著者
中川 洋一
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.35, no.1, pp.28-34, 2016 (Released:2016-05-10)
参考文献数
49
被引用文献数
3

A global consensus regarding the terminology of dry mouth is needed in order to facilitate diagnosis and treatment as well as future research and education. This review summarizes the terms concerning dry mouth, including : xerostomia, hyposalivation, altered salivary composition, salivary gland dysfunction, and salivary dysfunction.
著者
金子 明寛
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.34, no.3, pp.85-93, 2015 (Released:2015-12-25)
参考文献数
27
被引用文献数
5

A number of odontogenic infections are often alleviated in a few days if inflammation is localized in the alveolar part, and appropriate surgical treatments such as incision or drainage as well as antibacterial chemotherapy are performed. However, in some cases, it may become desperately ill due to delay of the initial treatment and develop extremely serious infections including cellulitis or necrotic fasciitis. The causative bacteria for these diseases are oral resident microbiota, and are frequently detected in the case of multiple bacterial infection caused by obligate and facultative anaerobic bacteria. From odontogenic infection, Prevotella sp., Peptostreptococcus sp., and Streptococcus sp. are detected at high rate and are regarded as the three major etiologic agents. The change with time in susceptibility of strains separated from closed abscess of odontogenic infection during 7 years from 2005 to 2011 against various antibacterial agents was investigated. The results showed a decreasing tendency of susceptibility to β-lactam, macrolide, and quinolone agents. In particular, there are many β-lactamase producing strains in the Prevotella sp. Thus, it is necessary to select antibacterial agents stable for β-lactamase in patients with suspected involvement of obligate anaerobic bacteria such as cellulitis around the maxilla or deep neck abscess.
著者
王 宝禮 砂川 正隆 山口 孝二郎 亀山 敦史 金子 明寛
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.34, no.1, pp.23-30, 2015-04-01 (Released:2015-06-01)
参考文献数
46

Kampo medicine has a long experience and actual performance over a long period of history. The first oriental medicine was approved by Japanese national health insurance in 1976, and 147 kinds of oriental medicine are currently approved by the National Health Insurance Drug Price. Those of 7 kinds of Kampo medicine were approved by Japan Dental Association of “National Health Insurance Drug Price Standard related with dental treatment” on April 2012. It has been reported that approximately 70 to 80% of doctors has an experience to use oriental medicine in a clinical site. Meanwhile, oriental medicine was used at more than 85% of medical facilities in a survey of Kampo medicine usage at oral surgery clinics in all Japanese Dental University hospital and Medical University hospital. However, only a few Kampo medicine was used at general dental clinics. Establishment of the evidence of oriental medical treatment in dental lesions is one of the solution of popularizing a treatment of Kampo medicine in oral surgery. Hence, efficacy of Kampo medicine which was approved by the new drug standard since 1986 was evaluated from the aspect of Evidence-based medicine(EBM).
著者
森 紀美江 大野 康亮 山本 麗子 根本 敏行 道 健一
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.11, no.3, pp.180-183, 1992-12-01 (Released:2010-06-08)
参考文献数
13

This has been a report of headache as side effects after administration of antimicrobial agent. We encountered two cases. Case 1 was diagnosed as having chronic mandibular osteomyelitis. Cefteram pivoxil (CFTM-PI) was administrated to this patient in three 200 mg doses daily, one dose after each meal. The patient complained of a headache 2 to 3 hours after receiving the initial dose of 200mg.Case 2 was diagnosed as possibly having postoperative infection. Roxithromycin (RU28965) was given in two 150 mg doses daily after breakfast and dinner for 4 days. This patient complained of a headache after the initial dose of 150mg, and it lasted for 4 days.In these two cases, appearance of the headache occurred at about the time of maximum serum level.We report these cases, because there have been few reports of headache as a side effect of these antibiotics.
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.18, no.3, pp.182-183, 1999-12-01 (Released:2010-06-08)
参考文献数
6
著者
千葉 智子 小川 隆志 阪田 久美子 宮崎 正三
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.19, no.2, pp.85-94, 2000-08-01 (Released:2010-06-08)
参考文献数
24

