著者

粟屋 潔 今井 聖

出版者

公益社団法人 計測自動制御学会

雑誌

計測と制御 (ISSN:04534662)

巻号頁・発行日

vol.3, no.2, pp.105-114, 1964-02-10 (Released:2011-05-24)

参考文献数

11

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D-C amplifiers are indispensable for analog computers, measuring instruments and industrial controlequipment.One of major considerations of the amplifiers is the minimum detectable signal which usually issubject to restriction by the drift.With synchronous clamp technique, reduction of the drift can be achieved. This technique is verysimple and yet effective.This paper presents both theoretical and experimental analyses of the effect of synchronous clamp ind-c amplifiers.

著者

村山熊次 編

出版者

南江堂

巻号頁・発行日

vol.後期, 1902

著者

小笠原 香苗 清河 幸子

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.28, no.Supplement, pp.ps04, 2020 (Released:2020-12-24)

著者

田中 浩史

出版者

跡見学園女子大学

雑誌

コミュニケーション文化 = Communication in culture (ISSN:18818374)

巻号頁・発行日

vol.9, pp.227-235, 2015-03

著者

田中 浩史

出版者

跡見学園女子大学

雑誌

コミュニケーション文化 = COMUNICATION IN CULTURE (ISSN:18818374)

巻号頁・発行日

no.9, pp.227-235, 2015-03

著者

池田 正弘

出版者

一般社団法人 日本応用数理学会

雑誌

応用数理 (ISSN:24321982)

巻号頁・発行日

vol.31, no.2, pp.2-10, 2021-06-24 (Released:2021-09-30)

参考文献数

29

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In the present paper, I review our recent two papers of the joint works with Atsushi Miyauchi (Tokyo Univ.), Yuuki Takai(KIT) and Yuichi Yoshida (NII). I mainly introduce the background of their papers and the fundamental notions for community detection of networks. First I review the notion of Laplacian and Cheegerʼs inequality for the usual undirected graph. After that, I introduce the definition of the (submodular) Laplacian for hypergraphs and the heat on them. Especially, I introduce several properties of the Laplacian and heat such as maximal monotonicity of the Laplacian and well-definedness of the heat and the Personalized PageRank respectively. Moreover, I introduce the application of the properties to the community detection on hypergraphs.

著者

道脇 幸博 角 保徳 三浦 宏子 永長 周一郎 米山 武義

雑誌

老年歯科医学 = Japanese journal of gerodontology (ISSN:09143866)

巻号頁・発行日

vol.17, no.3, pp.275-280, 2003-03-31

参考文献数

14

被引用文献数

5

著者

荒木 臣紀

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.86, no.5, pp.323-327, 2020-05-05 (Released:2020-05-05)

参考文献数

3

著者

柳原 崇男

出版者

公益社団法人 土木学会

雑誌

土木学会論文集D3(土木計画学) (ISSN:21856540)

巻号頁・発行日

vol.71, no.5, pp.I_459-I_465, 2015 (Released:2015-12-21)

参考文献数

25

被引用文献数

8 12

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高齢者の外出頻度は心身機能や社会活動性を包含した健康指標であるとも考えられている.つまり,健康指標として,外出頻度を交通施策等の評価にも応用できると考えられる.高齢化社会に向けては,交通施策等が健康維持や介護予防に寄与することを,実証的データにより立証していくことも重要となる.本研究では,外出頻度と移動手段,活動能力の関係を実証的データから検討し,今後の高齢者の介護予防や健康維持の観点から移動手段のあり方について考察する.その結果,外出頻度に最も影響を与えるのは,移動手段であり,特に「車(自分で運転)」であり,自分で運転しない場合は,年齢やIADL(手段的自立)が影響している.また,本調査地域においては,公共交通や家族送迎・タクシー等の交通手段は,外出頻度に影響を与えていないことがわかった.

