著者

半場 道子

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.3, pp.156-164, 1999-12-01 (Released:2010-06-08)

参考文献数

29

著者

服部 孝範 古賀 賢三郎 可知 久志 後藤 学 田中 悟 成田 秀貴 生川 哲也 河合 幹

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.6-8, 1982-12-31 (Released:2010-06-08)

参考文献数

3

---

Agar well method was compared with cup method. Diameter of inhibition zone of Agar well method was smaller than diameter of inhibition zone of cup method.Diameter of inhibition zone of Agar well method was almost same size and the measured value of Agar well method was low in aberration.

著者

久野 吉雄

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.125-144, 1982-12-31 (Released:2010-06-08)

著者

道 健一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.1, no.1, pp.145-155, 1982-12-31 (Released:2010-06-08)

被引用文献数

1

著者

黒木 祐吾 岡本 喜之 石橋 真乃介 川田 賢介 石川 好美

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.1, pp.9-15, 2015-04-01 (Released:2015-06-01)

参考文献数

15

---

Hunter glossitis is a relatively rare disease caused by vitaminB12 deficiency. We clinically studied six cases of Hunter glossitis caused by vitamin B12 deficiency. All cases complained tongue pain and dysgeusia, and they showed atrophy of lingual papillae and vitamin B12 deficiency in blood examination. Macrocytic anemia was found out in five cases but one case was not anemia. Two cases were under treatment of chronic gastritis and three cases were total gastric resection in past. Untreated atrophic gastritis was found out in one case by upper gastrointestinal endoscopy. We treated all cases by oral administered vitamin B12 therapy 1500 µg/day. After this therapy, red smooth tongue, oral pain, dysgeusia and level of vitamin B12 in blood were improved in all cases. It is popular that the treatment of vitamin B12 deficiency is based on parenteral vitamin B12 administered intramuscular injection. But recently, a few reports documented positive results following oral vitamin B12 therapy. As the result of these cases, oral administered vitamin B12 therapy was effective to Hunter glossitis.

著者

牛山 美奈 池田 龍二 新田 哲也 田實 裕介 宮脇 昭彦 山口 辰哉 下堂薗 権洋 牛之濱 風見 松井 竜太郎 杉原 一正 中村 典史 山田 勝士

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.3, pp.143-150, 2008-12-01 (Released:2010-06-08)

参考文献数

14

---

In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.

著者

金川 昭啓

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.32, no.3, pp.167-171, 2013-12-01 (Released:2014-09-05)

参考文献数

10

被引用文献数

1

著者

伊藤 公一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.2, pp.68-78, 2008-08-01 (Released:2010-06-08)

参考文献数

16

---

Gingival hyperplasia (overgrowth) is a well-documented unwanted effect, associated with phenytoin, the calcium channel blockers, and cyclosporin. The pathogenesis of drug-induced gingival hyperplasia is uncertain. However, the identification of risk factors associated with both the prevalence and severity of drug-induced gingival hyperplasia is important for all parties involved with this unwanted effect. Prevalence of gingival hyperplasia with phenytoin, the calcium channel blockers, and cyclosporin is approximately 50%, 10-20%, and 8-70%, respectively. The inflammatory components of drug-induced gingival hyperplasia can be managed effectively for the majority of patients with a plaque control program and nonsurgical periodontal therapy including oral hygiene instruction, scaling and root planing coupled with continued periodontal maintenance procedures. After reevaluation, some patients may need surgical periodontal therapy and maintenance procedures. Maintenance therapy including appropriate oral home care appear to be effective in controlling the drug-induced gingival hyperplasia and in maintaining clinical improvements for a long time.

著者

竹味 利晃 岩瀬 正泰 上條 竜太郎 倉地 洋一 水野 隆 南雲 正男

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.15, no.1, pp.8-11, 1996-04-01 (Released:2010-06-08)

参考文献数

15

被引用文献数

1

---

A study was carried out to evaluate the efficacy of allopurinol mouthwash on mucositis induced by chemotherapy or/and radiotherapy in patients with oral cancer. The effect of allopurinol mouthwash was judged according to the World Health Organization grading system. Eight of the nine patients (89%) were reduced clinical status on mucositis. Treatment with allopurinol mouthwash was well tolerated in all patients. There were no adverse effects in trial of allopurinol mouthwash. Allopurinol mouthwash was considerably effective against mucositis induced by chemo- and radiotherapy.

