著者

閔 丙燦 MlN Byung-chan

出版者

筑波大学大学院博士課程文芸・言語研究科応用言語学コース

雑誌

筑波応用言語学研究 (ISSN:13424823)

巻号頁・発行日

no.3, pp.115-128, 1996-12-25

著者

Md. Mahbubur RAHMAN Sei-Jin LEE Gi-Beum KIM Dong Kwon YANG Md. Rafiqul ALAM Shang-Jin KIM

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.11, pp.1489-1493, 2015 (Released:2015-12-01)

参考文献数

21

被引用文献数

4 5

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Fatalities among avian species due to multiple bee stings are rare. Sixteen pigeons on a farm in Bangladesh each suffered multiple bee stings. Ten of the pigeons died before treatment, 5 (4–11 stings) died within 12 hr after treatment, and 1 pigeon (only 3 stings) survived. Body temperature, heart rate, respiratory rate, hematocrit, hemoglobin, erythrocytes, thrombocytes, MCV, MCH and MCHC decreased significantly after the incident, but leucocytes, heterophils, basophils, eosinophils, monocytes, ALT, AST, LDH, CK, creatinine, BUN and UA increased markedly. Overall, the hematological and biochemical changes in the bee-stung pigeons were similar to those of mammals; however, avian species may be more sensitive to bee stings than mammals.

著者

sous la direction de Marie-Gabrielle Soret

出版者

BnF éditions : Opéra national de Paris : AROP, les Amis de l'Opéra

巻号頁・発行日

2021

著者

Shin'ichiro KANOH Ko-ichiro MIYAMOTO Tatsuo YOSHINOBU

出版者

The Japan Society of Mechanical Engineers

雑誌

Journal of Biomechanical Science and Engineering (ISSN:18809863)

巻号頁・発行日

vol.5, no.1, pp.32-40, 2010 (Released:2010-01-29)

参考文献数

8

被引用文献数

9 14

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An auditory brain-computer interface (BCI) which detects event-related potentials (ERPs) elicited by selective attention to one of the tone streams was proposed. Two frequency oddball tone sequences with different tone frequency ranges were alternately presented to subjects, and were perceived by subjects as two kinds of segregated streams. Event-related potentials elicited by two kinds of deviant tones were classified by linear discriminant analysis (LDA) to find the stream subjects paid selective attention to. Experiments with six subjects have shown that this system could realize binary selection from two tone streams.

著者

Erina Ota-Tsukada

出版者

Keio University Faculty of Letters, Department of Asian History

雑誌

Al-Madaniyya (ISSN:24360678)

巻号頁・発行日

vol.1, pp.41-61, 2021 (Released:2021-09-22)

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Zayn al-Dīn Abū Bakr ibn Muzhir was one of the most prominent bureaucrats of the late Mamlūk period. It is worth noting that during the financial crisis of the fifteenth century, Zayn al-Dīn maintained the highest authority as an administrator for a considerably long time. In this paper, we focus on the relationship between Zayn al-Dīn and his contemporary scholars, who were an important part of his horizontal networks. Most of them described Zayn al-Dīn as a virtuous, ideal bureaucrat; however, historical facts reconstructed by al-Biqāʻī’s chronicle are in great discord with the image of Zayn al-Dīn narrated by many historians. Zayn al-Dīn’s charitable projects for scholars not only extended his influence by gaining the scholars’ support and controlling them at the same time but also functioned as an investment from a long-term perspective, to pass down his positions, wealth, and human networks to the next generation. Al-Biqāʻī’s letter to Zayn al-Dīn, written after the controversy of Ibn al-Fāriḍ, reflects his wide authority over personnel affairs. His acquisition of an exceptionally long period of service could be attributed to his vertical and horizontal networks, based on the exceptional scale of his patronage as a civilian bureaucrat of his time.