著者

Kentaro UMEDA Atsuko IKEDA Ryo UCHIDA Ikuko SASAHARA Tomoyuki MINE Hitoshi MURAKAMI Keishi KAMEYAMA

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.34-48, 2023 (Released:2023-01-01)

参考文献数

79

被引用文献数

2

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The genus Bifidobacterium comprises beneficial intestinal bacteria that play a crucial role in the regulation of human health. Traditional prebiotics are known to increase intestinal bifidobacteria by supplying a carbon source necessary for their growth. However, intestinal bifidobacteria need not only a carbon source but also a nitrogen source for growth. Moreover, the growth of bifidobacteria is known to be inhibited in a culture medium that does not contain glutamic acid. Based on these reports, we hypothesized that the combined intake of traditional prebiotics and glutamic acid would be beneficial for growth of bifidobacteria in the gut. In this study, we investigated the effects of the combination of galactooligosaccharide (GOS; traditional prebiotic material) and poly-γ-glutamic acid (γ-PGA; source of glutamic acid) and only GOS on the intestinal microbiota and health conditions (including intestinal regulation, mood status, gastrointestinal condition, skin condition, and sleep quality) in a randomized, double-blind, parallel-group comparison trial in healthy subjects. The combined intake of GOS and γ-PGA significantly increased the prevalence of B. longum compared to the intake of GOS alone. A minimum effective dose of 2.0 g GOS and 0.3 g γ-PGA improved defecation and mood status. We revealed the combined effects of GOS and γ-PGA on intestinal microbiota as well as physical condition and concluded that the delivery of glutamic acid to the large intestine with traditional prebiotics is useful as an advanced prebiotic.

著者

Shanshan QI Donghua LIU Bo MA Lei YANG Haitao YU

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.13-23, 2023 (Released:2023-01-01)

参考文献数

42

被引用文献数

1

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Screening efficient strains by cell platform is cost-effective, but to date, no screening experiments have been performed for targeted lactic acid bacteria with hypoxic/reoxygenation (H/R)-treated cardiomyocytes, and their effects on the phosphoinositide 3-kinase (PI3K)/protein kinase b (Akt)/endothelial nitric oxide synthase (eNOS) pathway in myocardial infarction (MI) are unclear. Here we activated 102 strains of lactic acid bacteria and inoculated them into MRS medium for fermentation. The fermentation supernatants of the lactic acid bacteria were incubated with an H/R model of H9C2 cells. We found that Bifidobacterium longum ZL0210 had the greatest potential for inhibiting the apoptosis of H/R-induced H9C2 cells. Furthermore, it significantly increased the expression of heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1) in H9C2 cardiomyocytes, as well as the Bcl-2/Bax protein ratio, protecting damaged myocardial cells via an anti-apoptotic pathway. Intragastric administration of B. longum ZL0210 to mice for one week before and after establishment of an MI model drastically attenuated the myocardial cell hypertrophy and fibrosis of the MI mice. Meanwhile, B. longum ZL0210 significantly reduced the secretion of myocardial enzymes, increased the activity of antioxidant enzymes, and inhibited lipid-oxidative malondialdehyde (MDA) levels. Moreover, it upregulated the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein and the phosphorylation levels of PI3K, Akt, and eNOS, resulting in increased NO contents. In summary, we screened 102 strains of lactic acid bacteria with a cell platform and determined that B. longum ZL0210 was a favorable candidate for protecting the myocardium. We are the first to reveal the protective effects of B. longum ZL0210 for MI via activation of the PI3K/Akt/eNOS pathway through TRAIL.

著者

Yuji OHASHI Tomohiko FUJISAWA

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.100-103, 2023 (Released:2023-01-01)

参考文献数

18

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The effects of lactate and probiotic lactic acid bacteria (LAB) on intestinal fermentation were analyzed using a fecal batch culture. Lactate was efficiently metabolized to butyrate and propionate by butyrate-utilizing bacteria in fecal fermentation. Probiotic LAB could stimulate butyrate and propionate production through their lactate production in fecal fermentation. It was considered that 109 cfu/g or more of probiotic LAB would be required to stimulate butyrate and propionate production in the large intestine. Due to the low production of lactate, a larger number of heterofermentative LAB than homofermentative LAB would be required for this stimulation.

