著者

Betty T. Izumi Andrea Bersamin Carmen Byker Shanks Gitta Grether-Sweeney Mary Murimi

出版者

The Japanese Society of Nutrition and Dietetics

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.76, no.Supplement, pp.S126-S132, 2018-07-01 (Released:2018-08-28)

参考文献数

37

被引用文献数

1 3

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Objective: The National School Lunch Program (NSLP) is a federally assisted meal program in the United States (US) that provides nutritionally balanced and free or low-cost lunches each school day to 30.4 million students, including more than 22 million low-income students. Since its inception in 1946, the program has undergone many modifications, including a shift in focus from addressing under- to over-nutrition. Most recently, the US Congress passed the Healthy, Hunger-Free Kids Act of 2010 to help address hunger and obesity among the nation's children. The purpose of this paper is to provide a brief overview of the NSLP.Methods: This paper is based on a review of relevant technical documents, peer-reviewed literature and grey literature. The authors also used their collective school lunch research and practice experience to identify the most salient points to address.Results: The following areas of the NSLP are presented: how it is administered; recent changes to the meal patterns and nutrition standards; revenue and costs; research and evaluation conducted after passage of the Healthy, Hunger-Free Kids Act; and current initiatives to enhance the NSLP.Conclusions: The Healthy, Hunger-Free Kids Act improved the NSLP meal patterns and nutrition standards by aligning them with the Dietary Guidelines for Americans. Early published research on the impact of the updated meal patterns and nutrition standards on student dietary outcomes is promising and efforts to further enhance the NSLP are being implemented across the nation.

著者

Takeshi Wada Mihoko Hagiwara-Nagasawa Ryuichi Kambayashi Ai Goto Koki Chiba Yoshio Nunoi Hiroko Izumi-Nakaseko Tadashi Koga Akio Matsumoto Yuji Nakazato Keith G. Lurie Atsushi Sugiyama

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.10, pp.1885-1891, 2021-09-24 (Released:2021-09-24)

参考文献数

29

被引用文献数

1

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Background:Effects of rapid electrical defibrillation and β-blockade on coronary ischemia/reperfusion-induced ventricular fibrillation (VF) during cardiopulmonary resuscitation (CPR) remain unknown.Methods and Results:After induction of VF by 30 min of ischemia followed by reperfusion, animals were treated with defibrillation alone (Group A, n=13), 2 min of open-chest cardiac massage followed by defibrillation (Group B, n=11), or the same therapy to Group B with propranolol (1 mg/kg, i.v.) treatment before ischemia/reperfusion (Group C, n=11). If return of spontaneous circulation (ROSC) was not attained, each therapy was repeated ≤3 times (Set-1). When ROSC was not obtained within Set-1, cardiac massage was applied to all animals followed by defibrillation, which was repeated ≤3 times (Set-2). ROSC after Set-1 was 8% in Group A, 82% in Group B and 82% in Group C, whereas that after Set-2 was 62% in Group A, 100% in Group B and 82% in Group C. Each animal with ROSC in Groups A (n=8) and B (n=11) showed sinus rhythm, whereas those in Group C (n=9) had sinus rhythm (n=5), atrial fibrillation (n=1), accelerated idioventricular rhythm (n=2) and atrioventricular block (n=1). Post ROSC heart rate and mean arterial pressure were significantly lower in Group C.Conclusions:Cardiac massage increased the likelihood of ROSC vs. rapid defibrillation, but β-blocker pretreatment may worsen hemodynamics and electrical stability after ROSC.

著者

Sang-il LEE Takeshi NISHI Masaya TAKAHASHI Shigekazu HIGUCHI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2020-0245, (Released:2021-09-28)

被引用文献数

4

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A nighttime nap is expected to mitigate melatonin suppression during night work by blocking light input to the retina, but it is unclear. In the present study, we investigated the effects of a nap break on melatonin level, subjective sleepiness, and vigilance performance during simulated night work. Eleven healthy young males (mean ± SD age: 22.2 ± 4.1 years) participated in counterbalanced crossover design experiments with two conditions (nap vs. no nap). The subjects performed 12-hour simulated night work from 21:00 to 9:00 h (illuminance: ~500 lx). Subjects with a nap condition took a nap for 2 hours in a dark room from 3:00, while subjects with a no nap condition continued the simulated night work. The results showed that immediately after the 2-h nap break, the melatonin level at 5:00 h temporarily recovered from light-induced melatonin suppression during the simulated night work but significantly suppressed again at 7:00 and 9:00 h. Subjective alertness and vigilance performance were impaired immediately after the nap break but subsequently enhanced. The results suggest that a single nap break for 2 hours could be a strategy to enhance alertness during the last part of night shift but inadequate for mitigating melatonin suppression.