As drug information service (DI) in a dental hospital, we evaluated the efficacy and safety of three products of the drug delivery system (DDS) (Periocline®, Elyzole®, Perio Chip®) for treatment of periodontitis, using literature of clinical trials.Nine literature references (4 for Periocline®, 4 for Elyzole®, 1 for Perio Chip®) were obtained from a MEDLINE database search on the Internet.The clinical trial design of each reference was a randomized control trial, and three were double blind randomized control trials. The treatment period and examination period were different for each reference. Items of clinical examination included pocket depth (PD), bleeding on probing (BOP), attachment level (AL), plaque index (PI) ; of these, PD was used in all trials.As for the efficacy of products evaluated by improvement of PD, two references for Periocline®, and one for Periochnp®, showed statistically significant improvement, but two references for Elyzole®, indicated superior improvement of PD in the control group rather than the test group. Only five of the references discussed side effects, but they were mild, transit, local effects.
著者
安藤 崇仁 下尾 嘉昭 中里 政可 吉田 久博
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.31, no.2, pp.53-61, 2012-08-01 (Released:2012-09-06)
参考文献数
13

歯科治療では浸潤麻酔が頻繁に行われている.しかし浸潤麻酔は患者に強い痛みを与えるため,前処置として表面麻酔が用いられており,口腔粘膜停滞性が悪く,麻酔効果も良好とは言い難い.そこで,表面麻酔薬塗布部の横に円筒形綿花を置き,さらに下口唇を術者が前方へ引き出すことで比較的簡便に表面麻酔薬の口腔粘膜停滞性を向上させる方法(改良法)を考案し,表面麻酔薬を塗布した後に口唇を閉じる方法(従来法)との間で試験を行った.複数の表面麻酔製剤を用い,表面麻酔効果の非使用部位への発現および浸潤麻酔時の除痛効果を検討した.対象は健常成人男女10名とし,試験部位は下顎前歯部歯槽粘膜とした.作用時間1分とし,注射針刺入時と薬液注入時の疼痛をVisual Analogue Scaleで評価した.その結果,改良法では,従来法よりも薬液注入時に良好な除痛効果を示した.また,従来法では1分以内に非使用部位で表面麻酔効果が認められたのに対し,改良法では認められなかった.これらの成績は,表面麻酔薬の口腔粘膜停滞性を向上させることにより副作用が軽減できること,また今回提示した改良法が薬剤の口腔粘膜停滞性向上に有効なことを示唆している.
著者
池田 裕子 岡本 真理子 山本 健 今村 武浩 山近 重生 斎藤 一郎 中川 洋一
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.33, no.1, pp.10-17, 2014-04-01 (Released:2014-09-05)
参考文献数
26
被引用文献数
4

Purpose: The purpose of this study was to investigate sleep quality and its related factors in dry-mouth patients. Subjects and Methods: A cross-sectional study was conducted in 362 patients who visited the Dry Mouth Clinic at Tsurumi University Dental Hospital with the complaint of oral dryness. Sleep quality was assessed using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J), and factors associated with the PSQI-J global score were analyzed by multiple regression. The dependent variable was the PSQI-J global score, while age, gender, resting saliva flow rate (RSFR), stimulated saliva flow rate (SSFR), VAS score of nocturnal dry mouth sensation, the presence or absence of snoring, grinding, clenching, and mouth breathing, and anxiety and depression score in the Hospital Anxiety Depression Scale (HADS) were used as the independent variables. Results: The mean PSQI-J global score was 7.9±3.9, and 232/362 (64.1%) cases were considered to be poor sleepers who showed a score of less than 5.5. The multiple regression analysis showed that anxiety (standardizing coefficient 0.330) and depression score (0.151) in HADS, nocturnal dry-mouth sensation (0.165), and age (0.209) were significantly associated with the PSQI-J global score. Conclusion: Anxiety, depression, and sleep-related xerostomia were found to be factors closely associated with the risk of disturbance of good sleep quality.
著者
松野 智宣 北原 和樹 田中 正司 佐藤 田鶴子 荒井 千明
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.21, no.2, pp.53-58, 2002-08-01 (Released:2010-06-08)
参考文献数
13
被引用文献数
2

Platelet-rich plasma (PRP), separated by centrifugation of autologous blood, is a plasma containing numerous platelets. Consequently, efficient separation of PRP can provide highly concentrated autologous growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), and insulin-like growth factor-I (IGF-I), derived from α granules. However, it requires a substance to trigger platelet aggregation, in order to activate platelets to release the growth factors.In the present study, we investigated a procedure of activating platelets (aggregation) with calcium chloride alone, in the absence of thrombin, the safety of which is suspected. Prior to the investigation, we sought the optimal centrifugal conditions, i.e., centrifugal gravity and time, for separation of PRP. As a result, we discovered that a centrifugal gravity of 130 (×g) and a centrifugal time of 10 min, are the optimal conditions for separating PRP. The time required for platelet aggregation was prolonged in platelet activation by calcium chloride alone, as compared with platelet activation by thrombin. However, activation of platelets with calcium chloride alone demonstrated gelatinization of PRP indicative of sufficient fibrin formation.
著者
土屋 博紀 加藤 博詞
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.17, no.3, pp.147-154, 1998-12-01 (Released:2010-06-08)
参考文献数
30
被引用文献数
1