著者

Tomoaki NAITO Masatoshi MORIKAWA Mayuko YAMAMOTO-FUJIMURA Akira IWATA Ayaka MAKI Noriko KATO-NAGAOKA Kosuke OANA Junko KIYOSHIMA-SHIBATA Yumi MATSUURA Rumi KAJI Osamu WATANABE Kan SHIDA Satoshi MATSUMOTO Tetsuji HORI

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.65-72, 2023 (Released:2023-01-01)

参考文献数

39

被引用文献数

1

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Mononuclear phagocytic cells (MPCs) are classified into monocytes (Mos)/macrophages and dendritic cells (DCs) based on their functions. Cells of MPCs lineage act as immune modulators by affecting effector cells, such as NK cells, T cells, and B cells. This study aimed to investigate the effects of Lacticaseibacillus paracasei strain Shirota (LcS) ingestion on peripheral MPCs, particularly on their expression of functional cell-surface molecules enhanced in healthy adults. Thus, twelve healthy office workers consumed a fermented milk drink containing 1.0 × 1011 cfu of LcS (LcS-FM) or a control unfermented milk drink (CM) once a day for 6 weeks. Peripheral blood mononuclear cells (PBMCs) were prepared from blood samples, and immune cells and functional cell-surface molecules were analyzed. We observed remarkable differences in the expression of HLAABC, MICA, CD40, and GPR43 in plasmacytoid DCs (pDCs) between the LcS-FM and CM groups, whereas no difference was found in CD86 or HLADR expression. The LcS-FM group exhibited higher CD40 expression in both conventional DCs (cDCs) and Mos, especially in type 2 conventional DCs (cDC2s) and classical monocytes (cMos); higher percentages of cMos, intermediate monocytes (iMos), and nonclassical monocytes; and higher numbers of cMos and iMos in PBMCs than the CM group. LcS ingestion increased the expression of HLAABC, MICA, CD40, and GPR43 in pDCs and CD40 in cDCs and Mos, particularly cDC2s and cMos. These results suggest that LcS modulates the function of MPCs that may lead to the regulation of immune effector functions in healthy adults.

著者

Shimpei WATANABE Akiko OHNO Satoshi YOMODA Satoshi INAMASU

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.49-55, 2023 (Released:2023-01-01)

参考文献数

36

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Several studies have suggested that the gut microbiota affect the health of the host. For example, the Firmicutes/Bacteroidetes (F/B) ratio and the proportion of Akkermansia muciniphila in the microbiota have been closely linked to obesity. In this study, we evaluated the effects of an anti-obesity lignan compound, arctigenin (AG), and burdock sprout extract (GSE), which contains AG, on the gut microbiota of an obese mouse model. C57BL/6J mice were fed high-fat, high-sucrose (HFHS) diets containing AG, GSE, or metformin (MF) for 8 weeks. The composition of the gut microbiota and the cecal content of short-chain fatty acids (SCFAs) were determined using 16S rRNA gene sequencing and high-performance liquid chromatography, respectively. Body weight gain was significantly suppressed in mice treated with AG, GSE, and MF. Analysis of the gut microbiota revealed that the F/B ratio was significantly reduced in the AG- and GSE-treated groups. Furthermore, the copy number of A. muciniphila in the feces was significantly increased in obese mice treated with AG and GSE. In addition, the amount of SCFAs (acetic, propionic, and butyric acids) in the cecal content and their fecal excretions were also significantly increased following AG and GSE treatment. Taken together, these results suggest that AG and GSE prevent obesity by improving the composition of the gut microbiota. Moreover, AG promoted the growth of A. muciniphila in vitro. Thus, AG and GSE may function as novel prebiotic supplements to ameliorate obesity, constipation, and intestinal disorders.