著者

Kim Chae-Su 金 采洙

出版者

筑波大学比較・理論文学会

雑誌

文学研究論集 (ISSN:09158944)

巻号頁・発行日

no.17, pp.17-39, 2000-03

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1. 西欧人の宇宙体験と文化意識 去る20世紀は資本主義、社会主義、共産主義といった政治的経済的思想によって支配されていた時代だというならば、これからの21世紀は文化に関する思想にとらわれる時代として診断される。 ...

著者

WELCOMME J-L

雑誌

C R Acad Sci Paris (Earth Planet Sci)

巻号頁・発行日

vol.325, pp.999-1004, 1997

被引用文献数

1 1

著者

V. L. Cruz-Hernández M. A. García-Rentería R. García-Hernández V. H. López-Morelos

出版者

The Japan Institute of Metals and Materials

雑誌

MATERIALS TRANSACTIONS (ISSN:13459678)

巻号頁・発行日

vol.58, no.2, pp.225-230, 2017-02-01 (Released:2017-01-25)

参考文献数

20

被引用文献数

3

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This study evaluated the suitability of the depassivator in revealing low degrees of sensitization (DOS) in samples of wrought AISI 347H austenitic stainless steel in the as-received condition and solution heat treated (SHT) at 1050℃. Assessment of the electrolyte composition was performed by the double loop electrochemical potentiokinetic reactivation (DL-EPR) test at room temperature. The electrolyte 1.0M H2SO4 + 0.50M HCl was found to be adequate for detecting low DOS. Microstructural characterization of the as-received material revealed the presence of Cr-rich carbides. These carbides were responsible of the susceptibility to IGC.

著者

SIM-SELLY L. J.

雑誌

Neuropharmacology

巻号頁・発行日

vol.45, pp.220-230, 2003

被引用文献数

1 17

著者

Hsin-Yu HUANG Kai-Yueh LIAO Wei-Yau SHIA Chao-Chin CHANG Hsien-Chi WANG

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0657, (Released:2021-10-08)

被引用文献数

1

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We aimed to determine whether dexmedetomidine administration with or without atropine increases cardiac troponin I (cTnI) level in healthy dogs. We hypothesized that 10 µg/kg dexmedetomidine + atropine increases the cTnI level, whereas 5 µg/kg dexmedetomidine + atropine does not. Eighteen healthy, pet dogs that underwent an orthopedic surgery or ovariohysterectomy were included in this study. The dogs were randomly assigned to atropine (0.02 mg/kg)–dexmedetomidine (10 µg/kg), saline–dexmedetomidine (10 µg/kg), and atropine (0.02 mg/kg)–dexmedetomidine (5 µg/kg) groups. Each dog was premedicated with atropine or saline intramuscularly (IM). After 10 min, they were IM injected with dexmedetomidine (10 or 5 µg/kg)–morphine (0.5 mg/kg)–midazolam (0.2 mg/kg). Following this, anesthesia was induced after 10 min with propofol and maintained with isoflurane in 100% oxygen. The median plasma cTnI level at 6, 12 and 24 hr after premedication was significantly higher than that at baseline. The cTnI level in the atropine–dexmedetomidine (10 µg/kg) group was significantly higher than that in the saline–dexmedetomidine (10 µg/kg) and atropine–dexmedetomidine (5 µg/kg) groups at 6 and 12 hr after premedication. The cTnI level returned to normal within 72 hr after premedication in all groups. The administration of atropine in combination with 10 µg/kg dexmedetomidine increased the cTnI level, indicating subclinical myocardial damage.

