autumn-Meeting1, pp.44-55, 1999 (Released:2010-07-01)

参考文献数

17