著者
Yue Junming Du Ziyun Zhou Fu-Ming Dong Peixin Pfeffer Lawrence M
出版者
OMICS International
雑誌
Cancer Medicine & Anti Cancer Drugs
巻号頁・発行日
vol.1, no.1, pp.1000103, 2016-03

The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.
著者
Abdukadir Ablimit Khan Babar Masuda Ryuichi Ohdachi Satoshi
出版者
Pakistan Wildlife Foundation
雑誌
Pakistan Journal of Wildlife (ISSN:22273158)
巻号頁・発行日
vol.1, no.2, pp.57-63, 2010

Asiatic wild cat, Felis silvestris ornata, once regarded as least concern is declining rapidly in its natural habitat in the Xinjiang desert region of China mainly because of excessive hunting for pelt trade followed by shrinkage of its habitat due to cultivation, oil and gas exploration and excessive use of pesticides. Prior to 1950, it was the most abundant felid in Xingjian dwelling along all major river basin systems and Taklimakan desert but later it got confined to three regions of southern Xinjiang only viz., Bayingolin Mongol Autonomous Oblast, Aksu and Hotan. Despite several expeditions, correct distribution and status of this illusive cat was unknown. This review article is an update on current status, distribution, ecological behavior, conservation and habitat characteristics of Asiatic wild cat in Xinjiang arid region of China. Specimen collected from various parts of Xinjiang exhibit varied phenotypic characters. It has protruding morphological features like many other desert animals. It has dense and soft hairs on the forelimb pads like other felids but rarely behaves nocturnally, adjusting its movement with seasonal variation and food availability. Tarim hare, Lepus yarkandensis, is the primary source of food followed by gerbil, jerboa, birds, fish and lizards. Literature and the statistics both reveal that it’s remnant population is declining fast limiting it to only a few fragmented habitats in the lower reaches of Hotan, Yarkand, Tarim, Qarqan, Niya and Keriya river basins, rendering it no more a least concern species at least in China. Therefore, adequate policy decisions and concrete conservation actions are required to halt and eventually reverse the declining population of the cat and its deteriorating habitat in Xinjiang.
出版者
日経BP社
雑誌
日経情報ストラテジ- (ISSN:09175342)
巻号頁・発行日
vol.9, no.10, pp.220-223, 2000-11

茨城県竜ヶ崎市の幹線沿いに立つ「サイクルヒット・竜ヶ崎店」は、ゲームソフトや音楽CD、単行本などを顧客から買い取って、中古品として販売するリサイクル店だ。幹線とはいえ近くに駅や商店街はなく、昼間の人通りは多いとは言えない。しかし夕方ともなると、10〜20歳代を中心とする顧客が続々と車や自転車で同店に乗りつけて来る。 「これが今日、買い取った商品です」。
著者
森田 健嗣
出版者
京都大学大学院アジア・アフリカ地域研究研究科
雑誌
アジア・アフリカ地域研究 (ISSN:13462466)
巻号頁・発行日
vol.15, no.1, pp.1-19, 2015-11

This paper discusses the decolonization process of Taiwanese aborigines. China, which governed Taiwan after World War II, was unaware of the existence of Taiwanese aborigines. Thus, they merely acted on the understanding that the people of the plains in Taiwan welcomed the government officials of the mother country. While a few aborigines had started a movement for decolonization after the 228 Incident of 1947, the movement was quickly suppressed. The following then happened in the 1950s. The administrator excluded all of the Chinese Communist Party, which was considered to be an "enemy." Furthermore, unitary policies evolved in Taiwan, such as national language education and the policy to make the mountains like the plains. Additionally, the aborigines' traditional religion began to be replaced by Christianity. Taiwanese aborigines were minorities, and the Han race was predominant in Taiwan. Because of these religious and policy-related changes, it became difficult to maintain and pass on the aborigines' original culture.
著者
森田 健嗣
出版者
京都大学大学院アジア・アフリカ地域研究研究科
雑誌
アジア・アフリカ地域研究 (ISSN:13462466)
巻号頁・発行日
vol.15, no.1, pp.1-19, 2015

This paper discusses the decolonization process of Taiwanese aborigines. China, which governed Taiwan after World War II, was unaware of the existence of Taiwanese aborigines. Thus, they merely acted on the understanding that the people of the plains in Taiwan welcomed the government officials of the mother country. While a few aborigines had started a movement for decolonization after the 228 Incident of 1947, the movement was quickly suppressed. The following then happened in the 1950s. The administrator excluded all of the Chinese Communist Party, which was considered to be an "enemy." Furthermore, unitary policies evolved in Taiwan, such as national language education and the policy to make the mountains like the plains. Additionally, the aborigines' traditional religion began to be replaced by Christianity. Taiwanese aborigines were minorities, and the Han race was predominant in Taiwan. Because of these religious and policy-related changes, it became difficult to maintain and pass on the aborigines' original culture.