著者

山下 知巳 鈴木 邦明 出山 義昭 山岡 真茂 北田 秀昭 福田 博

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.21, no.1, pp.4-12, 2002-04-01 (Released:2010-06-08)

参考文献数

19

---

Nedaplatin (NDP), an anticancer platinum complex, is supposed to have stronger action on malignant tumor and less nephrotoxicity than cisplatin. As details of the nephrotoxicity of NDP are not known, we studied the effect of NDP on pig kidney Na+, K+-ATPase activity and human renal proximal tubule epithelial cells (HRPTE cells) . The pig kidney Na+, K+-ATPase activity was inhibited by NDP, and the inhibition depended on the incubation time and the concentration of NDP, and the activity was recovered by sulfides. NDP decreased Na+, K+-ATPase and acid phosphatase activities of HRPTE cells, and the decrease was partially inhibited by addition of 2-mercaptoethanol (2ME) . HRPTE cell death by apoptosis was observed in the presence of NDP, and it was also partially inhibited by 2ME. These results suggest that the inhibition of enzyme activities by NDP may be related to nephrotoxicity, and that some sulfides can recover the activities and may reduce nephrotoxicity.

著者

山根 伸夫

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.3, pp.121-124, 2017 (Released:2017-12-27)

著者

山崎 隆廣 吉位 尚 黒木 栄司 宮井 大介 林 徹 西村 栄高 吉川 朋宏 吉岡 歩 古土井 春吾 竹野々 巌 市来 浩司 大塚 芳基 中尾 薫 古森 孝英

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.2, pp.54-58, 1999-08-01 (Released:2010-06-08)

参考文献数

24

被引用文献数

2

---

Cases with postoperative infections following teeth extraction are experienced occasionally, however, there have been few reports about the problems following teeth extraction. The purpose of this study was to investigate the influence of general and local background of cases with infections following teeth extraction. The results were as follows:1) The infections following teeth extraction occurred in 11 (2.1%) out of 517 cases.2) There was no relationship between age or underlying disease and the postoperative infection rate.3) The incidence of the infection was the highest after mandibular third molar surgery, however, the relationship between the surgical procedure such as incision or removal of the bone and the infection rate was not found.4) The infection rate of cases with acute inflammation before surgery was higher than that of the cases without any inflammatory signs.5) Prophylactic antibiotic administration was performed on 282 (54.5%) out of 517 cases. The incidence of the infections of the cases with prophylaxis was almost the same as the cases without prophylaxis.6) The postoperative pain in infection cases tends to last longer than the normal course. Therefore, it is important to observe carefully the course of pain to make a diagnosis of postoperative infection.

著者

王 宝禮 今村 泰弘 藤井 健男 音琴 淳一 太田 紀雄 大浦 清

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.23, no.3, pp.101-107, 2004-12-01 (Released:2010-06-08)

参考文献数

29

---

本研究では, ヒスタチンを用いて歯肉組織中に最も多く存在するヒト歯肉線維芽細胞に対する影響について検討を行った.ヒスタチンは新鮮ヒト耳下腺唾液を用いてハイドロキシアパタイトクロマトグラフィーによって分離, 精製された.ヒト歯肉線維芽細胞は, インフォームドコンセントのもと抜歯後の歯に付着する歯肉組織から摘出した.ヒト歯肉線維芽細胞は, ヒスタチンを添加し培養された.細胞増殖はMTT分析, DNA合成はBrdU法, Ki-67タンパク質の検出はウエスタンブロット法で行われた.結合分析はオプティカルバイオセンサーによって行われた.ヒスタチンは, ヒト歯肉線維芽細胞に対して増殖率, DNA合成率, Ki-67タンパク質量を増加させた.ヒスタチンとヒト歯肉線維芽細胞の結合が確認できた.以上の結果から, ヒスタチンがヒト歯肉線維芽細胞の増殖を誘導したことを示唆した.将来的に, ヒスタチンが歯周病患者における歯肉線維芽細胞の再生を誘導する可能性があるかもしれない.

著者

郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.1-8, 2010-04-01

---

Many epidemiological studies have shown that the prevention of dental caries by fluoride is a basic and indispensable method to maintain and improve dental health. However, the countermeasures for maintenance of dental health and implementation of preventive programs for caries are still not satisfactory in Japan. In developed countries, it is thought that the prevalence of water fluoridation and use of fluoride-containing dentifrices are the primary factors responsible for the remarkable decrease in the prevalence of dental caries in children. Topical application of fluorides, especially fluoride mouth rinsing, has an extremely important role in Japan as compared with various other countries, because systemic application of fluorides, such as water fluoridation and use of fluoride tablets are not yet available in Japan. However, fluoride mouth rinsing has not become prevalent on a nationwide scale. Therefore, it is hoped that fluoride mouth rinsing will be enforced in more kindergartens, elementary schools, and junior high schools to contribute to the improvement of dental health in the future.