著者

Yoshimitsu Soga Osamu Iida Masahiko Fujihara Daizo Kawasaki Shigeru Saito Kazushi Urasawa Hiroyoshi Yokoi Eric J. Fernandez Jia Guo Masato Nakamura on behalf of the IN.PACT Japan Post-Market Surveillance Study

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0491, (Released:2021-10-06)

参考文献数

27

被引用文献数

4

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Background:To confirm the safety and efficacy of the IN.PACT Admiral drug-coated balloon (DCB) based on the indication approved by the Pharmaceuticals and Medical Devices Agency Japan in real-world patients with femoropopliteal artery disease.Methods and Results:IN.PACT PMS Japan was a prospective, multicenter, single-arm, post-market surveillance (PMS) study conducted in Japan that enrolled 304 participants (mean age 75.3±7.9 years). The primary endpoint was primary patency at 6 months following the index procedure, defined as freedom from clinically driven target lesion revascularization (CD-TLR) and freedom from restenosis as determined by duplex ultrasound (DUS) peak systolic velocity ratio (PSVR) ≤2.4 (assessed by the independent DUS core laboratory). Secondary endpoints included acute outcomes, primary patency at 12 months post-index procedure, freedom from CD-TLR, and major adverse events at 12 months. The mean lesion length was 97.81±58.97 mm. The primary endpoint, 6-month primary patency, was 91.3% (240/263). Kaplan-Meier estimates of primary patency and freedom from CD-TLR through 12 months were 91.5% and 94.1%, respectively. The CD-TLR rate was 5.8% (14/240) with low rates of thrombosis (0.8%) and target limb amputation (0.4%) at 12 months.Conclusions:The results of this real-world PMS study were consistent with outcomes from previous IN.PACT DCB studies, confirming the safety and efficacy of the IN.PACT Admiral DCB for broader use in patients seen in everyday practice.

著者

齋藤 義文 小嶋 浩嗣 小川 泰信 SS-520-3 観測ロケット実験PIチーム Saito Yoshifumi Kojima Hirotsugu Ogawa Yasunobu

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

観測ロケットシンポジウム2018 講演集 = Proceedings of Sounding Rocket Symposium 2018

巻号頁・発行日

2018-07

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第1回観測ロケットシンポジウム(2018年7月17日-18日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)), 相模原市, 神奈川県

著者

Mitsutoshi Munakata Kaori Kobayashi Junko Niisato-Nezu Souichiro Tanaka Yosuke Kakisaka Takae Ebihara Satoru Ebihara Kazuhiro Haginoya Shigeru Tsuchiya Akira Onuma

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.214, no.4, pp.327-332, 2008 (Released:2008-04-26)

参考文献数

15

被引用文献数

18 24

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Patients with severe neurological disorders often require enteral nutrition (EN). Since long-term EN can cause multiple complications, reinstating the oral intake of food is beneficial. Olfactory stimulation using black pepper oil (BPO), a strong appetite stimulant, was reported to facilitate swallowing in older people. Therefore, the effects of olfactory stimulation with BPO were investigated in pediatric patients receiving long-term EN due to neurological disorders. The effects of scenting with BPO for 1 min immediately before every meal were evaluated in ten patients: 4 boys and 6 girls, aged 19-97 months (51 ± 26 months). The neurological disorders included periventricular leukomalacia (3 patients), hypoxic ischemic encephalopathy (3), Costello syndrome (1), Russell-Silver syndrome (1), Miller-Dieker syndrome (1), and cerebral palsy of unknown etiology (1). In eight of these patients, BPO intervention was continued for 3 months. Five of these eight patients showed increases in the amount of oral intake with desirable effects including facilitated swallowing movement, although complete elimination of the need for EN was not achieved. In the other three patients, BPO intervention was not effective; severe cerebral tissue loss, profound malformation or intractable seizures seemed to reduce the efficacy of BPO. In two cases, BPO intervention was discontinued due to cough or because the odor of BPO was unbearable to the family. In conclusion, olfactory stimulation with BPO facilitated oral intake in a subset of patients on long-term EN. BPO stimulation may be useful for facilitating oral intake when used in combination with conventional methods.