著者

Ramírez-Moreno Carlos

出版者

立命館大学ゲーム研究センター

雑誌

REPLAYING JAPAN = REPLAYING JAPAN (ISSN:24338060)

巻号頁・発行日

vol.1, pp.52-63, 2019-03

著者

Masahiro Natsuaki Takeshi Morimoto Hiroki Shiomi Ko Yamamoto Kyohei Yamaji Hirotoshi Watanabe Takashi Uegaito Mitsuo Matsuda Toshihiro Tamura Ryoji Taniguchi Moriaki Inoko Hiroshi Mabuchi Teruki Takeda Takenori Domei Manabu Shirotani Natsuhiko Ehara Hiroshi Eizawa Katsuhisa Ishii Masaru Tanaka Tsukasa Inada Tomoya Onodera Ryuzo Nawada Eiji Shinoda Miho Yamada Takashi Yamamoto Hiroshi Sakai Mamoru Toyofuku Takashi Tamura Mamoru Takahashi Tomohisa Tada Hiroki Sakamoto Takeshi Tada Kazuhisa Kaneda Shinji Miki Takeshi Aoyama Satoru Suwa Yukihito Sato Kenji Ando Yutaka Furukawa Yoshihisa Nakagawa Kazushige Kadota Takeshi Kimura on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0526, (Released:2021-09-16)

参考文献数

27

被引用文献数

1

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Background:Optimal intensity is unclear for P2Y12receptor blocker therapy after percutaneous coronary intervention (PCI) in real-world clinical practice.Methods and Results:From the CREDO-Kyoto Registry, the current study population consisted of 25,419 patients (Cohort-2: n=12,161 and Cohort-3: n=13,258) who underwent their first PCI. P2Y12receptor blocker therapies were reduced dose of ticlopidine (200 mg/day), and global dose of clopidogrel (75 mg/day) in 87.7% and 94.8% of patients in Cohort-2 and Cohort-3, respectively. Cumulative 3-year incidence of GUSTO moderate/severe bleeding was significantly higher in Cohort-3 than in Cohort-2 (12.1% and 9.0%, P<0.0001). After adjusting 17 demographic factors and 9 management factors potentially related to the bleeding events other than the type of P2Y12receptor blocker, the higher bleeding risk in Cohort-3 relative to Cohort-2 remained significant (hazard ratio (HR): 1.52 95% confidence interval (CI) 1.37–1.68, P<0.0001). Cohort-3 compared with Cohort-2 was not associated with lower adjusted risk for myocardial infarction/ischemic stroke (HR: 0.96, 95% CI: 0.87–1.06, P=0.44).Conclusions:In this historical comparative study, Cohort-3 compared with Cohort-2 was associated with excess bleeding risk, which might be at least partly explained by the difference in P2Y12receptor blockers.

著者

落合-大平 知美

出版者

一般社団法人 日本霊長類学会

雑誌

霊長類研究 (ISSN:09124047)

巻号頁・発行日

vol.24, no.3, pp.405-411, 2009-03-31 (Released:2010-06-17)

参考文献数

14

被引用文献数

2 2

著者

Matsuda Yoichi Nishida-Umehara Chizuko Tarui Hiroshi Kuroiwa Asato Yamada Kazuhiko Isobe Taku Ando Junko Fujiwara Atushi Hirao Yukako Nishimura Osamu Ishijima Junko Hayashi Akiko Saito Toshiyuki Murakami Takahiro Murakami Yasunori Kuratani Shigeru Agata Kiyokazu

出版者

Springer Netherlands

雑誌

Chromosome Research (ISSN:09673849)

巻号頁・発行日

vol.13, no.6, pp.601-615, 2005-08

被引用文献数

1

著者

Atsuhiro KISHIMOTO Atsushi IMAIZUMI Hiromichi WADA Hajime YAMAKAGE Noriko SATOH-ASAHARA Tadashi HASHIMOTO Koji HASEGAWA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.67, no.4, pp.249-252, 2021-08-31 (Released:2021-08-31)

参考文献数

16

被引用文献数

18

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Elevated neutrophil/lymphocyte ratio (NLR) has been reported as a sensitive marker for predicting poor prognosis in chronic inflammation-based diseases such as stroke, heart failure, cancers, and diabetes, as well as acute inflammatory diseases such as bacterial and viral infections, including COVID-19. NLR is also known to increase with age and is considered to be an aging marker. We conducted a double-blind, placebo-controlled trial in elderly volunteers to examine the effect of a newly developed, highly bioavailable curcumin formulation (curcuRougeTM) on NLR. Both the white blood cell count and the neutrophil rate decreased significantly, and the lymphocyte rate increased significantly from baseline to after curcuRougeTM administration for 4 wk. curcuRougeTM significantly reduced the NLR (p=0.020). On the other hand, in the placebo group, there were no changes in white blood cell count, neutrophil ratio, lymphocyte ratio, or NLR. The present study demonstrates for the first time, in elderly volunteers, that administration of curcuRougeTM significantly reduces NLR, an indicator of prognosis in cardiovascular diseases, cancer, infectious diseases, and aging. Thus, curcuRougeTM might be expected to improve the prognosis of these diseases as well as exhibit anti-aging effects.

