著者

桑原 昌広 吉岡 顕 本間 由紀子 宇野 伸宏 中村 俊之 SCHMÖCKER Jan-Dirk

出版者

公益社団法人 土木学会

雑誌

土木学会論文集D3(土木計画学)

巻号頁・発行日

vol.74, no.5, pp.I_1187-I_1195, 2018

被引用文献数

1

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ワンウェイ型カーシェアリング(OWCS)はマルチモーダル交通環境における1つの交通手段として期待されている.本研究では,ユーザのトリップチェーン視点でOWCSの使われ方を評価するため,公共交通駅,カーシェアステーション(st),登録住所の関係を踏まえたトリップ判別モデルを定義する.<br>OWCSである豊田市のHa:moRIDEは,自家用車利用に近いラウンド利用トリップは少なく提供エリア外会員の二次交通トリップが最も多いこと,公共交通駅から離れたstを増加させることにより補完交通トリップ比率が経年で増加している等,本モデル利用により実態としてOWCSが公共交通補完に利用されていることを明らかにした.

著者

鈴木 利貞 長谷川 宏司 富田-横谷 香織 津布楽 洋和 吉田 滋樹 日下部 功 小瀬村 誠治 山村 庄亮 山田 小須弥 三木 洋一

出版者

日本雑草学会

雑誌

雑草研究 (ISSN:0372798X)

巻号頁・発行日

vol.46, pp.106-107, 2001

著者

Komai Tomoyuki Hayashi Ken-Ichi Kohtsuka Hisanori

出版者

日本甲殻類学会

雑誌

Crustacean research (ISSN:02873478)

巻号頁・発行日

no.33, pp.103-125, 2004-12

被引用文献数

1

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Two new species of hippolytid shrimp, Lebbeus elegans sp. nov. and L. polyacanthus sp. nov., are described from the Sea of Japan, at depths of 250-400m. Lebbeus elegans is characterized by the absence of epipods on the second and third pereopods, distinct ventral blade of the rostrum and the rounded fourth abdominal pleuron. Lebbeus polyacanthus is compared with L. antarcticus (Hale, 1941), L. carinatus Zarenkov, 1976, and L. washingtonianus (Rathbun, 1902). Lebbeus polyacanthus differs from the latter three species in the more posteriorly arising posteriormost tooth of the dorsal rostral series and more numerous lateral spines on the meri of the third to fifth pereopods. Examination of the newly obtained material of L. kuboi Hayashi, 1992, enabled us to assess intraspecific variations of the species, including a variation in the development of the pereopodal epipods. Redescription of Lebbeus kuboi is provided and its affinity is discussed. These three species occur sympatrically. A brief note on the taxonomy and distribution of species of Lebbeus is also provided.

著者

金 基弘 森 文哉 岩宮 眞一郎 キム キホン モリ フミヤ イワミヤ シンイチロウ Ki-Hong Kim Fumiya Mori Shin-ichiro Iwamiya

出版者

駿河台大学メディア情報学部

雑誌

メディアと情報資源 : 駿河台大学メディア情報学部紀要 = Media and information resources : bulletin of the Faculty of Media and Information Resources (ISSN:2187073X)

巻号頁・発行日

vol.21, no.2, pp.15-28, 2015-03

著者

Ryo INABA Ryouka KAWAHARA-MIKI Akihisa SHINOZAWA Taichi YASUHARA Takashi FUJII Keisuke KOYAMA Michiko MURATA-OKUBO Kousaku SOUMA Hiroki HIRAYAMA

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2021-094, (Released:2021-10-31)

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Although hormonal induction of parturition in cattle results in the successful delivery of healthy calves, the risk of retained fetal membrane is significantly increased. In a previous study, a combination of the long-acting glucocorticoid, triamcinolone acetonide, with a high dose of betamethasone partially normalized the placentomal gene expression during parturition; however, the incidence of retained fetal membrane remained high. This study further explored placentomal dysfunction and aimed to elucidate the mechanism of retained fetal membrane in parturition-induced cows. In this study, transcriptome analysis revealed that enhanced glucocorticoid exposure normalized the expression of a substantial fraction of genes in the cotyledons. In contrast, a significant reduction in the multiple signaling pathway activities, including interferon signaling, was found in the caruncles during induced parturition. Real-time PCR showed that the expression of interferon-tau in the caruncles, but not interferon-alpha or interferon-gamma, was significantly lower in induced parturition than spontaneous parturition. Interferon-stimulated gene expression was also significantly decreased in the caruncles during induced parturition. These results indicate that interferon signaling could be important for immunological control in placentomes during parturition. Additionally, this suggests that interferon-tau might be a pivotal ligand for interferon receptors in the caruncles. This study revealed that peripheral blood leukocytes in prepartum cows transcribed interferon-tau. Macrophage infiltration in the placentome is known to participate in the detachment of the fetal membrane from the caruncle. Thus, this study raised the possibility that immune cells migrating into the caruncles at parturition may act as a source of ligands that activate interferon signaling.