著者

影向 範昭 山本 加代子 高橋 美枝子 岡田 道子 遠藤 泰 千葉 智子 遠藤 初恵 鬼頭 健二 鈴木 恵美子 森塚 光子 吉田 紀昭 遠山 邦子 大久保 幸子 大橋 恵 上中 清隆

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.1, pp.36-44, 2008-04-01 (Released:2010-06-08)

参考文献数

10

被引用文献数

2

---

The present study surveyed the application of antimicrobials in dental practice in 17 private dental college or university hospitals in Japan, in order to investigate the actual conditions of using antimicrobials.According to the medicinal virtues, a drug list with percentage was prepared depending upon the number of actual use of internal medicine, injections provided in the prescription or instructions for the 10-day period from September 4 to 15, 2006. Furthermore, a survey of the kind of antimicrobials with consumption for each hospital was also done for the six-month period from April 1, 2006 to September 30, 2006.Classified by medicinal virtues by internal use medicines, the proportion of antibacterial and anti-inflammatory analgesic drugs accounted for 32% each, and gargle and gastrointestinal medicine for 12% and 10% respectively. Among the internal use antimicrobials, usage of the cephem system was 54% whereas penicillin and macrolide system were 23% and 21%, respectively. The largest consumption was cefcapene pivoxil hydrochloride for antibacterial medicines. This drug was widely used in 10 out of 17 hospitals. Erythromycin ethylsuccinate was in second position, followed by cefdinir, rifampicin and ampicillin.The method of marking order of each hospital and order of the total consumption were analyzed and some differences in consumption of different drugs were observed. Many hospitals suggested the use of clarithromycin, cefaclor and amoxicillin although consumption was low.According to the medicinal virtues of injectable medicines, the frequency of use of antimicrobials was the highest (34%) . Among the injectable antimicrobials, the cephem based system (60%) and penicillin system (33%) accounted for more than 90% of the total use. Cefazolin was the most consumed drug, followed by asoxicillin, flomoxef sodium and ceftriaxone.

著者

牛山 美奈 池田 龍二 新田 哲也 田實 裕介 宮脇 昭彦 山口 辰哉 下堂薗 権洋 牛之濱 風見 松井 竜太郎 杉原 一正 中村 典史 山田 勝士

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.3, pp.143-150, 2008

---

In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.<BR>We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.

著者

岸本 裕充

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.33, no.3, pp.143-148, 2014-12-01 (Released:2015-01-28)

参考文献数

8

著者

榎本 鈴代 長畠 駿一郎 鶴田 敬司 貞森 平樹 三宅 実 合田 恵子

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.10, no.1, pp.74-80, 1991-04-01 (Released:2010-06-08)

参考文献数

20

---

The effects of eperisone hydrochloride (Myonal®) on 40 patients with temporomandibular arthrosis are evaluated.The results of improvement are as follows : Out of 40 patients, overall improvement was found to be 65 %, pain in improvement was 75.7 %, trismus improvement was 76.2 %, articu-larprocess noises improvement was 27.8 %. Myonal was effective for patients with type I (damage in muscle of mastication), and type II (chronic traumato-disease) was significantly more superior than type III (internal derangements) . The side effects were noted tobe 17.5 %, but there was no specifically serious case, and the cause-and-effect relationship with Myonal was unpredictable.

著者

牛山 美奈 池田 龍二 新田 哲也 田實 裕介 宮脇 昭彦 山口 辰哉 下堂薗 権洋 牛之濱 風見 松井 竜太郎 杉原 一正 中村 典史 山田 勝士

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.3, pp.143-150, 2008-12-01

著者

神谷 洋子 浅田 洸一 栃原 しほみ 山近 重生 石橋 克禮

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.1, pp.32-35, 2003-04-01 (Released:2010-06-08)

参考文献数

18

被引用文献数

1

---

Recently, the use of angiotensin converting enzyme (ACE) inhibitors has increased and so angioedema as a side effect of ACE inhibitor administration is probably increasing. However, angioedema induced by ACE inhibitors has rarely been reported. We reported a case of angioedema (Quincke's edema) of the face that recurred following the administration of a double dose of ACE inhibitor.