著者

Shinsuke Kawagucci Yohei Matsui Gretchen L. Früh-Green

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.54, no.3, pp.129-138, 2020 (Released:2020-06-22)

参考文献数

45

被引用文献数

1 5

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Here we quantify radiocarbon (14C) content in CO2 and CH4 from hydrothermal fluids collected at 5 vent sites in the Okinawa Trough. These data provide preliminary insights on how different carbon sources and circulation processes contribute to vent fluids and take into consideration all potential contaminations during sample processing and analysis with accelerator mass spectrometer. For CO2, 14C-dead values observed in fluids of most sites (Hatoma, Hitoshi, Noho) demonstrate the complete removal of the inorganic carbon in the recharged seawater. Conversely, the significantly positive 14CO2 are detected in fluids from the Daiyon-Yonaguni site, which implies the persistence of the recharged seawater-derived inorganic carbon and/or a contribution from thermal degradation of sedimentary 14C-containing carbon during fluid upwelling. The CH4 in these fluids were predominantly 14C-dead or nearly 14C-dead, suggesting a source of deep-buried, 14C-dead sedimentary carbon. The methods outlined in our study exemplify a useful way of elucidating radiocarbon contents of geofluids, and provide future studies with a means to improve our understanding of carbon circulation between hydrosphere and lithosphere.

著者

Hiratsuka Naohide Shimabukuro Shun-ichi 平塚 直秀 島袋 俊一

出版者

琉球大学農学部

雑誌

琉球大学農学部学術報告 = Science bulletin of the Faculty of Agriculture, University of the Ryukyus