著者

Schlitzer Reiner Anderson Robert F. Dodas Elena Masferrer Lohan Maeve Geibert Walter Tagliabue Alessandro Bowie Andrew Jeandel Catherine Maldonado Maria T. Landing William M. Cockwell Donna Abadie Cyril Abouchami Wafa Achterberg Eric P. Agather Alison Aguliar-Islas Ana van Aken Hendrik M. Andersen Morten Archer Corey Auro Maureen de Baar Hein J. Baars Oliver Baker Alex R. Bakker Karel Basak Chandranath Baskaran Mark Bates Nicholas R. Bauch Dorothea van Beek Pieter Behrens Melanie K. Black Erin Bluhm Katrin Bopp Laurent Bouman Heather Bowman Katlin Bown Johann Boyd Philip Boye Marie Boyle Edward A. Branellec Pierre Bridgestock Luke Brissebrat Guillaume Browning Thomas Bruland Kenneth W. Brumsack Hans-Jürgen Brzezinski Mark Buck Clifton S. Buck Kristen N. Buesseler Ken Bull Abby Butler Edward Cai Pinghe Mor Patricia Cámara Cardinal Damien Carlson Craig Carrasco Gonzalo Casacuberta Núria Casciotti Karen L. Castrillejo Maxi Chamizo Elena Chance Rosie Charette Matthew A. Chaves Joaquin E. Cheng Hai Chever Fanny Christl Marcus Church Thomas M. Closset Ivia Colman Albert Conway Tim M. Cossa Daniel Croot Peter Cullen Jay T. Cutter Gregory A. Daniels Chris Dehairs Frank Deng Feifei Dieu Huong Thi Duggan Brian Dulaquais Gabriel Dumousseaud Cynthia Echegoyen-Sanz Yolanda Edwards R. Lawrence Ellwood Michael Fahrbach Eberhard Fitzsimmons Jessica N. Russell Flegal A. Fleisher Martin Q. van de Flierdt Tina Frank Martin Friedrich Jana Fripiat Francois Fröllje Henning Galer Stephen J.G. Gamo Toshitaka Ganeshram Raja S. Garcia-Orellana Jordi Garcia-Solsona Ester Gault-Ringold Melanie George Ejin Gerringa Loes J.A. Gilbert Melissa Godoy Jose M. Goldstein Steven L. Gonzalez Santiago R. Grissom Karen Hammerschmidt Chad Hartman Alison Hassler Christel S. Hathorne Ed C. Hatta Mariko Hawco Nicholas Hayes Christopher T. Heimbürger Lars-Eric Helgoe Josh Heller Maija Henderson Gideon M. Henderson Paul B. van Heuven Steven Ho Peng Horner Tristan J. Hsieh Yu-Te Huang Kuo-Fang Humphreys Matthew P. Isshiki Kenji Jacquot Jeremy E. Janssen David J. Jenkins William J. John Seth Jones Elizabeth M. Jones Janice L. Kadko David C. Kayser Rick Kenna Timothy C. Khondoker Roulin Kim Taejin Kipp Lauren Klar Jessica K. Klunder Maarten Kretschmer Sven Kumamoto Yuichiro Laan Patrick Labatut Marie Lacan Francois Lam Phoebe J. Lambelet Myriam Lamborg Carl H. Le Moigne Frédéric A.C. Le Roy Emilie Lechtenfeld Oliver J. Lee Jong-Mi Lherminier Pascale Little Susan López-Lora Mercedes Lu Yanbin Masque Pere Mawji Edward Mcclain Charles R. Measures Christopher Mehic Sanjin Barraqueta Jan-Lukas Menzel van der Merwe Pier Middag Rob Mieruch Sebastian Milne Angela Minami Tomoharu Moffett James W. Moncoiffe Gwenaelle Moore Willard S. Morris Paul J. Morton Peter L. Nakaguchi Yuzuru Nakayama Noriko Niedermiller John Nishioka Jun Nishiuchi Akira Noble Abigail Obata Hajime Ober Sven Ohnemus Daniel C. van Ooijen Jan O'Sullivan Jeanette Owens Stephanie Pahnke Katharina Paul Maxence Pavia Frank Pena Leopoldo D. Peters Brian Planchon Frederic Planquette Helene Pradoux Catherine Puigcorbé Viena Quay Paul Queroue Fabien Radic Amandine Rauschenberg S. Rehkämper Mark Rember Robert Remenyi Tomas Resing Joseph A. Rickli Joerg Rigaud Sylvain Rijkenberg Micha J.A. Rintoul Stephen Robinson Laura F. Roca-Martí Montserrat Rodellas Valenti Roeske Tobias Rolison John M. Rosenberg Mark Roshan Saeed Rutgers van der Loeff Michiel M. Ryabenko Evgenia Saito Mak A. Salt Lesley A. Sanial Virginie Sarthou Geraldine Schallenberg Christina Schauer Ursula Scher Howie Schlosser Christian Schnetger Bernhard Scott Peter Sedwick Peter N. Semiletov Igor Shelley Rachel Sherrell Robert M. Shiller Alan M. Sigman Daniel M. Singh Sunil Kumar Slagter Hans A. Slater Emma Smethie William M. Snaith Helen Sohrin Yoshiki Sohst Bettina Sonke Jeroen E. Speich Sabrina Steinfeldt Reiner Stewart Gillian Stichel Torben Stirling Claudine H. Stutsman Johnny Swarr Gretchen J. Swift James H. Thomas Alexander Thorne Kay Till Claire P. Till Ralph Townsend Ashley T. Townsend Emily Tuerena Robyn Twining Benjamin S. Vance Derek Velazquez Sue Venchiarutti Celia Villa-Alfageme Maria Vivancos Sebastian M. Voelker Antje H.L. Wake Bronwyn Warner Mark J. Watson Ros van Weerlee Evaline Alexandra Weigand M. Weinstein Yishai Weiss Dominik Wisotzki Andreas Woodward E. Malcolm S. Wu Jingfeng Wu Yingzhe Wuttig Kathrin Wyatt Neil Xiang Yang Xie Ruifang C. Xue Zichen Yoshikawa Hisayuki Zhang Jing Zhang Pu Zhao Ye Zheng Linjie Zheng Xin-Yuan Zieringer Moritz Zimmer Louise A. Ziveri Patrizia Zunino Patricia Zurbrick Cheryl