著者

Osamu Arisaka Megumi Iijima-Nozawa Yukiko Shimada Yoshiya Ito George Imataka Junko Naganuma Go Ichikawa Satomi Koyama

出版者

獨協医学会

雑誌

Dokkyo Journal of Medical Sciences (ISSN:03855023)

巻号頁・発行日

vol.48, no.1, pp.1-7, 2021-03-25

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Human behavioral sex differences are currently understood to result from a combination of social, cultural, cognitive, and biological mechanisms. To understand how gender identity as the sexuality of the mind is formed is important for understanding psychosexual problems of children and to consider how to manage patients with disorders of sex development(DSD), in which the development of gonads and genitals is atypical and it is difficult to determine the gender of boys and girls. There is consistent evidence that early testosterone exposure influences childhood gender role behavior, as well as gender identity and sexual orientation. In this review, we summarize the most relevant studies on the biological basis of sexual development. In particular, we focus on the impact of sex hormones and genetic background on development of sexual differentiation and gender identity, with introduction of our research using figure drawings by pediatric patients with congenital adrenal hyperplasia, which is also a DSD.

著者

Hiroshi Tateishi Mika Tateishi Mohamed O Radwan Takuya Masunaga Kosuke Kawatashiro Yasunori Oba Misato Oyama Natsuki Inoue-Kitahashi Mikako Fujita Yoshinari Okamoto Masami Otsuka

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.69, no.11, pp.1123-1130, 2021-11-01 (Released:2021-11-01)

参考文献数

41

被引用文献数

12

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A disintegrin and metalloproteinase 17 (ADAM17) is a zinc-dependent enzyme that catalyzes the cleavage of the extracellular domains of various transmembrane proteins. ADAM17 is regarded as a promising drug target for the suppression of various diseases, including cancer metastasis. We synthesized a new ADAM17 inhibitor, SN-4, composed of a zinc-binding dithiol moiety and an appendage that specifically binds to a pocket of ADAM17. We show that SN-4 inhibits the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro. This activity was reduced by the addition of zinc, indicating the importance of the zinc chelating dithiol moiety. Inhibition of TNF-α cleavage by SN-4 in cells was also observed, and with an IC50 of 3.22 µM, SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat. Furthermore, SN-4 was shown to inhibit cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion. Molecular docking showed good fitting of the specificity pocket-binding group and one SH of SN-4 and hinted at possible means of structural optimization. This study provides clues for the development of potent and selective ADAM17 inhibitors.

著者

Dunzik-Gougar Mary Lou

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会誌ATOMOΣ (ISSN:18822606)

巻号頁・発行日

vol.63, no.8, pp.561-562, 2021

著者

Da Hye Hong Hongliang Li Han Sol Kim Hye Won Kim Sung Eun Shin Won-Kyo Jung Sung Hun Na Il-Whan Choi Amy Leanne Firth Won Sun Park Dae-Joong Kim

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.38, no.8, pp.1208-1213, 2015-08-01 (Released:2015-08-01)

参考文献数

40

被引用文献数

10 10

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We demonstrated the inhibitory effect of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Fluvoxamine reduced the amplitude of Kv currents in a concentration-dependent manner with an IC50 value of 3.71±1.09 µM and a Hill coefficient of 0.62±0.14. Although fluvoxamine did not significantly affect the steady-state activation curve, it shifted the steady-state inactivation curve toward a more negative potential. Pretreatment with another SSRI, paroxetine, did not affect the basal Kv current and did not alter the inhibitory effect of fluvoxamine on Kv channels. We concluded that fluvoxamine inhibits the Kv current in a concentration-dependent manner and in a closed (inactivated) state of the Kv channels independent of serotonin reuptake inhibition.