巻号頁・発行日

no.1, pp.1-56, 1954-04

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本研究に先鞭をつけたのは平塚直治博士(著者の1人平塚の実父)である。同氏は1899年9月,沖縄中学校(後の沖縄第1中学校)に博物担当教師として来任,翌年4月病を得て退職帰郷するまで,在職わづかに7ケ月間ではあつたが,その間菌学者である同氏は沖縄島所産の銹菌類にとくに興味を持ち,公務の余暇にこれらの採集調査を行つた。これらの採集品のうち首里城瑞泉門外で発見採集されたチシャノキの葉上の1銹菌は1900年,同氏著の"Notes on some Melampsorae of Japan. 3.Japanese species of Phacopsora." (植物学雑誌,14,p.91) と云う表題の論文中で,Phacopsora Ehretiae Hiratsuka(新種)として公表された。この論文は琉球諸島所産銹菌類に関する研究発表の最初のものである。爾来1940年にいたる40年間に,三宅勉氏,伊藤誠哉博士およびDr.P.& H. Sydow,著者の1人平塚らによつて公表された同諸島産の銹菌類は,Phakopsora属1種,Coleosporium属1種,Poliotelium属1種,Puccinia属5種およびUromyces属1種,計5属9種であり,これらのうちPuccinia Ophiopogonis Cummins(Uredo Ophiopogonis Syd.)をのぞけば他の8種はすべて平塚直治博士ならびに宮城鉄夫氏の採集に係るものである。1940年1月上旬,著者の1人平塚は銹菌類研究のため沖縄島を訪れ約3週間にわたり平良芳久君を助手として同島各地において銹菌類の採集調査を行つたが,さらに平塚の離島後は同年4月下旬まで平良君によつて採集がつづけられ多くの興味ある銹菌類を得た。これらの採集品を主な研究資料として平塚は同年,"Materials for a rustflora of Riukiu Islands, 1 & 2. "(植物学雑誌,54,p.157~166,373~377)と題して,奄美群島なども含む琉球諸島産銹菌類19属76種を公表した。ついで,翌1941年,さらに平塚は"Uredinales of Okinawa Island" (札幌博物学会報,17,p.16~39)という表題で,沖縄本島産銹菌類20属96種(新種3種を含む)をあげ,同島の銹菌類フロラを論じた。1953年4月下旬,平塚は本学の招聘教授として来島,2ヶ月講義,実験指導のかたわら著者の1人島袋とともに同島各地の銹菌類の採集調査を行った。平塚は同年6月下旬帰国したが,その後は島袋によって沖縄本島のみならず,久米島,宮古島などにおける採取調査がつづけられた。奄美大島産の銹菌類については保 虎太郎氏の採集品約20個にもとづいて公表されたのみであったが,昨年末,新納義馬君によって多数の同島産銹菌類が採集され著者らに提供された。本報文は,琉球諸島,即ち,奄美群島,沖縄群島,宮古群島,および八重山群島において採集された銹菌類の種類を検討せる結果を発表したもので,著者らが近い将来公表するべく企図している「琉球諸島銹菌フロラに関する研究」の前篇とも見做されるべきものである。本研究の概要はつぎの如くである。(1) 琉球諸島所産の銹菌類として,層生銹菌科(Melampsoraceae)に属する9属,32種,柄生銹菌科(Pucciniaceae)に属する15属,109種ならびに不完全銹菌類(Uredinales Imperfecti)に属する2属18種,計26属,159種を列挙した。(2) 新種として命名記載した種類は, HamasPora okinawensis Hiratsuka,f.(3.ホザキイチゴに寄生),Puccinia Caricis-Boottianae Hiratsuka,f.(0,1.ツワブキ;2,3.コゴメスゲに寄生)および Uredo thermopsidicola Hiratsuka,f.(2.クソエンドウに寄生)の3種であり,新組合せの学名を与えたものは,Didymop-sorella lemanesis (Doidge) Hiratsuka,f.の1種である。(3) 日本列島においてはじめて発見採集された種類は,Crossopsora Antidesmaedioicae(Syd,)Arthur et Cummins(2,(3).ヤマヒハツに寄生), Uromyces Baeumlerianus Bubák(2,3.コゴメハギに寄生)および Uredo psychotricola Hennings(リュウキュウアオキに寄生)の3種である。(4)琉球諸島において今回はじめて産することの明かとなった種類は,前掲の Hamaspora okinawensis, Uredo thermopsidicola, Crossopsora Antidesmaedioicae, Uromyces Baeumlerianus および Uredo psychotricolaの5種を除けば,Uredinopsis属1種,Milesina属1種,Pucciniastrum属2種,Crossopsora属1種,Phakopsora属2種,Colepucciniella属1種,Coleospoium属2種,Kuchneola属1種, Maravalia属1種. Gymnosporangium 属1種,Xenostele属1種,Uromyces属7種,Puccinia属19種,Aecidium属7種およびUredo属2種で,総計15属49種である。

著者

劉 宗徳 LIOU Tzong-Der

出版者

名古屋大学大学院法学研究科

雑誌

名古屋大学法政論集 (ISSN:04395905)

巻号頁・発行日

no.277, pp.185-215, 2018-03

著者

Haruhisa Ibayashi Yoshihisa Fujino Truong-Minh Pham Shinya Matsuda

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.215, no.3, pp.237-245, 2008 (Released:2008-07-19)

参考文献数

38

被引用文献数

33 47

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In Japan, one of the duties of the long-term care insurance system is the prevention of oral function degradation. Although various exercise programs for oral function have been developed and practiced in Japan, to date, no study has reported their effects. In the present study, we examined the effects of an exercise program on oral functions in healthy elderly people. Healthy elderly people participated in the study and were randomly divided into intervention and control groups (39 subjects/group). The exercise program consisted of four exercises: exercise for expression muscles, tongue, salivary glands, and swallowing. Before and after a six-month intervention period, we evaluated changes in oral functions, namely bite force, swallowing ability, and salivary flow rate. Fifty-four subjects completed the study protocol: 26 and 28 subjects from intervention and control groups, respectively. A significant improvement in all oral functions, including bite force, swallowing ability, as well as unstimulated and stimulated salivary flow rate, was observed in the intervention group after six months, whereas no improvement was observed in the control group. Further, among the intervention group, a significant improvement in oral functions was observed in 17 subjects with 20 or more remaining teeth, whereas no improvement was observed in the other nine with less than 20 teeth. Our results suggest that oral functions significantly improve after conducting a six-month exercise program for oral function. Further, this improvement appears to be influenced by the number of remaining teeth.