著者

Takayuki TOSHIMITSU

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.3-7, 2023 (Released:2023-01-01)

参考文献数

26

被引用文献数

1

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Chronic inflammation caused by aging, obesity, and lifestyle disturbances can lead to the production of inflammatory cytokines and insulin resistance, reducing glucose and lipid metabolism. Lactic acid bacteria (LAB) have various bioactivities, and certain types of LAB have been reported to exhibit anti-inflammatory effects. We hypothesized that LAB strains, which can strongly induce the production of anti-inflammatory cytokines by immune cells in the intestinal tract, may improve glucose and lipid metabolism by suppressing chronic inflammation. We selected Lactiplantibacillus plantarum OLL2712 (OLL2712) from the LAB library owned by Meiji Co., Ltd. based on its ability to induce the production of interleukin-10 (IL-10), optimized the culture conditions of OLL2712 for industrial applications, and verified the efficacy of the strain in animal and clinical studies. The results showed that OLL2712 bacterial cells in the exponential phase had notably higher anti-inflammatory properties than the cells in the stationary phase and led to the inhibition of chronic inflammation and improvement of glucose and lipid metabolism in animal studies. Two randomized controlled trials consisting of healthy adults with elevated blood glucose levels or body mass indices (BMIs) also showed that the intake of OLL2712 suppressed the aggravation of chronic inflammation and improved glucose and lipid metabolism. This review identified a novel LAB strain that may contribute to diabetes and obesity prevention and demonstrated its clinical efficacy. In addition, the mechanism of action of this LAB strain through the intestinal immune system was partially elucidated, and the importance of optimizing the culture conditions of LAB was clarified.

著者

Eisaku ITO Takao OHKI Naoki TOYA Hikaru NAKAGAWA Ayako HORIGOME Toshitaka ODAMAKI Jin-zhong XIAO Shigeo KOIDO Yuriko NISHIKAWA Toshifumi OHKUSA Nobuhiro SATO

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.81-86, 2023 (Released:2023-01-01)

参考文献数

31

被引用文献数

3

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The relationships between various diseases and the human gut microbiota (GM) have been revealed. However, the relationships between the human abdominal aortic aneurysm (AAA) and GM remains unknown. The aim of this cross-sectional study was to clarify the association between the human AAA and GM. Stool samples from 30 consecutive patients with AAA before aneurysm repair and those of 30 controls without vascular diseases were analyzed by 16S rRNA gene (V3–4) sequencing using an Illumina MiSeq system and QIIME 2. There was no significant difference in age (75 vs. 75 years) or gender (80% vs. 87% males) between the groups. No significant difference in GM composition was observed in principal coordinate analysis between the two groups, whereas the AAA group showed a significantly lower abundance of Bifidobacterium adolescentis (p<0.01) at the species level than the controls. This study demonstrated that the abundance of B. adolescentis decreased in patients with AAA. This is the first study to show the characteristics of the GM in patients with AAA. Studies are needed to reveal if causal relationships exists between the human AAA and GM.

著者

Suguru SAITO Musin KELEL

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.94-99, 2023 (Released:2023-01-01)

参考文献数

37

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Angiogenesis is a highly regulated biological event and requires the participation of neutrophils, which are innate immune cells, to initiate the systematic responses. Some strains of lactic acid bacteria (LAB) can be used for probiotics that provide functional modifications in our immune systems. Here, we show that oral administration of Lacticaseibacillus casei ATCC393 promoted inflammatory angiogenesis accompanied by enhanced neutrophil activity. Heat-killed L. casei (HK-LC) administration improved angiogenesis in a murine hind-limb ischemia (HLI) model. The recruitment and activity of neutrophils were enhanced by HK-LC administration under the HLI conditions. Our results provide novel evidence of an immunological contribution of LAB uptake in the prevention of or recovery from cardiovascular diseases.