Green tea catechins with the anticariogenic activity have been recently revealed to maintain their salivary concentrations after mouthrinsing. The mechanism underlying such retention in the oral cavity was studied by quantitatively evaluating the adsorption of catechins after vortex-mixing with hydroxyapatite, buccal mucosal cells, and proteins in artificial saliva. Treatment with hydroxyapatite decreased catechins in supernatants and such a decrease was more significant by coating hydroxyapatite with saliva as an experimental pellicle. When treating with mucosal cells, unwashed cells decreased catechins in ultrafiltrates more significantly than washed cells. Catechins in ultrafiltrates were decreased by treating with albumin and mucin depending on protein concentrations. These reduced concentrations in supernatants and ultrafiltrates meant the adsorption of catechins to hydroxyapatite, mucosal cells, and proteins. In structural comparison, four gallate esters were superior in the adsorptive activity to the corresponding non-esters. Concentration changes of salivary ctechins after mouthrinsing with green tea extracts showed that the retention of catechins in the oral cavity was associated with their adsorption. The present results suggested that green tea catechins are adsorbed by the teeth, pellicles and oral mucosa, and that salivary proteins such as albumin and mucin are responsible for the adsorption. The adsorbed catechins are considered to gradually be released to maintain the salivary concentrations after oral application.
著者
寺門 永顕 新谷 悟 原 慎吾 篠原 裕志 矢野 淳也 栢原 浩彰 中城 公一 日野 聡史 浜川 裕之
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.22, no.2, pp.76-82, 2003-08-01 (Released:2010-06-08)
参考文献数
8

The efficacy of azithromycin as a chemoprophylactic agent for acute dental infection was assessed, and a questionnaire survey about the impression of azithromycin was conducted. METHODS: Eighty-three patients were given 500 mg of azithromycin for three days. Seven days after the onset of the treatment, we evaluated the clinical symptoms and collected the questionnaires. RESULTS: Clinical efficacy was observed in 89.2% of the patients, and that by questionnaire was 86.7%. Diarrhea as a side effect was seen in two patients. In the questionnaire, 79% of patients noted its effect from the second to fourth day after the medication. Although half of the patients did not care about the convenience, of taking the medication once a day, which is one of the advantages of azithromycin, most of the patients were satisfied with its efficacy.Furthermore, 72.3% of patients considered azithromycin to be significantly more acceptable compared with other antibiotics. CONCLUSION : Azithromycin is a useful therapeutic regimen for the treatment of acute dental infections.
著者
鎌谷 宇明 池田 幸 朽名 智彦 飯島 毅彦 吉濱 泰斗 近藤 誠二 代田 達夫 新谷 悟
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.31, no.3, pp.96-100, 2012-12-01 (Released:2013-02-25)
参考文献数
9

Distigmine bromide is an anticholinesterase used to treat urinary retention. We describe a case of decreased serum cholinesterase caused by a usual oral dose of distigmine bromide for urinary retention. An 84-year-old man, who had been received chemotherapy for carcinoma of the lower gingiva, suddenly decreased serum cholinesterase to 21 IU/L in 7 days of administration of distigmine bromide 5mg without clinical symptoms. Serum cholinesterase improved after stopping the administration of distigmine bromide. This case shows that oral surgeons should be aware of the possibility of decreased serum cholinesterase in patients taking distigmine bromide.
著者
郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.28, no.3, pp.109-116, 2009-12-01
参考文献数
39

Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.<br>Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.<br>From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.
著者
豊福 明
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.36, no.3, pp.117-120, 2017 (Released:2017-12-27)
参考文献数
13

Historically, chronic oral pain with unknown origin had been treated as a “psychogenic” condition in dentistry. Although tricyclic antidepressants have been widely used to treat chronic oral pain such as glossodynia or atypical odontalgia, the mechanisms on how they work is not precisely elucidated still now. Strong evidences have been accumulated on pathophysiological interactions between chronic pain and psychosocial factors. Dopamine system has been found to play a key role for bridging chronic pain and psychosocial factors. To treat chronic oral pain better, we dentists should search for a new pharmacotherapy based on brain function, especially with a focus on the relationship between chronic oral pain and dysfunction of mesolimbic dopamine system.
著者
前田 伸子
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.35, no.3, pp.115-122, 2016 (Released:2017-01-14)
参考文献数
35