出版者

Elsevier BV

雑誌

Chemical Geology (ISSN:00092541)

巻号頁・発行日

vol.493, pp.210-223, 2018-08-20

被引用文献数

258

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The GEOTRACES Intermediate Data Product 2017 (IDP2017) is the second publicly available data product of the international GEOTRACES programme, and contains data measured and quality controlled before the end of 2016. The IDP2017 includes data from the Atlantic, Pacific, Arctic, Southern and Indian oceans, with about twice the data volume of the previous IDP2014. For the first time, the IDP2017 contains data for a large suite of biogeochemical parameters as well as aerosol and rain data characterising atmospheric trace element and isotope (TEI) sources. The TEI data in the IDP2017 are quality controlled by careful assessment of intercalibration results and multi-laboratory data comparisons at crossover stations. The IDP2017 consists of two parts: (1) a compilation of digital data for more than 450 TEIs as well as standard hydrographic parameters, and (2) the eGEOTRACES Electronic Atlas providing an on-line atlas that includes more than 590 section plots and 130 animated 3D scenes. The digital data are provided in several formats, including ASCII, Excel spreadsheet, netCDF, and Ocean Data View collection. Users can download the full data packages or make their own custom selections with a new on-line data extraction service. In addition to the actual data values, the IDP2017 also contains data quality flags and 1-σ data error values where available. Quality flags and error values are useful for data filtering and for statistical analysis. Metadata about data originators, analytical methods and original publications related to the data are linked in an easily accessible way. The eGEOTRACES Electronic Atlas is the visual representation of the IDP2017 as section plots and rotating 3D scenes. The basin-wide 3D scenes combine data from many cruises and provide quick overviews of large-scale tracer distributions. These 3D scenes provide geographical and bathymetric context that is crucial for the interpretation and assessment of tracer plumes near ocean margins or along ridges. The IDP2017 is the result of a truly international effort involving 326 researchers from 25 countries. This publication provides the critical reference for unpublished data, as well as for studies that make use of a large cross-section of data from the IDP2017. This article is part of a special issue entitled: Conway GEOTRACES - edited by Tim M. Conway, Tristan Horner, Yves Plancherel, and Aridane G. González.

著者

Song-Ju Kim Hiroyuki Yasuda Ryoma Kitagawa Mikio Hasegawa

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Communications Express (ISSN:21870136)

巻号頁・発行日

pp.2021XBL0165, (Released:2021-10-01)

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We propose a simple channel-allocation method based on tug-of-war (TOW) dynamics, combined with the time scheduling based on nonlinear oscillator synchronization to efficiently use of the space (channel) and time resources in wireless communications. This study demonstrates that synchronization groups, where each node selects a different channel, are non-uniformly distributed in phase space such that every distance between groups is larger than the area of influence. New type of self-organized spatiotemporal patterns can be formed for resource allocation according to channel rewards.