著者

David MARTÍN-HIDALGO Beatriz MACÍAS-GARCÍA Lauro GONZÁLEZ-FERNÁNDEZ

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2021-075, (Released:2021-10-24)

被引用文献数

6

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We aimed to analyze the influence of different cellular concentrations of boar sperm suspensions on the induction of capacitation and acrosome reaction. When spermatozoa were incubated at 100 or 200 mill/ml, significant increases in protein tyrosine phosphorylation in the p32 protein were observed, compared to those at 50 mill/ml. In addition, sperm concentration-dependent increases were observed in plasma membrane lipid disorganization (50 mill/ml vs. 200 mill/ml), induction of the acrosome reaction (50 mill/ml vs. 100 mill/ml and 200 mill/ml), and sperm viability (50 mill/ml vs. 100 mill/ml and 200 mill/ml). Our data indicate that an increase in sperm concentration stimulates the induction of capacitation and acrosome reaction in boars.

著者

ROBIN N.M. FEENEY JOHN P. ZERMENO DONALD J. REID SYOZI NAKASHIMA HIROSHI SANO ARMASASTRA BAHAR JEAN-JACQUES HUBLIN TANYA M. SMITH

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.118, no.3, pp.191-198, 2010 (Released:2010-12-21)

参考文献数

48

被引用文献数

25 35

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Dental enamel thickness continues to feature prominently in anthropological studies of ape and human evolution, as well as studies of preventative oral care and treatment. Traditional studies of enamel thickness require physical sectioning of teeth for linear and scaled measurements. Recent applications of microtomographic imaging allow scientists to employ larger and more diverse samples, including global samples of recent humans as well as fossil hominin teeth. Unfortunately, little is known about the degree of enamel thickness variation among human populations, particularly across the dentition. This study employed microtomography to virtually image, section, and quantify the average enamel thickness of a sample of clinically extracted Indonesian canine and premolar teeth. This virtual sample was compared to physically sectioned African and European teeth. The results demonstrate that average enamel thickness is similar among human dentitions; no significant differences were detected within tooth positions, which is surprising given developmental differences between European and African canines and premolars. When populations were combined, differences were found in average enamel thickness between maxillary and mandibular premolars, and between canines and premolars within both dental arcades. This finding is potentially due to differences in premolar morphology and a trend of increasing enamel thickness distally throughout the dentition. The finding of limited population variation within tooth positions and significant variation between tooth positions is consistent with previous two-dimensional and three-dimensional studies of human molar enamel thickness. Average enamel thickness in canines and premolars does not differ between the sexes in our sample, although male teeth tend to have larger enamel and dentine cross-sectional areas, enamel–dentine junction lengths, and bi-cervical diameters. Males have significantly greater dentine area and enamel–dentine junction length than females for maxillary canines and premolars. The results of this study suggest that enamel thickness values in mixed-populations of humans are appropriate for comparisons with fossil hominins.

著者

Takanari Kitazono Kazunori Toyoda Kazuo Kitagawa Takehiko Nagao Hiroshi Yamagami Shinichiro Uchiyama Norio Tanahashi Masayasu Matsumoto Kazuo Minematsu Izumi Nagata Masakatsu Nishikawa Shinsuke Nanto Yasuo Ikeda Toshiaki Shirai Kenji Abe Akira Ogawa PRASTRO-I Study Group

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.56093, (Released:2020-06-04)

参考文献数

19

被引用文献数

10

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Aims: The efficacy of antiplatelet therapy may vary among different disease subtypes. Prasugrel is generally a more potent, consistent, and fast-acting platelet inhibitor than clopidogrel. This sub-analysis of the phase III comparison of PRAsugrel and clopidogrel in Japanese patients with ischemic STROke (PRASTRO-I) trial aimed to assess the differences in efficacy of these treatments for each stroke subtype. Methods: In the PRASTRO-I trial, a total of 3,753 patients with ischemic stroke were recruited from 224 centers throughout Japan and randomized (1:1) to prasugrel (3.75 mg/day) or clopidogrel (75 mg/day) for 96 weeks. For the sub-analysis, strokes were classified as large-artery atherosclerosis, small-artery occlusion (lacunar), stroke of other etiology, and stroke of undetermined etiology. The cumulative incidence of primary events (ischemic stroke, myocardial infarction, and death from other vascular cause) and hazard ratios (HRs) were calculated for each subgroup. Results: For patients with large-artery atherosclerosis, the primary event incidence was 3.8% in the prasugrel group and 4.8% in the clopidogrel group (HR 0.79; 95% confidence interval [CI] 0.45–1.40). For patients with small-artery occlusion, the incidence was 3.3% in the prasugrel group and 3.9% in the clopidogrel group (HR 0.83; 95% CI 0.46–1.53). For patients with stroke of undetermined etiology, the incidence was 4.6% in the prasugrel group and 3.0% in the clopidogrel group (HR 1.56; 95% CI 0.90–2.72). The incidence of bleeding was similar across subtypes. Conclusions: Although statistical significance was not reached, the efficacy of prasugrel was potentially different between stroke subtypes, warranting further studies.