著者

ヴォイチェフ ヤストシェンボフスキ:ポーランド語原本 ダヌータ コルデツカ:復刻版編集者 テレサ バウカ-ウレヴィチョヴァ:英語訳 斉藤 進:日本語訳 松田 文子:日本語訳 酒井 一博:日本語訳

出版者

公益財団法人大原記念労働科学研究所

雑誌

労働科学 (ISSN:0022443X)

巻号頁・発行日

vol.88, no.6, pp.189-219, 2012 (Released:2014-07-25)

被引用文献数

1

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人間工学のルーツは,1857年にポーランドの科学者ヤストシェンボフスキが,ギリシャ語に由来するエルゴノミクスを「働くことの科学」として造語したことに遡る。人間工学の誕生である。ヤストシェンボフスキは,エルゴノミクスの概念を1857年発行の「自然と産業」誌にポーランド語で発表した。ポーランド労働保護中央研究所では原典を英訳し,「エルゴノミクス概説-自然についての知識から導かれる真理に基づく労働の科学」として,国際人間工学連合と米国人間工学会大会が2000年に併催されたときに記念出版した。歴史的に重要な書籍の復刻版を日本語で公開することに対し,快諾頂いたポーランドの英語版編集者ダヌータ・コルデツカ労働保護中央研究所長に感謝する。

著者

Ken-ichiro YASUBA Hidehito KUROSAKI Takehiko HOSHI Takashi OKAYASU Yoshiyuki TANAKA Tanjuro GOTO Yuichi YOSHIDA

出版者

Japanese Society of Agricultural, Biological and Environmental Engineers and Scientists

雑誌

Environmental Control in Biology (ISSN:1880554X)

巻号頁・発行日

vol.56, no.3, pp.107-112, 2018 (Released:2018-07-20)

参考文献数

17

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A program library for use on open-source hardware was developed in order to construct a low-cost environmental control system for greenhouses. The library facilitated the development of environmental sensing and control devices that conform to the protocols of the Ubiquitous Environment Control System (UECS). The open-source hardware used was the "Arduino Ethernet" and the "Arduino Mega 2560 with Ethernet Shield" microcontroller boards. UECS is a system for controlling greenhouse environments that communicates information via a local area network, and devices utilizing the library that we developed can perform the UECS defined communication tasks automatically. With the help of this library, device developers no longer need to program the communications aspects of the device and can concentrate on programming setting and control logic of the device. The library occupies about 29 kilobytes of the read only memory area of the target board. The library and associated open-source microcontroller boards are powerful tools for developing low-cost environmental control systems.

著者

Mari Yamasue Shin-ichi Nureki Hiroyuki Matsumoto Takamasa Kan Takehiro Hashimoto Ryoichi Ushijima Yuko Usagawa Jun-ichi Kadota

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.239, no.3, pp.223-230, 2016 (Released:2016-07-09)

参考文献数

28

被引用文献数

4 9

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Relapsing polychondritis (RP) is a rare systemic disorder characterized by recurrent, widespread chondritis of the auricular, nasal, and tracheal cartilages. IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease characterized by the infiltration of IgG4-bearing plasma cells into systemic organs. Although 25% to 35% of patients with RP have a concurrent autoimmune disease, coexistence of RP and IgG4-RD is rare. We herein report a case of RP complicated by IgG4-RD. A 63-year-old man developed recurrent bilateral ear pain and swelling, recurrent blurred and decreased vision, and migratory multiple joint pain, sequentially within one year. Fourteen months after the first symptom, he experienced dry cough and dyspnea with exertion. A computed tomography (CT) scan detected interstitial pneumonia, swelling of bilateral submandibular glands, bilateral hilar and mediastinal lymphadenopathy, and several nodules in bilateral kidneys. His serum levels of IgG and IgG4 were elevated. The biopsy specimen of auricular cartilage showed infiltrations of inflammatory cells and fibrosis consistent with RP. The IgG4-positive cells were not observed in auricular cartilage. The patient met the diagnostic criteria of RP, including bilateral auricular chondritis, conjunctivitis, iritis and polyarthritis. The biopsy specimens of lung and kidney revealed the significant infiltrations of IgG4-positive plasma cells and fibrosis. We also diagnosed him as having IgG4-RD, affecting bilateral submandibular glands, hilar and mediastinal lymph nodes, lungs, and kidneys. Thus, RP preceded the onset of IgG4-RD. Corticosteroid therapy improved the symptoms and CT scan findings. In conclusion, RP and IgG4-RD do coexist; however, the pathogenesis of their coexistence is unknown.