著者

Xiao-cong ZUO Ya-nan ZHOU Bi-kui ZHANG Guo-ping YANG Ze-neng CHENG Hong YUAN Dong-sheng OUYANG Shi-kun LIU Jeffrey S. BARRETT Pei-jiong LI Zhi LIU Hong-yi TAN Ren GUO Ling-yun ZHOU Yue-liang XIE Zuo-jun LI Jing LI Chun-jiang WANG Jiang-lin WANG

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

vol.28, no.5, pp.398-405, 2013 (Released:2013-10-25)

参考文献数

51

被引用文献数

19

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The objective of this study was to evaluate the effect of the CYP3A5*3 allele on the pharmacokinetics of tacrolimus and amlodipine, and drug-drug interactions between them in healthy subjects. Pharmacokinetic drug interactions between tacrolimus and amlodipine were evaluated in a randomized, 3-period, 6-sequence crossover study in healthy Chinese volunteers according to CYP3A5 genotype. A single-dose and multiple-dose study were designed. A 96-h pharmacokinetic study followed either tacrolimus or amlodipine dose, and the washout periods between the study phases were 14 days. In the single-dose study, apparent oral clearance (CL/F) of tacrolimus (5 mg) in CYP3A5 expressers was 3.8-fold (p = 0.008) higher than that in CYP3A5 non-expressers. Amlodipine decreased mean tacrolimus CL/F in CYP3A5 expressers by 2.2-fold (p = 0.005), while it had no effect on that in CYP3A5 non-expressers. The CL/F of amlodipine in CYP3A5 non-expressers was 2.0-fold (p = 0.001) higher than that in CYP3A5 expressers. Tacrolimus increased mean amlodipine CL/F in CYP3A5 expressers by 1.4-fold (p = 0.016) while it had no effect on that in CYP3A5 non-expressers. Tacrolimus slightly reduced the AUC0–∞ of amlodipine in both CYP3A5 expressers and non-expressers. Dose adjustment of tacrolimus should be considered according to CYP3A5*3 genetic polymorphism when tacrolimus is coadministered with amlodipine.

著者

Ryotaro Bouchi Kazuo Izumi Hiroshi Ohtsu Kengo Miyo Shigeho Tanaka Noriko Satoh-Asahara Kazuo Hara Masato Odawara Yoshiki Kusunoki Hidenori Koyama Takeshi Onoue Hiroshi Arima Kazuyo Tsushita Hirotaka Watada Takashi Kadowaki Kohjiro Ueki

出版者

National Center for Global Health and Medicine

雑誌

GHM Open (ISSN:2436293X)

巻号頁・発行日

vol.1, no.1, pp.3-11, 2021-08-29 (Released:2021-09-01)

参考文献数

30

被引用文献数

1

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The use of the Internet-of-Things has improved glycemic control in individuals with diabetes in several small-scale studies with a short follow-up period. This large-scale randomized controlled trial investigates whether a smartphone-based self-management support system prevents the worsening of glycemic control in individuals with type 2 diabetes. Individuals with type 2 diabetes (age range 20-74 years; n = 2,000) will be recruited, enrolled, and randomly assigned to two groups: the intensive therapy group and the conventional therapy group. Participants in the intensive therapy group will be supervised to use an automated Internet-of-Things system that demonstrates a summary of lifelogging data (e.g., weight, blood pressure, and daily activities) obtained from each measurement device and will receive feedback messages via smartphone applications to encourage them to increase their physical activity and to monitor weight and blood pressure. Participants in the conventional therapy group are allowed to use the same measurement devices as part of the routine diabetes care but without the Internet-of-Things system. The primary endpoint is the between-group difference in HbA1c levels from baseline to 52 weeks. This randomized controlled study will test the hypothesis that an Internet-of-Things-based self-monitoring system could effectively prevent the worsening of diabetes in individuals with type 2 diabetes. The expected results of the study should facilitate the development of novel strategies for both diabetes treatment and social health.