著者

Robert Baden-Powell preface by Shigeo Fujimoto

出版者

Eureka Press

巻号頁・発行日

2012

著者

Kazuo Kitagawa Naohisa Hosomi Yoji Nagai Tatsuo Kagimura Toshiho Ohtsuki Hirofumi Maruyama Hideki Origasa Kazuo Minematsu Shinichiro Uchiyama Masakazu Nakamura Masayasu Matsumoto for the J-STARS collaborators

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.26, no.5, pp.432-441, 2019-05-01 (Released:2019-05-01)

参考文献数

18

被引用文献数

17 24

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Aims: To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history of ischemic stroke.Methods: A total of 1095 patients with non-cardioembolic ischemic stroke were randomized into two groups: control and patients receiving 10 mg of pravastatin per day. After excluding 18 patients who did not have baseline CRP data, the effects of LDL cholesterol and CRP on recurrent stroke and TIA were prospectively assessed in 1077 patients.Results: During the follow-up of 4.9±1.4 years, there were 131 recurrent stroke or TIA cases. Patients with ontreatment LDL cholesterol <120 mg/dL showed 29% reduction in recurrent stroke and TIA than those with LDL cholesterol ≥ 120 mg/dL (event rate 2.20 vs. 3.11 per 100 person-years, hazard ratio [HR] 0.71, 95% confidence interval (CI) 0.50–0.99, p=0.048). Patients with CRP <1 mg/L had 32% reduction compared with that of patients with CRP ≥ 1 mg/L (event rate 2.26 vs. 3.40 per 100 person-years; HR 0.68, 95% CI 0.48–0.96, p=0.031). Although LDL cholesterol and CRP levels were not correlated in individual patients, those who achieved both LDL cholesterol <120 mg/dL and CRP <1 mg/L showed 51% reduction compared with that of patients with LDL cholesterol ≥ 120 mg/dL and CRP ≥ 1 mg/L (event rate 2.02 vs. 4.19 per 100 person-years; HR 0.49, 95% CI 0.31–0.79).Conclusions: The control of both LDL cholesterol and CRP levels appears to be effective for preventing recurrent stroke and TIA in patients with non-cardiogenic ischemic stroke.

著者

[Texte Hans-Jürgen Imiela]

出版者

[Institut für Auslandsbeziehungen]

巻号頁・発行日

1980

著者

王 怡人 Wang Yi-Jen

出版者

国際地域創造学部 経営プログラム

雑誌

琉球大学経営研究 = University of the Ryukyus Management Research (ISSN:24361380)

巻号頁・発行日

no.1, pp.1-25, 2021-01

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デジタル社会において,企業はインターネットを活用した様々なマーケティング活動を行っている。本稿は,製造企業のこのようなマーケティング活動に焦点を当て,統計データおよびネットワーク理論の概念を使って,企業の試みと産業特性とのマッチング度を検証し,さらに製造企業にとって今後の展開の課題を整理した。

著者

Kaiyu KUBOTA Masafumi MIWA Ken-Go HAYASHI Misa HOSOE Miki SAKATANI

出版者

The Society for Reproduction and Development

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2021-087, (Released:2021-10-14)

被引用文献数

3

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In cow herd management, inadequate embryo implantation leads to pregnancy loss and causes severe economic losses. Thus, it is crucial to understand the molecular mechanisms underlying endometrial receptivity and subsequent embryo implantation. Transmembrane glycocalyx mucin 1 (MUC1) has a large and highly glycosylated extracellular domain known to inhibit embryo implantation via steric hindrance. The role of MUC1 in the bovine endometrium remains to be explored. Herein, we used simple but reliable in vivo and in vitro experiments to investigate the expression and regulation of MUC1 in the bovine endometrium. MUC1 gene expression was analyzed in endometrial epithelial cells collected by the cytobrush technique using reverse transcription-quantitative polymerase chain reaction. MUC1 protein expression was evaluated by immunohistochemical analysis of endometrial samples collected from slaughtered cows. We used an in vitro cell culture model to study the regulation of MUC1 expression by treating cells with sex steroidal hormones or co-culturing cells with a blastocyst. The results revealed that MUC1 was expressed and localized to the apical surface of luminal epithelial cells in the bovine endometrium. MUC1 expression disappeared during the luteal phase of the estrous cycle and during pregnancy. 17β-estradiol induced MUC1 expression, whereas progesterone inhibited its increase and co-culturing with blastocysts did not affect the expression. A long postpartum interval is a known risk factor for reduced fertility, and MUC1 expression was higher in this compromised condition. Our results demonstrated the MUC1 regulation by steroid hormones in bovine endometrium for embryo implantation, and we observed a negative correlation between MUC1 expression and fertility.