著者

Tianyang HUANG Jianhui JIANG YongJun CAO Junze HUANG Fuan ZHANG Guozhen CUI

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.56-64, 2023 (Released:2023-01-01)

参考文献数

37

被引用文献数

7

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Atherosclerosis is the main cause of cardiovascular diseases, and healthy dietary habits are a feasible strategy to prevent atherosclerosis development. Camellia oil, an edible plant oil, exhibits multiple beneficial cardiovascular effects. Our previous study showed that oral administration of camellia oil attenuated hyperglycemia, fat deposits in the liver, and the atherosclerosis index in high-fat diet (HFD)-induced obese mice. Here, an atherosclerosis model of apolipoprotein E (ApoE)−/− mice induced by HFD was used to study the effect of camellia oil on atherosclerosis, and 16S rRNA gene sequencing was used to analyze the changes in gut microbiota composition. The results showed that camellia oil significantly inhibited the formation of atherosclerotic plaques in ApoE−/− mice, which were characterized by significantly reduced levels of serum total cholesterol and enhanced levels of serum high-density lipoprotein cholesterol. The aortic levels of interleukin-6 and tumor necrosis factor were decreased. The results of the 16S rRNA analysis showed that after camellia oil interventions, the intestinal flora of ApoE−/− mice changed significantly, with the diversity of intestinal flora especially increasing, the relative abundances of Bacteroides, Faecalibaculum, Bilophila, and Leuconostoc increasing, and the Firmicutes/Bacteroidetes ratio and Firmicutes abundance decreasing. Collectively, our findings confirmed the promising value of camellia oil in preventing the development of atherosclerosis in ApoE−/− mice. Mechanistically, this preventive effect of camellia oil was probably due to its lipid-lowering activity, anti-inflammatory effects, and alteration of the gut microbiota composition in the mice.

著者

Hideto SHIRASAWA Chisato NISHIYAMA Rika HIRANO Takashi KOYANAGI Shujiro OKUDA Hiroki TAKAGI Shin KURIHARA

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.24-33, 2023 (Released:2023-01-01)

参考文献数

58

被引用文献数

1

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It has been reported that the intake of polyamines contributes to the extension of healthy life span in animals. Fermented foods contain high concentrations of polyamines thought to be derived from fermentation bacteria. This suggests that bacteria that produce high levels of polyamines could be isolated from fermented foods and utilized as a source of polyamines for human nutrition. In this study, Staphylococcus epidermidis FB146 was isolated from miso, a Japanese fermented bean paste, and found to have a high concentration of putrescine in its culture supernatant (452 μM). We analyzed the presence of polyamines in the culture supernatants and cells of the type strains of 21 representative Staphylococcus species in addition to S. epidermidis FB146, and only S. epidermidis FB146 showed high putrescine productivity. Furthermore, whole-genome sequencing of S. epidermidis FB146 was performed, and the ornithine decarboxylase gene (odc), which is involved in putrescine synthesis, and the putrescine:ornithine antiporter gene (potE), which is thought to contribute to the release of putrescine into the culture supernatant, were present on plasmid DNA harbored by S. epidermidis FB146.

著者

Motoki MURATA Satomi KOMATSU Emi MIYAMOTO Chihiro OKA Ichian LIN Motofumi KUMAZOE Shuya YAMASHITA Yoshinori FUJIMURA Hirofumi TACHIBANA

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.87-93, 2023 (Released:2023-01-01)

参考文献数

48

被引用文献数

5

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Quercetin, a flavonol present in many vegetables and fruits, has been identified as a chemoprevention agent in several cancer models. However, the molecular mechanism of quercetin’s anticancer activity is not entirely understood. MicroRNAs (miRNAs), small noncoding RNAs, have been reported to play key roles in various biological processes by regulating their target genes. We hypothesized that quercetin can exert an anticancer effect through the regulation of miRNAs. To test this hypothesis, we investigated the effects of quercetin on the expression of tumor-suppressive miRNAs in cervical cancer. Quercetin up-regulated the in vivo and in vitro expression of tumor-suppressive miRNAs miR-26b, miR-126, and miR-320a. Quercetin suppressed the level of β-catenin, encoded by catenin beta 1 (CTNNB1), by up-regulating miR-320a in HeLa cells. Moreover, quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. The results from this study show that quercetin has the potential to prevent cervical cancer by regulating the expression of tumor-suppressive miRNAs.