著者

Collins NIMAKO Yoshinori IKENAKA Yuko OKAMATSU-OGURA Jussiaea V. BARIUAN Atsushi KOBAYASHI Ryo YAMAZAKI Kumiko TAIRA Nobuhiko HOSHI Tetsushi HIRANO Shouta M. M. NAKAYAMA Mayumi ISHIZUKA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.83, no.3, pp.487-500, 2021 (Released:2021-04-03)

参考文献数

47

被引用文献数

1 5

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Hepatic steatosis is known to precede a continuum of events that lead to hepatic metabolic dysfunction, inflammation and carcinogenesis. Recently, studies have linked xenobiotic exposures to hepatic steatogenesis and its associated metabolic disorders; however, the underlying mechanisms remain elusive. This study aimed to elucidate the mechanistic role of imidacloprid in the prevalence of high fat diet (HFD)-induced liver steatosis, using a C57BL/6J mice model. Mice (3 weeks old) were fed with HFD and treated with 0.6 mg/kg bw/day (one-tenth of the NOAEL) of imidacloprid through water or diet, for 24 weeks. In a controlled group, mice were fed with only HFD. At the end of the study, imidacloprid treatment significantly potentiated HFD-induced body weight gain in mice. Also, imidacloprid increased the liver weights of mice, with complimentary reductions in mesenteric and gonadal white adipose tissue weights. Histopathological analysis of liver revealed a drastic steatosis in imidacloprid treated mice. Following a real-time qPCR analysis, imidacloprid upregulated transcriptions of hepatic fatty acid biosynthesis-related transcription factors and genes. Imidacloprid also induced hepatic expression of the gene encoding pregnane X receptor; but had no significant effect on hepatic expressions of liver X receptor and aryl hydrocarbon receptor. The imidacloprid treatment further enhanced serum alanine aminotransferase levels but downregulated hepatic antioxidant mRNA expressions. Ultimately, this study suggested an imidacloprid-potentiation effects on prevalence of HFD-induced liver steatosis via transcriptional modulations of the hepatic FA biosynthesis pathway.

著者

Chun-Ho PARK Sayaka KUBONIWA Ryo MURAKAMI Nozomi SHIWA Satoshi INOUE Kazunori KIMITSUKI Ma. Ricci R. GOMEZ Mark Joseph M. ESPINO Alpha Grace B. CABIC Sheila Marie C. ESPOSO Daria L. MANALO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0438, (Released:2021-09-02)

被引用文献数

2

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The rabies virus is one of the most neurotropic of all viruses infecting mammals. During the terminal phases of infection, the virus spreads to peripheral tissues, including the skin. The external skin of the nose, called the nasal planum, is a sensory organ where numerous nerve bundles and terminal nerves are distributed. Therefore, the nasal planum is expected to serve as a postmortem diagnostic material. However, the distribution of rabies virus antigens in the nasal planum in rabid animals has not yet been studied. In this study, the nasal planum was obtained from 45 rabid dogs. In all rabid dogs, the viral antigen was detected in the peripheral nerve tissues, Merkel cells, and squamous cells. The viral antigen in the epidermis exhibited three patterns: first, a diffuse positive pattern from the basal layer to the squamous layer; second, a reticular positive pattern along the cell membrane in the squamous layer; and third, a basal layer pattern of the epidermis. In the dermis, viral antigens were detected more often in lamellated corpuscles just beneath the rete pegs. These results suggest that the nasal planum could serve as a useful alternative source for postmortem diagnosis in rabies endemic countries.

著者

Bayrak-Toydemir Pinar Pergament Eugene Fiddler Morris

出版者

Springer-Verlag Tokyo

雑誌

Journal of human genetics (ISSN:14345161)

巻号頁・発行日

vol.48, no.12, pp.665-667, 2003-12-01

参考文献数

9