著者

Yoichi Sunagawa Nobuko Okamura Yusuke Miyazaki Kana Shimizu Mai Genpei Masafumi Funamoto Satoshi Shimizu Yasufumi Katanasaka Eriko Morimoto Hajime Yamakage Maki Komiyama Noriko Satoh-Asahara Hiromichi Wada Mika Suzuki Koji Hasegawa Tatsuya Morimoto

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.41, no.4, pp.504-509, 2018-04-01 (Released:2018-04-01)

参考文献数

24

被引用文献数

2 7

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Neck and shoulder stiffness is a typical subjective symptom in developed countries. This stiffness is caused by factors such as muscle tension and poor blood flow, leading to reduce work efficiency and diminish QOL. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood viscosity-lowering effects. Here, we investigated the effect of NKCP® on neck and shoulder stiffness in a double-blind placebo-controlled randomized crossover study. Thirty subjects with neck and shoulder stiffness were randomly divided into 2 groups and ingested 250 mg of NKCP® or placebo daily for 4 weeks. Headache score significantly improved in the NKCP® group compared to the placebo group. Moreover, NKCP® significantly improved the score of visual analogue scale for neck and shoulder stiffness and pain, reduced muscle stiffness of the neck, and increased the skin surface temperature of neck and shoulders, compared to before ingestion. No adverse effects were observed during this study. These results suggest that NKCP® may alleviate headaches and chronic neck and shoulder stiffness and pain.

著者

Chung-Kun Lee Shizuka Fuse Minoru N. Tamura

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.68, no.3, pp.193-198, 2017-10-31 (Released:2017-11-24)

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Commelina, the pantropical and largest genus in Commelinaceae, consists of ca. 205 species with characteristic conduplicate involucral bracts. Previous phylogenetic studies of Commelina, which mainly used African and North American species, suggested that the ancestral character state of the margins of the involucral bracts of Commelina was free and that free to fused occurred only once. To test this evolutionary scenario, we performed parsimony and likelihood analyses with partial matK sequences using 25 individuals from 11 species of Commelina, primarily from eastern and southeastern Asia, with Aneilema and Pollia as outgroups. Results showed that Commelina comprises two major clades, one consisting of four species, and the other consisting of seven species. Species with free margins of the involucral bracts were in both major clades: C. suffruticosa in the first clade and C. coelestis, C. communis, C. diffusa, C. purpurea and C. sikkimensis in the latter. The phylogenetic trees suggested that the number of shifts is fewer when the ancestral state was fused and that there were two parallel evolutionary trends toward free.

著者

Masato Iwabu Miki Okada-Iwabu Takashi Kadowaki Toshimasa Yamauchi

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ21-0294, (Released:2021-09-11)

被引用文献数

2

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While it is well recognized that exercise represents a radical preventive and therapeutic measure for lifestyle-related diseases, it is clear that contemporary lifestyles abound with situations where exercise may be found difficult to implement on a continuous basis. Indeed, this has led to global expectations for elucidation of the exercise-activated skeletal muscle signaling pathways as well as for development of exercise mimics that effectively activate such pathways. It is shown that exercise activates the transcriptional coactivator PGC-1α via AMPK/SIRT1 in muscle, thereby not only enhancing mitochondrial function and muscle endurance but upregulating energy metabolism. Further, adipocyte-derived adiponectin is also shown to activate AMPK/SIRT1/PGC-1α via its receptor AdipoR1 in skeletal muscles. Thus, adiponectin/AdipoR1 signaling is thought to constitute exercise-mimicking signaling. Indeed, it has become clear that AMPK, SIRT1 and AdipoR activators act as exercise mimetics. With the crystal structures of AdipoR elucidated and humanized AdipoR mice generated toward optimization of candidate AdipoR-activators for human use, expectations are mounting for the clinical application in the near future of AdipoR activators as exercise mimetics in humans. This review provides an overview of molecules activated by exercise and compounds activating these molecules, with a focus on the therapeutic potential of AdipoR activators as exercise mimetics.