著者

Yu Inoue Seiji Hasegawa Yuichi Hasebe Mika Kawagishi-Hotta Ryosuke Okuno Takaaki Yamada Hiroaki Adachi Katsuma Miyachi Yoshie Ishii Kazumitsu Sugiura Hirohiko Akamatsu

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.44, no.10, pp.1403-1412, 2021-10-01 (Released:2021-10-01)

参考文献数

29

被引用文献数

6

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Currently, human-skin derived cell culture is a basic technique essential for dermatological research, cellular engineering research, drug development, and cosmetic development. But the number of donors is limited, and primary cell function reduces through cell passage. In particular, since adult stem cells are present in a small amount in living tissues, it has been difficult to obtain a large amount of stem cells and to stably culture them. In this study, skin derived cells were isolated from the epidermis, dermis, and adipose tissue collected from single donor, and immortalization was induced through gene transfer. Subsequently, cell lines that could be used as stem cell models were selected using the differentiation potential and the expression of stem cell markers as indices, and it was confirmed that these could be stably cultured. The immortalized cell lines established in this study have the potential to be applied not only to basic dermatological research but also to a wide range of fields such as drug screening and cell engineering.

著者

Tsujiyama Sho-ichi Nakano Naoko

出版者

Mycological Society of Japan

雑誌

Mycoscience (ISSN:13403540)

巻号頁・発行日

vol.37, no.3, pp.289-294, 1996-10-15

被引用文献数

4 10

著者

YOKOTA Shun-ichi

出版者

東京大学大学院農学生命科学研究科附属演習林

雑誌

東京大学農学部演習林報告 (ISSN:03716007)

巻号頁・発行日

no.52, pp.165-171, 1956

著者

Takayuki Tajima Yoshinobu Saito Riri Kato Yayoi Kibayashi Motohiko Miyachi I-Min Lee Yuko Oguma

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.7, no.2, pp.113-119, 2018-03-25 (Released:2018-03-16)

参考文献数

29

被引用文献数

2 2

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This study describes relationships between awareness of physical activity (PA) promotion and duration of PA and sedentary behavior (SB) in elderly Japanese. Following a community-wide intervention, 874 individuals 65 years or over were selected via population-based random sampling of 3,000 adults aged 20 years or over living in Fujisawa City, and asked to complete self-administered questionnaires; 550 responded and 373 with data on pertinent variables were included. Forty-eight percent (179/373) stated that they recognized elements of the Japanese PA guidelines such as the “Active Guide” and “+10 (plus ten).” The median duration of PA, of intensity at least equal to walking, and SB among all participants were 100 minutes/day and 300 minutes/day, respectively. Duration of PA did not significantly differ by promotion awareness (Odds Ratio (OR) for ≥100 minutes/day among those aware = 1.02, 95% Confidence Interval (CI) = 0.65-1.62); however, duration of SB did (OR for <300 minutes/day = 1.60, 95% CI = 1.01-2.53). Awareness of PA promotion in elderly Japanese is related to decreased SB, but not increased PA of intensity at least equal to walking.

著者

齋藤 めぐみ 山田 和芳 スタッフ リチャード 中川 毅 米延 仁志 原口 強 竹村 恵二 ラムジー クリストファー Megumi SAITO-KATO Kazuyoshi YAMADA Richard A STAFF Takeshi NAKAGAWA Hitoshi YONENOBU Tsuyoshi HARAGUCHI Keiji TAKEMURA RAMSEY Christopher BRONK

出版者

東京地学協会

雑誌

地学雑誌 = Journal of geography (ISSN:0022135X)

巻号頁・発行日

vol.122, no.3, pp.493-501, 2013

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Sediment cores from Lake Suigetsu, Japan, reveal the absence of seawater intrusion into the lake caused by the historically documented tsunami of AD 1586 (Tensho Tsunami). A highprecision chronology of the cores established by Bayesian modeling radiocarbon determinations enables us to ascertain the precise position of the historical event in the sediment depth. Diatom analysis of the core shows that a diatom assemblage dominated by freshwater taxa persisted through the period. This makes a clear contrast with the core section around AD 1664 when the lake was artificially connected to the sea by a channel, and the subsequent intrusion of seawater was clearly recorded in the sediment cores by the occurrence of marine diatom fossils.