Candida is the most significant species among fungi, because it is not only a member of the normal microbiota of oral cavity, skin, gastrointestinal tract and vagina, but also one of the pathogens for opportunistic infections(candidiasis). Recently incidence and prevalence of candidiasis have increased in large populations of compromised hosts. Studies of poly-microbial Candida biofilms suggest that the hyphae of Candida provides the scaffold for oral bacteria in biofilms and show the interactions with many oral infections such as dental caries, periodontal disease, endodontic infection, and denture stomatitis. Candida has a number of virulence factors, the most important is aspartic proteinase (Sap). Sap plays a central role in the pathogenicity of Candida destroying human proteins and invading tissues. The gold standard of diagnosis for candidiasis is based on clinical findings and confirmed by identification of colonies cultured on the media for Candida. However, microscopic examinations of staining smear samples are faster and simpler methods than culture methods, if the staining is sufficiently accurate. We compared staining methods of candidiasis smear samples, and suggest that Fungiflora Y staining is useful for the diagnosis of oral erythematous candidiasis. Right now, we are doing both, basic and clinical research to reduce Candida colonization in the oral cavity. Basic research includes the development of probiotics with lactobacilli as well as biogenic products of lactobacilli for controlling Candida colonization in the oral cavity. Clinical research comprises of reducing the number of Candida in the oral cavity by gargling with a diluted antifungal drug(amphotericin B). The goal of our studies is to improve QOL, not restricted to the oral cavity, but for the entire body by eliminating Candida from the oral cavity.
著者
八木沢 就真 栗林 伸行 川又 均
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.38, no.3, pp.195-199, 2019 (Released:2020-03-31)
参考文献数
12

In this study, we examined the effectiveness and adverse events of pilocarpine hydrochloride (pilocarpine) gargle in the treatment of xerostomia in Sjogren's syndrome (SS). Dryness of the mouth, salivary flow rate, adverse events associated with oral administration or gargle method were compared before and after 4 weeks of administration in the eight SS patients enrolled in this study. Dryness of the mouth in seven patients was significantly improved by oral administration. Gargling also improved dryness of mouth but did not reach statistical significance. The salivary flow rate based on the gum test was significantly increased with the gargle method as well as with oral administration. The salivary flow rate by the Saxon test also increased with both oral administration and gargling but did not reach statistical significance. Increased rate of salivary flow was equally observed in both methods. An adverse event associated with oral administration was sweating, and one patient could not continue the study due to uncomfortable sweating and palpitation. In contrast, the gargle method induced slight sweating alone in six of seven patients. These results indicate that the gargle method, compared with oral administration improves xerostomia with equivalent efficacy without inducing excessive sweating.
著者
佐藤 真理子 石田 孝文 岩渕 絵美 岩渕 博史
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.39, no.1, pp.9-15, 2020 (Released:2020-05-16)
参考文献数
19

Patient`s with Sjögren’s syndrome(SS)are prone to the development of dental caries as a result of reduced salivary flow. As no studies to date have reported on the association between improved salivary flow in patients with SS and caries prevention, we conducted a retrospective study on the influence of salivary secretion on the number of decayed/missing/filled(DMF)teeth. This study involved a total of 165 patients with a mean observation period of 57.7±8.62 months. The results showed a significant negative correlation between the change in the number of missing teeth from baseline to end point and the mean stimulated whole salivary flow(SWSF), which was based on the mean baseline and end point SWSF(r=−0.155, P=0.047). In addition, an increase in the number of missing teeth in patients with a mean SWSF not exceeding 6 mL/10min was observed compared to patients with a mean SWSF of more than 6 mL/10min. Logistic regression analysis showed SWSF to be a risk factor for increased number of missing teeth(OR=0.905, 95 % CI=0.832–0.985, P=0.021). During the observation period, although SWSF increased between baseline and end point, increase in SWSF did not prevent an increase of DMF. As this study showed that SS patients were susceptible to missing teeth with no clear evidence of reduced number of DMF teeth associated with increased salivation, the results suggest that SS patients require all available caries prevention interventions, including not only salivary secretagogue, but also topical measures such as fluoride, antimicrobials and non-fluoride re-mineralizing agents.